D C Whiteman

Summary

Affiliation: Queensland Institute of Medical Research
Country: Australia

Publications

  1. doi request reprint Genome-wide copy number analysis in esophageal adenocarcinoma using high-density single-nucleotide polymorphism arrays
    Derek J Nancarrow
    Oncogenomics, Queensland Institute of Medical Research, Herston, Queensland, Australia
    Cancer Res 68:4163-72. 2008
  2. pmc Exercise and the Prevention of Oesophageal Cancer (EPOC) study protocol: a randomized controlled trial of exercise versus stretching in males with Barrett's oesophagus
    Brooke M Winzer
    The University of Queensland, School of Medicine, Burns, Trauma and Critical Care Research Centre, Brisbane, QLD 4029, Australia
    BMC Cancer 10:292. 2010
  3. ncbi request reprint The modern researcher and the peacock's tail
    David Whiteman
    Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Lancet 369:449-50. 2007
  4. ncbi request reprint Anatomic site, sun exposure, and risk of cutaneous melanoma
    David C Whiteman
    Division of Population Studies and Human Genetics, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Queensland 4029 Australia e mail
    J Clin Oncol 24:3172-7. 2006
  5. ncbi request reprint Combined effects of obesity, acid reflux and smoking on the risk of adenocarcinomas of the oesophagus
    D C Whiteman
    Division of Population Studies and Human Genetics, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Queensland 4029, Australia
    Gut 57:173-80. 2008
  6. ncbi request reprint A comparison of the anatomic distribution of cutaneous melanoma in two populations with different levels of sunlight: the west of Scotland and Queensland, Australia 1982-2001
    David C Whiteman
    Division of Population Studies and Human Genetics, Queensland Institute for Medical Research, Post Office Royal Brisbane Hospital, Brisbane, QLD, Australia
    Cancer Causes Control 18:485-91. 2007
  7. pmc Does type 2 diabetes influence the risk of oesophageal adenocarcinoma?
    R E Neale
    Queensland Institute of Medical Research, Australia
    Br J Cancer 100:795-8. 2009
  8. doi request reprint Do low control response rates always affect the findings? Assessments of smoking and obesity in two Australian case-control studies of cancer
    Nirmala Pandeya
    Queensland Institute of Medical Research, Division of Population Studies, The University of Queensland, Australia
    Aust N Z J Public Health 33:312-9. 2009
  9. doi request reprint Gastro-oesophageal reflux symptoms and the risks of oesophageal cancer: are the effects modified by smoking, NSAIDs or acid suppressants?
    N Pandeya
    Queensland Institute of Medical Research, Brisbane, Australia
    Gut 59:31-8. 2010
  10. ncbi request reprint p53 expression and risk factors for cutaneous melanoma: a case-control study
    D C Whiteman
    Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    Int J Cancer 77:843-8. 1998

