J A Hawley

Summary

Affiliation: RMIT University
Country: Australia

Publications

  1. ncbi request reprint Introduction-preventing insulin resistance through exercise: a cellular approach
    John A Hawley
    Exercise Metabolism Group, School of Medical Sciences, R M I T University, Bundoora, Victoria, Australia
    Med Sci Sports Exerc 36:1187-90. 2004
  2. pmc Daytime pattern of post-exercise protein intake affects whole-body protein turnover in resistance-trained males
    Daniel R Moore
    Nestle Research Centre, Nestec Ltd, Lausanne, Switzerland
    Nutr Metab (Lond) 9:91. 2012
  3. doi request reprint Skeletal muscle respiratory capacity is enhanced in rats consuming an obesogenic Western diet
    Erin J Stephenson
    School of Medical Sciences, Royal Melbourne Institute of Technology University, Bundoora, Australia
    Am J Physiol Endocrinol Metab 302:E1541-9. 2012
  4. doi request reprint What's new since Hippocrates? Preventing type 2 diabetes by physical exercise and diet
    J A Hawley
    Exercise Metabolism Group, Health Innovations Research Institute, School of Medical Sciences, RMIT University, PO Box 71, Bundoora, VIC 3083, Australia
    Diabetologia 55:535-9. 2012
  5. ncbi request reprint Symposium: Limits to fat oxidation by skeletal muscle during exercise--introduction
    John A Hawley
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, PO Box 71, Bundoora, Victoria 3083, Australia
    Med Sci Sports Exerc 34:1475-6. 2002
  6. ncbi request reprint Effect of increased fat availability on metabolism and exercise capacity
    John A Hawley
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, PO Box 71, Bundoora, Victoria 3083, Australia
    Med Sci Sports Exerc 34:1485-91. 2002
  7. doi request reprint The battle against obesity-attacking physical inactivity as a primary means of defense
    John A Hawley
    School of Medical Sciences, RMIT University, Melbourne, Australia
    Nat Clin Pract Endocrinol Metab 4:548-9. 2008
  8. doi request reprint Exercise training-induced improvements in insulin action
    J A Hawley
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, Bundoora, Vic, Australia
    Acta Physiol (Oxf) 192:127-35. 2008
  9. pmc Specificity of training adaptation: time for a rethink?
    John A Hawley
    School of Medical Sciences, RMIT University, Bundoora, Victoria 3083, Australia
    J Physiol 586:1-2. 2008
  10. ncbi request reprint Innovations in athletic preparation: role of substrate availability to modify training adaptation and performance
    John A Hawley
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, Bundoora, VIC 3083, Australia
    J Sports Sci 25:S115-24. 2007

Collaborators

Detail Information

Publications106 found, 100 shown here

  1. ncbi request reprint Introduction-preventing insulin resistance through exercise: a cellular approach
    John A Hawley
    Exercise Metabolism Group, School of Medical Sciences, R M I T University, Bundoora, Victoria, Australia
    Med Sci Sports Exerc 36:1187-90. 2004
    ..The five papers comprising this symposium provide a state-of-the-art synopsis of the metabolic, cellular, and molecular mechanisms positively affected by exercise training in individuals who are insulin resistant...
  2. pmc Daytime pattern of post-exercise protein intake affects whole-body protein turnover in resistance-trained males
    Daniel R Moore
    Nestle Research Centre, Nestec Ltd, Lausanne, Switzerland
    Nutr Metab (Lond) 9:91. 2012
    ..abstract:..
  3. doi request reprint Skeletal muscle respiratory capacity is enhanced in rats consuming an obesogenic Western diet
    Erin J Stephenson
    School of Medical Sciences, Royal Melbourne Institute of Technology University, Bundoora, Australia
    Am J Physiol Endocrinol Metab 302:E1541-9. 2012
    ..This is likely due to an increase in mitochondrial density, which at least in the short term, and in the absence of increased energy demand, may protect the tissue from lipid-induced impairments in glycemic control...
  4. doi request reprint What's new since Hippocrates? Preventing type 2 diabetes by physical exercise and diet
    J A Hawley
    Exercise Metabolism Group, Health Innovations Research Institute, School of Medical Sciences, RMIT University, PO Box 71, Bundoora, VIC 3083, Australia
    Diabetologia 55:535-9. 2012
    ....
  5. ncbi request reprint Symposium: Limits to fat oxidation by skeletal muscle during exercise--introduction
    John A Hawley
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, PO Box 71, Bundoora, Victoria 3083, Australia
    Med Sci Sports Exerc 34:1475-6. 2002
    ....
  6. ncbi request reprint Effect of increased fat availability on metabolism and exercise capacity
    John A Hawley
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, PO Box 71, Bundoora, Victoria 3083, Australia
    Med Sci Sports Exerc 34:1485-91. 2002
    ..Despite substantial muscle glycogen sparing (15-48% compared with control), exercise capacity is not systematically improved in the face of increased FA availability...
  7. doi request reprint The battle against obesity-attacking physical inactivity as a primary means of defense
    John A Hawley
    School of Medical Sciences, RMIT University, Melbourne, Australia
    Nat Clin Pract Endocrinol Metab 4:548-9. 2008
  8. doi request reprint Exercise training-induced improvements in insulin action
    J A Hawley
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, Bundoora, Vic, Australia
    Acta Physiol (Oxf) 192:127-35. 2008
    ....
