Bruce C V Campbell

Summary

Affiliation: Royal Melbourne Hospital
Country: Australia

Publications

  1. doi request reprint Endovascular Therapy Proven for Stroke – Finally!
    Bruce C V Campbell
    Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia Electronic address
    Heart Lung Circ 24:733-5. 2015
  2. doi request reprint Endovascular stent thrombectomy: the new standard of care for large vessel ischaemic stroke
    Bruce C V Campbell
    Department of Medicine and Neurology, Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia Electronic address
    Lancet Neurol 14:846-54. 2015
  3. pmc Failure of collateral blood flow is associated with infarct growth in ischemic stroke
    Bruce C V Campbell
    Departments of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    J Cereb Blood Flow Metab 33:1168-72. 2013
  4. doi request reprint CT perfusion improves diagnostic accuracy and confidence in acute ischaemic stroke
    Bruce C V Campbell
    Department of Medicine, Melbourne Brain Centre at Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    J Neurol Neurosurg Psychiatry 84:613-8. 2013
  5. ncbi request reprint Comparison of computed tomography perfusion and magnetic resonance imaging perfusion-diffusion mismatch in ischemic stroke
    Bruce C V Campbell
    Department of Medicine, The Melbourne Brain Centre at Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    Stroke 43:2648-53. 2012
  6. pmc Fluid-attenuated inversion recovery hyperintensity in acute ischemic stroke may not predict hemorrhagic transformation
    Bruce C V Campbell
    Department of Medicine and Neurology, The Royal Melbourne Hospital, University of Melbourne, Parkville, Vic, Australia
    Cerebrovasc Dis 32:401-5. 2011
  7. doi request reprint Cerebral blood flow is the optimal CT perfusion parameter for assessing infarct core
    Bruce C V Campbell
    Department of Medicine, The Royal Melbourne Hospital, University of Melbourne, Grattan Street, Parkville VIC 3050, Australia
    Stroke 42:3435-40. 2011
  8. doi request reprint Assessing response to stroke thrombolysis: validation of 24-hour multimodal magnetic resonance imaging
    Bruce C V Campbell
    BMedSc, FRACP, Department of Neurology, Royal Melbourne Hospital, Grattan Street, Parkville, Victoria 3050, Australia
    Arch Neurol 69:46-50. 2012
  9. pmc The infarct core is well represented by the acute diffusion lesion: sustained reversal is infrequent
    Bruce C V Campbell
    Department of Medicine and Neurology, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    J Cereb Blood Flow Metab 32:50-6. 2012
  10. doi request reprint How much diffusion lesion reversal occurs after treatment within three-hours of stroke onset?
    Bruce C V Campbell
    Departments of Medicine and Neurology, Melbourne Brain Centre at Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    Int J Stroke 8:329-30. 2013

Collaborators

Detail Information

Publications36

  1. doi request reprint Endovascular Therapy Proven for Stroke – Finally!
    Bruce C V Campbell
    Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia Electronic address
    Heart Lung Circ 24:733-5. 2015
    ..We will outline the new evidence, contrast the recent trials with the earlier negative studies and discuss some important differences between acute myocardial infarction and ischaemic stroke and the techniques required to treat them. ..
  2. doi request reprint Endovascular stent thrombectomy: the new standard of care for large vessel ischaemic stroke
    Bruce C V Campbell
    Department of Medicine and Neurology, Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia Electronic address
    Lancet Neurol 14:846-54. 2015
    ....
  3. pmc Failure of collateral blood flow is associated with infarct growth in ischemic stroke
    Bruce C V Campbell
    Departments of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    J Cereb Blood Flow Metab 33:1168-72. 2013
    ..68, P<0.001). Deterioration in Tmax hypoperfusion severity was also significantly associated with absolute (P=0.003) and relative (P=0.002) infarct growth. Collateral flow is dynamic and failure is associated with infarct growth. ..
