David Adams

Summary

Affiliation: RMIT University
Location: Melbourne, Australia

Publications

  1. doi request reprint Localization of Nav 1.7 in the normal and injured rodent olfactory system indicates a critical role in olfaction, pheromone sensing and immune function
    Darshani B Rupasinghe
    Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, Australia
    Channels (Austin) 6:103-10. 2012
  2. ncbi request reprint Physiological roles of ion channels in adult neural stem cells and their progeny
    Takahiro Yasuda
    Health Innovations Research Institute, RMIT University, Melbourne, Victoria, Australia
    J Neurochem 114:946-59. 2010
  3. doi request reprint Stabilization of α-conotoxin AuIB: influences of disulfide connectivity and backbone cyclization
    Erica S Lovelace
    Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia
    Antioxid Redox Signal 14:87-95. 2011
  4. ncbi request reprint Analgesic α-conotoxins Vc1.1 and RgIA inhibit N-type calcium channels in sensory neurons of α9 nicotinic receptor knockout mice
    Brid Callaghan
    Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia
    Channels (Austin) 4:51-4. 2010
  5. doi request reprint Solving the alpha-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antagonists
    Markus Muttenthaler
    Institute for Molecular Bioscience, Division of Chemistry and Structural Biology, The University of Queensland, Brisbane, Queensland 4072, Australia
    J Am Chem Soc 132:3514-22. 2010
  6. doi request reprint Analgesic (omega)-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels
    G Berecki
    Department of Physiology and Pharmacology, University of Calgary, Alberta, T2N4N1 Canada
    Mol Pharmacol 77:139-48. 2010
  7. pmc Scanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha9alpha10 nicotinic acetylcholine receptor
    Reena Halai
    Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia
    J Biol Chem 284:20275-84. 2009
  8. pmc Reactive oxygen species modulate neuronal excitability in rat intrinsic cardiac ganglia
    K A Whyte
    School of Biomedical Sciences, University of Queensland, Brisbane QLD 4072, Australia
    Auton Neurosci 150:45-52. 2009
  9. doi request reprint Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3
    Jonas E Jensen
    Institute for Molecular Bioscience, The University of Queensland, 306 Carmody Road, St Lucia, QLD 4072, Australia
    Toxicon 54:56-61. 2009
  10. doi request reprint Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-Conotoxin GID and analogues
    Emma L Millard
    Institute for Molecular Bioscience, University of Queensland, Brisbane QLD 4072, Australia
    J Biol Chem 284:4944-51. 2009

Collaborators

Detail Information

Publications53

  1. doi request reprint Localization of Nav 1.7 in the normal and injured rodent olfactory system indicates a critical role in olfaction, pheromone sensing and immune function
    Darshani B Rupasinghe
    Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, Australia
    Channels (Austin) 6:103-10. 2012
    ..These findings support an emerging role for Nav 1.7 in immune function. This sodium channel may provide an important pharmacological target for treatment of inflammatory injury and inflammatory pain syndromes...
  2. ncbi request reprint Physiological roles of ion channels in adult neural stem cells and their progeny
    Takahiro Yasuda
    Health Innovations Research Institute, RMIT University, Melbourne, Victoria, Australia
    J Neurochem 114:946-59. 2010
    ..In focusing on the early stages of the neurogenic process during which NSCs give rise to neuroblasts, this review highlights the latent ability of ion channels to act as functional regulators of adult neurogenesis...
  3. doi request reprint Stabilization of α-conotoxin AuIB: influences of disulfide connectivity and backbone cyclization
    Erica S Lovelace
    Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia
    Antioxid Redox Signal 14:87-95. 2011
    ..Overall, the results of this study provide important insights into factors influencing the stability and oxidative folding of α-conotoxin AuIB and might be valuable in the design of more stable antagonists of nAChRs...
  4. ncbi request reprint Analgesic α-conotoxins Vc1.1 and RgIA inhibit N-type calcium channels in sensory neurons of α9 nicotinic receptor knockout mice
    Brid Callaghan
    Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia
    Channels (Austin) 4:51-4. 2010
    ..These results demonstrate that the inhibition of N-type Ca(2+) channel channels by Vc1.1 and RgIA is not mediated by the expression of alpha9alpha10 nAChRs in DRG neurons...
  5. doi request reprint Solving the alpha-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antagonists
    Markus Muttenthaler
    Institute for Molecular Bioscience, Division of Chemistry and Structural Biology, The University of Queensland, Brisbane, Queensland 4072, Australia
    J Am Chem Soc 132:3514-22. 2010
    ....
