Angeline Bartholomeusz

Summary

Affiliation: Royal Melbourne Hospital
Country: Australia

Publications

  1. ncbi request reprint HBV drug resistance: mechanisms, detection and interpretation
    Tim Shaw
    Victorian Infectious Diseases Reference Laboratory, Locked Bag 815, Carlton South, VIC 3053, Australia
    J Hepatol 44:593-606. 2006
  2. ncbi request reprint Hepatitis B virus mutations associated with antiviral therapy
    A Bartholomeusz
    Victorian Infectious Disease Reference Laboratory, North Melbourne, Australia
    J Med Virol 78:S52-5. 2006
  3. ncbi request reprint Comparisons of the HBV and HIV polymerase, and antiviral resistance mutations
    Angeline Bartholomeusz
    Victorian Infectious Diseases Reference Laboratory, North Melbourne, Victoria, Australia
    Antivir Ther 9:149-60. 2004
  4. ncbi request reprint Identification of a novel hepatitis B virus precore/core deletion mutant in HIV/hepatitis B virus co-infected individuals
    Peter A Revill
    Victorian Infectious Diseases Reference Laboratory, 10 Wreckyn Street, North Melbourne, Victoria 3051, Australia
    AIDS 21:1701-10. 2007
  5. pmc The L80I substitution in the reverse transcriptase domain of the hepatitis B virus polymerase is associated with lamivudine resistance and enhanced viral replication in vitro
    Nadia Warner
    Victorian Infectious Diseases Reference Laboratory, North Melbourne, Victoria, Australia
    Antimicrob Agents Chemother 51:2285-92. 2007
  6. ncbi request reprint Lamivudine and Famciclovir resistant hepatitis B virus associated with fatal hepatic failure
    Anna Ayres
    Victorian Infectious Diseases Reference Laboratory, 10 Wreckyn Street, Melbourne, Victoria, 3051, Australia
    J Clin Virol 27:111-6. 2003
  7. ncbi request reprint Prevalence and characterization of lamivudine-resistant hepatitis B virus mutations in HIV-HBV co-infected individuals
    Louise Cooley
    Victorian Infectious Diseases Reference Laboratory, North Melbourne, Victoria, Australia
    AIDS 17:1649-57. 2003
  8. ncbi request reprint SeqHepB: a sequence analysis program and relational database system for chronic hepatitis B
    Lilly K W Yuen
    Victorian Infectious Diseases Reference Laboratory, 10 Wreckyn Street, North Melbourne, 3051 Vic, Australia
    Antiviral Res 75:64-74. 2007
  9. ncbi request reprint Antiviral drug resistance: clinical consequences and molecular aspects
    Angeline Bartholomeusz
    Victorian Infectious Diseases Reference Laboratory, North Melbourne, Victoria, Australia
    Semin Liver Dis 26:162-70. 2006
  10. ncbi request reprint Hepatitis B virus genotypes: comparison of genotyping methods
    Angeline Bartholomeusz
    Victorian Infectious Diseases Reference Laboratory, North Melbourne 3051, Australia
    Rev Med Virol 14:3-16. 2004

