D P Eisen

Summary

Affiliation: Royal Melbourne Hospital
Country: Australia

Publications

  1. pmc Activation of the lectin pathway of complement in experimental human keratitis with Pseudomonas aeruginosa
    Michael Osthoff
    Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville VIC, Australia Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Vic, Australia
    Mol Vis 20:38-45. 2014
  2. pmc Significance of mannose-binding lectin deficiency and nucleotide-binding oligomerization domain 2 polymorphisms in Staphylococcus aureus bloodstream infections: a case-control study
    Michael Osthoff
    Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, Australia Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Victoria, Australia
    PLoS ONE 8:e76218. 2013
  3. doi request reprint Manifold beneficial effects of acetyl salicylic acid and nonsteroidal anti-inflammatory drugs on sepsis
    Damon P Eisen
    Victorian Infectious Diseases Service, Royal Melbourne Hospital, Grattan St, Parkville, VIC 3050, Australia
    Intensive Care Med 38:1249-57. 2012
  4. doi request reprint Acetyl salicylic acid usage and mortality in critically ill patients with the systemic inflammatory response syndrome and sepsis
    Damon P Eisen
    Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Crit Care Med 40:1761-7. 2012
  5. pmc Limited polymorphism in Plasmodium falciparum ookinete surface antigen, von Willebrand factor A domain-related protein from clinical isolates
    Jack S Richards
    Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, Grattan St, Parkville, Victoria, 3050, Australia
    Malar J 5:55. 2006
  6. doi request reprint No association between mannose-binding lectin deficiency and H1N1 2009 infection observed during the first season of this novel pandemic influenza virus
    Damon P Eisen
    Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Hum Immunol 72:1091-4. 2011
  7. doi request reprint Mannose-binding lectin deficiency does not appear to predispose to cryptococcosis in non-immunocompromised patients
    Damon P Eisen
    Centre for Clinical Research Excellence in Infectious Diseases, Victorian Infectious Diseases Service, Royal Melbourne Hospital, Victoria, Australia
    Med Mycol 46:371-5. 2008
  8. doi request reprint Low serum mannose-binding lectin level increases the risk of death due to pneumococcal infection
    Damon P Eisen
    Centre for Clinical Research Excellence in Infectious Diseases, Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Clin Infect Dis 47:510-6. 2008
  9. doi request reprint Decreased viral load and symptoms of polyomavirus-associated chronic interstitial cystitis after intravesical cidofovir treatment
    Damon P Eisen
    Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Australia
    Clin Infect Dis 48:e86-8. 2009
  10. doi request reprint Reduced valve replacement surgery and complication rate in Staphylococcus aureus endocarditis patients receiving acetyl-salicylic acid
    Damon P Eisen
    Victorian Infectious Diseases Service, Royal Melbourne Hospital, Grattan St, Parkville, Victoria 3050, Australia
    J Infect 58:332-8. 2009

