Jonathan R Carapetis

Summary

Affiliation: Royal Children's Hospital
Country: Australia

Publications

  1. pmc The clinical course of acute otitis media in high-risk Australian Aboriginal children: a longitudinal study
    Katherine B Gibney
    Department of Medicine, Royal Darwin Hospital, Australia
    BMC Pediatr 5:16. 2005
  2. ncbi request reprint The global burden of group A streptococcal diseases
    Jonathan R Carapetis
    Centre for International Child Health, University of Melbourne, Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Australia
    Lancet Infect Dis 5:685-94. 2005
  3. ncbi request reprint Acute rheumatic fever
    Jonathan R Carapetis
    Centre for International Child Health, University of Melbourne Department of Paediatrics and Murdoch Children s Research Institute, Melbourne, Australia
    Lancet 366:155-68. 2005
  4. ncbi request reprint The burden and cost of hospitalised varicella and zoster in Australian children
    Jonathan R Carapetis
    Department of Paediatrics, Murdoch Children s Research Institute, Royal Children s Hospital, University of Melbourne, Melbourne, Australia
    Vaccine 23:755-61. 2004
  5. doi request reprint Prospective surveillance of streptococcal sore throat in a tropical country
    Andrew C Steer
    Centre for International Child Health, University of Melbourne, Melbourne, Australia
    Pediatr Infect Dis J 28:477-82. 2009
  6. ncbi request reprint Acute rheumatic fever and rheumatic heart disease in Fiji: prospective surveillance, 2005-2007
    Andrew C Steer
    Centre for International Child Health, University of Melbourne, Melbourne, Vic
    Med J Aust 190:133-5. 2009
  7. ncbi request reprint Burden of acute sore throat and group A streptococcal pharyngitis in school-aged children and their families in Australia
    Margaret H Danchin
    Department of Paediatrics, University of Melbourne, Melbourne, Australia
    Pediatrics 120:950-7. 2007
  8. pmc Prospective surveillance of invasive group a streptococcal disease, Fiji, 2005-2007
    Andrew C Steer
    University of Melbourne, Melbourne, Victoria, Australia
    Emerg Infect Dis 15:216-22. 2009
  9. ncbi request reprint Strain prevalence, rather than innate virulence potential, is the major factor responsible for an increase in serious group A streptococcus infections
    Susan Rogers
    Department of Paediatrics, University of Melbourne, Melbourne, Australia
    J Infect Dis 195:1625-33. 2007
  10. pmc Normal ranges of streptococcal antibody titers are similar whether streptococci are endemic to the setting or not
    Andrew C Steer
    Centre for International Child Health, University of Melbourne, Melbourne, Victoria, Australia
    Clin Vaccine Immunol 16:172-5. 2009

Collaborators

Detail Information

Publications54

  1. pmc The clinical course of acute otitis media in high-risk Australian Aboriginal children: a longitudinal study
    Katherine B Gibney
    Department of Medicine, Royal Darwin Hospital, Australia
    BMC Pediatr 5:16. 2005
    ..Our aim was to describe the clinical course of AOM and the associated bacterial nasopharyngeal colonisation in a high-risk population of Australian Aboriginal children...
  2. ncbi request reprint The global burden of group A streptococcal diseases
    Jonathan R Carapetis
    Centre for International Child Health, University of Melbourne, Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Australia
    Lancet Infect Dis 5:685-94. 2005
    ..On a global scale, GAS is an important cause of morbidity and mortality. These data emphasise the need to reinforce current control strategies, develop new primary prevention strategies, and collect better data from developing countries...
  3. ncbi request reprint Acute rheumatic fever
    Jonathan R Carapetis
    Centre for International Child Health, University of Melbourne Department of Paediatrics and Murdoch Children s Research Institute, Melbourne, Australia
    Lancet 366:155-68. 2005
    ..The most effective approach for control of ARF and RHD is secondary prophylaxis, which is best delivered as part of a coordinated control programme...