  9. pmc Specificity of training adaptation: time for a rethink?
    John A Hawley
    School of Medical Sciences, RMIT University, Bundoora, Victoria 3083, Australia
    J Physiol 586:1-2. 2008
  10. ncbi request reprint Innovations in athletic preparation: role of substrate availability to modify training adaptation and performance
    John A Hawley
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, Bundoora, VIC 3083, Australia
    J Sports Sci 25:S115-24. 2007
    ..These and other diet-training interactions with the potential to alter training adaptation and performance are discussed...
  11. ncbi request reprint Metabolic adaptations to marathon training and racing
    John A Hawley
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, Melbourne, Victoria, Australia
    Sports Med 37:328-31. 2007
    ..In this brief commentary, we summarise some of the major cellular and molecular adaptations in human skeletal muscle resulting from the intense endurance training required to run a marathon...
  12. ncbi request reprint Integration of metabolic and mitogenic signal transduction in skeletal muscle
    John A Hawley
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, Bundoora, Victoria, Australia
    Exerc Sport Sci Rev 32:4-8. 2004
    ..The role of several parallel signaling cascades are discussed in an effort to assign a physiological role for these targets in the regulation of exercise-mediated responses on metabolism and gene expression...
  13. ncbi request reprint Exercise as a therapeutic intervention for the prevention and treatment of insulin resistance
    John A Hawley
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, Bundoora, Victoria, Australia
    Diabetes Metab Res Rev 20:383-93. 2004
    ....
  14. ncbi request reprint Mitochondrial function: use it or lose it
    J A Hawley
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, P O Box 71, Bundoora, 3083, Vic, Australia
    Diabetologia 50:699-702. 2007
  15. ncbi request reprint Signalling mechanisms in skeletal muscle: role in substrate selection and muscle adaptation
    John A Hawley
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, Bundoora 3083, Australia
    Essays Biochem 42:1-12. 2006
    ..The role of these signal transducers in the regulation of carbohydrate and fat metabolism in response to increased contractile activity has been the focus of intense research efforts during the past decade...
  16. doi request reprint Exercise: it's the real thing!
    John A Hawley
    School of Medical Sciences, RMIT University, Bundoora, Victoria 3083, Australia
    Nutr Rev 67:172-8. 2009
    ..This article provides an overview of the role of skeletal muscle in health and disease and discusses whether "exercise mimetics" have any potential to combat metabolic diseases...
  17. doi request reprint Molecular responses to strength and endurance training: are they incompatible?
    John A Hawley
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, Bundoora, Australia
    Appl Physiol Nutr Metab 34:355-61. 2009
    ....
  18. ncbi request reprint Effect of altering substrate availability on metabolism and performance during intense exercise
    J A Hawley
    Exercise Metabolism Group, Department of Human Biology and Movement Science, R M I T University, Victoria 3083, Australia
    Br J Nutr 84:829-38. 2000
    ....
  19. ncbi request reprint Adaptations to training in endurance cyclists: implications for performance
    J A Hawley
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, Bundoora, Victoria, Australia
    Sports Med 31:511-20. 2001
    ..Using experimental data we provide evidence to support the model...
  20. ncbi request reprint Promoting training adaptations through nutritional interventions
    John A Hawley
    School of Medical Sciences, RMIT University, Bundoora, Vic, Australia
    J Sports Sci 24:709-21. 2006
    ..g. carbohydrate, fat, protein) to affect many of the adaptive responses to training...
  21. doi request reprint Nutritional modulation of training-induced skeletal muscle adaptations
    John A Hawley
    Health Innovations Research Institute, School of Medical Sciences, RMIT University, P O Box 71, Bundoora, Victoria 3083 Australia
    J Appl Physiol 110:834-45. 2011
    ....
  22. ncbi request reprint Adaptations of skeletal muscle to prolonged, intense endurance training
    John A Hawley
    Exercise Metabolism Group, School of Medical Sciences, Faculty of Life Sciences, RMIT University, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 29:218-22. 2002
    ..Taken collectively, these adaptations result in an enhanced performance capacity...
  23. doi request reprint Carbohydrate availability and training adaptation: effects on cell metabolism
    John A Hawley
    Health Innovations Research Institute, School of Medical Sciences, RMIT University, Bundoora, Victoria, Australia
    Exerc Sport Sci Rev 38:152-60. 2010
    ..The potential mechanisms underlying the cellular responses arising from such nutrient-exercise interactions are discussed in the context of promoting training adaptation...
  24. pmc Exercise training reverses impaired skeletal muscle metabolism induced by artificial selection for low aerobic capacity
    Sarah J Lessard
    Royal Melbourne Institute of Technology, Bundoora, Victoria, Australia
    Am J Physiol Regul Integr Comp Physiol 300:R175-82. 2011
    ..Furthermore, we identify Nur77 as a potential mechanism for improved skeletal muscle metabolism in response to EXT...
