Research Topics
Species | Anne Bernadette ChangSummaryAffiliation: Royal Children's Hospital Country: Australia Publications
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Publications
Relation between measurements of cough severityA B Chang
Department of Respiratory Medicine, Royal Children s Hospital Foundation, Brisbane, Australia
Arch Dis Child 88:57-60. 2003..While the relation between determinants of asthma severity is known, that for cough is unknown. We hypothesised that cough sensitivity changes relate to changes in cough scores and objectively measured cough frequency...
Agreement in surfactant measurements of sputum induced with hypertonic and normal salineAnne B Chang
Department of Respiratory Medicine, Royal Children s Hospital, Brisbane and University of Queensland, Australia
Respirology 8:41-4. 2003..However, the influence of hypertonic saline on DPPC content of sputum is unknown. In this study the level of DPPC in induced sputum obtained using hypertonic saline is examined and compared with that obtained using normal saline...
Exacerbations in cystic fibrosis: 4--Non-cystic fibrosis bronchiectasisA B Chang
Department of Respiratory Medicine, Royal Children s Hospital, Herston Road, Brisbane, Queensland 4029, Australia
Thorax 63:269-76. 2008..Some of the management issues are common to non-CF and CF bronchiectasis, but it would be unwise to extrapolate from CF studies to non-CF bronchiectasis. In some situations this may be harmful...- CoughAnne B Chang
Menzies School of Health Research, Charles Darwin University, Queensland Children s Respiratory Centre, Royal Children s Hospital, Brisbane, Queensland 4029, Australia
Pediatr Clin North Am 56:19-31, ix. 2009..In all children with cough, exacerbation factors should be sought and intervention options for cessation advised or initiated. Parental expectations and specific concerns should also be sought and addressed... - Pediatric cough: children are not miniature adultsAnne B Chang
Queensland Children s Respiratory Centre, Royal Children s Hospital, Herston, Brisbane, QLD, 4029, Australia
Lung 188:S33-40. 2010..Indeed, there is some evidence that an empirical approach is potentially harmful; this is related to the use of medications and the delay in obtaining a correct diagnosis such as missed foreign body aspiration... - A cough algorithm for chronic cough in children: a multicenter, randomized controlled studyAnne Bernadette Chang
FRACP, Old Children s Respiratory Centre, Royal Children s Hospital, Herston, Brisbane, Queensland 4029, Australia
Pediatrics 131:e1576-83. 2013.... - Bronchiectasis exacerbation study on azithromycin and amoxycillin-clavulanate for respiratory exacerbations in children (BEST-2): study protocol for a randomized controlled trialAnne B Chang
Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia
Trials 14:53. 2013.... - A multicenter study on chronic cough in children : burden and etiologies based on a standardized management pathwayAnne B Chang
Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia
Chest 142:943-50. 2012..We hypothesized that the etiology, but not the burden, of chronic cough in children is dependent on the clinical setting and age... - Antibiotics for bronchiectasis exacerbations in children: rationale and study protocol for a randomised placebo-controlled trialAnne B Chang
Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia
Trials 13:156. 2012.... - Pulmonary innate immunity in children with protracted bacterial bronchitisAnne B Chang
Queensland Children s Respiratory Centre, and Queensland Children s Medical Research Institute, Royal Children s Hospital, Brisbane, Australia
J Pediatr 161:621-5.e1. 2012.... - Emerging drugs for bronchiectasisAnne B Chang
Queensland Children s Medical Research Institute, Royal Children s Hospital, Queensland
Expert Opin Emerg Drugs 17:361-78. 2012..A concerted, global effort to coordinate studies of both the pathophysiology and potential treatments of bronchiectasis, in its many forms, could lead to substantial improvements in outcomes... - Management of bronchiectasis and chronic suppurative lung disease in indigenous children and adults from rural and remote Australian communitiesAnne B Chang
Department of Respiratory Medicine, Royal Children s Hospital, Brisbane, QLD