  4. doi request reprint CT perfusion improves diagnostic accuracy and confidence in acute ischaemic stroke
    Bruce C V Campbell
    Department of Medicine, Melbourne Brain Centre at Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    J Neurol Neurosurg Psychiatry 84:613-8. 2013
    ..CT perfusion (CTP) is rapid and accessible for emergency ischaemic stroke diagnosis. The feasibility of introducing CTP and diagnostic accuracy versus non-contrast CT (NCCT) in a tertiary hospital were assessed...
  5. ncbi request reprint Comparison of computed tomography perfusion and magnetic resonance imaging perfusion-diffusion mismatch in ischemic stroke
    Bruce C V Campbell
    Department of Medicine, The Melbourne Brain Centre at Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    Stroke 43:2648-53. 2012
    ..We tested the correspondence of computed tomography perfusion (CTP)-derived mismatch with contemporaneous perfusion-diffusion magnetic resonance imaging (MRI)...
  6. pmc Fluid-attenuated inversion recovery hyperintensity in acute ischemic stroke may not predict hemorrhagic transformation
    Bruce C V Campbell
    Department of Medicine and Neurology, The Royal Melbourne Hospital, University of Melbourne, Parkville, Vic, Australia
    Cerebrovasc Dis 32:401-5. 2011
    ..Given the important implications for clinical practice, we examined the prevalence of FLAIR hyperintensity in patients 3-6 h from stroke onset and its relationship to parenchymal hematoma (PH)...
  7. doi request reprint Cerebral blood flow is the optimal CT perfusion parameter for assessing infarct core
    Bruce C V Campbell
    Department of Medicine, The Royal Melbourne Hospital, University of Melbourne, Grattan Street, Parkville VIC 3050, Australia
    Stroke 42:3435-40. 2011
    ..Cerebral blood volume (CBV) has been proposed as the best predictor of infarct core. We tested CBV against other common CTP parameters using contemporaneous diffusion MRI...
  8. doi request reprint Assessing response to stroke thrombolysis: validation of 24-hour multimodal magnetic resonance imaging
    Bruce C V Campbell
    BMedSc, FRACP, Department of Neurology, Royal Melbourne Hospital, Grattan Street, Parkville, Victoria 3050, Australia
    Arch Neurol 69:46-50. 2012
    ..Imaging is used as a surrogate for clinical outcome in early-phase stroke trials. Assessment of infarct growth earlier than the standard 90 days used for clinical end points may be equally accurate and more practical...
  9. pmc The infarct core is well represented by the acute diffusion lesion: sustained reversal is infrequent
    Bruce C V Campbell
    Department of Medicine and Neurology, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    J Cereb Blood Flow Metab 32:50-6. 2012
    ..Clinically relevant DLR is uncommon and rarely alters perfusion-diffusion mismatch. The acute diffusion lesion is generally a reliable signature of the infarct core...
  10. doi request reprint How much diffusion lesion reversal occurs after treatment within three-hours of stroke onset?
    Bruce C V Campbell
    Departments of Medicine and Neurology, Melbourne Brain Centre at Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    Int J Stroke 8:329-30. 2013
    ..For the present, it appears that intravenous tissue plasminogen activator rarely achieves substantial permanent reversal of diffusion lesions, even when administered within three-hours...
  11. doi request reprint Pre-stroke CHADS2 and CHA2DS2-VASc scores are useful in stratifying three-month outcomes in patients with and without atrial fibrillation
    Hans T H Tu
    University Department of Medicine and Department of Neurology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Vic, Australia
    Cerebrovasc Dis 36:273-80. 2013
    ..We investigated whether these scores are associated with 3-month stroke outcomes and evaluated the utility of these scores in stratifying 3-month stroke outcomes in both patients with and without AF...
  12. doi request reprint Pathophysiological determinants of worse stroke outcome in atrial fibrillation
    Hans T H Tu
    Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Grattan Street, Parkville, VIC 3050, Australia
    Cerebrovasc Dis 30:389-95. 2010
    ..We aimed to elucidate the pathophysiological determinants of poorer stroke outcome in patients with AF using systematic MRI data from the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET)...