  25. ncbi request reprint Effects of fat adaptation and carbohydrate restoration on prolonged endurance exercise
    A L Carey
    Exercise Metabolism Group, Department of Human Biology and Movement Science, RMIT University, Bundoora, Victoria 3083, Australia
    J Appl Physiol 91:115-22. 2001
    ..However, this study failed to detect a significant benefit of fat adaptation to performance of a 1-h TT undertaken after 4 h of cycling...
  26. ncbi request reprint Effects of endurance training status and sex differences on Na+,K+-pump mRNA expression, content and maximal activity in human skeletal muscle
    K T Murphy
    Muscle, Ions and Exercise Group, School of Human Movement, Recreation and Performance, Centre for Ageing, Rehabilitation, Exercise and Sport Science CARES, Victoria University, Melbourne, Vic, Australia
    Acta Physiol (Oxf) 189:259-69. 2007
    ..This study investigated the effects of endurance training status and sex differences on skeletal muscle Na+,K+-pump mRNA expression, content and activity...
  27. ncbi request reprint Interaction of diet and training on endurance performance in rats
    J S Lee
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, Bundoora 3083, Victoria, Australia
    Exp Physiol 86:499-508. 2001
    ..Experimental Physiology (2001) 86.4, 499-508...
  28. ncbi request reprint Effect of carbohydrate ingestion on metabolism during running and cycling
    M J Arkinstall
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, Bundoora, Victoria, 3083, Australia
    J Appl Physiol 91:2125-34. 2001
    ....
  29. ncbi request reprint Effect of caffeine co-ingested with carbohydrate or fat on metabolism and performance in endurance-trained men
    T L Jacobson
    Exercise Metabolism Group, Department of Human Biology and Movement Science, RMIT University, Bundoora 3083, Victoria, Australia
    Exp Physiol 86:137-44. 2001
    ..Experimental Physiology (2001) 86.1, 137-144...
  30. ncbi request reprint Postexercise muscle glycogen resynthesis in obese insulin-resistant Zucker rats
    C R Bruce
    Exercise Metabolism Group, School of Medical Sciences, Faculty of Life Sciences, RMIT University, Bundoora, Victoria 3083, Australia
    J Appl Physiol 91:1512-9. 2001
    ..We conclude that the increased glucose availability with carbohydrate refeeding after glycogen-depleting exercise resulted in glycogen supercompensation, even in the face of muscle insulin-resistance...
  31. ncbi request reprint Interleukin-6 and tumor necrosis factor-alpha are not increased in patients with Type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness
    A L Carey
    Skeletal Muscle Research Laboratory, School of Medical Sciences, RMIT University, PO Box 71, Bundoora 3083, Victoria, Australia
    Diabetologia 47:1029-37. 2004
    ..Our aim was to examine the possible direct relationship of interleukin-6 and TNFalpha with insulin sensitivity in humans...
  32. ncbi request reprint Metabolic demands of intense aerobic interval training in competitive cyclists
    N K Stepto
    Department of Human Biology and Movement Science, RMIT University, Melbourne, Victoria 3083, Australia
    Med Sci Sports Exerc 33:303-10. 2001
    ....
  33. ncbi request reprint The effect of insulin and exercise on c-Cbl protein abundance and phosphorylation in insulin-resistant skeletal muscle in lean and obese Zucker rats
    G D Wadley
    School of Health Sciences, Deakin University, 3125, Burwood, Victoria, Australia
    Diabetologia 47:412-9. 2004
    ..The activation of this pathway by insulin or exercise has yet to be reported in skeletal muscle...
  34. doi request reprint High rates of muscle glycogen resynthesis after exhaustive exercise when carbohydrate is coingested with caffeine
    David J Pedersen
    School of Medical Sciences, RMIT University, Bundoora 3083, Victoria, Australia
    J Appl Physiol 105:7-13. 2008
    ..We provide the first evidence that in trained subjects coingestion of large amounts of Caff (8 mg/kg BM) with CHO has an additive effect on rates of postexercise muscle glycogen accumulation compared with consumption of CHO alone...
  35. ncbi request reprint Discordant gene expression in skeletal muscle and adipose tissue of patients with type 2 diabetes: effect of interleukin-6 infusion
    A L Carey
    Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, RMIT University, Bundoora, Vic, Australia
    Diabetologia 49:1000-7. 2006
    ..Our secondary aim was to determine the effect of Interleukin-6 (IL6) infusion on circulating adipokines and on gene expression in human adipose tissue. To do this we used real-time RT-PCR...
  36. ncbi request reprint Muscle Na+-K+-ATPase activity and isoform adaptations to intense interval exercise and training in well-trained athletes
    R J Aughey
    Muscle, Ions and Exercise Group, Centre for Ageing, Rehabilitation, Exercise and Sport, School of Human Movement, Recreation and Performance, Victoria University, Melbourne, Australia
    J Appl Physiol 103:39-47. 2007
    ..The Na+ -K+ -ATPase mRNA response to interval exercise of increased alpha- but not beta-mRNA was largely preserved posttrain, suggesting a functional role of alpha mRNA upregulation...
  37. ncbi request reprint Interaction of contractile activity and training history on mRNA abundance in skeletal muscle from trained athletes
    Vernon G Coffey
    School of Medical Sciences, RMIT University, Melbourne, Australia
    Am J Physiol Endocrinol Metab 290:E849-55. 2006
    ..7-fold) and myostatin (approximately 0.6-fold) decreased in ET but not in ST. We conclude that prior training history can modify the acute gene responses in skeletal muscle to subsequent exercise...
