Stephen M Davis

Summary

Affiliation: Royal Melbourne Hospital
Country: Australia

Publications

  1. doi request reprint Perfusion/Diffusion mismatch is valid and should be used for selecting delayed interventions
    Stephen Davis
    Department of Medicine, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Melbourne, Victoria, 3050, Australia
    Transl Stroke Res 3:188-97. 2012
  2. ncbi request reprint CT screening for thrombolysis: uncertainties remain
    Stephen M Davis
    Department of Neurology, Royal Melbourne Hospital and the University of Melbourne, Parkville Victoria 3050, Australia
    Stroke 34:822-3. 2003
  3. ncbi request reprint Ischemic penumbra: MRI or PET
    Stephen M Davis
    Department of Neurology, Royal Melbourne Hospital, Parkville Victoria 3050, Australia
    Stroke 34:2536. 2003
  4. ncbi request reprint Blood pressure reduction and ACE inhibition in secondary stroke prevention: mechanism uncertain
    Stephen M Davis
    Department of Neurology, Royal Melbourne Hospital, University of Melbourne, Australia
    Stroke 34:1335-6. 2003
  5. ncbi request reprint Steroids for stroke: another potential therapy discarded prematurely?
    Stephen M Davis
    Department of Neurology, Royal Melbourne Hospital and University of Melbourne, Parkville, Victoria, Australia 3050
    Stroke 35:230-1. 2004
  6. ncbi request reprint Stroke unit design: high tech versus low tech
    Stephen M Davis
    Department of Neurology, Royal Melbourne Hospital and University of Melbourne, Parkville, Victoria, Australia 3050
    Stroke 35:1021. 2004
  7. ncbi request reprint Why lacunar syndromes are different and important
    Stephen M Davis
    Department of Neurology, Royal Melbourne Hospital and University of Melbourne, Parkville, Victoria, Australia 3050
    Stroke 35:1780-1. 2004
  8. ncbi request reprint The stroke-prone state: rapid assessment of transient ischemic attacks
    Stephen M Davis
    Department of Neurology, Royal Melbourne Hospital, University of Melbourne, Australia
    Stroke 37:1140. 2006
  9. ncbi request reprint Selection of thrombolytic therapy beyond 3 h using magnetic resonance imaging
    Stephen M Davis
    Department of Neurology, Royal Melbourne Hospital University of Melbourne, Australia
    Curr Opin Neurol 18:47-52. 2005
  10. doi request reprint Thunderclap headache: CT and lumbar puncture but occasionally more!
    Stephen M Davis
    Royal Melbourne Hospital, Melbourne Neuroscience Centre, Parkville, Australia
    Stroke 39:1396. 2008

Detail Information

Publications115 found, 100 shown here

  1. doi request reprint Perfusion/Diffusion mismatch is valid and should be used for selecting delayed interventions
    Stephen Davis
    Department of Medicine, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Melbourne, Victoria, 3050, Australia
    Transl Stroke Res 3:188-97. 2012
    ....
  2. ncbi request reprint CT screening for thrombolysis: uncertainties remain
    Stephen M Davis
    Department of Neurology, Royal Melbourne Hospital and the University of Melbourne, Parkville Victoria 3050, Australia
    Stroke 34:822-3. 2003
  3. ncbi request reprint Ischemic penumbra: MRI or PET
    Stephen M Davis
    Department of Neurology, Royal Melbourne Hospital, Parkville Victoria 3050, Australia
    Stroke 34:2536. 2003
  4. ncbi request reprint Blood pressure reduction and ACE inhibition in secondary stroke prevention: mechanism uncertain
    Stephen M Davis
    Department of Neurology, Royal Melbourne Hospital, University of Melbourne, Australia
    Stroke 34:1335-6. 2003
  5. ncbi request reprint Steroids for stroke: another potential therapy discarded prematurely?
    Stephen M Davis
    Department of Neurology, Royal Melbourne Hospital and University of Melbourne, Parkville, Victoria, Australia 3050
    Stroke 35:230-1. 2004
  6. ncbi request reprint Stroke unit design: high tech versus low tech
    Stephen M Davis
    Department of Neurology, Royal Melbourne Hospital and University of Melbourne, Parkville, Victoria, Australia 3050
    Stroke 35:1021. 2004
  7. ncbi request reprint Why lacunar syndromes are different and important
    Stephen M Davis
    Department of Neurology, Royal Melbourne Hospital and University of Melbourne, Parkville, Victoria, Australia 3050
    Stroke 35:1780-1. 2004
  8. ncbi request reprint The stroke-prone state: rapid assessment of transient ischemic attacks
    Stephen M Davis
    Department of Neurology, Royal Melbourne Hospital, University of Melbourne, Australia
    Stroke 37:1140. 2006
  9. ncbi request reprint Selection of thrombolytic therapy beyond 3 h using magnetic resonance imaging
    Stephen M Davis
    Department of Neurology, Royal Melbourne Hospital University of Melbourne, Australia
    Curr Opin Neurol 18:47-52. 2005
    ..There are a number of current prospective trials that are testing the hypothesis that the presence of the penumbra will predict thrombolytic responders beyond 3 h...
  10. doi request reprint Thunderclap headache: CT and lumbar puncture but occasionally more!