Research Grants

Detail Information

Publications90

  1. doi request reprint Genome-wide copy number analysis in esophageal adenocarcinoma using high-density single-nucleotide polymorphism arrays
    Derek J Nancarrow
    Oncogenomics, Queensland Institute of Medical Research, Herston, Queensland, Australia
    Cancer Res 68:4163-72. 2008
    ..The focal gains and deletions documented here are a step toward identifying the key genes involved in EAC development...
  2. pmc Exercise and the Prevention of Oesophageal Cancer (EPOC) study protocol: a randomized controlled trial of exercise versus stretching in males with Barrett's oesophagus
    Brooke M Winzer
    The University of Queensland, School of Medicine, Burns, Trauma and Critical Care Research Centre, Brisbane, QLD 4029, Australia
    BMC Cancer 10:292. 2010
    ..Body composition, gastro-oesophageal reflux disease symptoms, cardiovascular fitness and muscular strength will also be assessed as secondary outcomes...
  3. ncbi request reprint The modern researcher and the peacock's tail
    David Whiteman
    Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Lancet 369:449-50. 2007
  4. ncbi request reprint Anatomic site, sun exposure, and risk of cutaneous melanoma
    David C Whiteman
    Division of Population Studies and Human Genetics, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Queensland 4029 Australia e mail
    J Clin Oncol 24:3172-7. 2006
    ..A current hypothesis postulates that the role of sunlight in causing melanoma differs according to anatomic site. We tested this hypothesis in a population-based case-case comparative study of melanoma patients...
  5. ncbi request reprint Combined effects of obesity, acid reflux and smoking on the risk of adenocarcinomas of the oesophagus
    D C Whiteman
    Division of Population Studies and Human Genetics, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Queensland 4029, Australia
    Gut 57:173-80. 2008
    ..To measure the relative risks of adenocarcinomas of the oesophagus and gastro-oesophageal junction associated with measures of obesity, and their interactions with age, sex, gastro-oesophageal reflux symptoms and smoking...
  6. ncbi request reprint A comparison of the anatomic distribution of cutaneous melanoma in two populations with different levels of sunlight: the west of Scotland and Queensland, Australia 1982-2001
    David C Whiteman
    Division of Population Studies and Human Genetics, Queensland Institute for Medical Research, Post Office Royal Brisbane Hospital, Brisbane, QLD, Australia
    Cancer Causes Control 18:485-91. 2007
    ..Identifying the causes of these differences is likely to provide better understanding of how sunlight causes melanoma...
  7. pmc Does type 2 diabetes influence the risk of oesophageal adenocarcinoma?
    R E Neale
    Queensland Institute of Medical Research, Australia
    Br J Cancer 100:795-8. 2009
    ..Diabetes increased the risk of OAC (adjusted odds ratio 1.59, 95% confidence interval (CI) 1.04-2.43), although the risk was attenuated after further adjusting for body mass index (1.32, 95% CI 0.85-2.05)...
  8. doi request reprint Do low control response rates always affect the findings? Assessments of smoking and obesity in two Australian case-control studies of cancer
    Nirmala Pandeya
    Queensland Institute of Medical Research, Division of Population Studies, The University of Queensland, Australia
    Aust N Z J Public Health 33:312-9. 2009
    ..Formal assessments of the effect of low participation on odds ratios (OR) are seldom presented however. We sought to quantify possible bias using multiple imputation techniques...
  9. doi request reprint Gastro-oesophageal reflux symptoms and the risks of oesophageal cancer: are the effects modified by smoking, NSAIDs or acid suppressants?
    N Pandeya
    Queensland Institute of Medical Research, Brisbane, Australia
    Gut 59:31-8. 2010
    ..To measure the extent to which risks of oesophageal cancers associated with gastro-oesophageal reflux (GOR) are modified by common factors including smoking, non-steroidal anti-inflammatory drugs (NSAIDs) and acid suppressant medications...
  10. ncbi request reprint p53 expression and risk factors for cutaneous melanoma: a case-control study
    D C Whiteman
    Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    Int J Cancer 77:843-8. 1998
    ..Our findings are consistent with at least 2 independent pathways in the pathogenesis of melanoma, characterized by environmental induction and p53 overexpression on the one hand and pigment cell instability on the other...
  11. doi request reprint Polymorphisms in MGMT and DNA repair genes and the risk of esophageal adenocarcinoma
    James Doecke
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Int J Cancer 123:174-80. 2008
    ..In summary, MGMT SNPs are associated with increased risks of EAC. Exposure to acid reflux, and possibly smoking, confer markedly higher risks among homozygous variant genotype carriers...
  12. ncbi request reprint Risk factors for benign, borderline and invasive mucinous ovarian tumors: epidemiological evidence of a neoplastic continuum?
    Susan J Jordan
    Cancer and Population Studies Group, The Queensland Institute of Medical Research, Brisbane, Australia
    Gynecol Oncol 107:223-30. 2007
    ..Such a sequence would predict some shared risk factors between the different tumor types. To investigate this, we examined risk factors for benign, borderline and invasive mucinous ovarian tumors...