  4. ncbi request reprint The burden and cost of hospitalised varicella and zoster in Australian children
    Jonathan R Carapetis
    Department of Paediatrics, Murdoch Children s Research Institute, Royal Children s Hospital, University of Melbourne, Melbourne, Australia
    Vaccine 23:755-61. 2004
    ..Economic analyses of varicella-zoster virus (VZV) immunisation are sensitive to the costs of hospitalised cases, so there is a need to validate VZV hospitalisation data...
  5. doi request reprint Prospective surveillance of streptococcal sore throat in a tropical country
    Andrew C Steer
    Centre for International Child Health, University of Melbourne, Melbourne, Australia
    Pediatr Infect Dis J 28:477-82. 2009
    ..We designed a study to estimate the prevalence of carriage of beta-hemolytic streptococci (BHS) and the incidence of BHS culture-positive sore throat in school aged children in Fiji...
  6. ncbi request reprint Acute rheumatic fever and rheumatic heart disease in Fiji: prospective surveillance, 2005-2007
    Andrew C Steer
    Centre for International Child Health, University of Melbourne, Melbourne, Vic
    Med J Aust 190:133-5. 2009
    ..To determine the incidence and clinical features of acute rheumatic fever (ARF) in Fiji, and the clinical features of patients presenting to hospital in Fiji with rheumatic heart disease (RHD)...
  7. ncbi request reprint Burden of acute sore throat and group A streptococcal pharyngitis in school-aged children and their families in Australia
    Margaret H Danchin
    Department of Paediatrics, University of Melbourne, Melbourne, Australia
    Pediatrics 120:950-7. 2007
    ..The objective of this study was to determine the incidence, transmission, carriage, and risk factors for group A streptococcal pharyngitis in school-aged children and their families...
  8. pmc Prospective surveillance of invasive group a streptococcal disease, Fiji, 2005-2007
    Andrew C Steer
    University of Melbourne, Melbourne, Victoria, Australia
    Emerg Infect Dis 15:216-22. 2009
    ..Our data support the view that invasive GAS disease is common in developing countries and deserves increased public health attention...
  9. ncbi request reprint Strain prevalence, rather than innate virulence potential, is the major factor responsible for an increase in serious group A streptococcus infections
    Susan Rogers
    Department of Paediatrics, University of Melbourne, Melbourne, Australia
    J Infect Dis 195:1625-33. 2007
    ..We used active, population-based surveillance of invasive GAS disease, serologically confirmed pharyngitis, and carriage to determine whether particular strains were associated with invasive disease...
  10. pmc Normal ranges of streptococcal antibody titers are similar whether streptococci are endemic to the setting or not
    Andrew C Steer
    Centre for International Child Health, University of Melbourne, Melbourne, Victoria, Australia
    Clin Vaccine Immunol 16:172-5. 2009
    ..Data from our study are similar to those found in countries with temperate climates, suggesting that a uniform upper limit of normal for streptococcal serology may be able to be applied globally...
  11. ncbi request reprint Global emm type distribution of group A streptococci: systematic review and implications for vaccine development
    Andrew C Steer
    Centre for International Child Health, University of Melbourne, Australia
    Lancet Infect Dis 9:611-6. 2009
    ....
  12. ncbi request reprint The epidemiology of invasive group A streptococcal disease in Victoria, Australia
    Kerry Ann F O'Grady
    School of Population Health, Department of Paediatrics, University of Melbourne, Melbourne, Vic
    Med J Aust 186:565-9. 2007
    ..To estimate the incidence and severity of invasive group A streptococcal infection in Victoria, Australia...
  13. pmc High burden of impetigo and scabies in a tropical country
    Andrew C Steer
    Centre for International Child Health, University of Melbourne, Melbourne, Australia
    PLoS Negl Trop Dis 3:e467. 2009
    ..Impetigo and scabies are endemic diseases in many tropical countries; however the epidemiology of these diseases is poorly understood in many areas, particularly in the Pacific...
