Timothy V Murphy

Summary

Affiliation: RMIT University
Country: Australia

Publications

  1. ncbi request reprint Tyrosine phosphorylation following alterations in arteriolar intraluminal pressure and wall tension
    T V Murphy
    Microvascular Biology Group, School of Medical Sciences, RMIT University, Bundoora, Victoria 3083, Australia
    Am J Physiol Heart Circ Physiol 281:H1047-56. 2001
  2. ncbi request reprint Mechanisms underlying pervanadate-induced contraction of rat cremaster muscle arterioles
    Timothy V Murphy
    Microvascular Biology Group, School of Medical Sciences, RMIT University, PO Box 71, 3083 Bundoora, Victoria, Australia
    Eur J Pharmacol 442:107-14. 2002
  3. ncbi request reprint Cellular signalling in arteriolar myogenic constriction: involvement of tyrosine phosphorylation pathways
    Timothy V Murphy
    Microvascular Biology Group, School of Medical Sciences, RMIT University, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 29:612-9. 2002
  4. doi request reprint Enhanced contractility in pregnancy is associated with augmented TRPC3, L-type, and T-type voltage-dependent calcium channel function in rat uterine radial artery
    Sevvandi Senadheera
    Department of Physiology, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia
    Am J Physiol Regul Integr Comp Physiol 305:R917-26. 2013
  5. pmc Transient receptor potential canonical type 3 channels facilitate endothelium-derived hyperpolarization-mediated resistance artery vasodilator activity
    Sevvandi Senadheera
    Department of Physiology, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney 2052, Australia
    Cardiovasc Res 95:439-47. 2012
  6. doi request reprint Dietary obesity increases NO and inhibits BKCa-mediated, endothelium-dependent dilation in rat cremaster muscle artery: association with caveolins and caveolae
    Lauren Howitt
    Department of Physiology, School of Medical Sciences, University of New South Wales, Sydney, Australia
    Am J Physiol Heart Circ Physiol 302:H2464-76. 2012
  7. pmc Pregnancy-induced remodelling and enhanced endothelium-derived hyperpolarization-type vasodilator activity in rat uterine radial artery: transient receptor potential vanilloid type 4 channels, caveolae and myoendothelial gap junctions
    Sevvandi Senadheera
    Department of Physiology, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia
    J Anat 223:677-86. 2013
  8. ncbi request reprint Membrane cholesterol depletion with beta-cyclodextrin impairs pressure-induced contraction and calcium signalling in isolated skeletal muscle arterioles
    Simon J Potocnik
    Microvascular Biology Group, School of Medical Sciences, RMIT University, Bundoora, Australia
    J Vasc Res 44:292-302. 2007
  9. doi request reprint Calcium and endothelium-mediated vasodilator signaling
    Shaun L Sandow
    Department of Physiology, School of Medical Sciences, University of New South Wales, 2052 Sydney, NSW, Australia
    Adv Exp Med Biol 740:811-31. 2012
  10. ncbi request reprint Matrix protein glycation impairs agonist-induced intracellular Ca2+ signaling in endothelial cells
    Nour B Bishara
    Microvascular Biology Group, School of Medical Sciences, RMIT University, Bundoora, Victoria, Australia
    J Cell Physiol 193:80-92. 2002

