Research Topics
Genomes and Genes
| Zhen Zhen ZhaoSummaryAffiliation: Queensland Institute of Medical Research Country: Australia Publications
| Collaborators
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Detail Information
Publications
A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adultsLouise M Randall
Queensland Institute of Medical Research and Australian Centre for Vaccine Development, 300 Herston Road, Herston, QLD 4006, Australia
Malar J 9:302. 2010..Previous studies indicate that tumour necrosis factor (TNF) and lymphotoxin alpha (LTĪ±) may be important for the development of cerebral malaria (CM) and other SM syndromes...- Common variation in the fibroblast growth factor receptor 2 gene is not associated with endometriosis riskZhen Zhen Zhao
Molecular Epidemiology Laboratory, Queensland Institute of Medical Research, 300 Herston Rd, Herston, Brisbane, QLD 4029, Australia
Hum Reprod 23:1661-8. 2008..We therefore hypothesized that variation in FGFR2 may contribute to the risk of endometriosis... - Evaluation of polymorphisms in predicted target sites for micro RNAs differentially expressed in endometriosisZhen Zhen Zhao
Queensland Institute of Medical Research, Herston, Brisbane, Queensland, Australia
Mol Hum Reprod 17:92-103. 2011..Replication studies in independent large sample sets to confirm and characterize the involvement of the gene variation in the pathogenesis of endometriosis are needed... 
Polymorphisms in the syntaxin 17 gene are not associated with human cutaneous malignant melanomaZhen Zhen Zhao
Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Melanoma Res 19:80-6. 2009..We conclude that common variants in the STX17 gene region do not play a key role in the pathogenesis of human melanoma...- Polymorphisms in the vascular endothelial growth factor gene and the risk of familial endometriosisZhen Zhen Zhao
Molecular Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
Mol Hum Reprod 14:531-8. 2008..Our detailed review and meta-analysis of the VEGF polymorphisms suggests that genotyping assay problems may underlie the previously reported associations between VEGF variants and endometriosis... 
Genetic variation in tumour necrosis factor and lymphotoxin is not associated with endometriosis in an Australian sampleZhen Zhen Zhao
Molecular Epidemiology, Queensland Institute of Medical Research, 300 Herston Road, Herston, Brisbane, Queensland 4029, Australia
Hum Reprod 22:2389-97. 2007..Tumour necrosis factor (TNF) is a pleiotropic cytokine with a wide range of immunoregulatory effects. Variation in the promoter region of TNF and the neighbouring lymphotoxin alpha (LTA) gene might be associated with endometriosis...- Variation in bone morphogenetic protein 15 is not associated with spontaneous human dizygotic twinningZhen Zhen Zhao
Molecular Epidemiology, Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, QLD, Australia
Hum Reprod 23:2372-9. 2008..Spontaneous dizygotic (DZ) twinning in humans is under genetic control. In sheep, heterozygous loss of function mutations in bone morphogenetic protein 15 (BMP15) increase ovulation and hence twinning rates... - KRAS variation and risk of endometriosisZhen Zhen Zhao
Molecular Epidemiology Laboratory and Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Mol Hum Reprod 12:671-6. 2006..No germline variants for KRAS or BRAF were detected. Our results demonstrate that any risk of endometriosis in women because of common variation in KRAS must be very small... - A deletion mutation in GDF9 in sisters with spontaneous DZ twinsGrant W Montgomery
Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
Twin Res 7:548-55. 2004..We conclude that rare mutations in GDF9 may influence twinning, but twinning frequency is not associated with common variation in GDF9... - Association of Helicobacter pylori infection with reduced risk for esophageal cancer is independent of environmental and genetic modifiersDavid C Whiteman
Queensland Institute of Medical Research, Brisbane, Australia
Gastroenterology 139:73-83; quiz e11-2. 2010..We sought to measure the association between H pylori infection and esophageal cancer and identify potential modifiers... - Single nucleotide polymorphisms in obesity-related genes and the risk of esophageal cancersJames D Doecke
Division of Population Studies and Human Genetics, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland, Australia
Cancer Epidemiol Biomarkers Prev 17:1007-12. 2008..0 kg/m(2), 25.0-29.9 kg/m(2), >30 kg/m(2)). In conclusion, our data suggest that these SNPs do not play a major role in esophageal carcinogenesis... - ATG16L1 T300A shows strong associations with disease subgroups in a large Australian IBD population: further support for significant disease heterogeneityElizabeth V Fowler