  14. ncbi request reprint Group A streptococcal infections in children
    Andrew C Steer
    Centre for International Child Health, University of Melbourne, Department of Paediatrics, Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Victoria, Australia
    J Paediatr Child Health 43:203-13. 2007
    ....
  15. doi request reprint Skin disease in the first two years of life in Aboriginal children in East Arnhem Land
    Erin McMeniman
    Department of Dermatology, Princess Alexandra Hospital, Brisbane, Queensland, Australia
    Australas J Dermatol 52:270-3. 2011
    ..The most common skin infections affecting children in remote Aboriginal communities are scabies and impetigo. Group A streptococcal skin infections are linked to the high rates of heart and renal disease occurring in Aboriginal Australians...
  16. ncbi request reprint Group A streptococcal vaccines: facts versus fantasy
    Andrew C Steer
    Centre for International Child Health, University of Melbourne, Melbourne, Victoria, Australia
    Curr Opin Infect Dis 22:544-52. 2009
    ..This review provides an overview of progress of the development of group A streptococcal (GAS) vaccines with a focus on recent advances...
  17. ncbi request reprint Acute rheumatic fever and rheumatic heart disease in indigenous populations
    Andrew C Steer
    Department of Paediatrics, Centre for International Child Health, University of Melbourne, Flemington Road, Parkville, 3052, Melbourne, Victoria, Australia
    Pediatr Clin North Am 56:1401-19. 2009
    ....
  18. ncbi request reprint High prevalence of rheumatic heart disease by clinical and echocardiographic screening among children in Fiji
    Andrew C Steer
    Centre for International Child Health, University of Melbourne, Department of Paediatrics, Royal Children s Hospital, Parkville, Melbourne, Vic, Australia 3052
    J Heart Valve Dis 18:327-35; discussion 336. 2009
    ..Many cases of RHD are first detected when they progress to cardiac failure. Screening for RHD represents a means of detecting cases early so that preventative measures to halt the disease progression can be put into place...
  19. doi request reprint Some of the people, some of the time: susceptibility to acute rheumatic fever
    Penelope A Bryant
    Department of Paediatrics, University of Melbourne, Parkville, Australia
    Circulation 119:742-53. 2009
    ..This review explores current understanding about host susceptibility to acute rheumatic fever and provides an overall perspective to the number of studies that have recently addressed this subject...
  20. ncbi request reprint Prevention and treatment of rheumatic heart disease in the developing world
    Andrew C Steer
    Centre for International Child Health, University of Melbourne, Parkville, VIC 3052, Australia
    Nat Rev Cardiol 6:689-98. 2009
    ..RHD will continue to cause high morbidity and mortality among the world's poorest populations unless current prevention initiatives expand and new programs are established...
  21. ncbi request reprint Treatment of sore throat in light of the Cochrane verdict: is the jury still out?
    Margaret H Danchin
    Clinical Research Fellow, University Department of General Paediatrics Murdoch Children s Research Institute, Royal Children s Hospital, Flemington Road, Parkville, VIC 3052, Australia
    Med J Aust 177:512-5. 2002
    ..Surveillance of GAS infections and acute rheumatic fever is needed in Australia, as are further studies of effectiveness (including cost-effectiveness) of antibiotic treatment of proven GAS pharyngitis...
  22. pmc emm and C-repeat region molecular typing of beta-hemolytic Streptococci in a tropical country: implications for vaccine development
    Andrew C Steer
    Centre for International Child Health, Department of Paediatrics, University of Melbourne, Victoria, Australia
    J Clin Microbiol 47:2502-9. 2009
    ....
  23. ncbi request reprint The burden of group A streptococcal pharyngitis in Melbourne families
    Margaret H Danchin
    University of Melbourne, Department of Paediatrics, Murdoch Children s Research Institute, Melboune, Australia
    Indian J Med Res 119:144-7. 2004
    ..The present study was undertaken to estimate the incidence and costs of GAS pharyngitis in school aged children in Melbourne, Australia. We report here the results after initial 11 months of surveillance...
