Shu Feng Zhou

Summary

Affiliation: RMIT University
Country: Australia

Publications

  1. ncbi Role of P-glycoprotein in the intestinal absorption of tanshinone IIA, a major active ingredient in the root of Salvia miltiorrhiza Bunge
    Xi Yong Yu
    Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou 510080, China
    Curr Drug Metab 8:325-40. 2007
  2. ncbi Placental drug disposition and its clinical implications
    Naomi Weier
    Division of Pharmacy, School of Life Sciences, Queensland University of Technology, Brisbane, Australia
    Curr Drug Metab 9:106-21. 2008
  3. ncbi Organic cation transporters
    G Ciarimboli
    Medizinische Klinik und Poliklinik D, Experimentelle Nephrologie, Universitatsklinikum Munster, Germany
    Xenobiotica 38:936-71. 2008
  4. pmc Insights into the substrate specificity, inhibitors, regulation, and polymorphisms and the clinical impact of human cytochrome P450 1A2
    Shu Feng Zhou
    Discipline of Chinese Medicine, School of Health Sciences, WHO Collaborating Center for Traditional Medicine, RMIT University, Bundoora, Victoria, Australia
    AAPS J 11:481-94. 2009
  5. doi Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2
    Shu Feng Zhou
    Discpline of Chinese Medicine, School of Health Sciences, RMIT University, Bundoora, Victoria 3083, Australia
    Drug Metab Rev 42:268-354. 2010
  6. doi Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II
    Shu Feng Zhou
    School of Health Sciences, RMIT University, Melbourne, Victoria, Australia
    Clin Pharmacokinet 48:761-804. 2009
  7. ncbi Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I
    Shu Feng Zhou
    Discipline of Chinese Medicine, School of Health Sciences, RMIT University, Victoria, Australia
    Clin Pharmacokinet 48:689-723. 2009
  8. ncbi Polymorphisms of human cytochrome P450 2C9 and the functional relevance
    Shu Feng Zhou
    School of Health Sciences, RMIT University, Victoria 3083, Australia
    Toxicology 278:165-88. 2010
  9. ncbi Insights into the structure, function, and regulation of human cytochrome P450 1A2
    Shu Feng Zhou
    School of Health Sciences, RMIT University, Victoria 3083, Australia
    Curr Drug Metab 10:713-29. 2009
  10. ncbi Substrate specificity, inhibitors and regulation of human cytochrome P450 2D6 and implications in drug development
    Shu Feng Zhou
    Discipline of Chinese Medicine, School of Health Sciences, RMIT University, Victoria, Australia
    Curr Med Chem 16:2661-805. 2009

Collaborators

  • Zhi Wei Zhou
  • Jun Ping Liu
  • Li Ping Yang
  • Eli Chan
  • Bo Wang
  • Jagat R Kanwar
  • Yong Li
  • Chunguang Li
  • Yu Sheng Cong
  • Ashok Chauhan
  • Guangji Wang
  • Jun Liang
  • Shi ming Chen
  • Yu-Zong Chen
  • Ka Yun Ng
  • Hui Zhao
  • Seng Lai Tan
  • He Li
  • Min Huang
  • Wei Duan
  • Xiao Chen
  • Xiao Xia Yang
  • Sui Lin Mo
  • Ze Ping Hu
  • Xue Ding Wang
  • Ya He Liu
  • Yuan Ming Di
  • Balram Chowbay
  • Xi Yong Yu
  • Ming Qian Wei
  • Qi Biao Su
  • Su Guan
  • Yi Zhun Zhu
  • Jia Li Li
  • Xue Qing Yu
  • Jie Cao
  • Jing Yuan Wen
  • Charlie Changli Xue
  • Jian Cheng Wang
  • Qiang Zhang
  • Jie Chen
  • An long Xu
  • Fwu Shan Sheu
  • Sui Yung Chan
  • An Kui Yang
  • Lin Lin Wang
  • Shu Ming He
  • Yan Lu
  • Xiao Tian Li
  • Shu guang Lin
  • Jin Song Bian
  • Quan Tian
  • Jing Zhang
  • Juan Li Lu
  • Mao Bo Cheng
  • G Ciarimboli