Med J Aust 189:386-93. 2008..Physiotherapy and exercise should be encouraged, nutrition optimised, environmental pollutants (including tobacco smoke) avoided, and immunisations maintained... - A 5- versus 3-day course of oral corticosteroids for children with asthma exacerbations who are not hospitalised: a randomised controlled trialAnne B Chang
Royal Children s Hospital, Brisbane, QLD, Australia
Med J Aust 189:306-10. 2008..To determine whether a 5-day course of oral prednisolone is superior to a 3-day course in reducing the 2-week morbidity of children with asthma exacerbations who are not hospitalised... - Chronic wet cough: Protracted bronchitis, chronic suppurative lung disease and bronchiectasisA B Chang
Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
Pediatr Pulmonol 43:519-31. 2008..The principles of managing PBB, CSLD and bronchiectasis are the same. Further work is required to improve recognition, diagnosis and management of these causes of chronic wet cough in children... - Calcitonin gene-related peptide relates to cough sensitivity in children with chronic coughA B Chang
Dept of Respiratory Medicine, Royal Children s Hospital, Brisbane, Queensland, Australia
Eur Respir J 30:66-72. 2007..Calcitonin gene-related peptide in bronchoalveolar lavage relates to cough sensitivity and is likely to be important in the pathophysiology of chronic cough... - The impact of viral respiratory infection on the severity and recovery from an asthma exacerbationAnne B Chang
Queensland Children s Respiratory Centre, Royal Children s Hospital, Brisbane, Queensland, Australia
Pediatr Infect Dis J 28:290-4. 2009.... - Lower respiratory tract infectionsAnne B Chang
Child Health Division, Menzies School of Health Research, Charles Darwin University Darwin, Rocklands Drive, Tiwi, NT 0811, Australia
Pediatr Clin North Am 56:1303-21. 2009..The prevention of repeat infections and the early detection and management of chronic lung disease is critical to the long-term respiratory and overall health of these children... - Cough in the pediatric populationAnne B Chang
Queensland Children s Respiratory Centre, Children s Medical Research Institute, Royal Children s Hospital, Herston, Brisbane, Queensland 4029, Australia
Otolaryngol Clin North Am 43:181-98, xii. 2010..This article highlights and focuses the discussion on the cough issues relevant to otolaryngologists... - An objective study of acid reflux and cough in children using an ambulatory pHmetry-cough loggerA B Chang
Queensland Children s Respiratory Centre, Royal Children s Hospital, Herston Rd, Herston, Queensland 4029, Australia
Arch Dis Child 96:468-72. 2011..25 Hz) that limit objective quantification of reflux and cough. The authors aimed to evaluate if there is a temporal association between cough and acid pH in ambulatory children with chronic cough... - Chronic suppurative lung disease and bronchiectasis in children and adults in Australia and New ZealandAnne B Chang
Royal Children s Hospital and Queensland Children s Medical Research Institute, Brisbane, QLD, Australia
Med J Aust 193:356-65. 2010..Individualised long-term use of oral or nebulised antibiotics, corticosteroids, bronchodilators and mucoactive agents may provide a benefit, but are not recommended routinely... - Can a management pathway for chronic cough in children improve clinical outcomes: protocol for a multicentre evaluationA B Chang
Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
Trials 11:103. 2010..Our study tests the hypothesis that the management of chronic cough in children with an evidence-based management pathway is feasible and reliable, and improves clinical outcomes... - Do sex and atopy influence cough outcome measurements in children?Anne B Chang
Queensland Children s Respiratory Centre, Royal Children s Hospital, Herston, Brisbane, QLD, 4029, Australia
Chest 140:324-30. 2011..We hypothesized that in contrast to adult data, sex does not influence cough outcome measures, and atopy is not a determinant of these cough measurements... - Randomized placebo-controlled trial on azithromycin to reduce the morbidity of bronchiolitis in Indigenous Australian infants: rationale and protocolAnne B Chang
Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
Trials 12:94. 2011..Our study tests the hypothesis that the anti-microbial and anti-inflammatory properties of azithromycin, improve the clinical outcomes of Indigenous Australian infants hospitalised with bronchiolitis... - Therapy for cough: where does it fall short?Anne B Chang
Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia
Expert Rev Respir Med 5:503-13. 2011..To achieve new cough therapeutics requires an improved understanding of cough in humans (i.e., not just in animals). Development of new medications without substantial adverse events is long awaited for cough... - Cough throughout life: children, adults and the senileAnne B Chang
Department Respiratory Medicine, Royal Children s Hospital, Herston, Queensland 4029, Australia
Pulm Pharmacol Ther 20:371-82. 2007..Age-related variation in cough sensitivity seems to be well established, but its quantitation and mechanisms require much further research... - A bronchoscopic scoring system for airway secretions--airway cellularity and microbiological validationA B Chang
Department of Respiratory Medicine, Royal Children s Hospital, Brisbane, Queensland, Australia
Pediatr Pulmonol 41:887-92. 2006..The system related well to airway cellularity and neutrophilia, as well as to an airway infective state. However, the system is only complementary to cell counts and cultures and cannot replace these laboratory quantification techniques... - Airway cellularity, lipid laden macrophages and microbiology of gastric juice and airways in children with reflux oesophagitisA B Chang
Department of Paediatrics, University of Queensland, Brisbane, Australia
Respir Res 6:72. 2005..The aims of the study were to compare (1) BAL cellularity and lipid laden macrophage index (LLMI) and, (2) microbiology of BAL and gastric juices of children with GORD (G+) to those without (G-)... - Guidelines for evaluating chronic cough in pediatrics: ACCP evidence-based clinical practice guidelinesAnne B Chang
Department of Respiratory Medicine, Royal Children s Hospital, Herston Rd, Brisbane, QLD 4029, Australia
Chest 129:260S-283S. 2006..To review relevant literature and present evidence-based guidelines to assist general and specialist medical practitioners in the evaluation and management of children who present with chronic cough... - Zinc and vitamin A supplementation in Indigenous Australian children hospitalised with lower respiratory tract infection: a randomised controlled trialAnne B Chang
Department of Respiratory Medicine, Royal Children s Hospital, Herston Road, Herston, Brisbane, QLD 4029, Australia
Med J Aust 184:107-12. 2006..To evaluate the efficacy of supplementation with zinc and vitamin A in Indigenous children hospitalised with acute lower respiratory infection (ALRI)... - Cough quality in children: a comparison of subjective vs. bronchoscopic findingsAnne Bernadette Chang
Dept of Paediatrics and Child Health, University of Queensland, Australia
Respir Res 6:3. 2005..The study aims were to compare (1) cough quality (wet/dry and brassy/non-brassy) to bronchoscopic findings of secretions and tracheomalacia respectively and, (2) parent's vs clinician's evaluation of the cough quality (wet/dry)... - Cough and reflux esophagitis in children: their co-existence and airway cellularityAnne B Chang
Department of Respiratory Medicine, Royal Children s Hospital, Herston, Brisbane, Queensland, Australia
BMC Pediatr 6:4. 2006.... - Diagnosing and preventing chronic suppurative lung disease (CSLD) and bronchiectasisA B Chang
Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT Queensland Children s Respiratory Centre and Queensland Children s Medical Research Institute, Royal Children s Hospital, Brisbane, Australia
Paediatr Respir Rev 12:97-103. 2011..Treatment is aimed at achieving a cure in those at the milder end of the spectrum to limiting further deterioration in those with severe 'irreversible' radiological bronchiectasis... - Cough in children: definitions and clinical evaluationAnne B Chang
Department of Respiratory Medicine, Royal Children s Hospital, Brisbane, Queensland
Med J Aust 184:398-403. 2006..Children should be reassessed within the expected timeframe of response to therapy... - Endoscopic intratracheal carbon dioxide measurements during pediatric flexible bronchoscopyAnne B Chang
Department of Respiratory Medicine, Royal Children s Hospital, Herston, Queensland, Australia