  24. ncbi request reprint Community epidemiology of human metapneumovirus, human coronavirus NL63, and other respiratory viruses in healthy preschool-aged children using parent-collected specimens
    Stephen B Lambert
    School of Population Health, University of Melbourne, Victoria, Australia
    Pediatrics 120:e929-37. 2007
    ..We also aimed to assess the use of parent collection to obtain an adequate respiratory specimen from acutely unwell children in the community...
  25. doi request reprint Acute rheumatic fever and rheumatic heart disease: incidence and progression in the Northern Territory of Australia, 1997 to 2010
    Joanna G Lawrence
    Department of Paediatrics, Royal Children s Hospital, Melbourne, Australia
    Circulation 128:492-501. 2013
    ..A control program, including a disease register, in the Northern Territory of Australia where the Indigenous population has high rates of ARF and RHD allowed us to examine current disease incidence and progression...
  26. ncbi request reprint Invasive group a streptococcal disease: epidemiology, pathogenesis and management
    Andrew C Steer
    Centre for International Child Health, Department of Paediatrics, The University of Melbourne, Parkville, Vic, Australia
    Drugs 72:1213-27. 2012
    ..Early surgical debridement of necrotic tissue is also an important part of management in cases of necrotizing fasciitis...
  27. doi request reprint East African immigrant children in Australia have poor immunisation coverage
    Georgia A Paxton
    Royal Children s Hospital, Murdoch Childrens Research Institute, Australia
    J Paediatr Child Health 47:888-92. 2011
    ..To provide data on the immunisation status of recently arrived East African children and adolescents in Australia...
  28. ncbi request reprint Current issues in managing group A streptococcal infections
    Jonathan R Carapetis
    Center for International Child Health, University of Melbourne Department of Pediatrics, Murdoch Children s Research Institute, Royal Children s Hospital, Australia
    Adv Exp Med Biol 549:185-90. 2004
  29. ncbi request reprint Acute hematogenous osteomyelitis in children: recognition and management
    Andrew C Steer
    Royal Children s Hospital, Melbourne, Victoria, Australia
    Paediatr Drugs 6:333-46. 2004
    ..Close monitoring and follow-up for at least 2 years are advised to detect complications...
  30. ncbi request reprint Subclinical carditis in rheumatic fever: a systematic review
    Marissa Tubridy-Clark
    Centre for International Child Health, University of Melbourne, Melbourne, Australia
    Int J Cardiol 119:54-8. 2007
    ..We aimed to review the existing literature on the prevalence and outcome of SCC in ARF...
  31. doi request reprint Diagnosis and treatment of invasive group A streptococcal infections
    Andrew C Steer
    Clinical and Public Health Research Fellow University of Melbourne, Centre for International Child Health, Department of Paediatrics, Royal Children s Hospital Melbourne, Flemington Road, Parkville, Victoria, 3052, Australia 613 9345 5522 613 9345 6667
    Expert Opin Med Diagn 2:289-301. 2008
    ..Recent studies suggest that the early use of intravenous immunoglobulin may reduce the need for radical debridement of tissue in cases of necrotising fasciitis...
  32. pmc Validation of an Integrated Management of Childhood Illness algorithm for managing common skin conditions in Fiji
    Andrew C Steer
    Centre for International Child Health, University of Melbourne, Vic, 3052, Australia
    Bull World Health Organ 87:173-9. 2009
    ..To assess the sensitivity of an Integrated Management of Childhood Illness (IMCI) algorithm to detect common skin conditions in children in Fiji...
  33. pmc Comparison of citrated human blood, citrated sheep blood, and defibrinated sheep blood Mueller-Hinton agar preparations for antimicrobial susceptibility testing of Streptococcus pneumoniae isolates
    Catherine Satzke
    Centre for International Child Health, Department of Paediatrics, University of Melbourne, Royal Children s Hospital, Parkville, Victoria, Australia
    J Clin Microbiol 48:3770-2. 2010
    ..The alternate supplements were found to be unsatisfactory, particularly for testing resistant isolates, and therefore are not recommended...