  6. doi request reprint Analgesic (omega)-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels
    G Berecki
    Department of Physiology and Pharmacology, University of Calgary, Alberta, T2N4N1 Canada
    Mol Pharmacol 77:139-48. 2010
    ..These N-type Ca(2+) channel-selective omega-conotoxins are therefore useful as neurophysiological tools and as potential therapeutic agents to inhibit nociceptive pain pathways...
  7. pmc Scanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha9alpha10 nicotinic acetylcholine receptor
    Reena Halai
    Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia
    J Biol Chem 284:20275-84. 2009
    ..These findings provide valuable insight into the interaction of Vc1.1 with the alpha9alpha10 nAChR subtype and will help in the further development of analogs of Vc1.1 as analgesic drugs...
  8. pmc Reactive oxygen species modulate neuronal excitability in rat intrinsic cardiac ganglia
    K A Whyte
    School of Biomedical Sciences, University of Queensland, Brisbane QLD 4072, Australia
    Auton Neurosci 150:45-52. 2009
    ..This affects action potential duration and therefore probably modifies autonomic control of the heart during ischemia/reperfusion...
  9. doi request reprint Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3
    Jonas E Jensen
    Institute for Molecular Bioscience, The University of Queensland, 306 Carmody Road, St Lucia, QLD 4072, Australia
    Toxicon 54:56-61. 2009
    ..The native chemical ligation approach should provide an efficient route for synthesis of other pharmacologically useful disulfide-rich toxins from venomous animals...
  10. doi request reprint Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-Conotoxin GID and analogues
    Emma L Millard
    Institute for Molecular Bioscience, University of Queensland, Brisbane QLD 4072, Australia
    J Biol Chem 284:4944-51. 2009
    ..Overall, our findings contribute to the understanding of the structure-activity relationships of alpha-conotoxins and may be beneficial for the ongoing attempts to exploit modulators of the neuronal nAChRs as therapeutic agents...
  11. doi request reprint A novel mechanism of inhibition of high-voltage activated calcium channels by α-conotoxins contributes to relief of nerve injury-induced neuropathic pain
    Harry Klimis
    University of Sydney, Royal North Shore Hospital, St Leonards NSW 2065, Australia
    Pain 152:259-66. 2011
    ....
  12. ncbi request reprint Regulation of voltage-gated ion channels in excitable cells by the ubiquitin ligases Nedd4 and Nedd4-2
    Daria Bongiorno
    Health Innovations Research Institute, School of Medical Sciences, RMIT University, Melbourne, Victoria, Australia
    Channels (Austin) 5:79-88. 2011
    ....
  13. pmc Structure and activity of alpha-conotoxin PeIA at nicotinic acetylcholine receptor subtypes and GABA(B) receptor-coupled N-type calcium channels
    Norelle L Daly
    Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia
    J Biol Chem 286:10233-7. 2011
    ..Furthermore, there is probably a much more diverse range of conotoxins that target the GABA(B) receptor than currently realized...
  14. pmc γ-Aminobutyric acid type B (GABAB) receptor expression is needed for inhibition of N-type (Cav2.2) calcium channels by analgesic α-conotoxins
    Hartmut Cuny
    Health Innovations Research Institute, RMIT University, Melbourne, Victoria 3083, Australia
    J Biol Chem 287:23948-57. 2012
    ..Together, these results confirm that GABA(B) receptors must be activated for the modulation of N-type (Ca(v)2.2) calcium channels by analgesic α-conotoxins Vc1.1 and RgIA...
  15. doi request reprint Isolation, characterization and total regioselective synthesis of the novel μO-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels
    Irina Vetter
    Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia
    Biochem Pharmacol 84:540-8. 2012
    ..5>1.6∼1.7∼1.3∼1.1∼1.2). This improved approach to μO-conotoxin synthesis will facilitate the optimization of μO-conotoxins as novel analgesic molecules to improve pain management...
  16. pmc Biophysical properties of Na(v) 1.8/Na(v) 1.2 chimeras and inhibition by µO-conotoxin MrVIB
    O Knapp
    Health Innovations Research Institute, RMIT University, Melbourne, Vic, Australia
    Br J Pharmacol 166:2148-60. 2012
    ..To determine which domain confers Na(v) 1.8 α-subunit its biophysical properties and MrVIB binding, we constructed various chimeric channels incorporating sequence from Na(v) 1.8 and the TTX-S Na(v) 1.2 using a domain exchange strategy...