  • Xuan Zhang
  • Naomi Weier
  • Xiao Yan Liu
  • Zhi Shu Huang
  • Yu Jing Lu
  • Li zi Zhao
  • Lian Quan Gu
  • Fan He
  • Xiao ying Deng
  • Urs Alex Boelsterli
  • Sui Sum Yeong
  • Paul Chi Liu Ho
  • Hui chang Bi
  • Yi Tao Wang
  • Ling Huang
  • Bing Fang Hu
  • Liang Liu
  • Vivian Deh Wei Chow
  • Da Wei Chen
  • Lai You Wang
  • Qian Fu
  • Shu Xin Zhao
  • Long Shan Liu
  • Zhi Yong Xie
  • Chang Xi Wang
  • Duan Wei
  • Pei Qing Liu
  • Jin Xin Zhang
  • Zhong Zuo
  • Qiu Tian Li
  • Derek Smith
  • Theresa May Chin Tan
  • Ming He
  • Yu Qiang Nie

Detail Information

Publications64

  1. ncbi Role of P-glycoprotein in the intestinal absorption of tanshinone IIA, a major active ingredient in the root of Salvia miltiorrhiza Bunge
    Xi Yong Yu
    Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou 510080, China
    Curr Drug Metab 8:325-40. 2007
    ..Further studies are needed to explore the role of other drug transporters and first-pass metabolism in the low bioavailability of TSA...
  2. ncbi Placental drug disposition and its clinical implications
    Naomi Weier
    Division of Pharmacy, School of Life Sciences, Queensland University of Technology, Brisbane, Australia
    Curr Drug Metab 9:106-21. 2008
    ....
  3. ncbi Organic cation transporters
    G Ciarimboli
    Medizinische Klinik und Poliklinik D, Experimentelle Nephrologie, Universitatsklinikum Munster, Germany
    Xenobiotica 38:936-71. 2008
    ....
  4. pmc Insights into the substrate specificity, inhibitors, regulation, and polymorphisms and the clinical impact of human cytochrome P450 1A2
    Shu Feng Zhou
    Discipline of Chinese Medicine, School of Health Sciences, WHO Collaborating Center for Traditional Medicine, RMIT University, Bundoora, Victoria, Australia
    AAPS J 11:481-94. 2009
    ..Further studies are warranted to explore the clinical and toxicological significance of altered CYP1A2 expression and activity caused by genetic, epigenetic, and environmental factors...
  5. doi Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2
    Shu Feng Zhou
    Discpline of Chinese Medicine, School of Health Sciences, RMIT University, Bundoora, Victoria 3083, Australia
    Drug Metab Rev 42:268-354. 2010
    ..Further studies are warranted to explore the clinical and toxicological significance of altered CYP1A2 expression and activity caused by genetic, epigenetic, and environmental factors...
  6. doi Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II
    Shu Feng Zhou
    School of Health Sciences, RMIT University, Melbourne, Victoria, Australia
    Clin Pharmacokinet 48:761-804. 2009
    ....
  7. ncbi Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I
    Shu Feng Zhou
    Discipline of Chinese Medicine, School of Health Sciences, RMIT University, Victoria, Australia
    Clin Pharmacokinet 48:689-723. 2009
    ..Further prospective studies on the clinical impact of CYP2D6-dependent metabolism of drugs are warranted in large cohorts of subjects...
  8. ncbi Polymorphisms of human cytochrome P450 2C9 and the functional relevance
    Shu Feng Zhou
    School of Health Sciences, RMIT University, Victoria 3083, Australia
    Toxicology 278:165-88. 2010
    ..However, prospective clinical studies with large samples are warranted to establish gene-dose and gene-effect relationships for CYP2C9 and its substrate drugs...
