Bruce C V Campbell

Summary

Affiliation: Royal Melbourne Hospital
Country: Australia

Publications

  1. pmc Failure of collateral blood flow is associated with infarct growth in ischemic stroke
    Bruce C V Campbell
    Departments of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    J Cereb Blood Flow Metab 33:1168-72. 2013
  2. pmc Fluid-attenuated inversion recovery hyperintensity in acute ischemic stroke may not predict hemorrhagic transformation
    Bruce C V Campbell
    Department of Medicine and Neurology, The Royal Melbourne Hospital, University of Melbourne, Parkville, Vic, Australia
    Cerebrovasc Dis 32:401-5. 2011
  3. doi request reprint CT perfusion improves diagnostic accuracy and confidence in acute ischaemic stroke
    Bruce C V Campbell
    Department of Medicine, Melbourne Brain Centre at Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    J Neurol Neurosurg Psychiatry 84:613-8. 2013
  4. pmc The infarct core is well represented by the acute diffusion lesion: sustained reversal is infrequent
    Bruce C V Campbell
    Department of Medicine and Neurology, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    J Cereb Blood Flow Metab 32:50-6. 2012
  5. doi request reprint Assessing response to stroke thrombolysis: validation of 24-hour multimodal magnetic resonance imaging
    Bruce C V Campbell
    BMedSc, FRACP, Department of Neurology, Royal Melbourne Hospital, Grattan Street, Parkville, Victoria 3050, Australia
    Arch Neurol 69:46-50. 2012
  6. doi request reprint Cerebral blood flow is the optimal CT perfusion parameter for assessing infarct core
    Bruce C V Campbell
    Department of Medicine, The Royal Melbourne Hospital, University of Melbourne, Grattan Street, Parkville VIC 3050, Australia
    Stroke 42:3435-40. 2011
  7. ncbi request reprint Comparison of computed tomography perfusion and magnetic resonance imaging perfusion-diffusion mismatch in ischemic stroke
    Bruce C V Campbell
    Department of Medicine, The Melbourne Brain Centre at Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    Stroke 43:2648-53. 2012
  8. doi request reprint How much diffusion lesion reversal occurs after treatment within three-hours of stroke onset?
    Bruce C V Campbell
    Departments of Medicine and Neurology, Melbourne Brain Centre at Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    Int J Stroke 8:329-30. 2013
  9. doi request reprint Pathophysiological determinants of worse stroke outcome in atrial fibrillation
    Hans T H Tu
    Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Grattan Street, Parkville, VIC 3050, Australia
    Cerebrovasc Dis 30:389-95. 2010
  10. pmc Advanced imaging improves prediction of hemorrhage after stroke thrombolysis
    Bruce C V Campbell
    Departments of Medicine and Neurology, Melbourne Brain Centre at Royal Melbourne Hospital, University of Melbourne, Parkville, Australia
    Ann Neurol 73:510-9. 2013