  13. doi request reprint Associations of duration, intensity, and quantity of smoking with adenocarcinoma and squamous cell carcinoma of the esophagus
    Nirmala Pandeya
    Population Studies and Human Genetics Division, Queensland Institute of Medical Research, Herston, Queensland, Australia
    Am J Epidemiol 168:105-14. 2008
    ..For all types of esophageal cancer, time since quitting was independently associated with approximately 15-19% risk reductions per decade...
  14. doi request reprint Endometrioid and clear cell ovarian cancers: a comparative analysis of risk factors
    Christina M Nagle
    Cancer and Population Studies Group, Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Eur J Cancer 44:2477-84. 2008
    ..Endometrioid and clear cell ovarian cancers have some shared as well as some distinct risk factors, and therefore should be considered separately in studies of ovarian cancer...
  15. ncbi request reprint Body size and ovarian cancer: case-control study and systematic review (Australia)
    D M Purdie
    Queensland Institute of Medical Research, Herston, Australia
    Cancer Causes Control 12:855-63. 2001
    ..We therefore investigated the association between measures of body mass index (BMI) and ovarian cancer risk...
  16. ncbi request reprint Childhood sun exposure as a risk factor for melanoma: a systematic review of epidemiologic studies
    D C Whiteman
    Epidemiology and Population Health Unit, Queensland Institute of Medical Research, Brisbane, Australia
    Cancer Causes Control 12:69-82. 2001
    ..To review the evidence that childhood is a period of particular susceptibility to the carcinogenic effects of solar radiation...
  17. doi request reprint The use of nonsteroidal anti-inflammatory drugs and the risk of Barrett's oesophagus
    A P Thrift
    School of Population Health, The University of Queensland, Public Health Building, Herston, Brisbane, Australia
    Aliment Pharmacol Ther 34:1235-44. 2011
    ....
  18. doi request reprint Leptin and the risk of Barrett's oesophagus
    B J Kendall
    Division of Population Studies and Human Genetics, Queensland Institute of Medical Research, Brisbane, Australia
    Gut 57:448-54. 2008
    ....
  19. pmc The Queensland Study of Melanoma: environmental and genetic associations (Q-MEGA); study design, baseline characteristics, and repeatability of phenotype and sun exposure measures
    Amanda J Baxter
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Twin Res Hum Genet 11:183-96. 2008
    ..Characteristics of the cases and repeatability of sun exposure and phenotype measures between the baseline and the follow-up surveys, from 6 to 17 years later, are also described...
  20. doi request reprint Single nucleotide polymorphisms in obesity-related genes and the risk of esophageal cancers
    James D Doecke
    Division of Population Studies and Human Genetics, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland, Australia
    Cancer Epidemiol Biomarkers Prev 17:1007-12. 2008
    ..0 kg/m(2), 25.0-29.9 kg/m(2), >30 kg/m(2)). In conclusion, our data suggest that these SNPs do not play a major role in esophageal carcinogenesis...
  21. doi request reprint Aspirin, nonsteroidal anti-inflammatory drugs, and the risks of cancers of the esophagus
    Shahram Sadeghi
    Queensland Institute of Medical Research, University of Queensland, Brisbane, Queensland 4029, Australia
    Cancer Epidemiol Biomarkers Prev 17:1169-78. 2008
    ....
  22. doi request reprint The incidence of esophageal adenocarcinoma continues to rise: analysis of period and birth cohort effects on recent trends
    A P Thrift
    Population Health Department, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Ann Oncol 23:3155-62. 2012
    ..During the past four decades, the incidence of esophageal adenocarcinoma (EAC) has increased markedly in Western populations. Recent reports have suggested that the rate of increase has slowed or plateaued...
  23. doi request reprint High-risk human papillomavirus in esophageal squamous cell carcinoma
    Annika Antonsson
    Queensland Institute of Medical Research, 300 Herston Road, Herston, QLD 4029, Australia
    Cancer Epidemiol Biomarkers Prev 19:2080-7. 2010
    ....
  24. doi request reprint Association of Helicobacter pylori infection with reduced risk for esophageal cancer is independent of environmental and genetic modifiers
    David C Whiteman
    Queensland Institute of Medical Research, Brisbane, Australia
    Gastroenterology 139:73-83; quiz e11-2. 2010
    ..We sought to measure the association between H pylori infection and esophageal cancer and identify potential modifiers...
  25. ncbi request reprint An analysis of risk factors for cutaneous melanoma by anatomical site (Australia)
    Victor Siskind
    Division of Population Studies and Human Genetics, Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Cancer Causes Control 16:193-9. 2005
    ..We sought to test this hypothesis in a population-based study in Queensland, Australia...
  26. ncbi request reprint Sun exposure and host phenotype as predictors of cutaneous melanoma associated with neval remnants or dermal elastosis
    Eva Y Lee
    Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Int J Cancer 119:636-42. 2006
    ..We conclude that melanomas with different histologic characteristics have different risk factor profiles, particularly on the head and neck. These data accord with the hypothesis that melanomas arise through different causal pathways...
  27. ncbi request reprint Healthcare resource use and medical costs for the management of oesophageal cancer