  9. ncbi Insights into the structure, function, and regulation of human cytochrome P450 1A2
    Shu Feng Zhou
    School of Health Sciences, RMIT University, Victoria 3083, Australia
    Curr Drug Metab 10:713-29. 2009
    ..Knockout of Cyp1a2 in mice has provided a very useful tool for the functional investigation of this gene. Further studies are needed to explore the clinical and toxicological significance of CYP1A2...
  10. ncbi Substrate specificity, inhibitors and regulation of human cytochrome P450 2D6 and implications in drug development
    Shu Feng Zhou
    Discipline of Chinese Medicine, School of Health Sciences, RMIT University, Victoria, Australia
    Curr Med Chem 16:2661-805. 2009
    ..Further studies are warranted to delineate the molecular mechanisms involved in the function and regulation of CYP2D6...
  11. ncbi Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring
    Shu Feng Zhou
    Division of Chinese Medicine, School of Health Sciences, WHO Collaborating Center for Traditional Medicine, RMIT University, Victoria, Australia
    Ther Drug Monit 29:687-710. 2007
    ....
  12. doi Polymorphism of human cytochrome P450 enzymes and its clinical impact
    Shu Feng Zhou
    School of Health Sciences, RMIT University, Bundoora, Victoria, Australia
    Drug Metab Rev 41:89-295. 2009
    ..Further studies are warranted to explore the gene-dose, gene-concentration, and gene-response relationships for these important drug-metabolizing CYPs...
  13. ncbi Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4
    Shu Feng Zhou
    Division of Chinese Medicine, School of Health Sciences, WHO Collaborating Center for Traditional Medicine, RMIT University, Victoria, Australia
    Curr Drug Metab 9:310-22. 2008
    ....
  14. ncbi Potential strategies for minimizing mechanism-based inhibition of cytochrome P450 3A4
    Shu Feng Zhou
    Division of Chinese Medicine, School of Health Sciences, WHO Collaborating Center for Traditional Medicine, RMIT University, PO Box 71, Bundoora, Victoria 3083, Australia
    Curr Pharm Des 14:990-1000. 2008
    ..Further studies are needed to explore the suitable approaches for minimizing mechanism-based inhibition of CYP3A4 and thus avoiding potential toxicities and unfavorable drug-drug interactions...
  15. ncbi Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development
    Shu Feng Zhou
    Discipline of Chinese Medicine, School of Health Sciences, RMIT University, Bundoora, Victoria 3083, Australia
    Curr Med Chem 16:3480-675. 2009
    ..Further studies are warranted to explore the molecular determinants for ligand-CYP2C9 binding and the structure-activity relationships...
  16. ncbi Clinical pharmacogenetics and potential application in personalized medicine
    Shu Feng Zhou
    School of Health Sciences, RMIT University, Victoria, Australia
    Curr Drug Metab 9:738-84. 2008
    ..As such, pharmacogenetics has the potential to achieve optimal quality use of medicines, and to improve the efficacy and safety of both prospective and licensed drugs...
  17. ncbi An update on clinical drug interactions with the herbal antidepressant St. John's wort
    Shu Feng Zhou
    School of Health Sciences, World Health Organization Collaborating Centre for Traditional Medicine, RMIT University, Bundoora, Victoria 3083, Australia
    Curr Drug Metab 9:394-409. 2008
    ..Further clinical and mechanistic studies are warranted to explore the interaction of SJW with other important drugs and clinical significance...
  18. ncbi Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition
    S F Zhou
    Division of Chinese Medicine, School of Health Science, WHO Collaborating Centre for Traditional Medicine, RMIT University, Bundoora, Vic, Australia
    Xenobiotica 38:802-32. 2008
    ..8. Further studies are warranted to explore the physiological function and pharmacological role of P-gp/MDR1...