Inflammatory Bowel Disease Laboratory, Royal Brisbane and Women s Research Foundation, Brisbane, Australia
Am J Gastroenterol 103:2519-26. 2008.... - Association study of common mitochondrial variants and cognitive abilityEnda M Byrne
Queensland Statistical Genetics, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, QLD, 4029, Australia
Behav Genet 39:504-12. 2009..These genes warrant further investigation in both functional and association studies with larger cohorts... - KCNN4 gene variant is associated with ileal Crohn's Disease in the Australian and New Zealand populationLisa A Simms
Royal Brisbane and Women s Research Foundation, Brisbane, Queensland, Australia
Am J Gastroenterol 105:2209-17. 2010..Our aim was to determine whether a gene in the IBD linkage region on chromosome 19q13, with a role in Paneth cell secretion and T-cell activation, conferred genetic susceptibility to the development of CD... - The search for genes contributing to endometriosis riskGrant W Montgomery
Genetic and Molecular Epidemiology Laboratories, Queensland Institute of Medical Research, Royal Brisbane Hospital, 300 Herston Road, Brisbane, QLD 4029, Australia
Hum Reprod Update 14:447-57. 2008..Genetic variation contributes to the risk of developing endometriosis. This review summarizes gene mapping studies in endometriosis and the prospects of finding gene pathways contributing to disease using the latest genome-wide strategies... - Variants in EMX2 and PTEN do not contribute to risk of endometriosisSusan A Treloar
Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia, and Nuffield Department of Obstetrics and Gynaecology, University of Oxford, UK
Mol Hum Reprod 13:587-94. 2007..It is unlikely that the EMX2 or PTEN gene variants investigated contribute to risk for initiation and/or development of endometriosis... - Novel variants in growth differentiation factor 9 in mothers of dizygotic twinsJames S Palmer
Molecular Epidemiology, Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia
J Clin Endocrinol Metab 91:4713-6. 2006..We previously identified a deletion mutation in GDF9 in sisters with spontaneous dizygotic (DZ) twins, but the prevalence of rare GDF9 variants in twinning families is unknown... - Association between polymorphisms in the progesterone receptor gene and endometriosisSusan A Treloar
Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Mol Hum Reprod 11:641-7. 2005..Further, analysis of our results pooled with those from two previous studies suggested that neither the T2 allele of the AluIns nor the T1/T2 genotype was associated with endometriosis... - A three-single-nucleotide polymorphism haplotype in intron 1 of OCA2 explains most human eye-color variationDavid L Duffy
Queensland Institute of Medical Research, Brisbane, Australia
Am J Hum Genet 80:241-52. 2007.... - The use of common mitochondrial variants to detect and characterise population structure in the Australian population: implications for genome-wide association studiesEnda M Byrne
Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Eur J Hum Genet 16:1396-403. 2008..No evidence was found for structure within ancestral groups. These results have implications for future association studies in the Australian population, and other populations of heterogeneous ancestry... - A comparison of DNA pools constructed following whole genome amplification for two-stage SNP genotyping designsZhen Zhen Zhao
Molecular Epidemiology and Genetic Epidemiology Laboratories, Queensland Institute of Medical Research, Brisbane, Australia
Twin Res Hum Genet 8:353-61. 2005..With current levels of accuracy, pooling is best suited to an initial screen in the SNP validation process that can provide high-throughput comparisons between cases and controls to prioritize SNPs for subsequent individual genotyping... - Dizygotic twinning is not associated with methylenetetrahydrofolate reductase haplotypesGrant W Montgomery
Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
Hum Reprod 18:2460-4. 2003..Polymorphisms in 5,10-methylenetetrahydrofolate reductase (MTHFR) have been associated with dizygotic (DZ) twinning through pregnancy loss... - Power and SNP tagging in whole mitochondrial genome association studiesAllan F McRae
Queensland Institute of Medical Research, Brisbane 4006, Australia
Genome Res 18:911-7. 2008..The strong concordance in allele frequencies and linkage disequilibrium between the European sequences and the Australian sample indicates that the results presented here are transferable across populations of European descent... - Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune controlManuel A R Ferreira