    Stephen M Davis
    Royal Melbourne Hospital, Melbourne Neuroscience Centre, Parkville, Australia
    Stroke 39:1396. 2008
  11. ncbi request reprint Using mismatch on MRI to select thrombolytic responders: an attractive hypothesis awaiting confirmation
    Stephen M Davis
    Department of Neurology, Royal Melbourne Hospital, and University of Melbourne, Parkville, Australia
    Stroke 36:1106-7. 2005
  12. ncbi request reprint Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial
    Stephen M Davis
    Department of Neurology, Royal Melbourne Hospital, University of Melbourne, Australia
    Lancet Neurol 7:299-309. 2008
    ..We aimed to test whether alteplase given 3-6 h after stroke onset promotes reperfusion and attenuates infarct growth in patients who have a mismatch in perfusion-weighted MRI (PWI) and diffusion-weighted MRI (DWI)...
  13. ncbi request reprint Carotid stenting is unproven: randomization is a must
    Stephen M Davis
    Department of Neurology, Royal Melbourne Hospital and the University of Melbourne, Parkville, Victoria, Australia
    Stroke 33:2522-3. 2002
  14. pmc Treating the acute stroke patient as an emergency: current practices and future opportunities
    S Davis
    Department of Neurology, The Royal Melbourne Hospital and University of Melbourne, Victoria, Australia
    Int J Clin Pract 60:399-407. 2006
    ..Virtually all stroke patients would benefit from receiving multidisciplinary care in acute stroke units...
  15. ncbi request reprint Unruptured brain arteriovenous malformations: another asymptomatic conundrum
    Stephen M Davis
    Royal Melbourne Hospital, Parkville, Australia
    Stroke 38:3312. 2007
  16. ncbi request reprint Medical management of haemorrhagic stroke
    S M Davis
    Department of Neurology, Royal Melbourne Hospital, University of Melbourne, Melbourne, VIC 3050, Australia
    Crit Care Resusc 7:185-8. 2005
    ..It is accepted that corticosteroids should not be used in ICH and may worsen outcomes. The management of acute hypertension is controversial and guidelines are based on little direct evidence...
  17. ncbi request reprint Hematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage
    S M Davis
    Department of Neurology, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia
    Neurology 66:1175-81. 2006
    ..Although volume of intracerebral hemorrhage (ICH) is a predictor of mortality, it is unknown whether subsequent hematoma growth further increases the risk of death or poor functional outcome...
  18. ncbi request reprint Advances in penumbra imaging with MR
    Stephen M Davis
    Department of Neurology, Royal Melbourne Hospital, Parkville, Vic, Australia
    Cerebrovasc Dis 17:23-7. 2004
    ..Such trials can be performed with 100-200 patients randomized between treated and control groups and provide a biological signal of efficacy with only 10% of the sample size required for a Phase III study...
  19. ncbi request reprint Persistent poststroke hyperglycemia is independently associated with infarct expansion and worse clinical outcome
    Tracey A Baird
    Department of Neurology, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Stroke 34:2208-14. 2003
    ..We measured the blood glucose profile after acute ischemic stroke and correlated it with infarct volume changes using T2- and diffusion-weighted MRI...
  20. ncbi request reprint Pre-stroke CHADS2 and CHA2DS2-VASc scores are useful in stratifying three-month outcomes in patients with and without atrial fibrillation
    Hans T H Tu
    University Department of Medicine and Department of Neurology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Vic, Australia
    Cerebrovasc Dis 36:273-80. 2013
    ..We investigated whether these scores are associated with 3-month stroke outcomes and evaluated the utility of these scores in stratifying 3-month stroke outcomes in both patients with and without AF...
  21. ncbi request reprint The benefits of intravenous thrombolysis relate to the site of baseline arterial occlusion in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET)
    Deidre A De Silva
    Department of Neurology, Royal Melbourne Hospital, Melbourne, Australia
    Stroke 41:295-9. 2010
    ..We studied the influence of site and degree of arterial obstruction patients enrolled in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET)...
  22. pmc Failure of collateral blood flow is associated with infarct growth in ischemic stroke
    Bruce C V Campbell
    Departments of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    J Cereb Blood Flow Metab 33:1168-72. 2013
    ..68, P<0.001). Deterioration in Tmax hypoperfusion severity was also significantly associated with absolute (P=0.003) and relative (P=0.002) infarct growth. Collateral flow is dynamic and failure is associated with infarct growth. ..
  23. pmc Fluid-attenuated inversion recovery hyperintensity in acute ischemic stroke may not predict hemorrhagic transformation
    Bruce C V Campbell
    Department of Medicine and Neurology, The Royal Melbourne Hospital, University of Melbourne, Parkville, Vic, Australia
    Cerebrovasc Dis 32:401-5. 2011
    ..Given the important implications for clinical practice, we examined the prevalence of FLAIR hyperintensity in patients 3-6 h from stroke onset and its relationship to parenchymal hematoma (PH)...
  24. ncbi request reprint Visual assessment of perfusion-diffusion mismatch is inadequate to select patients for thrombolysis
    Bruce C V Campbell
    Department of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Parkville, Vic, Australia
    Cerebrovasc Dis 29:592-6. 2010
    ..We compared the accuracy of visually rating console-generated images with offline volumetric measurements using data from the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET)...