  38. ncbi request reprint Intensified exercise training does not alter AMPK signaling in human skeletal muscle
    S A Clark
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, PO Box 71, Bundoora, Victoria 3083, Australia
    Am J Physiol Endocrinol Metab 286:E737-43. 2004
    ..Our results indicate that, in well-trained individuals, short-term HIT improves metabolic control but does not blunt AMPK signaling in response to intense exercise...
  39. ncbi request reprint Disassociation of muscle triglyceride content and insulin sensitivity after exercise training in patients with Type 2 diabetes
    C R Bruce
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, PO Box 71, Bundoora, Victoria 3083, Australia
    Diabetologia 47:23-30. 2004
    ..We determined the effect of exercise training on insulin sensitivity and muscle lipids (triglyceride [TG(m)] and long-chain fatty acyl CoA [LCACoA] concentration) in patients with Type 2 diabetes...
  40. ncbi request reprint Pacing strategy in simulated cycle time-trials is based on perceived rather than actual distance
    V Nikolopoulos
    Department of Human Biology and Movement Science, Faculty of Biomedical and Health Sciences and Nursing, RMIT University, Victoria, Australia
    J Sci Med Sport 4:212-9. 2001
    ..In conclusion, well-trained cyclists rode at similar power outputs and HR during time trials they perceived to be the same distance, but which varied in actual distance from 34 to 46 km...
  41. doi request reprint Fat adaptation followed by carbohydrate restoration increases AMPK activity in skeletal muscle from trained humans
    Wee Kian Yeo
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, Victoria, Australia
    J Appl Physiol 105:1519-26. 2008
    ..Our results demonstrate that AMPK-alpha1 and AMPK-alpha2 activity and fuel selection in skeletal muscle in response to exercise can be manipulated by diet and/or the interactive effects of diet and exercise training...
  42. ncbi request reprint Regulation of fuel metabolism by preexercise muscle glycogen content and exercise intensity
    Melissa J Arkinstall
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, Bundoora, Victoria 3083, Australia
    J Appl Physiol 97:2275-83. 2004
    ..We conclude that, in moderately trained individuals, muscle glycogen availability (low vs. high) does not influence rates of plasma glucose disposal during either low- or moderate-intensity exercise...
  43. doi request reprint Skeletal muscle adaptation and performance responses to once a day versus twice every second day endurance training regimens
    Wee Kian Yeo
    Exercise Metabolism Group, School of Medical Sciences, Bldg 223 2 52, RMIT University, PO Box 71, Bundoora, Victoria 3083, Australia
    J Appl Physiol 105:1462-70. 2008
    ....
  44. ncbi request reprint A short-term, high-fat diet up-regulates lipid metabolism and gene expression in human skeletal muscle
    David Cameron-Smith
    School of Health Sciences, Deakin University, Burwood, Victoria, Australia
    Am J Clin Nutr 77:313-8. 2003
    ..Dietary fatty acids may be important in regulating gene expression. However, little is known about the effect of changes in dietary fatty acids on gene regulation in human skeletal muscle...
  45. ncbi request reprint Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism
    Clinton R Bruce
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, Bundoora, Victoria, Australia
    Diabetes 52:2338-45. 2003
    ..The data provide new evidence that the pathogenesis of type 2 diabetes involves perturbations to the antioxidant defense mechanism within skeletal muscle...
  46. ncbi request reprint Postexercise muscle triacylglycerol and glycogen metabolism in obese insulin-resistant zucker rats
    Clinton R Bruce
    Exercise Metabolism Group School of Medical Sciences, RMIT University, PO Box 71, Bundoora 3083, Australia
    Obes Res 12:1158-65. 2004
    ..To determine the impact of insulin resistance and obesity on muscle triacylglycerol (IMTG) and glycogen metabolism during and after prolonged exercise...
  47. ncbi request reprint Failure to repeatedly supercompensate muscle glycogen stores in highly trained men
    Patrick McInerney
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, Victoria, Australia
    Med Sci Sports Exerc 37:404-11. 2005
    ..It is not known whether it is possible to repeatedly supercompensate muscle glycogen stores after exhaustive exercise bouts undertaken within several days...
  48. ncbi request reprint Interaction of exercise and diet on GLUT-4 protein and gene expression in Type I and Type II rat skeletal muscle
    J S Lee
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, Bundoora, Victoria, Australia
    Acta Physiol Scand 175:37-44. 2002
    ....
  49. ncbi request reprint Interspersed normoxia during live high, train low interventions reverses an early reduction in muscle Na+, K +ATPase activity in well-trained athletes
    R J Aughey
    Muscle, Ions and Exercise Group, Centre for Aging, Rehabilitation, Exercise and Sport, School of Human Movement, Recreation and Performance, Victoria University, MCMC, Melbourne, Vic, Australia
    Eur J Appl Physiol 98:299-309. 2006
    ..There were no effects of consecutive or intermittent nightly LHTL on the acute decrease in Na(+), K(+)ATPase activity with sprint exercise effects or on plasma [K(+)] during exercise...
