Naomi R Wray

Summary

Affiliation: Queensland Institute of Medical Research
Country: Australia

Publications

  1. pmc Narrowing the boundaries of the genetic architecture of schizophrenia
    Naomi R Wray
    Genetic Epidemiology and Queensland Statistical Genetics, Queensland Institute of Medical Research, 330 Herston Road, Brisbane 4029, Australia
    Schizophr Bull 36:14-23. 2010
  2. doi request reprint Prediction of individual genetic risk of complex disease
    Naomi R Wray
    Genetic Epidemiology and Queensland Statistical Genetics, Queensland Institute of Medical Research, Brisbane, Australia
    Curr Opin Genet Dev 18:257-63. 2008
  3. pmc Multi-locus models of genetic risk of disease
    Naomi R Wray
    Genetic Epidemiology and, Queensland Institute of Medical Research, Herston Road, Brisbane, Queensland 4006, Australia
    Genome Med 2:10. 2010
  4. pmc Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo
    P F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Mol Psychiatry 14:359-75. 2009
  5. pmc Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned
    N R Wray
    Genetic Epidemiology, Molecular Epidemiology, Psychiatric Genetics and Queensland Statistical Genetics Laboratories, Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Mol Psychiatry 17:36-48. 2012
  6. doi request reprint Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the Netherlands
    Naomi R Wray
    Department of Genetic Epidemiology, Queensland Institute of Medical Research, 300 Herston Rd, Brisbane, Australia 4029
    Arch Gen Psychiatry 65:649-58. 2008
  7. doi request reprint Association study of candidate variants of COMT with neuroticism, anxiety and depression
    Naomi R Wray
    Queensland Institute of Medical Research, Brisbane, Australia
    Am J Med Genet B Neuropsychiatr Genet 147:1314-8. 2008
  8. doi request reprint Association study of candidate variants from brain-derived neurotrophic factor and dystrobrevin-binding protein 1 with neuroticism, anxiety, and depression
    Naomi R Wray
    Queensland Institute of Medical Research, Brisbane, Australia
    Psychiatr Genet 18:219-25. 2008
  9. ncbi request reprint Genetic and phenotypic stability of measures of neuroticism over 22 years
    Naomi R Wray
    Genetic Epidermology, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 10:695-702. 2007
  10. pmc Prediction of individual genetic risk to disease from genome-wide association studies
    Naomi R Wray
    Genetic Epidemiology, Queensland Institute of Medical Research, Queensland 4029, Brisbane, Australia
    Genome Res 17:1520-8. 2007