Paediatr Anaesth 14:650-5. 2004..The aim of this study was to describe and validate endoscopic intratracheal CO2 measurements in children undergoing FB under spontaneously breathing GA... - 'Free' surfactant in gastric aspirates and bronchoalveolar lavage in children with and without reflux oesophagitisA B Chang
Department of Respiratory Medicine, Royal Children s Hospital, Queensland, Australia
Intern Med J 36:226-30. 2006.... - The physiology of coughAnne B Chang
Department of Respiratory Medicine, Royal Children s Hospital, Herston Road, Herston, Brisbane, Queensland 4029, Australia
Paediatr Respir Rev 7:2-8. 2006..Plasticity of the peripheral and central afferent pathways in cough has recently been shown to be important in pathological states associated with increased cough. To date, little is known of the developmental aspects of cough... - Systematic review and meta-analysis of randomised controlled trials of gastro-oesophageal reflux interventions for chronic cough associated with gastro-oesophageal refluxA B Chang
Department of Respiratory Medicine, Royal Children s Hospital, Herston, Brisbane, QLD 4029, Australia
BMJ 332:11-7. 2006..To evaluate the efficacy of treatment for gastro-oesophageal reflux disease (GORD) on chronic cough in children and adults without an underlying respiratory disease... - Respiratory morbidity in central Australian Aboriginal children with alveolar lobar abnormalitiesAnne B Chang
Department of Respiratory Medicine, Royal Children s Hospital, Herston Road, Herston, QLD 4006, Australia
Med J Aust 178:490-4. 2003..Participants were to have a predischarge radiograph and be followed up for 12 months... - Effect of inspiratory flow on methacholine challenge in childrenAnne B Chang
Department of Respiratory Medicine, Royal Children s Hospital, Herston, Queensland, Australia
J Asthma 41:349-54. 2004..Laboratories and research measuring change in airway hyperrepsonsiveness to MHC should determine and report reproducibility indices of the challenge so airway hyperresponsiveness changes can be interpreted meaningfully... - Zinc and vitamin A supplementation in Australian Indigenous children with acute diarrhoea: a randomised controlled trialPatricia C Valery
Population Studies and Human Genetics, Queensland Institute of Medical Research, Herston, Australia
Med J Aust 182:530-5. 2005..To evaluate the role of zinc and vitamin A supplementation in the recovery of Indigenous children hospitalised for acute diarrhoea... - Evaluation and outcome of young children with chronic coughJulie M Marchant
Department of Respiratory Medicine, Royal Children s Hospital, Herston 4029, QLD, Australia
Chest 129:1132-41. 2006..To evaluate the use of an adult-based algorithmic approach to chronic cough in a cohort of children with a history of > 3 weeks of cough and to describe the etiology of chronic cough in this cohort... - Asthma and protracted bronchitis: who fares better during an acute respiratory infection?Helen L Petsky
Department of Respiratory Medicine, Royal Children s Hospital, Queensland, Australia
J Paediatr Child Health 45:42-7. 2009..The aim of this study was to determine if children with asthma have more severe ARI episodes compared with children with protracted bronchitis and controls... - Increased risk of hospitalization for acute lower respiratory tract infection among Australian indigenous infants 5-23 months of age following pneumococcal vaccination: a cohort studyKerry Ann F O'Grady
Child Health Division, Menzies School of Health Research, Charles Darwin University, Tiwi, London, England
Clin Infect Dis 50:970-8. 2010..We evaluated this program's effectiveness in reducing the risk of hospitalization for acute lower respiratory tract infection (ALRI) in Northern Territory (NT) Indigenous children aged 5-23 months... - Exacerbations in noncystic fibrosis bronchiectasis: Clinical features and investigationsNitin Kapur
Queensland Children s Respiratory Centre, Royal Children s Hospital, Australia
Respir Med 103:1681-7. 2009..Our aim was to determine the clinical and investigational features of exacerbations in bronchiectasis, the proportion that fail to resolve on oral antibiotics and the factors associated with it... - Prospective assessment of protracted bacterial bronchitis: airway inflammation and innate immune activationJulie M Marchant
Department of Respiratory Medicine, Royal Children s Hospital, Brisbane, Australia