  25. doi request reprint Expediting MRI-based proof-of-concept stroke trials using an earlier imaging end point
    Martin Ebinger
    Department of Neurology, The Royal Melbourne Hospital, Grattan Street, Parkville, Australia
    Stroke 40:1353-8. 2009
    ..These trials could be expedited if subacute diffusion-weighted imaging lesion volume replaced late T2-weighted lesion volume as the primary end point...
  26. pmc Pretreatment diffusion- and perfusion-MR lesion volumes have a crucial influence on clinical response to stroke thrombolysis
    Mark W Parsons
    Department of Neurology, John Hunter Hospital, University of Newcastle, Newcastle, New South Wales, Australia
    J Cereb Blood Flow Metab 30:1214-25. 2010
    ..Clinical responsiveness to IV-tPA, and stroke outcome, depends more on baseline DWI and PWI lesion volumes than the extent of perfusion-diffusion mismatch...
  27. doi request reprint Regional very low cerebral blood volume predicts hemorrhagic transformation better than diffusion-weighted imaging volume and thresholded apparent diffusion coefficient in acute ischemic stroke
    Bruce C V Campbell
    Department of Neurology, Royal Melbourne Hospital, Grattan Street, Parkville VIC 3050, Australia
    Stroke 41:82-8. 2010
    ..Preliminary studies have suggested that very low cerebral blood volume (VLCBV) predicts HT. We compared HT prediction by VLCBV and DWI using data from the EPITHET study...
  28. ncbi request reprint Pathophysiological determinants of worse stroke outcome in atrial fibrillation
    Hans T H Tu
    Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Grattan Street, Parkville, VIC 3050, Australia
    Cerebrovasc Dis 30:389-95. 2010
    ..We aimed to elucidate the pathophysiological determinants of poorer stroke outcome in patients with AF using systematic MRI data from the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET)...
  29. pmc Advanced imaging improves prediction of hemorrhage after stroke thrombolysis
    Bruce C V Campbell
    Departments of Medicine and Neurology, Melbourne Brain Centre at Royal Melbourne Hospital, University of Melbourne, Parkville, Australia
    Ann Neurol 73:510-9. 2013
    ..We aimed to compare these parameters, validate VLCBV in an independent cohort using DEFUSE study data, and investigate the interaction of VLCBV with regional reperfusion...
  30. doi request reprint Prediction of poststroke hemorrhagic transformation using computed tomography perfusion
    Nawaf Yassi
    From the Departments of Medicine and Neurology, Melbourne Brain Centre N Y, A B, S M D, B C V C, and Department of Radiology N Y, S C, G S, P M D, B C V C, Royal Melbourne Hospital, and Florey Institute of Neuroscience and Mental Health G A D, University of Melbourne, Parkville, Victoria, Australia and Priority Research Centre for Translational Neuroscience and Mental Health, University of Newcastle and Hunter Medical Research Institute, Newcastle, New South Wales, Australia M W P, C R L
    Stroke 44:3039-43. 2013
    ..Intracerebral hemorrhage is a serious potential complication of stroke thrombolysis. We investigated the optimal computed tomography perfusion (CTP) parameter to predict cerebral parenchymal hematoma (PH) in acute ischemic stroke...
  31. doi request reprint Moving beyond a single perfusion threshold to define penumbra: a novel probabilistic mismatch definition
    Yoshinari Nagakane
    National Stroke Research Institute, Florey Neuroscience Institutes, Austin Health, University of Melbourne, Victoria 3053, Australia
    Stroke 43:1548-55. 2012
    ....
  32. ncbi request reprint Apparent diffusion coefficient thresholds do not predict the response to acute stroke thrombolysis
    Poh Sien Loh
    Department of Neurology, Royal Melbourne Hospital, Melbourne, Victoria, Australia
    Stroke 36:2626-31. 2005
    ..IV tissue plasminogen activator (tPA) is associated with tissue salvage. We hypothesized that tPA would lower the ADC threshold for infarction...
  33. doi request reprint EPITHET: Positive Result After Reanalysis Using Baseline Diffusion-Weighted Imaging/Perfusion-Weighted Imaging Co-Registration
    Yoshinari Nagakane
    National Stroke Research Institute, University of Melbourne, Australia
    Stroke 42:59-64. 2011
    ..We hypothesized that assessing the extent of mismatch by coregistration of perfusion and diffusion MRI maps may more accurately allow the effects of alteplase vs placebo to be evaluated...
  34. ncbi request reprint The use of PWI and DWI measures in the design of "proof-of-concept" stroke trials
    P Alan Barber
    Department of Neurology, Royal Melbourne Hospital, Parkville, VIC 3050, Australia
    J Neuroimaging 14:123-32. 2004
    ..The authors used serial magnetic resonance perfusion-weighted imaging (PWI) and diffusion-weighted imaging (DWI) to determine whether major reperfusion and the attenuation of infarct expansion are associated with improved stroke outcome...
  35. doi request reprint Multiattribute selection of acute stroke imaging software platform for Extending the Time for Thrombolysis in Emergency Neurological Deficits (EXTEND) clinical trial
    Leonid Churilov
    National Stroke Research Institute, Florey Neuroscience Institutes, Melbourne, Australia
    Int J Stroke 8:204-10. 2013
    ..5 hours and for stroke patient care outcomes...