Collaborators

Detail Information

Publications21

  1. pmc Failure of collateral blood flow is associated with infarct growth in ischemic stroke
    Bruce C V Campbell
    Departments of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    J Cereb Blood Flow Metab 33:1168-72. 2013
    ..68, P<0.001). Deterioration in Tmax hypoperfusion severity was also significantly associated with absolute (P=0.003) and relative (P=0.002) infarct growth. Collateral flow is dynamic and failure is associated with infarct growth. ..
  2. pmc Fluid-attenuated inversion recovery hyperintensity in acute ischemic stroke may not predict hemorrhagic transformation
    Bruce C V Campbell
    Department of Medicine and Neurology, The Royal Melbourne Hospital, University of Melbourne, Parkville, Vic, Australia
    Cerebrovasc Dis 32:401-5. 2011
    ..Given the important implications for clinical practice, we examined the prevalence of FLAIR hyperintensity in patients 3-6 h from stroke onset and its relationship to parenchymal hematoma (PH)...
  3. doi request reprint CT perfusion improves diagnostic accuracy and confidence in acute ischaemic stroke
    Bruce C V Campbell
    Department of Medicine, Melbourne Brain Centre at Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    J Neurol Neurosurg Psychiatry 84:613-8. 2013
    ..CT perfusion (CTP) is rapid and accessible for emergency ischaemic stroke diagnosis. The feasibility of introducing CTP and diagnostic accuracy versus non-contrast CT (NCCT) in a tertiary hospital were assessed...
  4. pmc The infarct core is well represented by the acute diffusion lesion: sustained reversal is infrequent
    Bruce C V Campbell
    Department of Medicine and Neurology, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    J Cereb Blood Flow Metab 32:50-6. 2012
    ..Clinically relevant DLR is uncommon and rarely alters perfusion-diffusion mismatch. The acute diffusion lesion is generally a reliable signature of the infarct core...
  5. doi request reprint Assessing response to stroke thrombolysis: validation of 24-hour multimodal magnetic resonance imaging
    Bruce C V Campbell
    BMedSc, FRACP, Department of Neurology, Royal Melbourne Hospital, Grattan Street, Parkville, Victoria 3050, Australia
    Arch Neurol 69:46-50. 2012
    ..Imaging is used as a surrogate for clinical outcome in early-phase stroke trials. Assessment of infarct growth earlier than the standard 90 days used for clinical end points may be equally accurate and more practical...
  6. doi request reprint Cerebral blood flow is the optimal CT perfusion parameter for assessing infarct core
    Bruce C V Campbell
    Department of Medicine, The Royal Melbourne Hospital, University of Melbourne, Grattan Street, Parkville VIC 3050, Australia
    Stroke 42:3435-40. 2011
    ..Cerebral blood volume (CBV) has been proposed as the best predictor of infarct core. We tested CBV against other common CTP parameters using contemporaneous diffusion MRI...
  7. ncbi request reprint Comparison of computed tomography perfusion and magnetic resonance imaging perfusion-diffusion mismatch in ischemic stroke
    Bruce C V Campbell
    Department of Medicine, The Melbourne Brain Centre at Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    Stroke 43:2648-53. 2012
    ..We tested the correspondence of computed tomography perfusion (CTP)-derived mismatch with contemporaneous perfusion-diffusion magnetic resonance imaging (MRI)...
  8. doi request reprint How much diffusion lesion reversal occurs after treatment within three-hours of stroke onset?
    Bruce C V Campbell
    Departments of Medicine and Neurology, Melbourne Brain Centre at Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    Int J Stroke 8:329-30. 2013
    ..For the present, it appears that intravenous tissue plasminogen activator rarely achieves substantial permanent reversal of diffusion lesions, even when administered within three-hours...
  9. doi request reprint Pathophysiological determinants of worse stroke outcome in atrial fibrillation
    Hans T H Tu
    Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Grattan Street, Parkville, VIC 3050, Australia
    Cerebrovasc Dis 30:389-95. 2010
    ..We aimed to elucidate the pathophysiological determinants of poorer stroke outcome in patients with AF using systematic MRI data from the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET)...
  10. pmc Advanced imaging improves prediction of hemorrhage after stroke thrombolysis
    Bruce C V Campbell
    Departments of Medicine and Neurology, Melbourne Brain Centre at Royal Melbourne Hospital, University of Melbourne, Parkville, Australia
    Ann Neurol 73:510-9. 2013
    ..We aimed to compare these parameters, validate VLCBV in an independent cohort using DEFUSE study data, and investigate the interaction of VLCBV with regional reperfusion...
  11. doi request reprint Visual assessment of perfusion-diffusion mismatch is inadequate to select patients for thrombolysis
    Bruce C V Campbell
    Department of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Parkville, Vic, Australia
    Cerebrovasc Dis 29:592-6. 2010
    ..We compared the accuracy of visually rating console-generated images with offline volumetric measurements using data from the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET)...