  19. ncbi Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development
    Shu Feng Zhou
    Division of Chinese Medicine, School of Health Sciences, WHO Collaborating Center for Traditional Medicine, RMIT University, Victoria, Australia
    Curr Med Chem 15:1981-2039. 2008
    ..A better understanding of their substrates and inhibitors has important implications in development of drugs for treatment of cancer and inflammation...
  20. ncbi Substrate specificity, regulation, and polymorphism of human cytochrome P450 2B6
    Sui Lin Mo
    Discipline of Chinese Medicine, School of Health Sciences, RMIT University, Bundoora, Victoria 3083, Australia
    Curr Drug Metab 10:730-53. 2009
    ..Further studies in the structure, function, regulation and polymorphism of CYP2B6 are warranted...
  21. ncbi Structure, function, regulation and polymorphism of human cytochrome P450 2A6
    Yuan Ming Di
    Discipline of Chinese Medicine, School of Health Sciences, RMIT University, Victoria 3083, Australia
    Curr Drug Metab 10:754-80. 2009
    ..Polymorphism of CYP2A6 has been associated with smoking behavior, drug clearance and lung cancer risk. Further studies are warranted to explore the role of CYP2A6 in clinical practice, drug development and toxicology...
  22. ncbi Computational and in vitro studies on the inhibitory effects of herbal compounds on human cytochrome P450 1A2
    Li Ping Yang
    School of Health Sciences and Health Innovations Research Institute, RMIT University, Bundoora, Victoria, Australia
    Xenobiotica 42:238-55. 2012
    ..A combination of computational and in vitro approaches, represent a useful tool to identify potential inhibitors for CYP1A2 from herbal compounds...
  23. doi Multidrug resistance-associated proteins and implications in drug development
    Ya He Liu
    Discipline of Chinese Medicine, School of Health Sciences, RMIT University, Melbourne, Victoria 3083, Australia
    Clin Exp Pharmacol Physiol 37:115-20. 2010
    ..5. A better understanding of the function and regulating mechanisms of MRPs could help minimize and avoid drug toxicity and unfavourable drug-drug interactions, as well as help overcome drug resistance...
  24. ncbi Clinical drugs that interact with St. John's wort and implication in drug development
    Yuan Ming Di
    Divison of Chinese Medicine, School of Health Sciences, RMIT University, Bundoora, Victoria 3083, Australia
    Curr Pharm Des 14:1723-42. 2008
    ..Further clinical and mechanistic studies are warranted to explore the interaction of SJW with other important drugs and the potential clinical impact...
  25. pmc Prediction of deleterious non-synonymous single-nucleotide polymorphisms of human uridine diphosphate glucuronosyltransferase genes
    Yuan Ming Di
    Discipline of Chinese Medicine, School of Health Sciences, RMIT University, Bundoora, Melbourne, Victoria, Australia
    AAPS J 11:469-80. 2009
    ..1% and 66.7%, respectively. These findings demonstrate the potential use of bioinformatics techniques to predict genotype-phenotype relationships which may constitute the basis for future functional studies...
  26. ncbi Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development
    Bo Wang
    Discipline of Chinese Medicine, School of Health Sciences, RMIT University, Bundoora, Victoria, Australia
    Curr Med Chem 16:4066-218. 2009
    ....
  27. ncbi Prediction of deleterious functional effects of non-synonymous single nucleotide polymorphisms in human nuclear receptor genes using a bioinformatics approach
    Ya He Liu
    Discipline of Chinese Medicine, School of Health Sciences, RMIT University, Bundoora, Victoria 3083, Australia
    Drug Metab Lett 3:242-86. 2009
    ..57%) and PolyPhen identified 159 out of 216 as "potentially intolerant" (73.61%). These results indicate that both SIFT and PolyPhen are useful and efficient tools to predict the functional effects of nsSNPs of human NR genes...