  36. ncbi request reprint Assessing reperfusion and recanalization as markers of clinical outcomes after intravenous thrombolysis in the echoplanar imaging thrombolytic evaluation trial (EPITHET)
    Deidre A De Silva
    Division of Neurosciences, Royal Melbourne Hospital, Grattan Street, Parkville 3050, Victoria, Australia
    Stroke 40:2872-4. 2009
    ..We aimed to prove that the beneficial impact of recanalization with intravenous tissue plasminogen activator on clinical outcomes is attributable to reperfusion in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET)...
  37. doi request reprint Assessing response to stroke thrombolysis: validation of 24-hour multimodal magnetic resonance imaging
    Bruce C V Campbell
    BMedSc, FRACP, Department of Neurology, Royal Melbourne Hospital, Grattan Street, Parkville, Victoria 3050, Australia
    Arch Neurol 69:46-50. 2012
    ..Imaging is used as a surrogate for clinical outcome in early-phase stroke trials. Assessment of infarct growth earlier than the standard 90 days used for clinical end points may be equally accurate and more practical...
  38. ncbi request reprint Rapid assessment of perfusion-diffusion mismatch
    Ken Butcher
    Department of Neurology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia
    Stroke 39:75-81. 2008
    ..We examined interrater variability in PWI/DWI volume measurements and developed a rapid assessment tool based on the Alberta Stroke Program Early CT Scores (ASPECTS) system...
  39. ncbi request reprint Stroke thrombolysis: save a minute, save a day
    Atte Meretoja
    From the Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia A M, M K, G A D, L C Departments of Neurology and Medicine, Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia A M, S M D Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland A M, T T, M K UCLA Stroke Center, Los Angeles, CA J L S John Hunter Hospital and the Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia M W P and School of Mathematical and Geospatial Sciences, RMIT University, Melbourne, Australia M K, L C
    Stroke 45:1053-8. 2014
    ..Stroke thrombolysis is highly time-critical, but data on long-term effects of small reductions in treatment delays have not been available. Our objective was to quantify patient lifetime benefits gained from faster treatment...
  40. ncbi request reprint Comparison of computed tomography perfusion and magnetic resonance imaging perfusion-diffusion mismatch in ischemic stroke
    Bruce C V Campbell
    Department of Medicine, The Melbourne Brain Centre at Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    Stroke 43:2648-53. 2012
    ..We tested the correspondence of computed tomography perfusion (CTP)-derived mismatch with contemporaneous perfusion-diffusion magnetic resonance imaging (MRI)...
  41. pmc The infarct core is well represented by the acute diffusion lesion: sustained reversal is infrequent
    Bruce C V Campbell
    Department of Medicine and Neurology, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    J Cereb Blood Flow Metab 32:50-6. 2012
    ..Clinically relevant DLR is uncommon and rarely alters perfusion-diffusion mismatch. The acute diffusion lesion is generally a reliable signature of the infarct core...
  42. ncbi request reprint Insular cortical ischemia is independently associated with acute stress hyperglycemia
    Louise E Allport
    Department of Neurology, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    Stroke 35:1886-91. 2004
    ..We tested the hypothesis that damage to the insular cortex, a site with autonomic connectivity, results in hyperglycemia reflecting sympathoadrenal dysregulation...
  43. doi request reprint Density and shape as CT predictors of intracerebral hemorrhage growth
    Christen D Barras
    Department of Neurology, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Stroke 40:1325-31. 2009
    ..We hypothesized that irregular hematoma shape and density heterogeneity, reflecting active, multifocal bleeding or a variable bleeding time course, would predict ICH growth...
  44. ncbi request reprint Clinical-diffusion mismatch and benefit from thrombolysis 3 to 6 hours after acute stroke
    Martin Ebinger
    Department of Neurology, Royal Melbourne Hospital, Parkville, Australia
    Stroke 40:2572-4. 2009
    ..We hypothesized that in the 3- to 6-hour time window, the effect of tPA was significantly greater in patients with CDM than in patients without CDM...
  45. ncbi request reprint A multicenter, randomized, controlled study to investigate EXtending the time for Thrombolysis in Emergency Neurological Deficits with Intra-Arterial therapy (EXTEND-IA)
    Bruce C V Campbell
    Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    Int J Stroke 9:126-32. 2014
    ....
  46. doi request reprint Cerebral blood flow is the optimal CT perfusion parameter for assessing infarct core
    Bruce C V Campbell
    Department of Medicine, The Royal Melbourne Hospital, University of Melbourne, Grattan Street, Parkville VIC 3050, Australia
    Stroke 42:3435-40. 2011
    ..Cerebral blood volume (CBV) has been proposed as the best predictor of infarct core. We tested CBV against other common CTP parameters using contemporaneous diffusion MRI...
  47. doi request reprint A multicentre, randomized, double-blinded, placebo-controlled Phase III study to investigate EXtending the time for Thrombolysis in Emergency Neurological Deficits (EXTEND)
    Henry Ma
    National Stroke Research Institute, Florey Neuroscience Institutes, Austin Health, University of Melbourne, Heidelberg Heights, Victoria, Australia
    Int J Stroke 7:74-80. 2012
    ....