  12. doi request reprint Regional very low cerebral blood volume predicts hemorrhagic transformation better than diffusion-weighted imaging volume and thresholded apparent diffusion coefficient in acute ischemic stroke
    Bruce C V Campbell
    Department of Neurology, Royal Melbourne Hospital, Grattan Street, Parkville VIC 3050, Australia
    Stroke 41:82-8. 2010
    ..Preliminary studies have suggested that very low cerebral blood volume (VLCBV) predicts HT. We compared HT prediction by VLCBV and DWI using data from the EPITHET study...
  13. doi request reprint Prediction of poststroke hemorrhagic transformation using computed tomography perfusion
    Nawaf Yassi
    From the Departments of Medicine and Neurology, Melbourne Brain Centre N Y, A B, S M D, B C V C, and Department of Radiology N Y, S C, G S, P M D, B C V C, Royal Melbourne Hospital, and Florey Institute of Neuroscience and Mental Health G A D, University of Melbourne, Parkville, Victoria, Australia and Priority Research Centre for Translational Neuroscience and Mental Health, University of Newcastle and Hunter Medical Research Institute, Newcastle, New South Wales, Australia M W P, C R L
    Stroke 44:3039-43. 2013
    ..Intracerebral hemorrhage is a serious potential complication of stroke thrombolysis. We investigated the optimal computed tomography perfusion (CTP) parameter to predict cerebral parenchymal hematoma (PH) in acute ischemic stroke...
  14. doi request reprint The effects of alteplase 3 to 6 hours after stroke in the EPITHET-DEFUSE combined dataset: post hoc case-control study
    Toshiyasu Ogata
    FRACP, Level 2 Alan Gilbert Bldg, 161 Barry St, Carlton S Victoria 3053, Australia
    Stroke 44:87-93. 2013
    ..The primary hypothesis was that alteplase would significantly attenuate infarct growth compared with placebo in mismatch-selected patients using coregistration techniques...
  15. doi request reprint Reperfusion after 4.5 hours reduces infarct growth and improves clinical outcomes
    Miguel R Picanço
    Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia
    Int J Stroke 9:266-9. 2014
    ..The currently proven time window for thrombolysis in ischemic stroke is 4.5 h. Beyond this, the risks and benefits of thrombolysis are uncertain...
  16. doi request reprint A multicentre, randomized, double-blinded, placebo-controlled Phase III study to investigate EXtending the time for Thrombolysis in Emergency Neurological Deficits (EXTEND)
    Henry Ma
    National Stroke Research Institute, Florey Neuroscience Institutes, Austin Health, University of Melbourne, Heidelberg Heights, Victoria, Australia
    Int J Stroke 7:74-80. 2012
    ....
  17. doi request reprint Helsinki model cut stroke thrombolysis delays to 25 minutes in Melbourne in only 4 months
    Atte Meretoja
    From the Departments of Neurology and Medicine A M, L W, M U, N Y, B Y, P H, S M D, B C V C, Nursing L W, and Emergency Department M T, The Royal Melbourne Hospital, University of Melbourne, Parkville, Australia and Department of Neurology A M, Helsinki University Central Hospital, Finland
    Neurology 81:1071-6. 2013
    ..To test the transferability of the Helsinki stroke thrombolysis model that achieved a median 20-minute door-to-needle time (DNT) to an Australian health care setting...
  18. doi request reprint Pre-stroke CHADS2 and CHA2DS2-VASc scores are useful in stratifying three-month outcomes in patients with and without atrial fibrillation
    Hans T H Tu
    University Department of Medicine and Department of Neurology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Vic, Australia
    Cerebrovasc Dis 36:273-80. 2013
    ..We investigated whether these scores are associated with 3-month stroke outcomes and evaluated the utility of these scores in stratifying 3-month stroke outcomes in both patients with and without AF...
  19. ncbi request reprint The spot sign and tranexamic acid on preventing ICH growth--AUStralasia Trial (STOP-AUST): protocol of a phase II randomized, placebo-controlled, double-blind, multicenter trial
    Atte Meretoja
    Department of Medicine, University of Melbourne, Parkville, Victoria, Australia Department of Neurology, The Royal Melbourne Hospital, Parkville, Victoria, Australia The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland
    Int J Stroke 9:519-24. 2014
    ..No evidence-based acute therapies exist for intracerebral hemorrhage. Intracerebral hemorrhage growth is an important determinant of patient outcome. Tranexamic acid is known to reduce hemorrhage in other conditions...
  20. doi request reprint Frequent early cardiac complications contribute to worse stroke outcome in atrial fibrillation
    Hans T H Tu
    University Department of Medicine, University of Melbourne, Melbourne, Vic, Australia
    Cerebrovasc Dis 32:454-60. 2011
    ..This might have important implications for acute stroke management in patients with AF...
  21. doi request reprint A multicenter, randomized, controlled study to investigate EXtending the time for Thrombolysis in Emergency Neurological Deficits with Intra-Arterial therapy (EXTEND-IA)
    Bruce C V Campbell
    Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    Int J Stroke 9:126-32. 2014
    ....