  50. ncbi request reprint Short-term high-fat diet alters substrate utilization during exercise but not glucose tolerance in highly trained athletes
    H M Staudacher
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, Bundoora, Victoria 3083, Australia
    Int J Sport Nutr Exerc Metab 11:273-86. 2001
    ....
  51. doi request reprint Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside
    Donato A Rivas
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, Bundoora, Victoria 3083, Australia
    J Endocrinol 202:441-51. 2009
    ....
  52. ncbi request reprint Reduced neuromuscular activity with carbohydrate ingestion during constant load cycling
    Vasilis Nikolopoulos
    Exercise Metabolism Group in the School of Medical Sciences at RMIT University, Bundoora, Victoria, Australia
    Int J Sport Nutr Exerc Metab 14:161-70. 2004
    ..The precise mechanism(s) underlying this effect cannot be attributed to alterations in CHO availability but, instead, may be linked to changes in afferent sensory input...
  53. doi request reprint Global gene expression in skeletal muscle from well-trained strength and endurance athletes
    Nigel K Stepto
    Department of Physiology, Monash University, Clayton, Victoria, Australia
    Med Sci Sports Exerc 41:546-65. 2009
    ..We used gene microarray analysis to compare the global expression profile of genes involved in adaptation to training in skeletal muscle from chronically strength-trained (ST), endurance-trained (ET), and untrained control subjects (Con)...
  54. ncbi request reprint Early signaling responses to divergent exercise stimuli in skeletal muscle from well-trained humans
    Vernon G Coffey
    School of Medical Sciences, RMIT University, Victoria, Australia
    FASEB J 20:190-2. 2006
    ..Moreover, prior training attenuates the exercise specific signaling responses involved in single mode adaptations to training...
  55. ncbi request reprint Improvements in insulin resistance with aerobic exercise training: a lipocentric approach
    Clinton R Bruce
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, Bundoora, Victoria, Australia
    Med Sci Sports Exerc 36:1196-201. 2004
    ..It will be demonstrated that aerobic exercise training is a potent and effective primary intervention strategy in the prevention and treatment of individuals with insulin resistance...
  56. ncbi request reprint Dysregulation of muscle lipid metabolism in rats selectively bred for low aerobic running capacity
    Fiona J Spargo
    Exercise Metabolism Group, School of Medical Sciences, Australia
    Am J Physiol Endocrinol Metab 292:E1631-6. 2007
    ..In conclusion, rats with low intrinsic aerobic capacity demonstrate abnormalities in lipid-handling capacity. These disruptions may, in part, be responsible for the increased risk of metabolic disorders observed in this phenotype...
  57. ncbi request reprint Dietary regulation of fat oxidative gene expression in different skeletal muscle fiber types
    Andrew J McAinch
    School of Health Sciences, Deakin University, Burwood, Victoria, Australia
    Obes Res 11:1471-9. 2003
    ....
  58. ncbi request reprint Effect of short-term fat adaptation on high-intensity training
    Nigel K Stepto
    Exercise Metabolism Group, School of Medical Sciences, Faculty of Health Sciences, RMIT University, Bundoora, 3083, Australia
    Med Sci Sports Exerc 34:449-55. 2002
    ..To determine the effect of short-term (3-d) fat adaptation on high-intensity exercise training in seven competitive endurance athletes (maximal O2 uptake 5.0 +/- 0.5 L x min(-1), mean +/-SD)...
  59. ncbi request reprint Effects of live high, train low hypoxic exposure on lactate metabolism in trained humans
    Sally A Clark
    School of Medical Sciences, RMIT University, Bundoora, Victoria 3083, Australia
    J Appl Physiol 96:517-25. 2004
    ..We conclude that 20 consecutive nights of hypoxia exposure decreased whole body Ra during intense exercise in well-trained athletes. However, muscle markers of lactate metabolism and pH regulation were unchanged by the LHTL intervention...
  60. ncbi request reprint The effect of exercise and training status on platelet activation: do cocoa polyphenols play a role?
    I Singh
    Division of Laboratory Medicine, School of Medical Sciences, RMIT University Bundoora, Victoria 3083, Australia
    Platelets 17:361-7. 2006
    ....
  61. ncbi request reprint Moderate levels of hypohydration impairs bowling accuracy but not bowling velocity in skilled cricket players
    L H Devlin
    Department of Human Biology and Movement Science, RMIT University, Bundoora, Victoria, Australia
    J Sci Med Sport 4:179-87. 2001
    ..01) of delivery after HYPO. We conclude that moderate (-2.8% of BM) exercise-induced hypohydration has minimal effect on maximal bowling velocity, but there is a detrimental effect on skilled motor performance in well-trained subjects...
  62. doi request reprint Skeletal muscle: increasing the size of the locomotor cell
    Leonidas G Karagounis
    Health Innovations Research Institute, School of Medical Sciences, RMIT University, Bundoora 3083, Australia
    Int J Biochem Cell Biol 42:1376-9. 2010
    ....
  63. ncbi request reprint Effect of high-frequency resistance exercise on adaptive responses in skeletal muscle
    Vernon G Coffey
    Exercise Metabolism Group, RMIT University, Bundoora, Australia
    Med Sci Sports Exerc 39:2135-44. 2007
    ..Regulation of skeletal muscle mass is highly dependent on contractile loading. The purpose of this study was to examine changes in growth factor and inflammatory pathways following high-frequency resistance training...