  48. ncbi request reprint Acute hyperglycemia adversely affects stroke outcome: a magnetic resonance imaging and spectroscopy study
    Mark W Parsons
    Royal Melbourne Hospital Echoplanar Imaging Stroke Study Group and Department of Medicine, University of Melbourne, Parkville VIC, Australia
    Ann Neurol 52:20-8. 2002
    ..These findings support the need for randomized controlled trials of aggressive glycemic control in acute stroke...
  49. ncbi request reprint Examining the lacunar hypothesis with diffusion and perfusion magnetic resonance imaging
    Richard P Gerraty
    Department of Neurology, Royal Melbourne Hospital, Melbourne, Victoria, Australia
    Stroke 33:2019-24. 2002
    ..New MRI techniques may allow more accurate determination of the stroke mechanism soon after admission...
  50. doi request reprint Rapid neurological recovery after intravenous tissue plasminogen activator in stroke: prognostic factors and outcome
    Bejoy Machumpurath
    Department of Neurology, Royal Melbourne Hospital, Melbourne, VIC 3050, Australia
    Cerebrovasc Dis 31:278-83. 2011
    ..This has previously not been systematically studied. We aimed to examine its incidence, predictive factors and correlation with clinical outcomes...
  51. ncbi request reprint Fragmentation of the classical magnetic resonance mismatch "penumbral" pattern with time
    Henry Ma
    National Stroke Research Institute, Austin Health, University of Melbourne, 300 Waterdale Rd, Heidelberg West, VIC 3081, Australia
    Stroke 40:3752-7. 2009
    ..Because of variable rates of tissue salvage, we hypothesized that this pattern may fragment over time and may be influenced by vessel patency, mismatch volume, and infarct core location...
  52. doi request reprint Reperfusion after 4.5 hours reduces infarct growth and improves clinical outcomes
    Miguel R Picanço
    Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia
    Int J Stroke 9:266-9. 2014
    ..The currently proven time window for thrombolysis in ischemic stroke is 4.5 h. Beyond this, the risks and benefits of thrombolysis are uncertain...
  53. doi request reprint Pilot study of intravenous glyburide in patients with a large ischemic stroke
    Kevin N Sheth
    From the Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Yale University School of Medicine, New Haven, CT K N S Division of Neurocritical Care and Emergency Neurology, Department of Neurology W T K and Division of Neuroradiology, Department of Radiology A J Y, Massachusetts General Hospital, Boston Department of Public Health Services, Medical University of South Carolina, Charleston J J E Department of Neurology, Michael E DeBakey VA Medical, Baylor College of Medicine, Houston, TX T A K, P M Department of Neurology, Klinik und Poliklinik fur Neurologie, Kopf und Neurozentrum, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany G T Department of Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Australia B C, G A D, S M D Department of Neurology, Stanford University School of Medicine, CA G W A Remedy Pharmaceuticals, Inc, New York, NY S J and Departments of Neurosurgery J M S and Neurology B J S, University of Maryland School of Medicine, Baltimore
    Stroke 45:281-3. 2014
    ..We assessed the feasibility of recruiting and treating patients with severe stroke while obtaining preliminary information on the safety and tolerability of RP-1127 (glyburide for injection)...
  54. ncbi request reprint Differential prognosis of isolated cortical swelling and hypoattenuation on CT in acute stroke
    Kenneth S Butcher
    Department of Neurology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia
    Stroke 38:941-7. 2007
    ..The hypothesis that these signs result from different pathophysiological processes was tested by comparing CT with diffusion and perfusion- weighted MRI...
  55. doi request reprint CT perfusion improves diagnostic accuracy and confidence in acute ischaemic stroke
    Bruce C V Campbell
    Department of Medicine, Melbourne Brain Centre at Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    J Neurol Neurosurg Psychiatry 84:613-8. 2013
    ..CT perfusion (CTP) is rapid and accessible for emergency ischaemic stroke diagnosis. The feasibility of introducing CTP and diagnostic accuracy versus non-contrast CT (NCCT) in a tertiary hospital were assessed...
  56. ncbi request reprint Diffusion- and perfusion-weighted MRI response to thrombolysis in stroke
    Mark W Parsons
    Royal Melbourne Hospital Echoplanar Imaging Stroke Study Group, Melbourne, Australia
    Ann Neurol 51:28-37. 2002
    ..This has implications for the use of diffusion- and perfusion-weighted imaging in selecting and monitoring patients for thrombolytic therapy...
  57. ncbi request reprint The influence of diabetes mellitus and hyperglycaemia on stroke incidence and outcome
    Tracey A Baird
    Department of Neurology, Royal Melbourne Hospital, Melbourne, Australia
    J Clin Neurosci 9:618-26. 2002
    ..Clinicians responsible for stroke patients should be aware of the importance of adequate glycaemic control in both primary and secondary prevention of stroke...
  58. doi request reprint The hidden mismatch: an explanation for infarct growth without perfusion-weighted imaging/diffusion-weighted imaging mismatch in patients with acute ischemic stroke
    Henry K Ma
    National Stroke Research Institute, Austin Health, University of Melbourne, 300 Waterdale Road, Heidelberg West, Victoria 3081, Australia
    Stroke 42:662-8. 2011
    ..We hypothesized that this observation may be attributable to the presence of undetected "hidden mismatch," which may become obvious when coregistration techniques are used...