  17. doi request reprint Intrathecal α-conotoxins Vc1.1, AuIB and MII acting on distinct nicotinic receptor subtypes reverse signs of neuropathic pain
    I A Napier
    Discipline of Pharmacology, The University of Sydney, NSW 2006, Australia
    Neuropharmacology 62:2202-7. 2012
    ..Intrathecal nAChR subunit-selective conotoxins are therefore promising tools for the effective treatment of neuropathic pain...
  18. doi request reprint RegIIA: an α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs
    Aldo Franco
    Department of Chemistry and Biochemistry, Florida Atlantic University, 777 Glades Rd, Boca Raton, FL 33431, USA
    Biochem Pharmacol 83:419-26. 2012
    ..Thus, while structurally related to other α4/7 conotoxins, RegIIA has an exquisite balance of shape, charge, and polarity exposed in its structure to potently block the α3β4 nAChRs...
  19. pmc Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (Ca(V) 2.2) calcium channels
    David J Adams
    Health Innovations Research Institute, RMIT University, Melbourne, Victoria, Australia
    Br J Pharmacol 166:486-500. 2012
    ..Understanding the molecular mechanisms of conotoxin action will lead to new ways to regulate VGCC block and modulation in normal and diseased states of the nervous system...
  20. doi request reprint Effects of cyclization on stability, structure, and activity of α-conotoxin RgIA at the α9α10 nicotinic acetylcholine receptor and GABA(B) receptor
    Reena Halai
    Institute for Molecular Bioscience, Division of Chemistry and Structural Biology, The University of Queensland, Brisbane, Queensland 4072, Australia
    J Med Chem 54:6984-92. 2011
    ....
  21. pmc Purification of immature neuronal cells from neural stem cell progeny
    Hassan Azari
    Queensland Brain Institute, The University of Queensland, Brisbane, Australia
    PLoS ONE 6:e20941. 2011
    ..The ability to provide defined neural cell populations from renewable sources such as NSC may find application for cell replacement therapies in the central nervous system...
  22. pmc Embryonic toxin expression in the cone snail Conus victoriae: primed to kill or divergent function?
    Helena Safavi-Hemami
    Department of Biochemistry and Molecular Biology, University of Melbourne, 3010 Victoria, Australia
    J Biol Chem 286:22546-57. 2011
    ....
  23. doi request reprint Analgesic alpha-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation
    Brid Callaghan
    Queensland Brain Institute and School of Biomedical Sciences, and Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
    J Neurosci 28:10943-51. 2008
    ..We propose a novel mechanism by which alpha-conotoxins Vc1.1 and Rg1A modulate native N-type (Ca(V)2.2) Ca2+ channel currents, namely acting as agonists via G-protein-coupled GABA(B) receptors...
  24. doi request reprint Molecular engineering of conotoxins: the importance of loop size to alpha-conotoxin structure and function
    Ai Hua Jin
    Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072 Australia
    J Med Chem 51:5575-84. 2008
    ..Docking simulations identified several hydrogen bonds lost upon truncation that provide an explanation for the reduced affinities observed at the alpha7 nAChR and AChBP...
  25. ncbi request reprint Polymodal regulation of NMDA receptor channels
    Anna Kloda
    School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland, Australia
    Channels (Austin) 1:334-43. 2007
    ..Here, we review the recent literature concerning structural and functional properties, as well as the physiological and pathological roles of NMDA receptor channels...
  26. ncbi request reprint Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by ubiquitination. Novel role for Nedd4-2
    Jenny Ekberg
    School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia
    J Biol Chem 282:12135-42. 2007
    ..Furthermore, Nedd4-2 could ubiquitinate KCNQ2/3 in transfected cells. Taken together, these data suggest that Nedd4-2 is potentially an important regulator of M-current activity in the nervous system...
  27. ncbi request reprint Omega-conotoxin CVIB differentially inhibits native and recombinant N- and P/Q-type calcium channels
    Leonid Motin
    School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia
    Eur J Neurosci 25:435-44. 2007
    ..Omega-conotoxins CVIB and CVID may be useful as antagonists of N- and P/Q-type VGCCs, particularly in sensory neurons involved in processing primary nociceptive information...