  13. pmc Advanced imaging improves prediction of hemorrhage after stroke thrombolysis
    Bruce C V Campbell
    Departments of Medicine and Neurology, Melbourne Brain Centre at Royal Melbourne Hospital, University of Melbourne, Parkville, Australia
    Ann Neurol 73:510-9. 2013
    ..We aimed to compare these parameters, validate VLCBV in an independent cohort using DEFUSE study data, and investigate the interaction of VLCBV with regional reperfusion...
  14. doi request reprint Regional very low cerebral blood volume predicts hemorrhagic transformation better than diffusion-weighted imaging volume and thresholded apparent diffusion coefficient in acute ischemic stroke
    Bruce C V Campbell
    Department of Neurology, Royal Melbourne Hospital, Grattan Street, Parkville VIC 3050, Australia
    Stroke 41:82-8. 2010
    ..Preliminary studies have suggested that very low cerebral blood volume (VLCBV) predicts HT. We compared HT prediction by VLCBV and DWI using data from the EPITHET study...
  15. doi request reprint Visual assessment of perfusion-diffusion mismatch is inadequate to select patients for thrombolysis
    Bruce C V Campbell
    Department of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Parkville, Vic, Australia
    Cerebrovasc Dis 29:592-6. 2010
    ..We compared the accuracy of visually rating console-generated images with offline volumetric measurements using data from the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET)...
  16. doi request reprint A multicenter, randomized, controlled study to investigate EXtending the time for Thrombolysis in Emergency Neurological Deficits with Intra-Arterial therapy (EXTEND-IA)
    Bruce C V Campbell
    Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    Int J Stroke 9:126-32. 2014
    ....
  17. doi request reprint Prediction of poststroke hemorrhagic transformation using computed tomography perfusion
    Nawaf Yassi
    From the Departments of Medicine and Neurology, Melbourne Brain Centre N Y, A B, S M D, B C V C, and Department of Radiology N Y, S C, G S, P M D, B C V C, Royal Melbourne Hospital, and Florey Institute of Neuroscience and Mental Health G A D, University of Melbourne, Parkville, Victoria, Australia and Priority Research Centre for Translational Neuroscience and Mental Health, University of Newcastle and Hunter Medical Research Institute, Newcastle, New South Wales, Australia M W P, C R L
    Stroke 44:3039-43. 2013
    ..Intracerebral hemorrhage is a serious potential complication of stroke thrombolysis. We investigated the optimal computed tomography perfusion (CTP) parameter to predict cerebral parenchymal hematoma (PH) in acute ischemic stroke...
  18. doi request reprint The effects of alteplase 3 to 6 hours after stroke in the EPITHET-DEFUSE combined dataset: post hoc case-control study
    Toshiyasu Ogata
    FRACP, Level 2 Alan Gilbert Bldg, 161 Barry St, Carlton S Victoria 3053, Australia
    Stroke 44:87-93. 2013
    ..The primary hypothesis was that alteplase would significantly attenuate infarct growth compared with placebo in mismatch-selected patients using coregistration techniques...
  19. doi request reprint Association between baseline peri-infarct magnetic resonance spectroscopy and regional white matter atrophy after stroke
    Nawaf Yassi
    Departments of Medicine and Neurology, Melbourne Brain Centre The Royal Melbourne Hospital, 4 Centre, The Royal Melbourne Hospital, Grattan St, Parkville, Victoria, 3050, Australia
    Neuroradiology 58:3-10. 2016
    ..We investigated the associations between peri-infarct metabolite concentrations measured by quantitative MRS and brain volume change in the infarct hemisphere after stroke...
  20. doi request reprint Worse stroke outcome in atrial fibrillation is explained by more severe hypoperfusion, infarct growth, and hemorrhagic transformation
    Hans T H Tu
    Department of Medicine and Neurology, The Royal Melbourne Hospital, University of Melbourne, Parkville, Vic, Australia
    Int J Stroke 10:534-40. 2015
    ....