Pediatr Pulmonol 43:1092-9. 2008.... - Hospital-based case-control study of bronchiectasis in indigenous children in Central AustraliaPatricia C Valery
Queensland Institute of Medical Research, Population Studies and Human Genetics, Brisbane, Australia
Pediatr Infect Dis J 23:902-8. 2004.... - What is the burden of chronic cough for families?Julie M Marchant
Department of Respiratory Medicine, Royal Children s Hospital, Herston, Queensland, Australia
Chest 134:303-9. 2008.... - Radiation doses to children during modified barium swallow studiesKelly A Weir
Discipline of Paediatrics and Child Health, School of Medicine, University of Queensland, Level 3 RCH Foundation Building, Royal Children s Hospital, Herston Road, Herston, Queensland, 4029, Australia
Pediatr Radiol 37:283-90. 2007..There are minimal data on radiation doses to infants and children undergoing a modified barium swallow (MBS) study... - Respiratory syncytial virus infection and immunoprophylaxis for selected high-risk children in Central AustraliaSrinivas Bolisetty
Department of Paediatrics, Alice Springs Hospital, Alice Springs, Australia
Aust J Rural Health 13:265-70. 2005..There are limited data on the epidemiology and viral aetiology of bronchiolitis in Central Australia and respiratory syncytial virus (RSV) immunoprophylaxis in an Australian population... - Hospitalisation of Indigenous children in the Northern Territory for lower respiratory illness in the first year of lifeKerry Ann F O'Grady
Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia
Med J Aust 192:586-90. 2010..To describe the epidemiology of acute lower respiratory infection (ALRI) and bronchiectasis in Northern Territory Indigenous infants hospitalised in the first year of life... - Stable prevalence of asthma symptoms in school-aged children in the Torres Strait regionPatricia C Valery
Queensland Institute of Medical Research, The Australian Centre for International and Tropical Health and Nutrition, University of Queensland, Brisbane, Queensland, Australia
Respirology 13:447-51. 2008..To (i) determine if the prevalence of asthma has altered in two previously studied communities and (ii) obtain baseline measures in two further communities in the Torres Strait region, Australia... - Risks of severity and readmission of Indigenous and non-Indigenous children hospitalised for bronchiolitisEmily J Bailey
Queensland Children s Respiratory Centre, Royal Children s Hospital, Brisbane, QLD, Australia
J Paediatr Child Health 45:593-7. 2009..To describe the characteristics of children admitted to Royal Darwin Hospital with bronchiolitis, and to compare the severity of illness and incidence of subsequent readmission in Indigenous and non-Indigenous children... - Is a longer time interval between recombinant human deoxyribonuclease (dornase alfa) and chest physiotherapy better? A multi-center, randomized crossover trialChristine J Wilson
Physiotherapy Department, Royal Children s Hospital, Brisbane, Queensland, Australia
Pediatr Pulmonol 42:1110-6. 2007..The aim of this study was to investigate if a longer time interval between dornase alfa nebulization and chest physiotherapy improves clinical outcomes of subjects with CF... - Oropharyngeal aspiration and pneumonia in childrenKelly Weir
Department of Paediatrics and Child Health, University of Queensland, Herston, Queensland, Australia
Pediatr Pulmonol 42:1024-31. 2007..We conclude that the impact of OPA on development of pneumonia is considerably reduced once other factors in children with multisystem involvement are taken into account... - Respiratory bacterial pathogens in the nasopharynx and lower airways of Australian indigenous children with bronchiectasisKim M Hare
Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
J Pediatr 157:1001-5. 2010..To test the hypothesis that bacterial density, strain diversity, and concordance of pathogens between upper and lower airways are higher in children with bronchiectasis than in those with non-bronchiectatic conditions... - Newly identified respiratory viruses in children with asthma exacerbation not requiring admission to hospitalKatherine E Arden
Queensland Paediatric Infectious Diseases Laboratory, Sir Albert Sakzewski Virus Research Centre, Queensland Children s Medical Research Institute, Royal Children s Hospital and Clinical Medical Virology Centre, University of Queensland, Brisbane, Queensland, Australia