  28. pmc Liposome reconstitution and modulation of recombinant N-methyl-D-aspartate receptor channels by membrane stretch
    Anna Kloda
    School of Biomedical Sciences, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia
    Proc Natl Acad Sci U S A 104:1540-5. 2007
    ....
  29. ncbi request reprint Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels
    Richard J Lewis
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
    Mol Pharmacol 71:676-85. 2007
    ..TIIIA and analogs provide new biochemical probes as well as insights into the structure-activity of mu-conotoxins...
  30. pmc muO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits
    J Ekberg
    Institute for Molecular Bioscience and School of Biomedical Sciences, University of Queensland, QLD 4072, Australia
    Proc Natl Acad Sci U S A 103:17030-5. 2006
    ..The actions of MrVIB reveal that VGSC antagonists displaying selectivity toward Na(v)1.8 can alleviate chronic pain behavior with a greater therapeutic index than nonselective antagonists...
  31. ncbi request reprint Neuronal voltage-gated sodium channel subtypes: key roles in inflammatory and neuropathic pain
    J Ekberg
    School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia
    Int J Biochem Cell Biol 38:2005-10. 2006
    ..Inflammatory and neuropathic pain states are characterised by alterations in VGSC subtype composition and activity in sensory neurons. This review focuses on the VGSC subtypes involved in such pain states...
  32. pmc Mutations within the selectivity filter of the NMDA receptor-channel influence voltage dependent block by 5-hydroxytryptamine
    A Kloda
    School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia
    Br J Pharmacol 149:163-9. 2006
    ..In the present study, we assessed whether point mutations of critical asparagine residues located within the selectivity filter of NR1 and NR2A subunits of NMDA receptor-channel affect voltage-dependent block by 5-HT...
  33. ncbi request reprint Identification of a novel class of nicotinic receptor antagonists: dimeric conotoxins VxXIIA, VxXIIB, and VxXIIC from Conus vexillum
    Marion Loughnan
    Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia
    J Biol Chem 281:24745-55. 2006
    ..These dimeric conotoxins represent a fifth and highly divergent structural class of conotoxins targeting nAChRs...
  34. ncbi request reprint The synthesis, structural characterization, and receptor specificity of the alpha-conotoxin Vc1.1
    Richard J Clark
    Institute for Molecular Bioscience and School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia
    J Biol Chem 281:23254-63. 2006
    ..The structure reported here should open new opportunities for further development of Vc1.1 or analogues as analgesic agents...
  35. ncbi request reprint Alpha-selenoconotoxins, a new class of potent alpha7 neuronal nicotinic receptor antagonists
    Christopher J Armishaw
    Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia
    J Biol Chem 281:14136-43. 2006
    ..These results demonstrate that selenoconotoxins can be used as highly stable scaffolds for the design of new drugs...
  36. ncbi request reprint NMDA receptor subunit-dependent modulation by conantokin-G and Ala7-conantokin-G
    L Ragnarsson
    School of Molecular and Microbial Sciences, University of Queensland, Brisbane, Queensland, Australia
    J Neurochem 96:283-91. 2006
    ..We conclude that the combinations of subunits that comprise the NMDA receptor complex influence conantokin and glutamate affinities and the nature of the responses to conantokins...
  37. ncbi request reprint NEDD4-2 as a potential candidate susceptibility gene for epileptic photosensitivity
    L M Dibbens
    Department of Genetic Medicine, Women s and Children s Hospital, North Adelaide, SA 5006, Australia
    Genes Brain Behav 6:750-5. 2007
    ..These data raise the possibility that photosensitive epilepsy may arise from defective interaction of NEDD4-2 with as yet unidentified accessory or target proteins...
  38. ncbi request reprint The doublecortin-expressing population in the developing and adult brain contains multipotential precursors in addition to neuronal-lineage cells
    Tara L Walker
    Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia
    J Neurosci 27:3734-42. 2007
    ..These results indicate that DCX(high) cells, regardless of location, are restricted to the neuronal lineage or are bone fide neurons, whereas some DCX(low) cells retain their multipotentiality...
  39. doi request reprint omega-Conotoxin inhibition of excitatory synaptic transmission evoked by dorsal root stimulation in rat superficial dorsal horn
    Leonid Motin
    Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia
    Neuropharmacology 55:860-4. 2008
    ....
  40. doi request reprint Neuronally micro-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels
    Christina I Schroeder
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
    J Biol Chem 283:21621-8. 2008
    ..The structure of SIIIA provides a new structural template for the development of neuronally selective inhibitors of TTX-sensitive VGSCs based on the smaller mu-conotoxin pharmacophore...