  34. pmc Disease burden and health-care clinic attendances for young children in remote aboriginal communities of northern Australia
    Danielle B Clucas
    Department of Paediatrics, University of Melbourne, Melbourne, Australia
    Bull World Health Organ 86:275-81. 2008
    ..To determine the frequency of presentations and infectious-disease burden at primary health care (PHC) services in young children in two remote Aboriginal communities in tropical northern Australia...
  35. ncbi request reprint Clinical implications of inducible beta-lactamase activity in Gram-negative bacteremia in children
    Robert J Boyle
    Department of Paediatrics, Murdoch Children s Research Institute, Melbourne University, Melbourne, Victoria, Australia
    Pediatr Infect Dis J 21:935-40. 2002
    ..AIM To determine the frequency with which beta-lactam resistance develops during ESCaPPM sepsis in children and the optimal treatment of such sepsis...
  36. pmc High prevalence of asymptomatic vitamin D and iron deficiency in East African immigrant children and adolescents living in a temperate climate
    George McGillivray
    Murdoch Children s Research Institute, Melbourne, Australia
    Arch Dis Child 92:1088-93. 2007
    ..We assessed the pattern of and risk factors for VDD in immigrant East African children living in Melbourne (latitude 37 degrees 49' South)...
  37. ncbi request reprint Group A streptococci from a remote community have novel multilocus genotypes but share emm types and housekeeping alleles with isolates from worldwide sources
    Karen F McGregor
    Department of Infectious Disease Epidemiology, Imperial College, London, United Kingdom
    J Infect Dis 189:717-23. 2004
    ....
  38. ncbi request reprint Impact of single dose azithromycin on group A streptococci in the upper respiratory tract and skin of Aboriginal children
    Tania M Shelby-James
    Menzies School of Health Research, Darwin, Australia
    Pediatr Infect Dis J 21:375-80. 2002
    ..Aboriginal children living in remote Australia experience high rates of bacterial infection such as trachoma, otitis media and streptococcal skin infection, which often progress to associated chronic diseases in later life...
  39. ncbi request reprint Acute rheumatic fever: a chink in the chain that links the heart to the throat?
    Malcolm McDonald
    Infectious Diseases and International Health Unit, Menzies School of Health Research and Charles Darwin University, Darwin, New Territories, Australia
    Lancet Infect Dis 4:240-5. 2004
    ..New understanding of the pathogenesis of ARF would have an immediate effect on primary prevention strategies and vaccine development...
  40. ncbi request reprint Low rates of streptococcal pharyngitis and high rates of pyoderma in Australian aboriginal communities where acute rheumatic fever is hyperendemic
    Malcolm I McDonald
    Tropical and Emerging Infectious Diseases Division, Menzies School of Health Research, Charles Darwin University, Casuarina, NT, Australia
    Clin Infect Dis 43:683-9. 2006
    ..A link between pyoderma and acute rheumatic fever has been proposed but is yet to be proven. Group C beta-hemolytic streptococci and group G beta-hemolytic streptococci have also been also implicated in the pathogenesis...
  41. ncbi request reprint An Australian guideline for rheumatic fever and rheumatic heart disease: an abridged outline
    Jonathan R Carapetis
    Menzies School of Health Research, Charles Darwin University, Darwin, NT
    Med J Aust 186:581-6. 2007
    ..Development of a structured care plan for all patients with a history of ARF or with established RHD, to be recorded in the patient's primary health care record...
  42. ncbi request reprint Apparent contrasting rates of pharyngitis and pyoderma in regions where rheumatic heart disease is highly prevalent
    Malcolm McDonald
    Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    Heart Lung Circ 16:254-9. 2007
    ....
  43. ncbi request reprint Rheumatic heart disease in developing countries
    Jonathan R Carapetis
    Menzies School of Health Research, Charles Darwin University, Casuarina, Northern Territory, Australia
    N Engl J Med 357:439-41. 2007
  44. pmc Epidemiology of Streptococcus dysgalactiae subsp. equisimilis in tropical communities, Northern Australia
    Malcolm McDonald
    Menzies School of Health Research, Charles Darwin University, Casuarina, Northern Territory, Australia
    Emerg Infect Dis 13:1694-700. 2007
    ..These communities already have high levels of streptococcal and poststreptococcal disease. GCS/GGS may increase in importance as it acquires key virulence factors from GAS by lateral gene transfer...