  59. doi request reprint Frequent early cardiac complications contribute to worse stroke outcome in atrial fibrillation
    Hans T H Tu
    University Department of Medicine, University of Melbourne, Melbourne, Vic, Australia
    Cerebrovasc Dis 32:454-60. 2011
    ..This might have important implications for acute stroke management in patients with AF...
  60. ncbi request reprint Controversy: the essence of medical debate
    Geoffrey A Donnan
    National Stroke Research Institute, Austin and Repatriation Medical Center and the University of Melbourne, Victoria, Australia
    Stroke 34:372-3. 2003
  61. ncbi request reprint Neuroimaging, the ischaemic penumbra, and selection of patients for acute stroke therapy
    Geoffrey A Donnan
    National Stroke Research Institute, Austin and Repatriation Medical Centre, University of Melbourne, West Heidelberg, Victoria, Australia
    Lancet Neurol 1:417-25. 2002
    ..Future developments in imaging technologies may provide other opportunities for surrogate outcome studies...
  62. ncbi request reprint Association of aspirin resistance with increased stroke severity and infarct size
    Amy S Y Zheng
    Melbourne Brain Centre, Department of Medicine, The University of Melbourne, Australia
    JAMA Neurol 70:208-13. 2013
    ..To investigate the relationship between aspirin resistance and clinical and neuroimaging measures of stroke severity in acute stroke patients...
  63. doi request reprint Helsinki model cut stroke thrombolysis delays to 25 minutes in Melbourne in only 4 months
    Atte Meretoja
    From the Departments of Neurology and Medicine A M, L W, M U, N Y, B Y, P H, S M D, B C V C, Nursing L W, and Emergency Department M T, The Royal Melbourne Hospital, University of Melbourne, Parkville, Australia and Department of Neurology A M, Helsinki University Central Hospital, Finland
    Neurology 81:1071-6. 2013
    ..To test the transferability of the Helsinki stroke thrombolysis model that achieved a median 20-minute door-to-needle time (DNT) to an Australian health care setting...
  64. doi request reprint The role of bolus delay and dispersion in predictor models for stroke
    Lisa Willats
    Melbourne Brain Centre, 245 Burgundy Street, Heidelberg, Victoria, 3084, Australia
    Stroke 43:1025-31. 2012
    ..This work investigates the infarct risk associated with delay/dispersion using multiparametric predictor models...
  65. doi request reprint How to make better use of thrombolytic therapy in acute ischemic stroke
    Geoffrey A Donnan
    Florey Neuroscience Institutes, University of Melbourne, Level 2, 161 Barry Street, Carlton South, VIC 3053, Australia
    Nat Rev Neurol 7:400-9. 2011
    ..Elimination of prehospital and in-hospital delays is an urgent priority...
  66. ncbi request reprint Hyperglycaemia and the ischaemic brain: continuous glucose monitoring and implications for therapy
    Louise E Allport
    Department of Neurology, Royal Melbourne Hospital, Parkville, VIC 3050, Australia
    Curr Diabetes Rev 4:245-57. 2008
    ....
  67. ncbi request reprint Acute stroke thrombolysis with intravenous tissue plasminogen activator in an Australian tertiary hospital
    Cassandra E I Szoeke
    Department of Neurology, Royal Melbourne Hospital, Parkville, Vic
    Med J Aust 178:324-8. 2003
    ..To report initial experience with the use of intravenous tissue plasminogen activator (tPA) to treat acute ischaemic stroke at an Australian tertiary-care hospital...
  68. doi request reprint Warfarin-associated intracerebral hemorrhage: volume, anticoagulation intensity and location
    Minmin Ma
    Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, PR China
    J Neurol Sci 332:75-9. 2013
    ..Although warfarin-associated intracerebral hemorrhages have greater volumes, there is uncertainty about the effects of location. We aimed to investigate the influence of warfarin on hematoma volume and location...
  69. ncbi request reprint Stroke drug development: usually, but not always, animal models
    Geoffrey A Donnan
    National Stroke Research Institute, Austin and Repatriation Medical Centre, University of Melbourne, Melbourne, Australia
    Stroke 36:2326. 2005
  70. ncbi request reprint The role of blood pressure lowering before and after stroke
    Geoffrey A Donnan
    National Stroke Research Institute, Austin and Repatriation Medical Centre, University of Melbourne, West Heidelberg, and Department of Neurology, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Curr Opin Neurol 16:81-6. 2003
    ..There have been a number of significant randomized controlled trials which may influence management in each of these three categories...
  71. ncbi request reprint Salvaging the ischaemic penumbra: more than just reperfusion?
    Thanh G Phan
    National Stroke Research Institute, West Heidelberg, Victoria, Australia
    Clin Exp Pharmacol Physiol 29:1-10. 2002
    ..Both animal and human models of cerebral ischaemia imaged using magnetic resonance and positron emission tomography techniques will be discussed...
  72. ncbi request reprint Penumbral selection of patients for trials of acute stroke therapy
    Geoffrey A Donnan
    National Stroke Research Institute, Austin Health, University of Melbourne, Australia
    Lancet Neurol 8:261-9. 2009
    ..Recent advances in penumbral imaging technology should enable a phase III alteplase trial to be done beyond 4.5 h by use of techniques to select patients with penumbral tissue...
