Zhen Zhen Zhao

Summary

Affiliation: Queensland Institute of Medical Research
Country: Australia

Publications

  1. pmc A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults
    Louise M Randall
    Queensland Institute of Medical Research and Australian Centre for Vaccine Development, 300 Herston Road, Herston, QLD 4006, Australia
    Malar J 9:302. 2010
  2. ncbi request reprint Genetic variation in tumour necrosis factor and lymphotoxin is not associated with endometriosis in an Australian sample
    Zhen Zhen Zhao
    Molecular Epidemiology, Queensland Institute of Medical Research, 300 Herston Road, Herston, Brisbane, Queensland 4029, Australia
    Hum Reprod 22:2389-97. 2007
  3. pmc Polymorphisms in the syntaxin 17 gene are not associated with human cutaneous malignant melanoma
    Zhen Zhen Zhao
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Melanoma Res 19:80-6. 2009
  4. pmc Evaluation of polymorphisms in predicted target sites for micro RNAs differentially expressed in endometriosis
    Zhen Zhen Zhao
    Queensland Institute of Medical Research, Herston, Brisbane, Queensland, Australia
    Mol Hum Reprod 17:92-103. 2011
  5. doi request reprint Polymorphisms in the vascular endothelial growth factor gene and the risk of familial endometriosis
    Zhen Zhen Zhao
    Molecular Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
    Mol Hum Reprod 14:531-8. 2008
  6. pmc Common variation in the fibroblast growth factor receptor 2 gene is not associated with endometriosis risk
    Zhen Zhen Zhao
    Molecular Epidemiology Laboratory, Queensland Institute of Medical Research, 300 Herston Rd, Herston, Brisbane, QLD 4029, Australia
    Hum Reprod 23:1661-8. 2008
  7. pmc Variation in bone morphogenetic protein 15 is not associated with spontaneous human dizygotic twinning
    Zhen Zhen Zhao
    Molecular Epidemiology, Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, QLD, Australia
    Hum Reprod 23:2372-9. 2008
  8. ncbi request reprint A deletion mutation in GDF9 in sisters with spontaneous DZ twins
    Grant W Montgomery
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res 7:548-55. 2004
  9. ncbi request reprint KRAS variation and risk of endometriosis
    Zhen Zhen Zhao
    Molecular Epidemiology Laboratory and Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Mol Hum Reprod 12:671-6. 2006
  10. doi request reprint Association of Helicobacter pylori infection with reduced risk for esophageal cancer is independent of environmental and genetic modifiers
    David C Whiteman
    Queensland Institute of Medical Research, Brisbane, Australia
    Gastroenterology 139:73-83; quiz e11-2. 2010