  45. ncbi request reprint Privacy legislation and research
    Jonathan R Carapetis
    Med J Aust 177:523. 2002
  46. ncbi request reprint Streptococcus pyogenes recruits collagen via surface-bound fibronectin: a novel colonization and immune evasion mechanism
    Katrin Dinkla
    Department of Microbial Pathogenecity and Vaccine Research, GBF National Centre for Biotechnology, Braunschweig, Germany
    Mol Microbiol 47:861-9. 2003
    ..Fibronectin-mediated collagen recruitment thus represents a novel aggregation, colonization and immune evasion mechanism of S. pyogenes...
  47. ncbi request reprint Current issues regarding the use of pneumococcal conjugate and polysaccharide vaccines in Australian children
    Grant A Mackenzie
    Menzies School of Health Research, Tropical and Emerging Infectious Diseases Division, Ear Health and Education Unit, Darwin, Northern Territory, Australia
    J Paediatr Child Health 41:201-8. 2005
    ..To present the results of child pneumococcal vaccination studies in the setting of current Australian disease epidemiology and immunization policy, and issues that clinicians should consider in discussions with families...
  48. doi request reprint Acute rheumatic fever: an important differential diagnosis of septic arthritis
    Reapi Mataika
    Department of Paediatrics, Fiji Ministry of Health, Colonial War Memorial Hospital, Suva, Fiji Islands
    J Trop Pediatr 54:205-7. 2008
    ....
  49. ncbi request reprint The high burden of rheumatic heart disease found on autopsy in Fiji
    Pritinesh I P K Singh
    Department of Pathology, Fiji Ministry of Health, Colonial War Memorial Hospital, Suva, Fiji Islands
    Cardiol Young 18:62-9. 2008
    ..Our findings reflect the high burden and early age of death due to rheumatic heart disease in Fiji and the Pacific region generally, and underline the need for early detection and adequate secondary penicillin prophylaxis in this region...
  50. ncbi request reprint B-cell antigen D8/17 is a marker of rheumatic fever susceptibility in Aboriginal Australians and can be tested in remote settings
    Zinta Harrington
    Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia
    Med J Aust 184:507-10. 2006
    ..To test the B-cell antigen D8/17 as a marker of past rheumatic fever (RF) in a predominantly Aboriginal Australian population, and to evaluate technical modifications to allow its use in remote settings...
  51. ncbi request reprint Practical challenges of conducting research into rheumatic fever in remote Aboriginal communities
    Malcolm I McDonald
    Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia
    Med J Aust 184:511-3. 2006
    ..Nevertheless, the study was completed and the results are being returned to the local councils and households. The research team continues to maintain its relationship with each study community...
  52. ncbi request reprint Controlling rheumatic heart disease in developing countries
    Jonathan R Carapetis
    Cardiovasc J S Afr 17:164-5. 2006
  53. pmc Use of a single-nucleotide polymorphism genotyping system to demonstrate the unique epidemiology of methicillin-resistant Staphylococcus aureus in remote aboriginal communities
    Malcolm McDonald
    Menzies School of Health Research, P O Box 41096, Casuarina, 0811 Northern Territory, Australia
    J Clin Microbiol 44:3720-7. 2006
    ..Monthly tracking of SNP-based cc types showed a highly dynamic process. ST75-MRSA-IV appears to be unique to the region and probably evolved de novo in remote Aboriginal communities...
  54. doi request reprint Evaluation of a screening protocol using auscultation and portable echocardiography to detect asymptomatic rheumatic heart disease in Tongan schoolchildren
    Jonathan R Carapetis
    Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Nat Clin Pract Cardiovasc Med 5:411-7. 2008
    ..Screening can detect cases earlier, but there are no screening guidelines...