  21. doi request reprint The association between lesion location and functional outcome after ischemic stroke
    Nawaf Yassi
    Department of Neurology, Melbourne Brain Centre Royal Melbourne Hospital, University of Melbourne, Parkville, Vic, Australia
    Int J Stroke 10:1270-6. 2015
    ..We performed a retrospective, hypothesis-generating study of the effect of infarct location on three-month functional outcome in a pooled analysis of the EPITHET and DEFUSE studies...
  22. doi request reprint Imaging selection in ischemic stroke: feasibility of automated CT-perfusion analysis
    Bruce C V Campbell
    Department of Medicine, Royal Melbourne Hospital, Melbourne, Australia Department of Radiology, Royal Melbourne Hospital, Melbourne, Australia
    Int J Stroke 10:51-4. 2015
    ..Advanced imaging may refine patient selection for ischemic stroke treatment but delays to acquire and process the imaging have limited implementation...
  23. doi request reprint Reperfusion after 4.5 hours reduces infarct growth and improves clinical outcomes
    Miguel R Picanço
    Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia
    Int J Stroke 9:266-9. 2014
    ..The currently proven time window for thrombolysis in ischemic stroke is 4.5 h. Beyond this, the risks and benefits of thrombolysis are uncertain...
  24. doi request reprint Know your tools--concordance of different methods for measuring brain volume change after ischemic stroke
    Nawaf Yassi
    Departments of Medicine and Neurology, Melbourne Brain Centre The Royal Melbourne Hospital, The University of Melbourne, Grattan St, Parkville, Victoria, 3050, Australia
    Neuroradiology 57:685-95. 2015
    ..We aimed to evaluate agreement between different analysis methods for the measurement of post-stroke brain volume change, and to explore technical challenges inherent to these methods...
  25. doi request reprint A multicentre, randomized, double-blinded, placebo-controlled Phase III study to investigate EXtending the time for Thrombolysis in Emergency Neurological Deficits (EXTEND)
    Henry Ma
    National Stroke Research Institute, Florey Neuroscience Institutes, Austin Health, University of Melbourne, Heidelberg Heights, Victoria, Australia
    Int J Stroke 7:74-80. 2012
    ....
  26. doi request reprint Frequent early cardiac complications contribute to worse stroke outcome in atrial fibrillation
    Hans T H Tu
    University Department of Medicine, University of Melbourne, Melbourne, Vic, Australia
    Cerebrovasc Dis 32:454-60. 2011
    ..This might have important implications for acute stroke management in patients with AF...
  27. doi request reprint Contralesional thalamic surface atrophy and functional disconnection 3 months after ischemic stroke
    Nawaf Yassi
    Departments of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, Parkville, Vic, Australia
    Cerebrovasc Dis 39:232-41. 2015
    ..We aimed to use multimodal MRI to investigate contralesional subcortical structural and functional changes 3 months after anterior circulation ischemic stroke...
  28. doi request reprint Helsinki model cut stroke thrombolysis delays to 25 minutes in Melbourne in only 4 months
    Atte Meretoja
    From the Departments of Neurology and Medicine A M, L W, M U, N Y, B Y, P H, S M D, B C V C, Nursing L W, and Emergency Department M T, The Royal Melbourne Hospital, University of Melbourne, Parkville, Australia and Department of Neurology A M, Helsinki University Central Hospital, Finland
    Neurology 81:1071-6. 2013
    ..To test the transferability of the Helsinki stroke thrombolysis model that achieved a median 20-minute door-to-needle time (DNT) to an Australian health care setting...
  29. doi request reprint The spot sign and tranexamic acid on preventing ICH growth--AUStralasia Trial (STOP-AUST): protocol of a phase II randomized, placebo-controlled, double-blind, multicenter trial
    Atte Meretoja
    Department of Medicine, University of Melbourne, Parkville, Victoria, Australia Department of Neurology, The Royal Melbourne Hospital, Parkville, Victoria, Australia The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland
    Int J Stroke 9:519-24. 2014
    ..No evidence-based acute therapies exist for intracerebral hemorrhage. Intracerebral hemorrhage growth is an important determinant of patient outcome. Tranexamic acid is known to reduce hemorrhage in other conditions...