  64. ncbi request reprint Chronic rosiglitazone treatment restores AMPKalpha2 activity in insulin-resistant rat skeletal muscle
    Sarah J Lessard
    School of Medical Sciences, RMIT University, Melbourne, Victoria, Australia
    Am J Physiol Endocrinol Metab 290:E251-7. 2006
    ..ACC phosphorylation was decreased with obesity (P < 0.05) but restored to the level of lean controls with RSG treatment. Our data demonstrate that RSG restores AMPK signaling in skeletal muscle of insulin-resistant obese Zucker rats...
  65. ncbi request reprint Effects of gamma-tocopherol supplementation on thrombotic risk factors
    Indu Singh
    Division of Laboratory Medicine, School of Medical Sciences, RMIT University, PO Box 71, Bundoora, Victoria 3083, Australia
    Asia Pac J Clin Nutr 16:422-8. 2007
    ..We determined the effect of 5 weeks of 100 mg/d or 200 mg/d gamma-T supplementation on thrombotic markers such as platelet reactivity, lipid profile and the inflammation marker C-reactive protein (CRP)...
  66. doi request reprint Oxidative stress-induced insulin resistance in skeletal muscle cells is ameliorated by gamma-tocopherol treatment
    Indu Singh
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, PO Box 71, Bundoora, Vic, 3083, Australia
    Eur J Nutr 47:387-92. 2008
    ..Oxidative stress-induced reactive oxygen species are associated with the clinical manifestation of insulin resistance. Evidence suggests that antioxidant treatment may reduce this incidence...
  67. ncbi request reprint PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle
    Robert J Southgate
    Cellular and Molecular Metabolism Laboratory, RMIT University, Bundoora, Victoria, Australia
    FASEB J 19:2072-4. 2005
    ..We conclude that insulin decreases the expression of genes involved in oxidative metabolism in healthy but not insulin resistant muscle, due to a decrease in FoxO1 phosphorylation and nuclear exclusion secondary to reduced Akt activity...
  68. ncbi request reprint Regulation of metabolic genes in human skeletal muscle by short-term exercise and diet manipulation
    Melissa J Arkinstall
    School of Medical Sciences, RMIT University, PO Box 71, Bundoora, Victoria 3083, Australia
    Am J Physiol Endocrinol Metab 287:E25-31. 2004
    ....
  69. doi request reprint Consecutive bouts of diverse contractile activity alter acute responses in human skeletal muscle
    Vernon G Coffey
    Exercise Metabolism Group, School of Medical Science, RMIT University, Melbourne, Australia
    J Appl Physiol 106:1187-97. 2009
    ..Moreover, undertaking divergent exercise in close proximity influences the acute molecular profile and likely exacerbates acute "interference."..
  70. ncbi request reprint Effect of training on activation of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase pathways in rat soleus muscle
    Jong Sam Lee
    Exercise Metabolism Group and Microvascular Biology Group, School of Medical Sciences, Faculty of Life Sciences, RMIT University, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 29:655-60. 2002
    ....
  71. doi request reprint Cytokine responses to carbohydrate ingestion during recovery from exercise-induced muscle injury
    Megan L R Ross
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, Bundoora, Victoria, Australia
    J Interferon Cytokine Res 30:329-37. 2010
    ..TNF-alpha mRNA expression did not change after either trial. Carbohydrate ingestion during early recovery from exercise-induced muscle injury may promote proinflammatory reactions within skeletal muscle...
  72. ncbi request reprint Influence of preexercise muscle glycogen content on transcriptional activity of metabolic and myogenic genes in well-trained humans
    Emmanuel G Churchley
    1School of Medical Sciences, RMIT University, Melbourne, Australia
    J Appl Physiol 102:1604-11. 2007
    ..We conclude that commencing resistance exercise with low muscle glycogen does not enhance the activity of genes implicated in promoting hypertrophy...
  73. doi request reprint Effect of consecutive repeated sprint and resistance exercise bouts on acute adaptive responses in human skeletal muscle
    Vernon G Coffey
    Exercise Metabolism Group, School of Medical Science, RMIT, Melbourne, Australia
    Am J Physiol Regul Integr Comp Physiol 297:R1441-51. 2009
    ..Accordingly, we suggest that sprint-activities are isolated from resistance training and that adequate recovery time is considered within periodized training plans that incorporate these divergent exercise modes...
  74. ncbi request reprint Rosiglitazone enhances glucose tolerance by mechanisms other than reduction of fatty acid accumulation within skeletal muscle
    Sarah J Lessard
    Exercise Metabolism Group, RMIT University School of Medical Sciences, Bundoora, Victoria, Australia
    Endocrinology 145:5665-70. 2004
    ..Our data suggest, therefore, that rosiglitazone enhances glucose tolerance by mechanisms other than reduction of fatty acid accumulation within skeletal muscle...