Queensland Institute of Medical Research, Brisbane, QLD, Australia
Am J Hum Genet 86:88-92. 2010.... - Polymorphisms in MGMT and DNA repair genes and the risk of esophageal adenocarcinomaJames Doecke
Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Int J Cancer 123:174-80. 2008..In summary, MGMT SNPs are associated with increased risks of EAC. Exposure to acid reflux, and possibly smoking, confer markedly higher risks among homozygous variant genotype carriers... - Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3Stuart Macgregor
Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Nat Genet 43:1114-8. 2011..3 locus span a region with ten genes, and plausible candidate genes for melanoma susceptibility include ARNT and SETDB1. Variants at the 1q21.3 locus do not seem to be associated with human pigmentation or measures of nevus density... - Age-related susceptibility to severe malaria associated with galectin-2 in highland PapuansLouise M Randall
Queensland Institute of Medical Research and Australian Centre for Vaccine Development, and The University of Queensland, School of Population Health, Herston, Queensland, Australia
J Infect Dis 202:117-24. 2010..Mutations in genes regulating LTalpha production contribute to other acute vascular diseases and may contribute to malaria pathogenesis... - Genetic susceptibility in IBD: overlap between ulcerative colitis and Crohn's diseaseJames D Doecke
The Australian e Health Research Centre, Queensland, Australia
Inflamm Bowel Dis 19:240-5. 2013.... - Highly cost-efficient genome-wide association studies using DNA pools and dense SNP arraysStuart Macgregor
Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
Nucleic Acids Res 36:e35. 2008..The large cost savings with Illumina HumanHap300-based pooling imply that future studies need only be limited by the availability of samples and not cost... - High prevalence of sessile serrated adenomas with BRAF mutations: a prospective study of patients undergoing colonoscopyKevin J Spring
Conjoint Gastroenterology Laboratory, Queensland Institute of Medical Research, Herston, Brisbane, Australia
Gastroenterology 131:1400-7. 2006..They are associated with BRAF mutation, proximal location, female sex, and presence of multiple polyps. These findings emphasize the importance of identifying and removing these lesions for endoscopic prevention of colorectal cancer... - Analysis of the 5q31 33 locus shows an association between single nucleotide polymorphism variants in the IL-5 gene and symptomatic infection with the human blood fluke, Schistosoma japonicumMagda K Ellis
Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research and University of Queensland, Australia
J Immunol 179:8366-71. 2007..This haplotype was located in the 3'-untranslated region of IL-5, suggesting that variants in this region of IL-5 may modulate the immune response in these individuals with symptomatic infection... - Oncogenic PIK3CA mutations in colorectal cancers and polypsVicki L J Whitehall
Queensland Institute of Medical Research, Brisbane, Australia
Int J Cancer 131:813-20. 2012..2%) and 1/4 (25.0%) tubulovillous adenomas with a focus of cancer. These data provide insight into the molecular events driving traditional versus serrated pathway tumorigenesis... - Common sequence variants on 20q11.22 confer melanoma susceptibilityKevin M Brown
Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, Arizona 85028, USA
Nat Genet 40:838-40. 2008..The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases... - A single SNP in an evolutionary conserved region within intron 86 of the HERC2 gene determines human blue-brown eye colorRichard A Sturm
Institute for Molecular Bioscience, University of Queensland, Brisbane QLD 4072, Australia
Am J Hum Genet 82:424-31. 2008.... - A genome-wide association study identifies novel alleles associated with hair color and skin pigmentationJiali Han
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Genet 4:e1000074. 2008..The signals detected in a region around the MC1R gene were explained by MC1R red hair color alleles. Our results suggest that the IRF4 and SLC24A4 loci are associated with human hair color and skin pigmentation... - Dizygotic twinningChantal Hoekstra
Department of Biological Psychology, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
Hum Reprod Update 14:37-47. 2008..Mutations in one of these genes (growth differentiation factor 9) are significantly more frequent in mothers of DZ twins. However, the mutations are rare and only account for a small part of the genetic contribution for twinning...