Collaborators

Detail Information

Publications32

  1. pmc Activation of the lectin pathway of complement in experimental human keratitis with Pseudomonas aeruginosa
    Michael Osthoff
    Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville VIC, Australia Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Vic, Australia
    Mol Vis 20:38-45. 2014
    ..aeruginosa. However, studies addressing the role of the lectin pathway in P. aeruginosa MK are lacking. Hence, we sought to determine the activity of the lectin pathway in human MK caused by P. aeruginosa...
  2. pmc Significance of mannose-binding lectin deficiency and nucleotide-binding oligomerization domain 2 polymorphisms in Staphylococcus aureus bloodstream infections: a case-control study
    Michael Osthoff
    Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, Australia Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Victoria, Australia
    PLoS ONE 8:e76218. 2013
    ..aureus) bloodstream infections (BSI) in animal models, but human data are limited. Here, we investigated the role of MBL deficiency and NOD2 mutations in the predisposition to and severity of S. aureus BSI...
  3. doi request reprint Manifold beneficial effects of acetyl salicylic acid and nonsteroidal anti-inflammatory drugs on sepsis
    Damon P Eisen
    Victorian Infectious Diseases Service, Royal Melbourne Hospital, Grattan St, Parkville, VIC 3050, Australia
    Intensive Care Med 38:1249-57. 2012
    ..Acetyl salicylic acid (ASA) and nonsteroidal anti-inflammatory drugs (NSAIDs) may have potential as adjunctive agents for sepsis...
  4. doi request reprint Acetyl salicylic acid usage and mortality in critically ill patients with the systemic inflammatory response syndrome and sepsis
    Damon P Eisen
    Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Crit Care Med 40:1761-7. 2012
    ..We sought to determine whether acetyl salicylic acid administration at the time of development of systemic inflammatory response syndrome is associated with reduced mortality...
  5. pmc Limited polymorphism in Plasmodium falciparum ookinete surface antigen, von Willebrand factor A domain-related protein from clinical isolates
    Jack S Richards
    Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, Grattan St, Parkville, Victoria, 3050, Australia
    Malar J 5:55. 2006
    ..In comparison to other stages of the malaria lifecycle, sexual stage antigens are under less immune selection pressure and hence are likely to have limited antigenic diversity...
  6. doi request reprint No association between mannose-binding lectin deficiency and H1N1 2009 infection observed during the first season of this novel pandemic influenza virus
    Damon P Eisen
    Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Hum Immunol 72:1091-4. 2011
    ..MBL appears to currently have little impact on innate immune responses to H1N1 2009 influenza...
  7. doi request reprint Mannose-binding lectin deficiency does not appear to predispose to cryptococcosis in non-immunocompromised patients
    Damon P Eisen
    Centre for Clinical Research Excellence in Infectious Diseases, Victorian Infectious Diseases Service, Royal Melbourne Hospital, Victoria, Australia
    Med Mycol 46:371-5. 2008
    ..It appears that MBL deficiency is not associated with cryptococcosis in non-immunocompromised hosts. Beta errors consequent on the small number of patients studied may account for the lack of association...
  8. doi request reprint Low serum mannose-binding lectin level increases the risk of death due to pneumococcal infection
    Damon P Eisen
    Centre for Clinical Research Excellence in Infectious Diseases, Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Clin Infect Dis 47:510-6. 2008
    ..However, MBL deficiency has not been rigorously defined, and associations with sepsis outcomes have not been subjected to multivariable analysis...
  9. doi request reprint Decreased viral load and symptoms of polyomavirus-associated chronic interstitial cystitis after intravesical cidofovir treatment
    Damon P Eisen
    Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Australia
    Clin Infect Dis 48:e86-8. 2009
    ..Another patient had milder symptoms of cystitis and intermittent polyomavirus shedding. Polyomaviruses, particularly BK virus, may cause some cases of interstitial cystitis...
  10. doi request reprint Reduced valve replacement surgery and complication rate in Staphylococcus aureus endocarditis patients receiving acetyl-salicylic acid
    Damon P Eisen
    Victorian Infectious Diseases Service, Royal Melbourne Hospital, Grattan St, Parkville, Victoria 3050, Australia
    J Infect 58:332-8. 2009
    ..To assess the influence of acetyl-salicylic acid (ASA) on clinical outcomes in Staphylococcus aureus infective endocarditis (SA-IE)...