  75. doi request reprint Contraction-induced changes in TNFalpha and Akt-mediated signalling are associated with increased myofibrillar protein in rat skeletal muscle
    Leonidas G Karagounis
    Health Innovations Research Institute, School of Medical Science, RMIT University, PO Box 71, Bundoora, Vic, 3083, Australia
    Eur J Appl Physiol 109:839-48. 2010
    ..Indeed, the cumulative effect of these signalling events was associated with myofibrillar protein accretion, which likely contributes to the early adaptations in response to resistance training overload in the skeletal muscle...
  76. doi request reprint Acute signalling responses to intense endurance training commenced with low or normal muscle glycogen
    Wee Kian Yeo
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, PO Box 71, Bundoora, VIC 3083, Australia
    Exp Physiol 95:351-8. 2010
    ....
  77. doi request reprint The 5' adenosine monophosphate-activated protein kinase: regulating the ebb and flow of cellular energetics
    Leonidas G Karagounis
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, Bundoora, Victoria 3083, Australia
    Int J Biochem Cell Biol 41:2360-3. 2009
    ..This brief review will describe the structure, function and activation of AMPK in skeletal muscle and how this ubiquitous molecule may be a plausible target for the treatment of several lifestyle-related metabolic disorders...
  78. ncbi request reprint The molecular bases of training adaptation
    Vernon G Coffey
    School of Medical Sciences, Exercise Metabolism Group, RMIT University, Melbourne, Victoria, Australia
    Sports Med 37:737-63. 2007
    ..This article highlights the effects of exercise on molecular and genetic mechanisms of training adaptation in skeletal muscle...
  79. ncbi request reprint Tissue-specific effects of rosiglitazone and exercise in the treatment of lipid-induced insulin resistance
    Sarah J Lessard
    School of Medical Sciences, RMIT University, P O Box 71, Bundoora, Victoria 3083, Australia
    Diabetes 56:1856-64. 2007
    ..Accordingly, exercise training and rosiglitazone may act as complementary therapies for the treatment of insulin resistance...
  80. ncbi request reprint Muscle oxidative capacity is a better predictor of insulin sensitivity than lipid status
    Clinton R Bruce
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, Bundoora, Victoria 3083, Australia
    J Clin Endocrinol Metab 88:5444-51. 2003
    ..Furthermore, skeletal muscle oxidative capacity was a better predictor of insulin sensitivity than either TG(m) concentration or long-chain fatty acyl CoA content...
  81. doi request reprint Short-term endurance training does not alter the oxidative capacity of human subcutaneous adipose tissue
    Donny M Camera
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, Bundoora, Vic, Australia
    Eur J Appl Physiol 109:307-16. 2010
    ..We conclude that 10 days training in previously untrained subjects results in adaptations in skeletal muscle but does not increase the oxidative capacity of WAT...
  82. ncbi request reprint The effects of polyphenols in olive leaves on platelet function
    Indu Singh
    School of Medical Sciences, RMIT University, Melbourne, Australia
    Nutr Metab Cardiovasc Dis 18:127-32. 2008
    ..The results from this study will help to improve our understanding of effects of polyphenol antioxidants in olive leaf extract on platelet function...
  83. pmc Low intrinsic running capacity is associated with reduced skeletal muscle substrate oxidation and lower mitochondrial content in white skeletal muscle
    Donato A Rivas
    Health Innovations Research Institute, School of Medical Sciences, RMIT University, Bundoora, Australia
    Am J Physiol Regul Integr Comp Physiol 300:R835-43. 2011
    ..These data provide evidence that differences in white muscle may have a role in the divergent aerobic capacity observed in this generation of LCR/HCR...
  84. doi request reprint Spectroscopic correlation analysis of NMR-based metabonomics in exercise science
    Gemma M Kirwan
    Applied Chemistry, School of Applied Sciences, RMIT University, Melbourne, Vic, Australia
    Anal Chim Acta 652:173-9. 2009
    ..The complementary nature of two-dimensional correlation analysis and statistical total correlation spectroscopy are highlighted...
  85. ncbi request reprint Decreased PDH activation and glycogenolysis during exercise following fat adaptation with carbohydrate restoration
    Trent Stellingwerff
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
    Am J Physiol Endocrinol Metab 290:E380-8. 2006
    ....
  86. ncbi request reprint It's all in the genes, so pick your parents wisely
    John A Hawley
    J Appl Physiol 100:1751-2. 2006
  87. ncbi request reprint Hypoxic ventilatory response is correlated with increased submaximal exercise ventilation after live high, train low
    Nathan E Townsend
    School of Exercise and Sport Science, Faculty of Health Sciences, University of Sydney, Lidcombe, Australia
    Eur J Appl Physiol 94:207-15. 2005
    ..51, P = 0.02) for the pooled data of LHTLc and LHTLi. These results suggest that enhanced hypoxic chemosensitivity contributes to increased exercise V(E) in normoxia following LHTL...
  88. ncbi request reprint Adaptations to short-term high-fat diet persist during exercise despite high carbohydrate availability
    Louise M Burke
    Sports Science and Sports Medicine, Australian Institute of Sport, Belconnen 2616, Australia
    Med Sci Sports Exerc 34:83-91. 2002
    ..We investigated whether enhanced rates of fat oxidation during submaximal exercise after 5 d of a high-fat diet would persist in the face of increased carbohydrate (CHO) availability before and during exercise...