  41. doi request reprint Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by serum- and glucocorticoid-regulated kinase-1
    Friderike Schuetz
    School of Biomedical Sciences and Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia
    Am J Physiol Cell Physiol 295:C73-80. 2008
    ..Taken together, these results demonstrate a potential mechanism for regulation of KCNQ2/3 and KCNQ3/5 channels by SGK-1 regulation of the activity of the ubiquitin ligase Nedd4-2...
  42. doi request reprint The three-dimensional structure of the analgesic alpha-conotoxin, RgIA
    Richard J Clark
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia
    FEBS Lett 582:597-602. 2008
    ..We determined the three-dimensional structure of RgIA using NMR methods to assist in elucidating the molecular role of RgIA in analgesia and inflammation...
  43. ncbi request reprint K(ir) and K(v) channels regulate electrical properties and proliferation of adult neural precursor cells
    Takahiro Yasuda
    School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia
    Mol Cell Neurosci 37:284-97. 2008
    ....
  44. ncbi request reprint Conotoxin modulation of voltage-gated sodium channels
    J Ekberg
    School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia
    Int J Biochem Cell Biol 40:2363-8. 2008
    ..Some of these toxins have potential therapeutic and research applications, in particular the microO-conotoxins, which may develop into potential drug leads for the treatment of pain states...
  45. ncbi request reprint Distinct activities of novel neurotoxins from Australian venomous snakes for nicotinic acetylcholine receptors
    L St Pierre
    The Queensland Cancer Fund Research Unit, The Queensland Institute of Medical Research, P O Box Royal Brisbane Hospital, Herston, Brisbane, 4029, Australia
    Cell Mol Life Sci 64:2829-40. 2007
    ..This study represents one of the most comprehensive descriptions to date of the sequences and activity of individual Australian elapid neurotoxins...
  46. ncbi request reprint Are alpha9alpha10 nicotinic acetylcholine receptors a pain target for alpha-conotoxins?
    S T Nevin
    School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia
    Mol Pharmacol 72:1406-10. 2007
    ..This suggests that alpha9alpha10 nAChRs are unlikely to be the molecular mechanism or therapeutic target of Vc1.1 for the treatment of neuropathic pain...
  47. ncbi request reprint Chemical modification of conotoxins to improve stability and activity
    David J Craik
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia
    ACS Chem Biol 2:457-68. 2007
    ..These manufactured interventions add to the array of post-translational modifications that occur naturally in conopeptides. They enhance the versatility of these peptides as tools in neuroscience and as drug leads...
  48. ncbi request reprint Purinergic receptor activation inhibits mitogen-stimulated proliferation in primary neurospheres from the adult mouse subventricular zone
    Mark R Stafford
    School of Biomedical Sciences, The University of Queensland, Brisbane 4072, Australia
    Mol Cell Neurosci 35:535-48. 2007
    ..The modulation of neural precursor cell proliferation by P2Y and adenosine receptors therefore represents a potential regulatory mechanism within the neurogenic microenvironment...
  49. pmc Structure of alpha-conotoxin BuIA: influences of disulfide connectivity on structural dynamics
    Ai Hua Jin
    Institute for Molecular Bioscience, Australian Research Council Special Research Centre for Functional and Applied Genomics, The University of Queensland, Brisbane QLD, Australia
    BMC Struct Biol 7:28. 2007
    ..BuIA is the only alpha-conotoxin containing a 4/4 cysteine spacing and thus it is of significant interest to examine the structure of this conotoxin...
  50. doi request reprint Mechanisms of conotoxin inhibition of N-type (Ca(v)2.2) calcium channels
    David J Adams
    Health Innovations Research Institute, RMIT University, Melbourne, Victoria, Australia
    Biochim Biophys Acta 1828:1619-28. 2013
    ..Understanding how conotoxins inhibit VGCCs is critical for developing these peptides into analgesics and may result in better pain management. This article is part of a Special Issue entitled: Calcium channels...
  51. pmc Conotoxins targeting neuronal voltage-gated sodium channel subtypes: potential analgesics?
    Oliver Knapp
    Health Innovations Research Institute, RMIT University, Melbourne, Victoria 3083, Australia
    Toxins (Basel) 4:1236-60. 2012
    ..Examples of how these conotoxins target various pharmacologically important neuronal ion channels, as well as potential problems with the development of drugs from conotoxins, will be discussed...