Detail Information

Publications37

  1. pmc A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults
    Louise M Randall
    Queensland Institute of Medical Research and Australian Centre for Vaccine Development, 300 Herston Road, Herston, QLD 4006, Australia
    Malar J 9:302. 2010
    ..Previous studies indicate that tumour necrosis factor (TNF) and lymphotoxin alpha (LTĪ±) may be important for the development of cerebral malaria (CM) and other SM syndromes...
  2. ncbi request reprint Genetic variation in tumour necrosis factor and lymphotoxin is not associated with endometriosis in an Australian sample
    Zhen Zhen Zhao
    Molecular Epidemiology, Queensland Institute of Medical Research, 300 Herston Road, Herston, Brisbane, Queensland 4029, Australia
    Hum Reprod 22:2389-97. 2007
    ..Tumour necrosis factor (TNF) is a pleiotropic cytokine with a wide range of immunoregulatory effects. Variation in the promoter region of TNF and the neighbouring lymphotoxin alpha (LTA) gene might be associated with endometriosis...
  3. pmc Polymorphisms in the syntaxin 17 gene are not associated with human cutaneous malignant melanoma
    Zhen Zhen Zhao
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Melanoma Res 19:80-6. 2009
    ..We conclude that common variants in the STX17 gene region do not play a key role in the pathogenesis of human melanoma...
  4. pmc Evaluation of polymorphisms in predicted target sites for micro RNAs differentially expressed in endometriosis
    Zhen Zhen Zhao
    Queensland Institute of Medical Research, Herston, Brisbane, Queensland, Australia
    Mol Hum Reprod 17:92-103. 2011
    ..Replication studies in independent large sample sets to confirm and characterize the involvement of the gene variation in the pathogenesis of endometriosis are needed...
  5. doi request reprint Polymorphisms in the vascular endothelial growth factor gene and the risk of familial endometriosis
    Zhen Zhen Zhao
    Molecular Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
    Mol Hum Reprod 14:531-8. 2008
    ..Our detailed review and meta-analysis of the VEGF polymorphisms suggests that genotyping assay problems may underlie the previously reported associations between VEGF variants and endometriosis...
  6. pmc Common variation in the fibroblast growth factor receptor 2 gene is not associated with endometriosis risk
    Zhen Zhen Zhao
    Molecular Epidemiology Laboratory, Queensland Institute of Medical Research, 300 Herston Rd, Herston, Brisbane, QLD 4029, Australia
    Hum Reprod 23:1661-8. 2008
    ..We therefore hypothesized that variation in FGFR2 may contribute to the risk of endometriosis...
  7. pmc Variation in bone morphogenetic protein 15 is not associated with spontaneous human dizygotic twinning
    Zhen Zhen Zhao
    Molecular Epidemiology, Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, QLD, Australia
    Hum Reprod 23:2372-9. 2008
    ..Spontaneous dizygotic (DZ) twinning in humans is under genetic control. In sheep, heterozygous loss of function mutations in bone morphogenetic protein 15 (BMP15) increase ovulation and hence twinning rates...
  8. ncbi request reprint A deletion mutation in GDF9 in sisters with spontaneous DZ twins
    Grant W Montgomery
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res 7:548-55. 2004
    ..We conclude that rare mutations in GDF9 may influence twinning, but twinning frequency is not associated with common variation in GDF9...
  9. ncbi request reprint KRAS variation and risk of endometriosis
    Zhen Zhen Zhao
    Molecular Epidemiology Laboratory and Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Mol Hum Reprod 12:671-6. 2006
    ..No germline variants for KRAS or BRAF were detected. Our results demonstrate that any risk of endometriosis in women because of common variation in KRAS must be very small...
  10. doi request reprint Association of Helicobacter pylori infection with reduced risk for esophageal cancer is independent of environmental and genetic modifiers
    David C Whiteman
    Queensland Institute of Medical Research, Brisbane, Australia
    Gastroenterology 139:73-83; quiz e11-2. 2010
    ..We sought to measure the association between H pylori infection and esophageal cancer and identify potential modifiers...
  11. doi request reprint Association study of common mitochondrial variants and cognitive ability
    Enda M Byrne
    Queensland Statistical Genetics, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, QLD, 4029, Australia
    Behav Genet 39:504-12. 2009
    ..These genes warrant further investigation in both functional and association studies with larger cohorts...
  12. doi request reprint KCNN4 gene variant is associated with ileal Crohn's Disease in the Australian and New Zealand population
    Lisa A Simms
    Royal Brisbane and Women s Research Foundation, Brisbane, Queensland, Australia
    Am J Gastroenterol 105:2209-17. 2010
    ..Our aim was to determine whether a gene in the IBD linkage region on chromosome 19q13, with a role in Paneth cell secretion and T-cell activation, conferred genetic susceptibility to the development of CD...
