Affiliation: Research and Development
White L, Sariol C, Mattocks M, Wahala M P B W, Yingsiwaphat V, Collier M, et al
. An alphavirus vector-based tetravalent dengue vaccine induces a rapid and protective immune response in macaques that differs qualitatively from immunity induced by live virus infection. J Virol. 2013;87:3409-24 pubmed publisher
..Balanced responses and protection in macaques provided further support for exploring the immunogenicity and safety of this vaccine candidate in humans. ..
Rockman S, Maher D, Middleton D. The use of hyperimmune serum for severe influenza infections*. Crit Care Med. 2012;40:973-5 pubmed publisher
..In highly pathogenic systemic influenza infections, the window for successful intervention by administration of hyperimmune serum may be narrow. ..
Rockman S, Middleton D, Pearse M, Barr I, Lowther S, Brown L. Control of pandemic (H1N1) 2009 influenza virus infection of ferret lungs by non-adjuvant-containing pandemic and seasonal vaccines. Vaccine. 2012;30:3618-23 pubmed publisher
..These results implicate non-classical protective mechanisms that prevent severe pulmonary disease but not viral shedding and imply that particular non-adjuvanted vaccines may have retained the ability to induce these responses. ..
Rockman S, Brown L, Barr I, Gilbertson B, Lowther S, Kachurin A, et al
. Neuraminidase-inhibiting antibody is a correlate of cross-protection against lethal H5N1 influenza virus in ferrets immunized with seasonal influenza vaccine. J Virol. 2013;87:3053-61 pubmed publisher
..The data also highlight that an inducer of cross-protective immunity is the NA, a protein whose levels are not normally monitored in vaccines and whose capacity to induce immunity in recipients is not normally assessed. ..