M A Febbraio

Summary

Affiliation: RMIT University
Country: Australia

Publications

  1. ncbi request reprint CHO feeding before prolonged exercise: effect of glycemic index on muscle glycogenolysis and exercise performance
    M A Febbraio
    Department of Human Movement Science, Royal Melbourne Institute of Technology, Bundoora, Australia
    J Appl Physiol 81:1115-20. 1996
  2. ncbi request reprint Effect of CHO ingestion on exercise metabolism and performance in different ambient temperatures
    M A Febbraio
    Department of Human Movement Science, Royal Melbourne Institute of Technology, Bundoora, Australia
    Med Sci Sports Exerc 28:1380-7. 1996
  3. ncbi request reprint 17beta-estradiol upregulates the expression of peroxisome proliferator-activated receptor alpha and lipid oxidative genes in skeletal muscle
    S E Campbell
    Department of Physiology, University of Melbourne, Parkville, Victoria 3010, Australia
    J Mol Endocrinol 31:37-45. 2003
  4. ncbi request reprint Interleukin-6 and tumor necrosis factor-alpha are not increased in patients with Type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness
    A L Carey
    Skeletal Muscle Research Laboratory, School of Medical Sciences, RMIT University, PO Box 71, Bundoora 3083, Victoria, Australia
    Diabetologia 47:1029-37. 2004
  5. ncbi request reprint Acute IL-6 treatment increases fatty acid turnover in elderly humans in vivo and in tissue culture in vitro
    E W Petersen
    Copenhagen Muscle Research Center, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 288:E155-62. 2005
  6. ncbi request reprint Suppression of plasma free fatty acids upregulates peroxisome proliferator-activated receptor (PPAR) alpha and delta and PPAR coactivator 1alpha in human skeletal muscle, but not lipid regulatory genes
    M J Watt
    Skeletal Muscle Research Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology, PO Box 27, Bundoora 3083, Victoria, Australia
    J Mol Endocrinol 33:533-44. 2004
  7. ncbi request reprint Ionomycin, but not physiologic doses of epinephrine, stimulates skeletal muscle interleukin-6 mRNA expression and protein release
    A G Holmes
    Skeletal Muscle Research Laboratory, The School of Medical Sciences, RMIT University, Bundoora 3038, Victoria, Australia
    Metabolism 53:1492-5. 2004
  8. ncbi request reprint Hormone-sensitive lipase is reduced in the adipose tissue of patients with type 2 diabetes mellitus: influence of IL-6 infusion
    M J Watt
    School of Medical Sciences, RMIT University, PO Box 71, Bundoora, 3083, Australia
    Diabetologia 48:105-12. 2005
  9. ncbi request reprint Recombinant human interleukin-6 infusion during low-intensity exercise does not enhance whole body lipolysis or fat oxidation in humans
    N Hiscock
    The Copenhagen Muscle Research Center, Rigshospitalet, Denmark
    Am J Physiol Endocrinol Metab 289:E2-7. 2005
  10. ncbi request reprint Discordant gene expression in skeletal muscle and adipose tissue of patients with type 2 diabetes: effect of interleukin-6 infusion
    A L Carey
    Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, RMIT University, Bundoora, Vic, Australia
    Diabetologia 49:1000-7. 2006

Collaborators

  • M Sacchetti
  • M Hargreaves
  • Bente K Pedersen
  • J A Hawley
  • G van Hall
  • C P Fischer
  • N Hiscock
  • Matthew J Watt
  • A L Carey
  • S E Campbell
  • R L Starkie
  • J Rolland
  • I Koukoulas
  • H B Nielsen
  • S K Pinnamaneni
  • R J Southgate
  • N H Secher
  • E W Petersen
  • C R Bruce
  • A G Holmes
  • C Barnett
  • G I Lancaster
  • J Proietto
  • B Saltin
  • M J Anderson
  • P U Saunders
  • D J Angus
  • A Steensberg
  • R C Walsh
  • P Krustrup
  • P Ott
  • H Pilegaard
  • E Wolsk Petersen
  • G R Steinberg
  • S L Macaulay
  • D Jenkins
  • D B Olsen
  • M Carey
  • B Nielsen
  • L Nybo
  • E Cerin
  • K Møller
  • S Andrikopoulos
  • B Lamont
  • D Cameron-Smith
  • K A Mehan
  • R J Tunstall
  • P L Moseley
  • A P Garnham
  • A Garnham
  • T Osada
  • P Schjerling
  • M J Arkinstall
  • L L Spriet