  73. doi request reprint Stroke
    Geoffrey A Donnan
    National Stroke Research Institute, Austin Hospital, University of Melbourne, Melbourne, Victoria, Australia
    Lancet 371:1612-23. 2008
    ..These advances have exposed a worldwide shortage of stroke health-care workers, especially in developing countries...
  74. doi request reprint Plasminogen activation and thrombolysis for ischemic stroke
    Robert L Medcalf
    Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia
    Int J Stroke 7:419-25. 2012
    ..Furthermore, we will also provide an overview of recent and current trials assessing tissue-type plasminogen activator and related thrombolytic agents as well as novel approaches for the treatment of ischemic stroke...
  75. ncbi request reprint A pilot study of resistance to aspirin in stroke patients
    Daniel Bennett
    Departments of Neurology, Royal Melbourne Hospital and University of Melbourne, Grattan Street, Parkville, Victoria 3050, Australia
    J Clin Neurosci 15:1204-9. 2008
    ..88; 95% confidence interval 0.54-29.87; p=0.18). This study shows that aspirin resistance is prevalent within the Australian ischaemic stroke population...
  76. ncbi request reprint Recommendations for the relationship between sponsors and investigators in the design and conduct of clinical stroke trials
    Geoffrey A Donnan
    National Stroke Research Institute, Department of Neurology, Austin and Repatriation Medical Centre, University of Melbourne, West Heidelberg, Victoria, Australia
    Stroke 34:1041-5. 2003
    ..Both parties need benchmarks or recommendations to act as a reference point when trials are initiated and conducted. These recommendations are designed to fulfill this role...
  77. ncbi request reprint Stenting for middle cerebral artery stenosis: inevitable but when and how
    Geoffrey A Donnan
    National Stroke Research Institute, Heidelberg Heights, Victoria, Australia
    Stroke 38:1422. 2007
  78. ncbi request reprint Refining the perfusion-diffusion mismatch hypothesis
    K S Butcher
    Department of Neurology, Royal Melbourne Hospital, University of Melbourne, Australia
    Stroke 36:1153-9. 2005
    ..There is no accepted standardized definition of PWI-DWI mismatch. We compared common mismatch definitions in the initial 40 EPITHET patients...
  79. ncbi request reprint Perfusion thresholds in acute stroke thrombolysis
    K Butcher
    Department of Neurology, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Stroke 34:2159-64. 2003
    ..Identification of threshold perfusion measures that predict infarction may assist in the selection of patients for thrombolysis...
  80. ncbi request reprint Brain imaging in transient ischemic attack--redefining TIA
    Aleksandra M Pavlovic
    Department of Neurology, Royal Melbourne Hospital, Grattan Street, Parkville, Melbourne, Victoria 3050, Australia
    J Clin Neurosci 17:1105-10. 2010
    ..Alongside clinical judgement, use of MRI has the potential to change the management of TIA patients and is the imaging modality of choice for this condition...
  81. doi request reprint Neuroprotection: still achievable in humans
    Geoffrey A Donnan
    Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    Stroke 39:525. 2008
  82. ncbi request reprint When to measure lipid profile after stroke?
    Bernard Yan
    Department of Neurology, Royal Melbourne Hospital, Melbourne, Australia
    Cerebrovasc Dis 19:234-8. 2005
    ..We therefore aimed to determine the optimal time for lipid measurements after stroke. We hypothesized that TC would acutely decrease after stroke and return to baseline by 12 weeks...
  83. ncbi request reprint Risk factor management and depression post-stroke: the value of an integrated model of care
    Jacques Joubert
    Department of Neurology, Royal Melbourne Hospital, Parkville, Australia
    J Clin Neurosci 13:84-90. 2006
    ....
  84. ncbi request reprint Basilar artery thrombosis: recanalization is the key
    Stephen M Davis
    Royal Melbourne Hospital, Australia
    Stroke 37:2440. 2006
  85. ncbi request reprint Effective prophylaxis for deep venous thrombosis after stroke: both low-dose anticoagulation and stockings for most cases
    Stephen M Davis
    Department of Neurology, Royal Melbourne Hospital and University of Melbourne, Parkville, Victoria, Australia 3050
    Stroke 35:2910. 2004
  86. ncbi request reprint MRI and stroke: why has it taken so long?
    Geoffrey A Donnan
    National Stroke Research Institute, Austin Hospital, University of Melbourne, Melbourne, Victoria 3081, Australia
    Lancet 369:252-4. 2007
  87. doi request reprint Integrated care improves risk-factor modification after stroke: initial results of the Integrated Care for the Reduction of Secondary Stroke model
    J Joubert
    Department of Neurology, Royal Melbourne Hospital, Melbourne, Australia
    J Neurol Neurosurg Psychiatry 80:279-84. 2009
    ..The aim was to implement and evaluate an integrated care programme in stroke...
  88. ncbi request reprint Evidence-based care and outcomes of acute stroke managed in hospital specialty units
    Brendan K Duffy
    Department of Medicine, Flinders University, Bedford Park, SA
    Med J Aust 178:318-23. 2003
    ..To assess the use of evidence-based investigations and treatments in patients with acute stroke in selected Australian hospitals and to compare management and outcomes between stroke and other types of hospital specialty unit...