J Med Virol 82:1458-61. 2010..Larger, PCR-based studies are required to elucidate further the true impact of HRV species in childhood asthma exacerbations of both hospitalized and non-hospitalized cohorts... - Longitudinal growth and lung function in pediatric non-cystic fibrosis bronchiectasis: what influences lung function stability?Nitin Kapur
Queensland Children s Respiratory Centre and Queensland Children s Medical Research Institute, Department of Respiratory Medicine, Royal Children s Hospital, Herston, QLD 4029, Australia
Chest 138:158-64. 2010..We longitudinally reviewed lung function and growth in children with non-CF BE and explored biologically plausible factors associated with changes in these parameters over time... - Longitudinal quantification of growth and changes in primary tracheobronchomalacia sites in childrenIan B Masters
School of Medicine, Discipline of Paediatric and Child Health, University of Queensland, Herston, Brisbane, Australia
Pediatr Pulmonol 42:906-13. 2007..Longitudinal follow-up of children with tracheobronchomalacia is essential to improving our understanding of these disorders, yet currently, there is no such data... - Quantified tracheobronchomalacia disorders and their clinical profiles in childrenIan B Masters
School of Medicine, University of Queensland, Brisbane, QLD, Australia
Chest 133:461-7. 2008..The objectives of the study were to prospectively examine the relationship between malacia lesions and their respiratory illness profiles... - The relationship between inflammation and dipalmitoyl phosphatidycholine in induced sputum of children with asthmaAnne B Chang
Flinders University Northern Territory Clinical School, Alice Springs Hospital, Northern Territory, Australia
J Asthma 40:63-70. 2003..In this study we hypothesized that the degree of inflammation influences the level of dipalmitoyl phosphatidycholine (DPPC) in airways of children with asthma... - Evaluation of hospitalisation for indigenous children with malnutrition living in central AustraliaBeth J Russell
Child and Youth Program, Ngaanyatjarra Pitjantjatjara Council, Darwin, Northern Territory
Aust J Rural Health 12:187-91. 2004.... - Relationship between cough, cough receptor sensitivity and asthma in childrenAnne B Chang
Department of Respiratory Medicine, Royal Children s Hospital, QLD 4029, Brisbane, Australia
Pulm Pharmacol Ther 15:287-91. 2002.... - Rates of radiologically confirmed pneumonia as defined by the World Health Organization in Northern Territory Indigenous childrenKerry Ann F O'Grady
Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia
Med J Aust 192:592-5. 2010..To determine the burden of hospitalised, radiologically confirmed pneumonia (World Health Organization protocol) in Northern Territory Indigenous children... - An education intervention for childhood asthma by Aboriginal and Torres Strait Islander health workers: a randomised controlled trialPatricia C Valery
Queensland Institute of Medical Research, and Australian Centre for International and Tropical Health, University of Queensland, Brisbane, QLD, Australia
Med J Aust 192:574-9. 2010..To assess the outcomes of an education intervention for childhood asthma conducted by Australian Indigenous health care workers (IHCWs)... - Inhaled non-steroid anti-inflammatories for children and adults with bronchiectasisSusan J Pizzutto
Child Health Division, Menzies School of Health Research, Charles Darwin University, Royal Darwin Hospital Campus, Darwin, Northern Territory, Australia, 0811
Cochrane Database Syst Rev 4:CD007525. 2010.... - Airway sizes and proportions in children quantified by a video-bronchoscopic techniqueIan B Masters
School of Medicine, University of Queensland, Herston 4029, Brisbane, Australia
BMC Pulm Med 6:5. 2006..The aims of this study were to measure large airway areas, and define proportions and factors that influence airway size in children... - Singing for children and adults with bronchiectasisJung Yoon Irons
Queensland s Children s Respiratory Centre, Royal Children s Hospital, Herston Road, Brisbane, Queensland, Australia, 4029
Cochrane Database Syst Rev 2:CD007729. 2010..Given the simplicity of the potentially beneficial intervention, future randomised controlled trials are required to evaluate singing therapy for people with bronchiectasis...