  11. ncbi request reprint Mannose-binding lectin deficiency and respiratory tract infection
    Damon P Eisen
    Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Vic, Australia
    J Innate Immun 2:114-22. 2010
    ..The available literature suggests that it may also be of benefit in MBL deficient patients with severe pneumonia. This review concentrates on clinical associations between MBL deficiency and susceptibility to respiratory tract infection...
  12. pmc Antibodies elicited in adults by a primary Plasmodium falciparum blood-stage infection recognize different epitopes compared with immune individuals
    Damon P Eisen
    Clinical Centre for Research Excellence in Infectious Diseases, Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Malar J 6:86. 2007
    ....
  13. pmc Low mannose-binding lectin complement activation function is associated with predisposition to Legionnaires' disease
    D P Eisen
    Clinical Centre for Research Excellence in Infectious Diseases, Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Clin Exp Immunol 149:97-102. 2007
    ..There was no significant interval change in MBL function or level after a mean of 46 days. MBL complement activation functional deficiency appears to predispose to Legionnaires' disease...
  14. ncbi request reprint Complete resolution of pulmonary Rhizopus oryzae infection with itraconazole treatment: more evidence of the utility of azoles for zygomycosis
    D P Eisen
    Infectious Diseases Unit, Royal Brisbane Hospital, Herston, Queensland, Australia
    Mycoses 47:159-62. 2004
    ..This patient was cured through the use of itraconazole alone and the literature on the utility of azole antifungals for zygomycosis is reviewed...
  15. ncbi request reprint Low mannose-binding lectin function is associated with sepsis in adult patients
    Damon P Eisen
    Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Vic, Australia
    FEMS Immunol Med Microbiol 48:274-82. 2006
    ..Deficiency of MBL function appears to be associated with bloodstream infection and the development of septic shock. High MBL levels may be protective against severe sepsis...
  16. pmc Mannose-binding lectin and susceptibility to tuberculosis: a meta-analysis
    J T Denholm
    Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Melbourne, Vic, Australia
    Clin Exp Immunol 162:84-90. 2010
    ..This analysis suggests that the relatively poorly characterized MBL2 genotypes reported are not associated significantly with susceptibility to pulmonary TB infection, but high MBL serum levels may be...
  17. ncbi request reprint Tropical pulmonary eosinophilia: a rare cause of cough in immigrants to Australia
    Michelle K Yong
    Victorian Infectious Diseases Service, Royal Melbourne Hospital, Melbourne, Vic, Australia
    Med J Aust 187:416-8. 2007
  18. ncbi request reprint Impact of mannose-binding lectin on susceptibility to infectious diseases
    Damon P Eisen
    Infectious Diseases Unit, Royal Brisbane Hospital, Herston, Queensland, Australia
    Clin Infect Dis 37:1496-505. 2003
    ..Numerous other potential infectious disease associations have been described. Therapy to supplement low MBL levels is being explored using either plasma-derived or recombinant material...
  19. doi request reprint Donor mannose-binding lectin deficiency increases the likelihood of clinically significant infection after liver transplantation
    Daniel L Worthley
    RBWH Foundation Clinical Research Centre, Royal Brisbane and Women s Hospital and Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Clin Infect Dis 48:410-7. 2009
    ..We report a large, retrospective study that examined the association between MBL status and clinically significant infection following orthotopic liver transplantation...
  20. ncbi request reprint Antibody recognition of heterologous variant surface antigens after a single Plasmodium falciparum infection in previously naive adults
    Salenna R Elliott
    Department of Medicine, The University of Melbourne, Royal Melbourne Hospital, Victoria, Australia
    Am J Trop Med Hyg 76:860-4. 2007
    ..Together these data suggest that a single P. falciparum infection can be sufficient to induce antibodies reactive with several PfEMP1 variants, although the repertoire of target epitopes they recognize may still be restricted...
  21. pmc If there is an evolutionary selection pressure for the high frequency of MBL2 polymorphisms, what is it?
    D P Eisen
    Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Vic, Australia Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Vic, Australia
    Clin Exp Immunol 176:165-71. 2014
    ..Ultimately, consideration of the context for possible future therapeutic manipulation of MBL means that this can proceed independently of resolution of the evolutionary forces that have shaped MBL2 polymorphism. ..