Collaborators

Detail Information

Publications30

  1. ncbi request reprint HBV drug resistance: mechanisms, detection and interpretation
    Tim Shaw
    Victorian Infectious Diseases Reference Laboratory, Locked Bag 815, Carlton South, VIC 3053, Australia
    J Hepatol 44:593-606. 2006
  2. ncbi request reprint Hepatitis B virus mutations associated with antiviral therapy
    A Bartholomeusz
    Victorian Infectious Disease Reference Laboratory, North Melbourne, Australia
    J Med Virol 78:S52-5. 2006
    ..Clearly, improved treatment strategies are required urgently to prevent the continued selection of HBV drug-resistant mutants...
  3. ncbi request reprint Comparisons of the HBV and HIV polymerase, and antiviral resistance mutations
    Angeline Bartholomeusz
    Victorian Infectious Diseases Reference Laboratory, North Melbourne, Victoria, Australia
    Antivir Ther 9:149-60. 2004
    ..In addition, the antiviral resistance mutations including potential compensatory mutations were mapped to determine their effect on the HBV polymerase model, especially in the nucleotide binding site...
  4. ncbi request reprint Identification of a novel hepatitis B virus precore/core deletion mutant in HIV/hepatitis B virus co-infected individuals
    Peter A Revill
    Victorian Infectious Diseases Reference Laboratory, 10 Wreckyn Street, North Melbourne, Victoria 3051, Australia
    AIDS 21:1701-10. 2007
    ..To test this hypothesis, we have analysed genome-length sequences of HBV DNA from patients both prior to and during antiviral therapy...
  5. pmc The L80I substitution in the reverse transcriptase domain of the hepatitis B virus polymerase is associated with lamivudine resistance and enhanced viral replication in vitro
    Nadia Warner
    Victorian Infectious Diseases Reference Laboratory, North Melbourne, Victoria, Australia
    Antimicrob Agents Chemother 51:2285-92. 2007
    ....
  6. ncbi request reprint Lamivudine and Famciclovir resistant hepatitis B virus associated with fatal hepatic failure
    Anna Ayres
    Victorian Infectious Diseases Reference Laboratory, 10 Wreckyn Street, Melbourne, Victoria, 3051, Australia
    J Clin Virol 27:111-6. 2003
    ..However, prolonged antiviral therapy results in the emergence of drug resistance HBV which can contribute to virological breakthroughs and recurrent hepatitis flares...
  7. ncbi request reprint Prevalence and characterization of lamivudine-resistant hepatitis B virus mutations in HIV-HBV co-infected individuals
    Louise Cooley
    Victorian Infectious Diseases Reference Laboratory, North Melbourne, Victoria, Australia
    AIDS 17:1649-57. 2003
    ....
  8. ncbi request reprint SeqHepB: a sequence analysis program and relational database system for chronic hepatitis B
    Lilly K W Yuen
    Victorian Infectious Diseases Reference Laboratory, 10 Wreckyn Street, North Melbourne, 3051 Vic, Australia
    Antiviral Res 75:64-74. 2007
    ....
  9. ncbi request reprint Antiviral drug resistance: clinical consequences and molecular aspects
    Angeline Bartholomeusz
    Victorian Infectious Diseases Reference Laboratory, North Melbourne, Victoria, Australia
    Semin Liver Dis 26:162-70. 2006
    ....
  10. ncbi request reprint Hepatitis B virus genotypes: comparison of genotyping methods
    Angeline Bartholomeusz
    Victorian Infectious Diseases Reference Laboratory, North Melbourne 3051, Australia
    Rev Med Virol 14:3-16. 2004
    ..A numbering system is presented which avoids this problem. In addition we discuss the currently available methods for genotyping HBV...
  11. ncbi request reprint Lamivudine resistance in patients with chronic hepatitis B: role of clinical and virological factors
    Alexander J V Thompson
    St Vincent s Hospital, Melbourne, Victoria, Australia
    J Gastroenterol Hepatol 22:1078-85. 2007
    ..The present study was designed to identify factors predictive of lamivudine resistance, with a particular focus on the role of precore and basal core promoter variants in the setting of hepatitis B e antigen-negative disease...
  12. ncbi request reprint HBV genotyping and analysis for unique mutations
    Anna Ayres
    Victorian Infectious Diseases Reference Laboratory, North Melbourne, Australia
    Methods Mol Med 95:125-49. 2004
  13. ncbi request reprint Lamivudine resistant occult HBV: implications for public health?
    Scott Bowden
    Victorian Infectious Diseases Reference Laboratory, 10 Wreckyn Street, North Melbourne, Vic 3051, Australia
    J Hepatol 38:526-8. 2003
  14. doi request reprint Targeting the hepatitis B virus precore antigen with a novel IgNAR single variable domain intrabody
    Renae Walsh
    Victorian Infectious Diseases Reference Laboratories, 10 Wreckyn Street, North Melbourne, Victoria 3051, Australia
    Virology 411:132-41. 2011
    ..In vitro data from HBV/precore hepatocyte cell lines demonstrated effective intrabody regulation of precore/HBeAg...
  15. ncbi request reprint The hepatitis B virus and common mutants
    Stephen Locarnini
    Victorian Infectious Diseases Reference Laboratory, North Melbourne, Australia
    Semin Liver Dis 23:5-20. 2003
    ..Such research should help improve the basic understanding of this unique virus-host relationship and provide new strategies for complete control of HBV infections...
  16. ncbi request reprint Evolving therapies for the treatment of chronic hepatitis B virus infection
    William Delaney
    Victorian Infectious Diseases Reference Laboratory, Carlton South, VIC 3053, Australia
    Expert Opin Investig Drugs 11:169-87. 2002
    ....
  17. ncbi request reprint Selection of hepatitis B virus polymerase mutations in HIV-coinfected patients treated with tenofovir
    Julie Sheldon
    Hospital Carlos Ill, Madrid, Spain
    Antivir Ther 10:727-34. 2005
    ..The aim of this study was to analyse the HBV polymerase (pol) from HIV/HBV-coinfected patients with detectable serum levels of HBV DNA during treatment with TDF for longer than 6 months...