  13. doi request reprint ATG16L1 T300A shows strong associations with disease subgroups in a large Australian IBD population: further support for significant disease heterogeneity
    Elizabeth V Fowler
    Inflammatory Bowel Disease Laboratory, Royal Brisbane and Women s Research Foundation, Brisbane, Australia
    Am J Gastroenterol 103:2519-26. 2008
    ....
  14. doi request reprint Single nucleotide polymorphisms in obesity-related genes and the risk of esophageal cancers
    James D Doecke
    Division of Population Studies and Human Genetics, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland, Australia
    Cancer Epidemiol Biomarkers Prev 17:1007-12. 2008
    ..0 kg/m(2), 25.0-29.9 kg/m(2), >30 kg/m(2)). In conclusion, our data suggest that these SNPs do not play a major role in esophageal carcinogenesis...
  15. ncbi request reprint Novel variants in growth differentiation factor 9 in mothers of dizygotic twins
    James S Palmer
    Molecular Epidemiology, Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia
    J Clin Endocrinol Metab 91:4713-6. 2006
    ..We previously identified a deletion mutation in GDF9 in sisters with spontaneous dizygotic (DZ) twins, but the prevalence of rare GDF9 variants in twinning families is unknown...
  16. ncbi request reprint Variants in EMX2 and PTEN do not contribute to risk of endometriosis
    Susan A Treloar
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia, and Nuffield Department of Obstetrics and Gynaecology, University of Oxford, UK
    Mol Hum Reprod 13:587-94. 2007
    ..It is unlikely that the EMX2 or PTEN gene variants investigated contribute to risk for initiation and/or development of endometriosis...
  17. pmc The search for genes contributing to endometriosis risk
    Grant W Montgomery
    Genetic and Molecular Epidemiology Laboratories, Queensland Institute of Medical Research, Royal Brisbane Hospital, 300 Herston Road, Brisbane, QLD 4029, Australia
    Hum Reprod Update 14:447-57. 2008
    ..Genetic variation contributes to the risk of developing endometriosis. This review summarizes gene mapping studies in endometriosis and the prospects of finding gene pathways contributing to disease using the latest genome-wide strategies...
  18. doi request reprint Genetic susceptibility in IBD: overlap between ulcerative colitis and Crohn's disease
    James D Doecke
    The Australian e Health Research Centre, Queensland, Australia
    Inflamm Bowel Dis 19:240-5. 2013
    ....
  19. ncbi request reprint Association between polymorphisms in the progesterone receptor gene and endometriosis
    Susan A Treloar
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Mol Hum Reprod 11:641-7. 2005
    ..Further, analysis of our results pooled with those from two previous studies suggested that neither the T2 allele of the AluIns nor the T1/T2 genotype was associated with endometriosis...
  20. pmc A three-single-nucleotide polymorphism haplotype in intron 1 of OCA2 explains most human eye-color variation
    David L Duffy
    Queensland Institute of Medical Research, Brisbane, Australia
    Am J Hum Genet 80:241-52. 2007
    ....
  21. ncbi request reprint The use of common mitochondrial variants to detect and characterise population structure in the Australian population: implications for genome-wide association studies
    Enda M Byrne
    Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Eur J Hum Genet 16:1396-403. 2008
    ..No evidence was found for structure within ancestral groups. These results have implications for future association studies in the Australian population, and other populations of heterogeneous ancestry...
  22. ncbi request reprint A comparison of DNA pools constructed following whole genome amplification for two-stage SNP genotyping designs
    Zhen Zhen Zhao
    Molecular Epidemiology and Genetic Epidemiology Laboratories, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 8:353-61. 2005
    ..With current levels of accuracy, pooling is best suited to an initial screen in the SNP validation process that can provide high-throughput comparisons between cases and controls to prioritize SNPs for subsequent individual genotyping...
  23. ncbi request reprint Dizygotic twinning is not associated with methylenetetrahydrofolate reductase haplotypes
    Grant W Montgomery
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Hum Reprod 18:2460-4. 2003
    ..Polymorphisms in 5,10-methylenetetrahydrofolate reductase (MTHFR) have been associated with dizygotic (DZ) twinning through pregnancy loss...
  24. pmc Power and SNP tagging in whole mitochondrial genome association studies
    Allan F McRae
    Queensland Institute of Medical Research, Brisbane 4006, Australia
    Genome Res 18:911-7. 2008
    ..The strong concordance in allele frequencies and linkage disequilibrium between the European sequences and the Australian sample indicates that the results presented here are transferable across populations of European descent...