  28. doi Regulation of human pregnane X receptor and its target gene cytochrome P450 3A4 by Chinese herbal compounds and a molecular docking study
    Ya He Liu
    School of Health Sciences and Health Innovations Research Institute, RMIT University, Bundoora, Victoria, Australia
    Xenobiotica 41:259-80. 2011
    ..These findings suggest that herbal medicines can significantly regulate PXR and CYP3A4 and this has important implication in herb-drug interactions...
  29. doi Application of mechanism-based CYP inhibition for predicting drug-drug interactions
    Zhi Wei Zhou
    RMIT University, Discipline of Chinese Medicine, School of Health Sciences, Bundoora, Victoria, Australia
    Expert Opin Drug Metab Toxicol 5:579-605. 2009
    ..A significant inactivation of CYPs and particularly the main human hepatic and intestinal CYPs could result in clinical drug-drug interactions (DDIs) and adverse drug reactions...
  30. doi Mechanism of reversal of high glucose-induced endothelial nitric oxide synthase uncoupling by tanshinone IIA in human endothelial cell line EA.hy926
    Zhi Wei Zhou
    Traditional and Complementary Medicine Program, RMIT Health Innovations Research Institute, School of Health Sciences, RMIT University, Bundoora, VIC 3083, Australia
    Eur J Pharmacol 697:97-105. 2012
    ..Tan IIA may be used as a prototype agent to restore eNOS coupling under certain cardiovascular and metabolic diseases...
  31. doi Nanoparticles in the treatment and diagnosis of neurological disorders: untamed dragon with fire power to heal
    Jagat R Kanwar
    Laboratory of Immunology and Molecular Biomedical Research, Centre for Biotechnology and Interdisciplinary Biosciences BioDeakin, Institute for Technology and Research Innovation, Deakin University, Geelong, Victoria, Australia
    Nanomedicine 8:399-414. 2012
    ..In addition, we discuss the integration of bioinformatics and modern genomic approaches in the development of nanoparticles...
  32. ncbi Regulation of telomerase activity by apparently opposing elements
    Jun Ping Liu
    Molecular Signaling Laboratory, Department of Immunology, Central Clinical School, Monash University, Alfred Medical Research and Education Precinct AMREP, Commercial Road, Melbourne, Victoria 3004, Australia
    Ageing Res Rev 9:245-56. 2010
    ..This review summarizes the advances in understanding of the positive and negative regulation by extracellular factors of telomerase activity in cancer, stem cells and other systems in mammals...
  33. ncbi Herbal interactions with anticancer drugs: mechanistic and clinical considerations
    An Kui Yang
    Department of Head and Neck Surgery, Cancer Center, Sun Yat Sen University, Guangzhou 510060, China
    Curr Med Chem 17:1635-78. 2010
    ..Further studies are warranted to investigate potentially harmful herbal interactions with anticancer drugs in patients...
  34. ncbi Identification of molecular targets associated with ethanol toxicity and implications in drug development
    Lin Lin Wang
    Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China
    Curr Pharm Des 16:1313-55. 2010
    ..Some of these agents have shown promising efficacy in initial clinical studies. However, further randomized studies with larger samples are warranted to establish their efficacy and safety profiles in the treatment of alcohol dependence...
  35. ncbi New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part II
    Sui Lin Mo
    Department of Chinese Medicine, First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, China
    Curr Drug Metab 10:1127-50. 2009
    ..Further studies are needed to investigate the molecular determinants for ligand-CYP2C9 interactions...
  36. ncbi New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part I
    Sui Lin Mo
    Department of Chinese Medicine, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, China
    Curr Drug Metab 10:1075-126. 2009
    ..Further studies are warranted to explore the molecular determinants for ligand-CYP2C9 binding and the structure-activity relationships...
  37. ncbi Drug-herb interactions: eliminating toxicity with hard drug design
    Xiao Xia Yang
    Department of Pharmacy, Faculty of Science, National University of Singapore, Science Drive 4, Singapore 117543
    Curr Pharm Des 12:4649-64. 2006
    ..More studies are needed and new approached are required to minimize toxicity arising from drug-herb interactions...