Detail Information

Publications40

  1. pmc Narrowing the boundaries of the genetic architecture of schizophrenia
    Naomi R Wray
    Genetic Epidemiology and Queensland Statistical Genetics, Queensland Institute of Medical Research, 330 Herston Road, Brisbane 4029, Australia
    Schizophr Bull 36:14-23. 2010
    ..The first generation of studies have generated hypotheses that should be testable in the near future and will further narrow the boundaries on genetic architectures that are consistent with empirical data...
  2. doi request reprint Prediction of individual genetic risk of complex disease
    Naomi R Wray
    Genetic Epidemiology and Queensland Statistical Genetics, Queensland Institute of Medical Research, Brisbane, Australia
    Curr Opin Genet Dev 18:257-63. 2008
    ..We conclude that with larger GWAS sample sizes or by combining studies, accurate prediction of genetic risk will be possible, even if the causal mutations or the mechanisms by which they affect susceptibility are unknown...
  3. pmc Multi-locus models of genetic risk of disease
    Naomi R Wray
    Genetic Epidemiology and, Queensland Institute of Medical Research, Herston Road, Brisbane, Queensland 4006, Australia
    Genome Med 2:10. 2010
    ..To reconcile the two descriptions requires a model of how risks from individual loci combine to determine an individual's overall risk...
  4. pmc Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo
    P F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Mol Psychiatry 14:359-75. 2009
    ..With the integrated replication effort, we present a specific hypothesis for further studies...
  5. pmc Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned
    N R Wray
    Genetic Epidemiology, Molecular Epidemiology, Psychiatric Genetics and Queensland Statistical Genetics Laboratories, Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Mol Psychiatry 17:36-48. 2012
    ..Larger study cohorts characterized for genetic and environmental risk factors accumulated prospectively are likely to be needed to dissect more fully the etiology of MDD...
  6. doi request reprint Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the Netherlands
    Naomi R Wray
    Department of Genetic Epidemiology, Queensland Institute of Medical Research, 300 Herston Rd, Brisbane, Australia 4029
    Arch Gen Psychiatry 65:649-58. 2008
    ..Studying this personality dimension can give insights into the etiology of these important psychiatric disorders...
  7. doi request reprint Association study of candidate variants of COMT with neuroticism, anxiety and depression
    Naomi R Wray
    Queensland Institute of Medical Research, Brisbane, Australia
    Am J Med Genet B Neuropsychiatr Genet 147:1314-8. 2008
    ..Haplotype T-G-G showed weak association (P = 0.042) with PDAG before correction for multiple testing; association between this haplotype and schizophrenia has been previously reported in an Australian sample...
  8. doi request reprint Association study of candidate variants from brain-derived neurotrophic factor and dystrobrevin-binding protein 1 with neuroticism, anxiety, and depression
    Naomi R Wray
    Queensland Institute of Medical Research, Brisbane, Australia
    Psychiatr Genet 18:219-25. 2008
    ..Here, association between variants of BDNF and DTNBP1, and multiple anxiety and depression phenotypes is explored...
  9. ncbi request reprint Genetic and phenotypic stability of measures of neuroticism over 22 years
    Naomi R Wray
    Genetic Epidermology, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 10:695-702. 2007
    ..33 for a single measure to .43 for mean score because of the reduction in the estimate of the environmental variance, and this will increase power in genetic linkage or association studies of neuroticism...
  10. pmc Prediction of individual genetic risk to disease from genome-wide association studies
    Naomi R Wray
    Genetic Epidemiology, Queensland Institute of Medical Research, Queensland 4029, Brisbane, Australia
    Genome Res 17:1520-8. 2007
    ..Whether an individual with known genetic risk develops the disease depends on known and unknown environmental factors...
  11. ncbi request reprint Anxiety and comorbid measures associated with PLXNA2
    Naomi R Wray
    Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, QLD 4029, Australia
    Arch Gen Psychiatry 64:318-26. 2007
    ..Common genetic liabilities have been reported between psychiatric and psychological measures, but few examples exist of common genetic variants...
  12. pmc Accurate, Large-Scale Genotyping of 5HTTLPR and Flanking Single Nucleotide Polymorphisms in an Association Study of Depression, Anxiety, and Personality Measures
    Naomi R Wray
    Genetic and Molecular Epidemiology Laboratories, Queensland Institute of Medical Research, 300 Herston Road, Brisbane 4006, Australia
    Biol Psychiatry 66:468-76. 2009
    ..However, the original 5HTTLPR assay is prone to bias toward short allele calling...
  13. pmc The genetic interpretation of area under the ROC curve in genomic profiling
    Naomi R Wray
    Genetic Epidemiology and Queensland Statistical Genetics, Queensland Institute of Medical Research, Brisbane, Australia
    PLoS Genet 6:e1000864. 2010
    ..We provide a strategy to estimate proportion of genetic variance explained on the liability scale from estimates of AUC, disease prevalence, and heritability (or sibling recurrence risk) available as an online calculator...
  14. pmc Do 5HTTLPR and stress interact in risk for depression and suicidality? Item response analyses of a large sample
    William L Coventry
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Am J Med Genet B Neuropsychiatr Genet 153:757-65. 2010
    ..01) and are not significantly associated with any of the genotype main effects (5HTTLPR, 5HTTLPR + rs25531) or interactions (stress x genotype). We find no evidence to support the hypothesis of any 5HTTLPR genotype by stress interaction...
  15. pmc Genetic and environmental influences on the co-morbidity between depression, panic disorder, agoraphobia, and social phobia: a twin study
    Miriam A Mosing
    Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia
    Depress Anxiety 26:1004-11. 2009
    ..However, the relative importance of genetic and environmental etiology of the covariation between these disorders, particularly the relationship between PD and AG, is less clear...
  16. pmc Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs
    S Hong Lee
    Queensland Brain Institute, University of Queensland, Brisbane, Australia
    Nat Genet 44:247-50. 2012
    ..6 × 10(-8)). These results are consistent with a polygenic genetic architecture and imply more individual SNP associations will be detected for this disease as sample size increases...
  17. pmc Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
    S Hong Lee
    The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, Australia
    Nat Genet 45:984-94. 2013
    ..This empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders. ..
  18. pmc Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis
    S Hong Lee
    The University of Queensland, Queensland Brain Institute, Brisbane, QLD 4072, Australia
    Hum Mol Genet 22:832-41. 2013
    ..We provide strong evidence that a substantial proportion of variation in liability is explained by common SNPs, and thereby give insights into the genetic architecture of the diseases...
  19. ncbi request reprint Use of monozygotic twins to investigate the relationship between 5HTTLPR genotype, depression and stressful life events: an application of Item Response Theory
    Naomi R Wray
    Genetic and Molecular Epidemiology Laboratories, Queensland Institute of Medical Research, Brisbane, 4006, Australia
    Novartis Found Symp 293:48-59; discussion 59-70. 2008
    ..The use of MZT provides a novel framework for examining genotype x environment interaction in the absence of measures on SLE...
  20. pmc A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality
    Karin J H Verweij
    Genetic Epidemiology, Molecular Epidemiology, and Queensland Statistical Genetics Laboratories, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Biol Psychol 85:306-17. 2010
    ....
  21. pmc A versatile gene-based test for genome-wide association studies
    Jimmy Z Liu
    Genetics and Population Health Division, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia
    Am J Hum Genet 87:139-45. 2010
    ..We have implemented the approach in both an easy-to-use web interface, which only requires the uploading of markers with their association p-values, and a separate downloadable application...
  22. doi request reprint Comparing apples and oranges: equating the power of case-control and quantitative trait association studies
    Jian Yang
    Queensland Institute of Medical Research, Brisbane, Australia
    Genet Epidemiol 34:254-7. 2010
    ..With equal sample size, when v=K, the power of CC association study is much less than that of QT association study because of the information lost by transforming a quantitative continuous trait to a binary trait...
  23. doi request reprint A genome-wide association study of sleep habits and insomnia
    Enda M Byrne
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Am J Med Genet B Neuropsychiatr Genet 162:439-51. 2013
    ..We did not replicate the results from previous genome-wide analyses of self-reported sleep phenotypes after correction for multiple testing...
  24. pmc Unraveling the genetic etiology of adult antisocial behavior: a genome-wide association study
    Jorim J Tielbeek
    Genetic Epidemiology, Molecular Epidemiology, and Queensland Statistical Genetics Laboratories, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    PLoS ONE 7:e45086. 2012
    ..Biosocial criminological research allows a more empirically grounded understanding of criminal behavior, which could ultimately inform and improve current treatment strategies...
  25. pmc Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia
    Manuel A R Ferreira
    Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Eur J Hum Genet 19:458-64. 2011
    ..In conclusion, we confirm the association between asthma risk and variants in ORMDL3 and identify a novel risk variant in IL1RL1. Follow-up of the 17q21 deletion in larger cohorts is warranted...
  26. pmc Impact of diagnostic misclassification on estimation of genetic correlations using genome-wide genotypes
    Naomi R Wray
    Queensland Institute of Medical Research, Brisbane, Australia
    Eur J Hum Genet 20:668-74. 2012
    ..2 in the presence of 10% reciprocal misdiagnosis. Strategies for minimizing the effects of misdiagnosis in cross-disorder genetic studies are discussed...
  27. doi request reprint Interpreting the role of de novo protein-coding mutations in neuropsychiatric disease
    Jacob Gratten
    The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, Australia
    Nat Genet 45:234-8. 2013
    ..Here, we consider several challenges for the interpretation of such mutations in the context of their role in neuropsychiatric disease...
  28. doi request reprint A better coefficient of determination for genetic profile analysis
    Sang Hong Lee
    Queensland Institute of Medical Research, Brisbane, QLD 4072, Australia
    Genet Epidemiol 36:214-24. 2012
    ..Furthermore, even when using ascertained case-control studies that are typical in human disease studies, we can obtain an R(2) measure on the liability scale that can be compared directly to heritability...
  29. pmc Sporadic cases are the norm for complex disease
    Jian Yang
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Eur J Hum Genet 18:1039-43. 2010
    ....
  30. pmc Estimating missing heritability for disease from genome-wide association studies
    Sang Hong Lee
    Queensland Institute of Medical Research, 300 Herston Road, Herston, Queensland 4006, Australia
    Am J Hum Genet 88:294-305. 2011
    ..We apply the method to data from the Wellcome Trust Case Control Consortium and show that a substantial proportion of variation in liability for Crohn disease, bipolar disorder, and type I diabetes is tagged by common SNPs...
  31. doi request reprint Heritability in the genomics era--concepts and misconceptions
    Peter M Visscher
    Queensland Institute of Medical Research, Royal Brisbane Hospital Post Office, Brisbane 4029, Queensland, Australia
    Nat Rev Genet 9:255-66. 2008
    ..Recent reports of substantial heritability for gene expression and new estimation methods using marker data highlight the relevance of heritability in the genomics era...
  32. pmc Assumptions and properties of limiting pathway models for analysis of epistasis in complex traits
    Sven Stringer
    Department of Psychiatry, Amsterdam Medical Center, Amsterdam, The Netherlands
    PLoS ONE 8:e68913. 2013
    ..Together with theoretical, empirical, and pragmatic arguments we conclude that in outbred populations the contribution of additive genetic variance is likely to be much more important than the contribution of non-additive variance. ..
  33. pmc Novel genetic analysis for case-control genome-wide association studies: quantification of power and genomic prediction accuracy
    Sang Hong Lee
    Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia
    PLoS ONE 8:e71494. 2013
    ..The expected values based on our derived equations for both power and prediction accuracy agree well with observed estimates from simulations. ..
  34. ncbi request reprint Shared temperament risk factors for anorexia nervosa: a twin study
    Tracey D Wade
    School of Psychology, Flinders University, P O Box 2100, Adelaide, SA 5001, Australia
    Psychosom Med 70:239-44. 2008
    ..To answer two questions about the nature of the relationship between anorexia nervosa (AN) and dimensional temperament traits: Which traits are comorbid with AN? Which traits share transmitted liabilities with AN?..
  35. ncbi request reprint Haplotype analysis and a novel allele-sharing method refines a chromosome 4p locus linked to bipolar affective disorder
    Stephanie Le Hellard
    Medical Genetics Section, School of Clinical and Molecular Medicine, Molecular Medicine Centre, University of Edinburgh, Scotland, United Kingdom
    Biol Psychiatry 61:797-805. 2007
    ..Previously, we described significant linkage of BPAD to a chromosome 4p locus within a large pedigree (F22). Others subsequently have found evidence for linkage of BPAD and SCZ to this region...
  36. ncbi request reprint Empirical evaluation of the genetic similarity of samples from twin registries in Australia and the Netherlands using 359 STRP markers
    Patrick F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 7264, United States of America
    Twin Res Hum Genet 9:600-2. 2006
    ..30% between the Australian and the Netherlands cohorts, a smaller value than between many European groups. We conclude that it is reasonable to combine the Australian and the Netherlands samples for joint genetic analyses...
  37. ncbi request reprint Allele frequencies and the r2 measure of linkage disequilibrium: impact on design and interpretation of association studies
    Naomi R Wray
    Department of Medical Sciences, University of Edinburgh, United Kingdom
    Twin Res Hum Genet 8:87-94. 2005
    ..5. For r(2) >/= .8 and allele frequency at one locus of .1, the maximum difference in allele frequency at the second locus is only +/- .02. The impact on the design and interpretation of association studies is discussed...
  38. pmc Conventional multipoint nonparametric linkage analysis is not necessarily inherently biased
    Peter M Visscher
    Am J Hum Genet 75:718-20; author reply 723-7. 2004
  39. ncbi request reprint Sex differences in symptoms of depression in unrelated individuals and opposite-sex twin and sibling pairs
    Christel M Middeldorp
    Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
    Twin Res Hum Genet 9:632-6. 2006
    ..This signifies that men and women are alike in their symptom profiles for major depression and genes for depression are probably expressed in the same way in the two sexes...
  40. pmc Response to Amar J. Klar: The chromosome 1;11 translocation provides the best evidence supporting genetic etiology for schizophrenia and bipolar affective disorders
    J Kirsty Millar
    Genetics 163:833-5; author reply 837-8. 2003