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Tyrosine phosphorylation following alterations in arteriolar intraluminal pressure and wall tension
    T V Murphy
    Microvascular Biology Group, School of Medical Sciences, RMIT University, Bundoora, Victoria 3083, Australia
    Am J Physiol Heart Circ Physiol 281:H1047-56. 2001
    ....
  2. ncbi request reprint Mechanisms underlying pervanadate-induced contraction of rat cremaster muscle arterioles
    Timothy V Murphy
    Microvascular Biology Group, School of Medical Sciences, RMIT University, PO Box 71, 3083 Bundoora, Victoria, Australia
    Eur J Pharmacol 442:107-14. 2002
    ..These observations suggest that pervanadate-induced contraction of smooth muscle in the cremaster arteriole involves Ca2+/calmodulin-dependent myosin phosphorylation and possibly sensitization of the contractile apparatus to Ca2+...
  3. ncbi request reprint Cellular signalling in arteriolar myogenic constriction: involvement of tyrosine phosphorylation pathways
    Timothy V Murphy
    Microvascular Biology Group, School of Medical Sciences, RMIT University, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 29:612-9. 2002
    ..The longer-term responses of blood vessels to increased transmural pressure that may involve tyrosine phosphorylation pathways include maintenance of myogenic constriction and vessel wall remodelling...
  4. doi request reprint Enhanced contractility in pregnancy is associated with augmented TRPC3, L-type, and T-type voltage-dependent calcium channel function in rat uterine radial artery
    Sevvandi Senadheera
    Department of Physiology, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia
    Am J Physiol Regul Integr Comp Physiol 305:R917-26. 2013
    ..These data suggest that TRPC3 channels act synergistically with L- and T-type channels to modulate radial artery vasoconstriction, with the mechanism being augmented in pregnancy. ..
  5. pmc Transient receptor potential canonical type 3 channels facilitate endothelium-derived hyperpolarization-mediated resistance artery vasodilator activity
    Sevvandi Senadheera
    Department of Physiology, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney 2052, Australia
    Cardiovasc Res 95:439-47. 2012
    ..This study determines the distribution and role of TRP canonical type 3 (C3) channels in the control of endothelium-derived hyperpolarization (EDH)-mediated vasodilator tone in rat mesenteric artery...
  6. doi request reprint Dietary obesity increases NO and inhibits BKCa-mediated, endothelium-dependent dilation in rat cremaster muscle artery: association with caveolins and caveolae
    Lauren Howitt
    Department of Physiology, School of Medical Sciences, University of New South Wales, Sydney, Australia
    Am J Physiol Heart Circ Physiol 302:H2464-76. 2012
    ....
  7. pmc Pregnancy-induced remodelling and enhanced endothelium-derived hyperpolarization-type vasodilator activity in rat uterine radial artery: transient receptor potential vanilloid type 4 channels, caveolae and myoendothelial gap junctions
    Sevvandi Senadheera
    Department of Physiology, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia
    J Anat 223:677-86. 2013
    ..The decreased myoendothelial gap junction density and lack of TRPV4 density at such sites is consistent with their having an integral, albeit complex, interactive role in uterine vascular signalling and remodelling in pregnancy. ..
  8. ncbi request reprint Membrane cholesterol depletion with beta-cyclodextrin impairs pressure-induced contraction and calcium signalling in isolated skeletal muscle arterioles
    Simon J Potocnik
    Microvascular Biology Group, School of Medical Sciences, RMIT University, Bundoora, Australia
    J Vasc Res 44:292-302. 2007
    ..Given evidence for clustering of signalling molecules and ion channels in cholesterol-rich membrane domains, the involvement of such structures in arteriolar smooth muscle mechanotransduction was examined...
  9. doi request reprint Calcium and endothelium-mediated vasodilator signaling
    Shaun L Sandow
    Department of Physiology, School of Medical Sciences, University of New South Wales, 2052 Sydney, NSW, Australia
    Adv Exp Med Biol 740:811-31. 2012
    ....
  10. ncbi request reprint Matrix protein glycation impairs agonist-induced intracellular Ca2+ signaling in endothelial cells
    Nour B Bishara
    Microvascular Biology Group, School of Medical Sciences, RMIT University, Bundoora, Victoria, Australia
    J Cell Physiol 193:80-92. 2002
    ..The results demonstrate that matrix glycation impairs agonist-induced Ca(2+) (i) increases which may impact on regulatory functions of the endothelium and implicate possible involvement of oxidative stress...
  11. ncbi request reprint Intraluminal pressure stimulates MAPK phosphorylation in arterioles: temporal dissociation from myogenic contractile response
    Brian E Spurrell
    Microvascular Biology Group, School of Medical Sciences, RMIT University, Plenty Rd, Bundoora, Victoria 3083, Australia
    Am J Physiol Heart Circ Physiol 285:H1764-73. 2003
    ....
  12. doi request reprint Increased caveolae density and caveolin-1 expression accompany impaired NO-mediated vasorelaxation in diet-induced obesity
    T Hilton Grayson
    Department of Pharmacology, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia
    Histochem Cell Biol 139:309-21. 2013
    ..Such altered signaling mechanisms in obesity-related vascular disease represent significant potential targets for therapeutic intervention...
  13. doi request reprint Endothelium-dependent vasodilation in myogenically active mouse skeletal muscle arterioles: role of EDH and K(+) channels
    Simon J Potocnik
    School of Medical Sciences, RMIT University, Victoria, Australia
    Microcirculation 16:377-90; 1 p following 390. 2009
    ....
  14. ncbi request reprint Approaches for introducing peptides into intact and functional arteriolar smooth muscle: manipulation of protein kinase-based signalling
    Kay Richards
    Microvascular Biology Group, School of Medical Sciences, RMIT University, Bundoora, Victoria 3083, Australia
    Clin Exp Pharmacol Physiol 30:653-8. 2003
    ..Protein transfection using polycationic lipids appears to be limited by the barrier provided by the adventitia or inherent differences between cells under cultured conditions compared within the intact arteriole...
  15. ncbi request reprint Effect of diet-induced obesity on BKCa function in contraction and dilation of rat isolated middle cerebral artery
    Lauren Howitt
    Department of Physiology, School of Medical Sciences, University of New South Wales, Sydney NSW 2052, Australia
    Vascul Pharmacol 61:10-5. 2014
    ..Obesity had variable effects on the functional role of BKCa in the middle-cerebral artery depending upon the agent used to stimulate the channel, reflecting the variety of mechanisms by which BKCa may be activated. ..
  16. doi request reprint Myoendothelial contacts, gap junctions, and microdomains: anatomical links to function?
    Shaun L Sandow
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia
    Microcirculation 19:403-15. 2012
    ..Diversity in the density and specific characteristics of MECC sites as signaling microdomains suggests considerable potential for functional diversity within and between arteries in health and disease...
  17. pmc Capacitative Ca(2+) entry in vascular endothelial cells is mediated via pathways sensitive to 2 aminoethoxydiphenyl borate and xestospongin C
    Nour B Bishara
    Microvascular Biology Group, School of Medical Sciences, RMIT University, Bundoora, Victoria 3083, Australia
    Br J Pharmacol 135:119-28. 2002
    ....
  18. doi request reprint Endothelium-dependent vasodilation in human mesenteric artery is primarily mediated by myoendothelial gap junctions intermediate conductance calcium-activated K+ channel and nitric oxide
    Preet S Chadha
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia
    J Pharmacol Exp Ther 336:701-8. 2011
    ..Myoendothelial microdomain signaling sites are present in human mesenteric artery and are likely to contribute to endothelium-dependent vasodilation via a mechanism that is conserved between species...
  19. ncbi request reprint Arteriolar myogenic signalling mechanisms: Implications for local vascular function
    Michael A Hill
    Department of Physiology and Pharmacology, University of New South Wales, Sydney, New South Wales 2052, Australia
    Clin Hemorheol Microcirc 34:67-79. 2006
    ....