Detail Information

Publications28

  1. ncbi request reprint CHO feeding before prolonged exercise: effect of glycemic index on muscle glycogenolysis and exercise performance
    M A Febbraio
    Department of Human Movement Science, Royal Melbourne Institute of Technology, Bundoora, Australia
    J Appl Physiol 81:1115-20. 1996
    ..These results demonstrate that preexercise CHO ingestion has no effect on muscle glycogen utilization or exercise performance, irrespective of the glycemic or insulinemic responses to the ingested meals...
  2. ncbi request reprint Effect of CHO ingestion on exercise metabolism and performance in different ambient temperatures
    M A Febbraio
    Department of Human Movement Science, Royal Melbourne Institute of Technology, Bundoora, Australia
    Med Sci Sports Exerc 28:1380-7. 1996
    ..In addition, during exercise in 5 degrees C a 7% CHO solution is more beneficial for exercise performance than a 14% CHO solution...
  3. ncbi request reprint 17beta-estradiol upregulates the expression of peroxisome proliferator-activated receptor alpha and lipid oxidative genes in skeletal muscle
    S E Campbell
    Department of Physiology, University of Melbourne, Parkville, Victoria 3010, Australia
    J Mol Endocrinol 31:37-45. 2003
    ..05) by E(2) treatment, although protein content remained unaltered. These data demonstrate the novel regulation of E(2) on PPARalpha and genes encoding key proteins that are pivotal in regulating skeletal muscle lipid oxidative flux...
  4. ncbi request reprint Interleukin-6 and tumor necrosis factor-alpha are not increased in patients with Type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness
    A L Carey
    Skeletal Muscle Research Laboratory, School of Medical Sciences, RMIT University, PO Box 71, Bundoora 3083, Victoria, Australia
    Diabetologia 47:1029-37. 2004
    ..Our aim was to examine the possible direct relationship of interleukin-6 and TNFalpha with insulin sensitivity in humans...
  5. ncbi request reprint Acute IL-6 treatment increases fatty acid turnover in elderly humans in vivo and in tissue culture in vitro
    E W Petersen
    Copenhagen Muscle Research Center, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 288:E155-62. 2005
    ..Moreover, IL-6 appears to be activating lipolysis independently of elevations in GH and/or cortisol and appears to be a potent catalyst for fat oxidation in muscle cells...
  6. ncbi request reprint Suppression of plasma free fatty acids upregulates peroxisome proliferator-activated receptor (PPAR) alpha and delta and PPAR coactivator 1alpha in human skeletal muscle, but not lipid regulatory genes
    M J Watt
    Skeletal Muscle Research Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology, PO Box 27, Bundoora 3083, Victoria, Australia
    J Mol Endocrinol 33:533-44. 2004
    ..Despite these changes in transcription factors/coactivators, the mRNA content of lipid regulatory proteins was generally unaffected by plasma FFA availability...
  7. ncbi request reprint Ionomycin, but not physiologic doses of epinephrine, stimulates skeletal muscle interleukin-6 mRNA expression and protein release
    A G Holmes
    Skeletal Muscle Research Laboratory, The School of Medical Sciences, RMIT University, Bundoora 3038, Victoria, Australia
    Metabolism 53:1492-5. 2004
    ..In addition, ionomycin can stimulate IL-6 gene expression and protein release after only 1 hour of exposure...
  8. ncbi request reprint Hormone-sensitive lipase is reduced in the adipose tissue of patients with type 2 diabetes mellitus: influence of IL-6 infusion
    M J Watt
    School of Medical Sciences, RMIT University, PO Box 71, Bundoora, 3083, Australia
    Diabetologia 48:105-12. 2005
    ..We assessed the adipose tissue hormone-sensitive lipase (HSL) mRNA expression, protein expression and HSL activity in patients with type 2 diabetes mellitus, and determined the effect of IL-6 administration on these measures...
  9. ncbi request reprint Recombinant human interleukin-6 infusion during low-intensity exercise does not enhance whole body lipolysis or fat oxidation in humans
    N Hiscock
    The Copenhagen Muscle Research Center, Rigshospitalet, Denmark
    Am J Physiol Endocrinol Metab 289:E2-7. 2005