    L G Gordon
    Queensland Institute of Medical Research, Population Health Department, Royal Brisbane Hospital, Brisbane, Queensland, Australia
    Br J Surg 98:1589-98. 2011
    ..This study examined the interaction between natural history, current practice patterns in diagnosis, monitoring and treatment of oesophageal cancer, and associated health resource utilization and costs...
  28. doi request reprint ATG16L1 T300A shows strong associations with disease subgroups in a large Australian IBD population: further support for significant disease heterogeneity
    Elizabeth V Fowler
    Inflammatory Bowel Disease Laboratory, Royal Brisbane and Women s Research Foundation, Brisbane, Australia
    Am J Gastroenterol 103:2519-26. 2008
    ....
  29. pmc IRF4 variants have age-specific effects on nevus count and predispose to melanoma
    David L Duffy
    Queensland Institute of Medical Research, Brisbane 4029, Australia
    Am J Hum Genet 87:6-16. 2010
    ..14, p = 0.0035; excluding Australian, the UK, and Swedish samples typed at rs12203592: OR 1.08, p = 0.08)...
  30. ncbi request reprint Multiple births and risk of epithelial ovarian cancer
    D C Whiteman
    Imperial Cancer Research Fund General Practice Research Group, University of Oxford, U K
    J Natl Cancer Inst 92:1172-7. 2000
    ..We estimated the relative risks of various histologic types of ovarian cancers associated with multiple births by using multivariable logistic regression analysis, adjusting for matching and confounding variables...
  31. doi request reprint Foveolar type dysplasia in Barrett esophagus
    Ian S Brown
    Department of Histopathology, Sullivan Nicolaides Pathology and Royal Brisbane and Women s Hospital Brisbane, Brisbane, Australia
    Mod Pathol 23:834-43. 2010
    ..In conclusion, our study provides evidence for a non intestinal pathway to neoplastic development in Barrett esophagus, that is, gastric metaplasia-foveolar dysplasia-adenocarcinoma...
  32. pmc High intake of folate from food sources is associated with reduced risk of esophageal cancer in an Australian population
    Torukiri I Ibiebele
    Queensland Institute of Medical Research, Genetics and Population Health Division, Herston, Brisbane, Australia
    J Nutr 141:274-83. 2011
    ..High intake of folate-containing foods may reduce risk of EAC, but our data raise the possibility that folic acid supplementation may increase risks of BE with dysplasia and EAC...
  33. doi request reprint Hyperplastic polyposis syndrome is associated with cigarette smoking, which may be a modifiable risk factor
    R Griff Walker
    Department of Gastroenterology and Hepatology, Royal Brisbane and Women s Hospital, Brisbane, Queensland, Australia
    Am J Gastroenterol 105:1642-7. 2010
    ....
  34. doi request reprint Body size and risk of epithelial ovarian and related cancers: a population-based case-control study
    Catherine M Olsen
    Cancer and Population Studies Group, Queensland Institute of Medical Research, Brisbane, Australia
    Int J Cancer 123:450-6. 2008
    ..These results add to the current evidence that obesity increases a woman's risk of developing distinct histological subtypes of ovarian cancer...
  35. doi request reprint Changes in the incidence of cutaneous melanoma in the west of Scotland and Queensland, Australia: hope for health promotion?
    David C Whiteman
    Division of Population Studies and Human Genetics, Queensland Institute for Medical Research, Herston, Brisbane, Queensland, Australia
    Eur J Cancer Prev 17:243-50. 2008
    ..Variations in rates of change at different body sites warrant further monitoring...
  36. doi request reprint Reduced expression of IL-18 is a marker of ultraviolet radiation-induced melanomas
    Elke Hacker
    Oncogenomics Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Int J Cancer 123:227-31. 2008
    ..011). We conclude that loss of IL-18 is a marker of UVR-induced melanoma, both in animal models and humans...
  37. doi request reprint The association between MC1R genotype and BRAF mutation status in cutaneous melanoma: findings from an Australian population
    Elke Hacker
    Genetics and Population Health Division, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    J Invest Dermatol 130:241-8. 2010
    ..BRAF-mutant melanomas have different origins from other cutaneous melanomas. These data support the divergent pathways hypothesis for melanoma, which may require a reappraisal of targeted cancer prevention activities...
  38. doi request reprint Estimating the attributable fraction for cancer: A meta-analysis of nevi and melanoma
    Catherine M Olsen
    Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Australia
    Cancer Prev Res (Phila) 3:233-45. 2010
    ..This work is the necessary first step in designing targeted preventive strategies for melanoma, which must now be overlaid with information about cost and utility...
  39. doi request reprint KCNN4 gene variant is associated with ileal Crohn's Disease in the Australian and New Zealand population
    Lisa A Simms
    Royal Brisbane and Women s Research Foundation, Brisbane, Queensland, Australia
    Am J Gastroenterol 105:2209-17. 2010
    ..Our aim was to determine whether a gene in the IBD linkage region on chromosome 19q13, with a role in Paneth cell secretion and T-cell activation, conferred genetic susceptibility to the development of CD...
  40. doi request reprint Current and past smoking significantly increase risk for Barrett's esophagus
    Kylie J Smith
    Division of Population Studies and Human Genetics, