Jian Yang

Summary

Affiliation: Queensland Institute of Medical Research
Country: Australia

Publications

  1. pmc The genetic interpretation of area under the ROC curve in genomic profiling
    Naomi R Wray
    Genetic Epidemiology and Queensland Statistical Genetics, Queensland Institute of Medical Research, Brisbane, Australia
    PLoS Genet 6:e1000864. 2010
  2. doi request reprint A commentary on 'common SNPs explain a large proportion of the heritability for human height' by Yang et al. (2010)
    Peter M Visscher
    Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 13:517-24. 2010
  3. pmc Sporadic cases are the norm for complex disease
    Jian Yang
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Eur J Hum Genet 18:1039-43. 2010
  4. doi request reprint Comparing apples and oranges: equating the power of case-control and quantitative trait association studies
    Jian Yang
    Queensland Institute of Medical Research, Brisbane, Australia
    Genet Epidemiol 34:254-7. 2010
  5. pmc Genomic inflation factors under polygenic inheritance
    Jian Yang
    Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Eur J Hum Genet 19:807-12. 2011
  6. pmc GCTA: a tool for genome-wide complex trait analysis
    Jian Yang
    Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4006, Australia
    Am J Hum Genet 88:76-82. 2011
  7. pmc Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits
    Jian Yang
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Nat Genet 44:369-75, S1-3. 2012
  8. doi request reprint Inference of the genetic architecture underlying BMI and height with the use of 20,240 sibling pairs
    Gibran Hemani
    The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD 4102, Australia The University of Queensland, Queensland Brain Institute, Brisbane, QLD 4027, Australia
    Am J Hum Genet 93:865-75. 2013
  9. doi request reprint Genome-wide complex trait analysis (GCTA): methods, data analyses, and interpretations
    Jian Yang
    University of Queensland Diamantina Institute, Princess Alexandra Hospital, University of Queensland, Brisbane, QLD, Australia
    Methods Mol Biol 1019:215-36. 2013
  10. pmc Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs
    S Hong Lee
    Queensland Brain Institute, University of Queensland, Brisbane, Australia
    Nat Genet 44:247-50. 2012

Detail Information

Publications18

  1. pmc The genetic interpretation of area under the ROC curve in genomic profiling
    Naomi R Wray
    Genetic Epidemiology and Queensland Statistical Genetics, Queensland Institute of Medical Research, Brisbane, Australia
    PLoS Genet 6:e1000864. 2010
    ..We provide a strategy to estimate proportion of genetic variance explained on the liability scale from estimates of AUC, disease prevalence, and heritability (or sibling recurrence risk) available as an online calculator...
  2. doi request reprint A commentary on 'common SNPs explain a large proportion of the heritability for human height' by Yang et al. (2010)
    Peter M Visscher
    Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 13:517-24. 2010
    ..We also report a number of additional results that show that the estimates of additive genetic variation are not driven by population structure...
  3. pmc Sporadic cases are the norm for complex disease
    Jian Yang
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Eur J Hum Genet 18:1039-43. 2010
    ....
  4. doi request reprint Comparing apples and oranges: equating the power of case-control and quantitative trait association studies
    Jian Yang
    Queensland Institute of Medical Research, Brisbane, Australia
    Genet Epidemiol 34:254-7. 2010
    ..With equal sample size, when v=K, the power of CC association study is much less than that of QT association study because of the information lost by transforming a quantitative continuous trait to a binary trait...
  5. pmc Genomic inflation factors under polygenic inheritance
    Jian Yang
    Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Eur J Hum Genet 19:807-12. 2011
    ..Our predictions are consistent with empirical observations on height in independent samples of ~4000 and ~133,000 individuals...
  6. pmc GCTA: a tool for genome-wide complex trait analysis
    Jian Yang
    Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4006, Australia
    Am J Hum Genet 88:76-82. 2011
    ..The GCTA software is a versatile tool to estimate and partition complex trait variation with large GWAS data sets...
  7. pmc Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits
    Jian Yang
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Nat Genet 44:369-75, S1-3. 2012
    ..The method we present is computationally fast and is also applicable to case-control data, which we demonstrate in an example from meta-analysis of type 2 diabetes by the DIAGRAM Consortium...
  8. doi request reprint Inference of the genetic architecture underlying BMI and height with the use of 20,240 sibling pairs
    Gibran Hemani
    The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD 4102, Australia The University of Queensland, Queensland Brain Institute, Brisbane, QLD 4027, Australia
    Am J Hum Genet 93:865-75. 2013
    ....
  9. doi request reprint Genome-wide complex trait analysis (GCTA): methods, data analyses, and interpretations
    Jian Yang
    University of Queensland Diamantina Institute, Princess Alexandra Hospital, University of Queensland, Brisbane, QLD, Australia
    Methods Mol Biol 1019:215-36. 2013
    ....
  10. pmc Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs
    S Hong Lee
    Queensland Brain Institute, University of Queensland, Brisbane, Australia
    Nat Genet 44:247-50. 2012
    ..6 × 10(-8)). These results are consistent with a polygenic genetic architecture and imply more individual SNP associations will be detected for this disease as sample size increases...
  11. pmc Common SNPs explain a large proportion of the heritability for human height
    Jian Yang
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Nat Genet 42:565-9. 2010
    ....
  12. pmc Ubiquitous polygenicity of human complex traits: genome-wide analysis of 49 traits in Koreans
    Jian Yang
    University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia
    PLoS Genet 9:e1003355. 2013
    ....
  13. pmc FTO genotype is associated with phenotypic variability of body mass index
    Jian Yang
    University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia
    Nature 490:267-72. 2012
    ....
  14. doi request reprint Estimation and partition of heritability in human populations using whole-genome analysis methods
    Anna A E Vinkhuyzen
    The University of Queensland, Queensland Brain Institute, Brisbane, 4072, Queensland, Australia Email
    Annu Rev Genet 47:75-95. 2013
    ..All SNPs together, however, do not account for all of the genetic variance estimated by pedigree-based methods. We explain possible reasons for this remaining "missing heritability." ..
  15. doi request reprint From Galton to GWAS: quantitative genetics of human height
    Peter M Visscher
    Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Herston, Brisbane 4006, Australia
    Genet Res (Camb) 92:371-9. 2010
    ....
  16. pmc Five years of GWAS discovery
    Peter M Visscher
    University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Queensland, Australia
    Am J Hum Genet 90:7-24. 2012
    ..We return to the perceived failure or disappointment about GWASs in the concluding section...
  17. pmc Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci
    Adrian Cortes
    University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia
    Nat Genet 45:730-8. 2013
    ..Protective variants at two of these loci are associated both with reduced aminopeptidase function and with MHC class I cell surface expression. ..
  18. doi request reprint Genome partitioning of genetic variation for complex traits using common SNPs
    Jian Yang
    Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Nat Genet 43:519-25. 2011
    ....