    ..These data suggest that the increase in fatty acid utilization seen during exercise at moderate compared with low intensity is not mediated via alterations in plasma IL-6...
  10. ncbi request reprint Discordant gene expression in skeletal muscle and adipose tissue of patients with type 2 diabetes: effect of interleukin-6 infusion
    A L Carey
    Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, RMIT University, Bundoora, Vic, Australia
    Diabetologia 49:1000-7. 2006
    ..Our secondary aim was to determine the effect of Interleukin-6 (IL6) infusion on circulating adipokines and on gene expression in human adipose tissue. To do this we used real-time RT-PCR...
  11. ncbi request reprint Interleukin-6 gene expression is increased in insulin-resistant rat skeletal muscle following insulin stimulation
    A L Carey
    Department of Physiology, The University of Melbourne, Parkville 3010, Vic, Australia
    Biochem Biophys Res Commun 302:837-40. 2003
    ..It is likely that the differences observed when comparing healthy with insulin resistant muscle are due to the differential activation of insulin sensitive signalling proteins responsible for activating IL-6...
  12. ncbi request reprint Effect of ovarian hormones on mitochondrial enzyme activity in the fat oxidation pathway of skeletal muscle
    S E Campbell
    Exercise Physiology and Metabolism Laboratory, Department of Physiology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Am J Physiol Endocrinol Metab 281:E803-8. 2001
    ..01); however, treatment with E(2) returned beta-HAD activity to C levels. These results suggest that E(2) plays a role in lipid metabolism by increasing the maximal activity of key enzymes in the fat oxidative pathway of skeletal muscle...
  13. pmc Carbohydrate ingestion attenuates the increase in plasma interleukin-6, but not skeletal muscle interleukin-6 mRNA, during exercise in humans
    R L Starkie
    Exercise Physiology and Metabolism Laboratory, Department of Physiology, The University of Melbourne, Parkville, Victoria 3010, Australia
    J Physiol 533:585-91. 2001
    ..However, because IL-6 mRNA expression was unaffected by CHO ingestion, it is likely that the ingestion of CHO during exercise attenuates IL-6 production by tissues other than skeletal muscle...
  14. pmc Adrenaline increases skeletal muscle glycogenolysis, pyruvate dehydrogenase activation and carbohydrate oxidation during moderate exercise in humans
    M J Watt
    School of Health Sciences, Deakin University, Burwood, 3125, Australia
    J Physiol 534:269-78. 2001
    ..Finally, the decreased glucose uptake observed during exercise in ADR is likely to be due to the increased intracellular G-6-P and a subsequent decrease in glucose phosphorylation...
  15. ncbi request reprint Glucose kinetics and exercise performance during phases of the menstrual cycle: effect of glucose ingestion
    S E Campbell
    Exercise Physiology and Metabolism Laboratory, Department of Physiology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Am J Physiol Endocrinol Metab 281:E817-25. 2001
    ..05) with the ingestion of glucose throughout exercise. These data demonstrate that substrate metabolism and exercise performance are influenced by the menstrual cycle phase, but ingestion of glucose minimizes these effects...
  16. ncbi request reprint Stearoyl CoA desaturase 1 is elevated in obesity but protects against fatty acid-induced skeletal muscle insulin resistance in vitro
    S K Pinnamaneni
    Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, RMIT University, Melbourne, Victoria, Australia
    Diabetologia 49:3027-37. 2006
    ..The aim of the present study was to assess the molecular mechanisms that implicate SCD1 in the aetiology of fatty acid-induced insulin resistance...
  17. ncbi request reprint Circulating monocytes are not the source of elevations in plasma IL-6 and TNF-alpha levels after prolonged running
    R L Starkie
    Exercise Physiology and Metabolism Laboratory, Department of Physiology, University of Melbourne, Parkville 3052, Victoria, Australia
    Am J Physiol Cell Physiol 280:C769-74. 2001
    ..In addition, it is likely that stress hormones result in a decrease in the amount of cytokine produced by LPS-stimulated cells postexercise...