  38. ncbi Multidrug resistance associated proteins as determining factors of pharmacokinetics and pharmacodynamics of drugs
    Xue Qing Yu
    Department of Nephrology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    Curr Drug Metab 8:787-802. 2007
    ..A better understanding of the function and regulating mechanism of MRPs can help minimize and avoid drug toxicity, unfavourable drug-drug interactions, and to overcome drug resistance...
  39. ncbi Topotecan is a substrate for multidrug resistance associated protein 4
    Quan Tian
    Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore 117543
    Curr Drug Metab 7:105-18. 2006
    ..These findings indicate that MRP4 confers resistance to TPT and TPT is the substrate for MRP4. Further studies are needed to explore the role of MRP4 in resistance to, toxicity and pharmacokinetics of TPT in cancer patients...
  40. ncbi Intra- and inter-ethnic differences in the allele frequencies of cytochrome P450 2B6 gene in Chinese
    Su Guan
    Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat Sen University, 74 Zhongshan Road, Section 2, Guangzhou 510080, People s Republic of China
    Pharm Res 23:1983-90. 2006
    ..05). These results indicate that there were marked ethnic differences in the mutant frequencies of CYP2B6 between Chinese and other ethnic groups. Further studies are warranted to explore the clinical impact of such ethnic differences...
  41. ncbi A pharmacogenetic study of pregnane X receptor (NR1I2) in Han Chinese
    Xue Ding Wang
    Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, China
    Curr Drug Metab 8:778-86. 2007
    ..Further studies are warranted to explore the clinical and toxicological impact of SNPs and haplotypes of NR1I2 in various ethnic groups...
  42. ncbi Characterization of water-in-oil microemulsion for oral delivery of earthworm fibrinolytic enzyme
    Mao Bo Cheng
    Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    J Control Release 129:41-8. 2008
    ..These findings indicated that the w/o microemulsion may represent a safe and effective oral delivery system for hydrophilic bioactivity macromolecules...
  43. ncbi A mechanistic study on altered pharmacokinetics of irinotecan by St. John's wort
    Ze Ping Hu
    Department of Pharmacy, Faculty of Science, National University of Singapore, Science Drive 4, 117543, Singapore
    Curr Drug Metab 8:157-71. 2007
    ..Further studies are needed to explore the role of both pharmacokinetic and pharmacodynamic components in the protective effect of SJW against the toxicities of CPT-11...
  44. ncbi Role of P-glycoprotein in the intestinal absorption of glabridin, an active flavonoid from the root of Glycyrrhiza glabra
    Jie Cao
    Department of Pharmacy, School of Life Sciences, Queensland University of Technology, 2 George Street, Brisbane, Queensland 4001 Australia
    Drug Metab Dispos 35:539-53. 2007
    ..8-fold higher than that in wild-type mice. These findings indicate that glabridin is a substrate for PgP and that both PgP/MDR1-mediated efflux and first-pass metabolism contribute to the low oral bioavailability of glabridin...
  45. ncbi St. John's wort attenuates irinotecan-induced diarrhea via down-regulation of intestinal pro-inflammatory cytokines and inhibition of intestinal epithelial apoptosis
    Ze Ping Hu
    Department of Pharmacy, Faculty of Science, National University of Singapore, Science Drive 4, Singapore 117543, Singapore
    Toxicol Appl Pharmacol 216:225-37. 2006
    ..Further studies are warranted to explore the potential for STW as an agent in combination with chemotherapeutic drugs to lower their dose-limiting toxicities...
  46. ncbi Reversal of resistance to oxazaphosphorines
    Jing Zhang
    Department of Pharmacology, Faculty of Medicine, National University of Singapore
    Curr Cancer Drug Targets 6:385-407. 2006
    ..To date, several types of these agents are being evaluated in Phase III trials in cancer patients. Further studies are needed to identify the molecular targets associated with resistance to oxazaphosphorines...