  89. ncbi request reprint Serum calcium as prognosticator in ischemic stroke
    Bruce Ovbiagele
    Stroke Center and Department of Neurology, University of California at Los Angeles Medical Center, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Stroke 39:2231-6. 2008
    ..Calcium (Ca(2+)) plays a role in the cellular and molecular pathways of ischemic neuronal death. We evaluated the impact of both early and delayed Ca(2+) levels on clinical outcomes from acute ischemic stroke...
  90. ncbi request reprint Dynamics of intraventricular hemorrhage in patients with spontaneous intracerebral hemorrhage: risk factors, clinical impact, and effect of hemostatic therapy with recombinant activated factor VII
    Thorsten Steiner
    Department of Neurology, Univesity of Heidelberg, Heidelberg, Germany
    Neurosurgery 59:767-73; discussion 773-4. 2006
    ..To evaluate predictors of intraventricular hemorrhage (IVH) and IVH growth, impact of IVH growth on outcome, and impact of recombinant activated factor VII (rFVIIa) in patients with intracerebral hemorrhage (ICH)...
  91. ncbi request reprint Proof-of-principle phase II MRI studies in stroke: sample size estimates from dichotomous and continuous data
    Thanh G Phan
    Stroke 37:2521-5. 2006
    ..We have formed an international collaborative group to assemble larger datasets and from these have generated sample size tables for MRI-based infarct expansion as the outcome measure...
  92. ncbi request reprint Relationship between severity of MR perfusion deficit and DWI lesion evolution
    Mark W Parsons
    Neurology 58:1707; author reply 1707. 2002
  93. ncbi request reprint Recombinant activated factor VII for acute intracerebral hemorrhage: US phase IIA trial
    Stephan A Mayer
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neurocrit Care 4:206-14. 2006
    ..We conducted this trial to evaluate the safety of activated recombinant factor VII (rFVIIa; NovoSeven) for preventing early hematoma growth in acute ICH...
  94. ncbi request reprint NXY-059 for acute ischemic stroke
    Kennedy R Lees
    Acute Stroke Unit and Cerebrovascular Clinic, University Department of Medicine and Therapeutics, Gardiner Institute, Western Infirmary, Glasgow, United Kingdom
    N Engl J Med 354:588-600. 2006
    ..NXY-059 is a free-radical-trapping agent that is neuroprotective in animal models of stroke. We tested whether it would reduce disability in humans after acute ischemic stroke...
  95. ncbi request reprint Thrombolysis for stroke: defining the time window
    Stephen M Davis
    Stroke 33:495-6. 2002
  96. ncbi request reprint Surgery for intracerebral hemorrhage: an evidence-poor zone
    Geoffrey A Donnan
    The National Stroke Research Institute, Austin and Repatriation Medical Centre, Level 1, Neuroscience Bldg, Banksia Street, Heidelberg VIC 3084 Australia
    Stroke 34:1569-70. 2003
  97. ncbi request reprint Can the time window for administration of thrombolytics in stroke be increased?
    Geoffrey A Donnan
    National Stroke Research Institute, Austin and Repatriation Medical Centre, 300 Waterdale Road, West Heidelberg, Victoria 3081, Australia
    CNS Drugs 17:995-1011. 2003
    ..Should these means of extending the time window for thrombolysis prove successful, a more widespread use of this form of acute stroke therapy will be possible...
  98. ncbi request reprint Additional outcomes and subgroup analyses of NXY-059 for acute ischemic stroke in the SAINT I trial
    Kennedy R Lees
    Acute Stroke Unit and Cerebrovascular Clinic, University Department of Medicine and Therapeutics, Gardiner Institute, Western Infirmary, 44 Church St, Glasgow, Scotland G11 6NT
    Stroke 37:2970-8. 2006
    ..NXY-059 is a free radical-trapping neuroprotectant demonstrated to reduce disability from ischemic stroke. We conducted analyses on additional end points and sensitivity analyses to confirm our findings...
  99. ncbi request reprint Determinants of intracerebral hemorrhage growth: an exploratory analysis
    Joseph P Broderick
    Department of Neurology, The Neuroscience Institute, University of Cincinnati Medical Center, Cincinnati, OH, USA
    Stroke 38:1072-5. 2007
    ..We report an exploratory analysis from a randomized study of recombinant activated factor VII (rFVIIa) in patients with intracerebral hemorrhage (ICH) examining potential factors associated with hemorrhage growth...
  100. doi request reprint NXY-059 for the treatment of acute stroke: pooled analysis of the SAINT I and II Trials
    Hans Christoph Diener
    Department of Neurology, University of Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Stroke 39:1751-8. 2008
    ..SAINT I and II were randomized, placebo-controlled, double-blind trials to investigate the efficacy of NXY-059 in patients with AIS...
  101. ncbi request reprint Risk of thromboembolic events in controlled trials of rFVIIa in spontaneous intracerebral hemorrhage
    Michael N Diringer
    Department of Neurology, Campus Box 8111, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Stroke 39:850-6. 2008
    ..Despite low incidences of such events in rFVIIa-treated hemophiliacs, the frequency in older patients with more atherosclerosis and immobility has yet to be defined...