  18. ncbi request reprint Heat stress, cytokines, and the immune response to exercise
    R L Starkie
    Department of Physiology, The University of Melbourne, Parkville, Australia
    Brain Behav Immun 19:404-12. 2005
    ..Heat stress did not, however, augment the suppression in the amount of cytokine produced by circulating monocytes upon stimulation, despite elevated catecholamines...
  19. pmc Exercise induces the release of heat shock protein 72 from the human brain in vivo
    G I Lancaster
    Skeletal Muscle Research Laboratory, School of Medical Sciences, RMIT University, Bundoora, 3083, Victoria, Australia
    Cell Stress Chaperones 9:276-80. 2004
    ..These data demonstrate that the human brain is able to release Hsp72 in vivo in response to a physical stressor such as exercise. Further study is required to determine the biological significance of these observations...
  20. ncbi request reprint Effect of adrenergic blockade on lymphocyte cytokine production at rest and during exercise
    R L Starkie
    Exercise Physiology and Metabolism Laboratory, Department of Physiology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Am J Physiol Cell Physiol 281:C1233-40. 2001
    ....
  21. pmc Exercise increases serum Hsp72 in humans
    R C Walsh
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Cell Stress Chaperones 6:386-93. 2001
    ..This study is the first to demonstrate that acute exercise can increase Hsp72 in the peripheral circulation, suggesting that during stress these proteins may indeed have a systemic role...
  22. ncbi request reprint Muscle metabolism during sprint exercise in man: influence of sprint training
    C Barnett
    School of Human Movement Studies, The University of Queensland, Queensland, Australia
    J Sci Med Sport 7:314-22. 2004
    ..Glycogen degradation during sprint exercise was unaffected by sprint training. These data demonstrate that sprint training may have enhanced muscle oxidative but not glycolytic capacity...
  23. ncbi request reprint Interleukin-6 and insulin sensitivity: friend or foe?
    A L Carey
    The Skeletal Muscle Research Laboratory, School of Medical Sciences, RMIT University, PO Box 71, Bundoora 3083, Victoria, Australia
    Diabetologia 47:1135-42. 2004
  24. ncbi request reprint No effect of mild heat stress on the regulation of carbohydrate metabolism at the onset of exercise
    P U Saunders
    Department of Physiology, The University of Melbourne, Parkville, Victoria 3010, Australia
    J Appl Physiol 91:2282-8. 2001
    ....
  25. ncbi request reprint Effects of ovarian hormones on exercise metabolism
    S E Campbell
    Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada
    Curr Opin Clin Nutr Metab Care 4:515-20. 2001
    ..Conversely, progesterone negates both these effects, and could therefore result in a state of relative metabolic inflexibility, similar to that observed in the metabolic syndrome...
  26. pmc Interleukin-6 production in contracting human skeletal muscle is influenced by pre-exercise muscle glycogen content
    A Steensberg
    The Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Denmark
    J Physiol 537:633-9. 2001
    ..A significant net IL-6 release was not observed until 2 h in the control leg. 4. This study demonstrates that glycogen availability is associated with alterations in the rate of IL-6 production and release in contracting skeletal muscle...
  27. ncbi request reprint Effect of the ovarian hormones on GLUT4 expression and contraction-stimulated glucose uptake
    S E Campbell
    Department of Physiology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Am J Physiol Endocrinol Metab 282:E1139-46. 2002
    ..However, changes in contraction-stimulated glucose uptake could not be explained by altered transporter protein content, since the absence of E(2) had no effect on GLUT4 protein...
  28. ncbi request reprint Hepatic lactate uptake versus leg lactate output during exercise in humans
    H B Nielsen
    Department of Anesthesia 2041, Rigshospitalet, Blegdamsvej 9, 2100 København Ø, Denmark
    J Appl Physiol 103:1227-33. 2007
    ..This drop in relative hepatic lactate extraction may contribute to the increase in arterial lactate during intense exercise...