  22. ncbi request reprint Alterations in Plasmodium falciparum genotypes during sequential infections suggest the presence of strain specific immunity
    Damon P Eisen
    Department of Microbiology, Monash University, Clayton, Victoria, Australia
    Am J Trop Med Hyg 67:8-16. 2002
    ..This strain was predominant at the first time point but had disappeared at the fourth time point. This significant change in malaria genotypes could be due to strain-specific immunity developing in this population...
  23. doi request reprint Aspergillus arachnoiditis post intrathecal baclofen pump insertion
    V Vivek
    Department of General Medicine, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    J Clin Neurosci 20:1159-60. 2013
    ..He subsequently presented with distinct neurological decline secondary to an intrathecal baclofen pump infection with Aspergillus terreus. ..
  24. ncbi request reprint Mannose binding lectin acute phase activity in patients with severe infection
    M M Dean
    Co operative Research Centre for Vaccine Technology, Australian Red Cross Blood Service, Adelaide St, Brisbane, Queensland, Australia
    J Clin Immunol 25:346-52. 2005
    ..These findings indicate MBL demonstrates a variable acute phase response in the clinical setting of sepsis and septic shock...
  25. pmc Personal protective equipment and antiviral drug use during hospitalization for suspected avian or pandemic influenza
    Ashwin Swaminathan
    Austin Health, Melbourne, Victoria, Australia
    Emerg Infect Dis 13:1541-7. 2007
    ..Up to 41% of HCW close contacts would have qualified for postexposure antiviral prophylaxis. These data indicate that many current national stockpiles of PPE and antiviral medication are likely inadequate for a pandemic...
  26. ncbi request reprint Increase in prevalence of nosocomial non-Candida albicans candidaemia and the association of Candida krusei with fluconazole use
    W Hope
    Infectious Diseases Unit, Royal Brisbane Hospital, Brisbane, Queensland, Australia
    J Hosp Infect 50:56-65. 2002
    ..78, P<0.001). There was no evidence of spread of C. krusei using random amplification of polymorphic DNA, suggesting the appearance of this organism was due to the selection pressure exerted by fluconazole...
  27. ncbi request reprint The body as fortress: innate immune surveillance
    R M Minchinton
    Australian Red Cross Blood Service, Post Office Box 10325 Adelaide Street, Brisbane, Queensland, Australia
    Vox Sang 87:30-4. 2004
  28. pmc Characterization of the antibody response against Plasmodium falciparum erythrocyte membrane protein 1 in human volunteers
    Darren R Krause
    Malaria Drug Resistance and Chemotherapy, Infectious Diseases and Immunology Division, The Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, QLD 4029, Australia
    Infect Immun 75:5967-73. 2007
    ..falciparum suggests that the anti-PfEMP1 antibodies often persisted for more than 100 days after a single infection. These results help to further our understanding of the development of acquired immunity to P. falciparum infections...
  29. ncbi request reprint Cryptococcal dementia in a patient with sarcoidosis
    Siddhartha Deb
    Melbourne Neuropsychiatry Centre, Royal Melbourne Hospital, Melbourne, Vic, Australia
    Med J Aust 184:86-7. 2006
  30. ncbi request reprint A human phase 1 vaccine clinical trial of the Plasmodium falciparum malaria vaccine candidate apical membrane antigen 1 in Montanide ISA720 adjuvant
    Allan Saul
    The Cooperative Research Centre for Vaccine Technology, Brisbane, QLD, Australia
    Vaccine 23:3076-83. 2005
    ..Six of the 29 subjects seroconverted. Only one of these developed a high antibody titre. However, the interpretation of this trial was compromised by a loss of potency of the formulated vaccine during the course of the study...
  31. ncbi request reprint An outbreak of Plasmodium vivax malaria in Far North Queensland, 2002
    Jeffrey N Hanna
    Tropical Public Health Unit, Queensland Health, PO Box 1103, Cairns, QLD 4870, Australia
    Med J Aust 180:24-8. 2004
    ..To describe an outbreak of Plasmodium vivax malaria in Far North Queensland in 2002...
  32. ncbi request reprint Immunity to malaria after administration of ultra-low doses of red cells infected with Plasmodium falciparum
    David J Pombo
    Queensland Institute of Medical Research, Australian Centre for International and Tropical Health and Nutrition, and Cooperative Research Centre for Vaccine Technology, PO Royal Brisbane Hospital, Australia
    Lancet 360:610-7. 2002
    ..Our aim was to ascertain whether or not development of cell-mediated immunity to Plasmodium falciparum blood-stage infection could be induced in human beings by exposure to malaria parasites in very low density...