  30. doi request reprint Does large vessel occlusion affect clinical outcome in stroke with mild neurologic deficits after intravenous thrombolysis?
    Wusheng Zhu
    Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu Province, China Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    J Stroke Cerebrovasc Dis 23:2888-93. 2014
    ..Given the uncertainty whether LVO has the same significance in mild and severe stroke, we compared functional outcomes after intravenous thrombolysis, based on severity and LVO...
  31. pmc Reperfusion of very low cerebral blood volume lesion predicts parenchymal hematoma after endovascular therapy
    Nishant K Mishra
    From the Stanford Stroke Center, Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA N K M, S C, M S, M M, S K, C W C, G W A, M G L Department of Experimental Neurology, KU Leuven, Leuven, Belgium A W Department of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Victoria, Australia B C V C Stroke Center, Department of Neurology, Neurocenter EOC of Southern Switzerland, Lugano, Switzerland C W C and Department of Radiology, Stanford University Medical Center, CA R B, M P M
    Stroke 46:1245-9. 2015
    ..We developed a method for automated detection of VLCBV and examined whether patients with reperfused-VLCBV are at increased risk of PH after endovascular reperfusion therapy...
  32. doi request reprint An improved method for simple, assumption-free ordinal analysis of the modified Rankin Scale using generalized odds ratios
    Leonid Churilov
    Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia RMIT University, Melbourne, Australia
    Int J Stroke 9:999-1005. 2014
    ..We aimed to develop a method to overcome these limitations...
  33. doi request reprint STroke imAging pRevention and treatment (START): A longitudinal stroke cohort study: Clinical trials protocol
    Leeanne M Carey
    National Stroke Research Institute, Florey Institute of Neuroscience and Mental Health, Heidelberg, Vic, Australia
    Int J Stroke 10:636-44. 2015
    ..However, reliable biological correlates of poststroke depression and functional outcome have not been well established in humans...
  34. doi request reprint Intravenous thrombolysis for acute ischaemic stroke in the setting of rivaroxaban use
    Andrew J Neal
    Department of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Grattan Street, Parkville, VIC 3052, Australia Electronic address
    J Clin Neurosci 21:2013-5. 2014
    ..We describe a patient with a large acute ischaemic stroke, who had a low calibrated anti-factor Xa level, who safely received thrombolysis 15-17 hours after standard dose rivaroxaban without subsequent intracerebral haemorrhage...
  35. pmc Brain edema predicts outcome after nonlacunar ischemic stroke
    Thomas W K Battey
    From the Center for Human Genetic Research T W K B, M K, W T K, Division of Neurocritical Care and Emergency Neurology T W K B, M K, W T K, J Philip Kistler Stroke Research Center T W K B, M K, A B S, O W, S S, W T K, and Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology O W, Massachusetts General Hospital, Boston Department of Radiology, Royal Melbourne Hospital, Parkville, Victoria, Australia B C V C, S M D Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia B C V C, G A D and Division of Neurocritical Care and Emergency Neurology, Yale New Haven Hospital, CT K N S
    Stroke 45:3643-8. 2014
    ..In malignant infarction, brain edema leads to secondary neurological deterioration and poor outcome. We sought to determine whether swelling is associated with outcome in smaller volume strokes...
  36. doi request reprint Role of imaging in current acute ischemic stroke workflow for endovascular therapy
    Bijoy K Menon
    From the Calgary Stroke Program and the Department of Clinical Neurosciences, Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada B K M, M G Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia B C V C and Priority Research Centre for Brain and Mental Health Research, John Hunter Hospital, University of Newcastle, Newcastle, New South Wales, Australia C L
    Stroke 46:1453-61. 2015
    ..Finally, we briefly comment on how imaging can integrate itself within various health systems of care in the future, thereby potentially improving patient outcomes further. ..