  25. ncbi request reprint Polymorphisms in MGMT and DNA repair genes and the risk of esophageal adenocarcinoma
    James Doecke
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Int J Cancer 123:174-80. 2008
    ..In summary, MGMT SNPs are associated with increased risks of EAC. Exposure to acid reflux, and possibly smoking, confer markedly higher risks among homozygous variant genotype carriers...
  26. pmc Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control
    Manuel A R Ferreira
    Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Am J Hum Genet 86:88-92. 2010
    ....
  27. pmc Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3
    Stuart Macgregor
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Nat Genet 43:1114-8. 2011
    ..3 locus span a region with ten genes, and plausible candidate genes for melanoma susceptibility include ARNT and SETDB1. Variants at the 1q21.3 locus do not seem to be associated with human pigmentation or measures of nevus density...
  28. pmc Age-related susceptibility to severe malaria associated with galectin-2 in highland Papuans
    Louise M Randall
    Queensland Institute of Medical Research and Australian Centre for Vaccine Development, and The University of Queensland, School of Population Health, Herston, Queensland, Australia
    J Infect Dis 202:117-24. 2010
    ..Mutations in genes regulating LTalpha production contribute to other acute vascular diseases and may contribute to malaria pathogenesis...
  29. pmc Highly cost-efficient genome-wide association studies using DNA pools and dense SNP arrays
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
    Nucleic Acids Res 36:e35. 2008
    ..The large cost savings with Illumina HumanHap300-based pooling imply that future studies need only be limited by the availability of samples and not cost...
  30. ncbi request reprint High prevalence of sessile serrated adenomas with BRAF mutations: a prospective study of patients undergoing colonoscopy
    Kevin J Spring
    Conjoint Gastroenterology Laboratory, Queensland Institute of Medical Research, Herston, Brisbane, Australia
    Gastroenterology 131:1400-7. 2006
    ..This prospective study examined the prevalence of sessile serrated adenomas and determined the incidence of BRAF and K-ras mutations in different types of polyps...
  31. pmc Analysis of the 5q31 33 locus shows an association between single nucleotide polymorphism variants in the IL-5 gene and symptomatic infection with the human blood fluke, Schistosoma japonicum
    Magda K Ellis
    Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research and University of Queensland, Australia
    J Immunol 179:8366-71. 2007
    ..This haplotype was located in the 3'-untranslated region of IL-5, suggesting that variants in this region of IL-5 may modulate the immune response in these individuals with symptomatic infection...
  32. pmc Assessment of PALB2 as a candidate melanoma susceptibility gene
    Lauren G Aoude
    QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia University of Queensland, Brisbane, QLD, Australia
    PLoS ONE 9:e100683. 2014
    ..Three other family members affected with melanoma did not carry the variant. Overall our data do not support a case for PALB2 being associated with melanoma predisposition. ..
  33. doi request reprint Oncogenic PIK3CA mutations in colorectal cancers and polyps
    Vicki L J Whitehall
    Queensland Institute of Medical Research, Brisbane, Australia
    Int J Cancer 131:813-20. 2012
    ..2%) and 1/4 (25.0%) tubulovillous adenomas with a focus of cancer. These data provide insight into the molecular events driving traditional versus serrated pathway tumorigenesis...
  34. pmc Common sequence variants on 20q11.22 confer melanoma susceptibility
    Kevin M Brown
    Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, Arizona 85028, USA
    Nat Genet 40:838-40. 2008
    ..The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases...
  35. pmc A single SNP in an evolutionary conserved region within intron 86 of the HERC2 gene determines human blue-brown eye color
    Richard A Sturm
    Institute for Molecular Bioscience, University of Queensland, Brisbane QLD 4072, Australia
    Am J Hum Genet 82:424-31. 2008
    ....
  36. pmc A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000074. 2008
    ..The signals detected in a region around the MC1R gene were explained by MC1R red hair color alleles. Our results suggest that the IRF4 and SLC24A4 loci are associated with human hair color and skin pigmentation...
  37. ncbi request reprint Dizygotic twinning
    Chantal Hoekstra
    Department of Biological Psychology, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
    Hum Reprod Update 14:37-47. 2008
    ..Mutations in one of these genes (growth differentiation factor 9) are significantly more frequent in mothers of DZ twins. However, the mutations are rare and only account for a small part of the genetic contribution for twinning...