  47. ncbi The last 10 amino acid residues beyond the hydrophobic motif are critical for the catalytic competence and function of protein kinase Calpha
    Sui Sum Yeong
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597
    J Biol Chem 281:30768-81. 2006
    ..Molecules that bind preferentially to the very C terminus of distinct PKC isozymes and suppress their catalytic activity may constitute a new class of selective inhibitors of PKC...
  48. ncbi A mechanistic study on reduced toxicity of irinotecan by coadministered thalidomide, a tumor necrosis factor-alpha inhibitor
    Xiao Xia Yang
    Department of Pharmacy, Faculty of Science, National University of Singapore, Science Drive 4, Singapore 117543
    J Pharmacol Exp Ther 319:82-104. 2006
    ..These results provide insights into the pharmacodynamic and pharmacokinetic mechanisms for the protective effects of thalidomide against CPT-11-induced intestinal toxicity...
  49. ncbi Genetic polymorphisms of cytochrome P450 2B6 gene in Han Chinese
    Su Guan
    Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, China
    Eur J Pharm Sci 29:14-21. 2006
    ..Further studies are required to explore the impact of these SNPs of CYP2B6 gene on the clinical response (efficacy and toxicity) to drugs that are substrates for CYP2B6 in patients...
  50. ncbi Small interfering RNA-mediated silencing of cytochrome P450 3A4 gene
    Jie Chen
    Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat Sen University, China
    Drug Metab Dispos 34:1650-7. 2006
    ..This study demonstrated, for the first time, the specific suppression of CYP3A4 expression and function using vector-based RNAi technique. The use of RNAi is a promising tool for the study of cytochrome P450 family function...
  51. ncbi Pharmacokinetic mechanisms for reduced toxicity of irinotecan by coadministered thalidomide
    Xiao Xia Yang
    Department of Pharmacy, Faculty of Science, National University of Singapore, Science Drive 4, Singapore 117543, Singapore
    Curr Drug Metab 7:431-55. 2006
    ..Further studies are needed to explore the role of both pharmacokinetics and pharmacodynamic components in the protective effect of thalidomide against the toxicities of CPT-11...
  52. ncbi Rapid and simultaneous determination of nifedipine and dehydronifedipine in human plasma by liquid chromatography-tandem mass spectrometry: Application to a clinical herb-drug interaction study
    Xue Ding Wang
    Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, China
    J Chromatogr B Analyt Technol Biomed Life Sci 852:534-44. 2007
    ..John's wort, a known herbal inducer of CYP3A4. St. John's wort was shown to induce NIF metabolism with increased plasma concentrations of DNIF...
  53. ncbi High performance liquid chromatography with ultraviolet detection for the determination of SYUIQ-5, a novel telomerase inhibitor for cancer therapy: application to an enzyme kinetic study in rat liver microsomes
    Qi Biao Su
    Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat Sen University, 74 Zhongshan Road, Section 2, Guangzhou, China
    J Chromatogr B Analyt Technol Biomed Life Sci 854:332-7. 2007
    ..0 microM. Kinetic analysis showed that beta-naphthofIavone and dexamethasone significantly induced SYUIQ-5 metabolism, suggesting that cytochrome P450 1A and 3A are the major contributor to SYUIQ-5 metabolism in rat liver microsomes...
  54. ncbi Transport of cryptotanshinone, a major active triterpenoid in Salvia miltiorrhiza Bunge widely used in the treatment of stroke and Alzheimer's disease, across the blood-brain barrier
    Xi Yong Yu
    Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou 510080, China
    Curr Drug Metab 8:365-78. 2007
    ..Further studies are needed to explore the role of other drug transporters in restricting the brain penetration of CTS and the clinical relevance...