  89. ncbi request reprint Exercise-induced phosphorylation of the novel Akt substrates AS160 and filamin A in human skeletal muscle
    Atul Deshmukh
    Karolinska Institutet, Department of Molecular Medicine and Surgery, Stockholm, Sweden
    Diabetes 55:1776-82. 2006
    ..0- and 4.9-fold, respectively; P<0.05) after endurance but not resistance exercise. In conclusion, AS160 and filamin A may provide an important link to mediate endurance exercise-induced bioeffects in skeletal muscle...
  90. pmc Skeletal muscle fiber type: influence on contractile and metabolic properties
    Juleen R Zierath
    Department of Surgical Sciences, Section of Integrative Physiology, Karolinska Institutet, Stockholm, Sweden
    PLoS Biol 2:e348. 2004
  91. ncbi request reprint Factors affecting running economy in trained distance runners
    Philo U Saunders
    Department of Physiology, Australian Institute of Sport, Belconnen, ACT
    Sports Med 34:465-85. 2004
    ..The importance of RE to successful distance running is well established, and future research should focus on identifying methods to improve RE. Interventions that are easily incorporated into an athlete's training are desirable...
  92. ncbi request reprint Greater effect of diet than exercise training on the fatty acid profile of rat skeletal muscle
    Nigel Turner
    Metabolic Research Centre, Department of Biomedical Sciences, University of Wollongong, New South Wales, Australia
    J Appl Physiol 96:974-80. 2004
    ....
  93. ncbi request reprint Fat and carbohydrate for exercise
    Louise M Burke
    Department of Sports Nutrition, Australian Institute of Sport, Belconnen, ACT, Australia
    Curr Opin Clin Nutr Metab Care 9:476-81. 2006
    ..To examine the results of new investigations that look at the efficacy of nutrient/training strategies on metabolism and athletic performance...
  94. ncbi request reprint Exercise alters the profile of phospholipid molecular species in rat skeletal muscle
    Todd W Mitchell
    Metabolic Research Centre, University of Wollongong, Wollongong, New South Wales 2522
    J Appl Physiol 97:1823-9. 2004
    ..Even though little is known about the physiological or pathophysiological role of specific phospholipid molecular species in skeletal muscle, it is likely that this remodeling will have an impact on a range of cellular functions...
  95. ncbi request reprint Commentary on Viewpoint: Exercise and cardiovascular risk reduction: time to update the rationale for exercise?
    Julianne J Reid
    J Appl Physiol 105:772. 2008
  96. pmc Activation of atypical protein kinase Czeta toward TC10 is regulated by high-fat diet and aerobic exercise in skeletal muscle
    Misato Saito
    Exercise Biochemistry Laboratory, Department of Kinesiology, California State University Northridge, CA 91330 8287, USA
    Metabolism 57:1173-80. 2008
    ..We also provide the first evidence that the CAP/c-Cbl insulin signaling cascade in skeletal muscle may directly interact with components of the classic (phosphoinositide 3-kinase dependent) insulin signaling cascade...
  97. ncbi request reprint Effects of short-term fat adaptation on metabolism and performance of prolonged exercise
    Louise M Burke
    Department of Sports Nutrition, Australian Institute of Sport, PO Box 176, Belconnen, A C T 2616, Australia
    Med Sci Sports Exerc 34:1492-8. 2002
    ..Yet, despite marked changes in the patterns of fuel utilization that favor fat oxidation, fat-adaptation/CHO restoration strategies do not provide clear benefits to the performance of prolonged endurance exercise...
  98. ncbi request reprint Exercise reverses high-fat diet-induced impairments on compartmentalization and activation of components of the insulin-signaling cascade in skeletal muscle
    Ben B Yaspelkis
    Exercise Biochemistry Laboratory, Dept of Kinesiology, California State University Northridge, 18111 Nordhoff St, Northridge, CA 91330 8287, USA
    Am J Physiol Endocrinol Metab 293:E941-9. 2007
    ..Our findings indicate that chronic exercise training, but not rosiglitazone, reverses high-fat diet induced impairments in compartmentalization and activation of components of the insulin-signaling cascade in skeletal muscle...
  99. ncbi request reprint Effect of different protocols of caffeine intake on metabolism and endurance performance
    Gregory R Cox
    Sports Science and Sports Medicine, Australian Institute of Sport, Belconnen, Australian Capital Territory 2616, Australia
    J Appl Physiol 93:990-9. 2002
    ..5 mg/kg)...
  100. ncbi request reprint Pre-exercise carbohydrate and fat ingestion: effects on metabolism and performance
    Mark Hargreaves
    Centre for Physical Activity and Nutrition Research, School of Health Sciences, Deakin University, Burwood, VIC 3125, Australia
    J Sports Sci 22:31-8. 2004
    ..Interventions to increase fat availability before exercise have been shown to reduce carbohydrate utilization during exercise, but do not appear to have ergogenic benefits...
  101. ncbi request reprint Short-term plyometric training improves running economy in highly trained middle and long distance runners
    Philo U Saunders
    Department of Physiology, Australian Institute of Sport, Belconnen, Australia
    J Strength Cond Res 20:947-54. 2006
    ..In a group of highly-trained distance runners, 9 weeks of PLY improved RE, with likely mechanisms residing in the muscle, or alternatively by improving running mechanics...