  18. ncbi request reprint A systematic review of T-cell epitopes in hepatitis B virus: identification, genotypic variation and relevance to antiviral therapeutics
    Christopher P Desmond
    Department of Gastroenterology, Alfred Hospital, Melbourne, Australia
    Antivir Ther 13:161-75. 2008
    ..The immune response to hepatitis B virus (HBV) is important for both viral control and disease pathogenesis. A detailed understanding of the HBV-specific T-cell responses may potentially lead to novel therapeutic strategies for HBV...
  19. pmc Genotype-specific genomic markers associated with primary hepatomas, based on complete genomic sequencing of hepatitis B virus
    Joseph J Y Sung
    Department of Medicine and Therapeutics, 9 F Prince of Wales Hospital, The Chinese University of Hong Kong, NT, Shatin, Hong Kong
    J Virol 82:3604-11. 2008
    ..Different HBV genotypes may have different virologic mechanisms of hepatocarcinogenesis...
  20. ncbi request reprint Selection of hepatitis B virus (HBV) vaccine escape mutants in HBV-infected and HBV/HIV-coinfected patients failing antiretroviral drugs with anti-HBV activity
    Julie Sheldon
    Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    J Acquir Immune Defic Syndr 46:279-82. 2007
    ..Given the overlap between envelope and polymerase in the hepatitis B virus (HBV) genome, changes in antigenic sites of the HBV surface antigen may occur as a result of selection of drug-resistance mutations...
  21. ncbi request reprint Advances in hepatitis C: what is coming in the next 5 years?
    Stephen A Locarnini
    Victorian Infectious Diseases Reference Laboratory VIDRL, Melbourne, LB 815, Carlton South, Victoria 3053, Australia
    J Gastroenterol Hepatol 17:442-7. 2002
    ..Current developments in antiviral agents are reviewed in the context of these potential new viral targets for the future treatment of HCV in chronically infected individuals...
  22. ncbi request reprint Preemptive use of lamivudine reduces hepatitis B exacerbation after allogeneic hematopoietic cell transplantation
    George K K Lau
    Division of Gastroenterology and Hepatology, University of Hong Kong, Hong Kong Special Administrative Region, China
    Hepatology 36:702-9. 2002
    ..09; P =.021). In conclusion, preemptive lamivudine reduced HBV exacerbation. The use of lamivudine with other immunosuppressive regimens to prevent exacerbation of HBV should be further explored...
  23. ncbi request reprint Antiviral drug-resistant HBV: standardization of nomenclature and assays and recommendations for management
    Anna S Lok
    Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109 0362, USA
    Hepatology 46:254-65. 2007
    ..Thus, there is a need to standardize nomenclature relating to hepatitis B antiviral resistance, and to define genotypic, phenotypic, and clinical resistance to NA therapy...
  24. ncbi request reprint Resistance to adefovir dipivoxil therapy associated with the selection of a novel mutation in the HBV polymerase
    Peter Angus
    Austin Hospital, Studley Road, Heidelberg, Victoria 3084, Australia
    Gastroenterology 125:292-7. 2003
    ..The aim of this study was to characterize adefovir resistance in a patient who developed clinical and virologic evidence of breakthrough during a 96-week course of treatment...
  25. pmc Comparison of sequence analysis and a novel discriminatory real-time PCR assay for detection and quantification of Lamivudine-resistant hepatitis B virus strains
    Fiona Wightman
    Department of Medicine, Monash University, Melbourne, Australia
    J Clin Microbiol 42:3809-12. 2004
    ..Excellent concordance was demonstrated between sequencing and the discriminatory real-time assay; however, a mixture of quasispecies was more frequently detected by discriminatory real-time PCR...
  26. ncbi request reprint Sexual transmission of hepatitis B infection despite the presence of hepatitis B virus immunity in recipients of allogeneic bone marrow transplantation
    Chee Kin Hui
    Division of Gastroenterology and Hepatology, University Department of Medicine, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, SAR, China
    J Clin Virol 32:173-8. 2005
    ..After hematopoietic cell transplantation (HCT), hepatitis due to hepatitis B virus (HBV) rarely occurred beyond the initial 12 months after transplantation...
  27. pmc Reduced hepatitis B virus (HBV)-specific CD4+ T-cell responses in human immunodeficiency virus type 1-HBV-coinfected individuals receiving HBV-active antiretroviral therapy
    J Judy Chang
    Infectious Diseases Unit, Alfred Hospital, Commercial Rd, Melbourne, Victoria 3004, Australia
    J Virol 79:3038-51. 2005
    ..Therefore, HIV-1 infection has a significant and specific effect on HBV-specific T-cell immunity...
  28. ncbi request reprint Characteristics of drug resistant HBV in an international collaborative study of HIV-HBV-infected individuals on extended lamivudine therapy
    Gail V Matthews
    National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, Sydney, Australia
    AIDS 20:863-70. 2006
    ..Little is known about the prevalence and pattern of hepatitis B virus (HBV) mutations in HIV/HBV co-infected individuals on long-term lamivudine (3TC) therapy...
  29. ncbi request reprint Epidemiological and virological characteristics of 2 subgroups of hepatitis B virus genotype C
    Henry L Y Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, People s Republic of China
    J Infect Dis 191:2022-32. 2005
    ..We aimed to investigate the characteristics of hepatitis B virus (HBV) genotype C subgroups in Hong Kong and their relationship with HBV genotype C in other parts of Asia...
  30. ncbi request reprint Transmission of G145R mutant of HBV to an unrelated contact
    Varsha Thakur
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    J Med Virol 76:40-6. 2005
    ..The data also reaffirms the earlier finding of HBsAg positivity in presence of G145R mutation of the S-gene. HBV exists as quasi-species and mixed population in subjects with chronic HBV infection...