  55. ncbi Self-microemulsifying drug delivery system (SMEDDS) improves anticancer effect of oral 9-nitrocamptothecin on human cancer xenografts in nude mice
    Juan Li Lu
    Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, PR China
    Eur J Pharm Biopharm 69:899-907. 2008
    ..9-NC SMEDDS represents a novel 9-NC therapy for cancer patients...
  56. ncbi Rapid and simultaneous determination of tacrolimus (FK506) and diltiazem in human whole blood by liquid chromatography-tandem mass spectrometry: application to a clinical drug-drug interaction study
    Jia Li Li
    Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat Sen University, 74 Zhongshan Road, Section 2, Guangzhou 510080, China
    J Chromatogr B Analyt Technol Biomed Life Sci 867:111-8. 2008
    ..The validated LC/MS/MS method has been successfully used to analyze the concentrations of FK506 and DTZ in whole blood samples from pharmacokinetic studies in renal transplanted patients...
  57. doi Single nucleotide polymorphisms of the pregnane x receptor gene in Han Chinese and a comparison with other ethnic populations
    Xue Ding Wang
    Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, China
    Pharmacology 81:350-4. 2008
    ..Further studies are needed to determine the impact of common SNPs of PXR in Han Chinese and other ethnic populations on the phenotypic activity of cytochrome P450s and drug transporters transactivated by PXR...
  58. ncbi Biotransformation and pharmacokinetics of the novel anticancer drug, SYUIQ-5, in the rat
    Qi Biao Su
    Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat Sen University, and Department of Pharmacy, Guangzhou Children s Hospital, Guangzhou, China
    Invest New Drugs 26:119-37. 2008
    ..These results indicate that that SYUIQ-5 exhibits dose-dependent pharmacokinetics in rats and it is mainly metabolized by Cyp3A1/2...
  59. ncbi Identification of drugs that interact with herbs in drug development
    Shu Feng Zhou
    School of Life Sciences, Queensland University of Technology, Brisbane, Australia
    Drug Discov Today 12:664-73. 2007
    ..In silico, in vitro, animal and human studies are often used to identify drug interactions with herbs. We propose that drug-herb and herb-CYP interaction studies should be incorporated into drug development...
  60. ncbi Metabolic activation of herbal and dietary constituents and its clinical and toxicological implications: an update
    Shu Feng Zhou
    Division of Pharmacy, School of Life Sciences, Faculty of Science, Queensland University of Technology, Brisbane, Queensland, Australia
    Curr Drug Metab 8:526-53. 2007
    ..Due to the wide use and easy availability of herbal medicines, further research should be conducted to ensure the safety and quality of herbal medicine...
  61. ncbi ERCC1 and non-small-cell lung cancer
    Shu Feng Zhou
    N Engl J Med 356:2540; author reply 2540-1. 2007
  62. ncbi Role of P-glycoprotein in limiting the brain penetration of glabridin, an active isoflavan from the root of Glycyrrhiza glabra
    Xi Yong Yu
    Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou, 510080, China
    Pharm Res 24:1668-90. 2007
    ..Recently, we have found that glabridin is a substrate of P-glycoprotein (PgP/MDR1). This study aimed to investigate the role of PgP in glabridin penetration across the blood-brain barrier (BBB) using several in vitro and in vivo models...
  63. ncbi A rapid and simple high-performance liquid chromatography method for the determination of human plasma levofloxacin concentration and its application to bioequivalence studies
    Zhi Ling Zhou
    Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangzhou 510080, People s Republic of China
    Biomed Chromatogr 21:1045-51. 2007
    ..The method described herein has been successfully used for the pharmacokinetic and bioequivalence studies of a levofloxacin formulation product after oral administration to healthy Chinese volunteers...
  64. ncbi Monitoring drug-protein interaction
    Xiao Xia Yang
    Department of Pharmacy, Faculty of Science, National University of Singapore, Science Drive 4, Singapore 117543, Singapore
    Clin Chim Acta 365:9-29. 2006
    ....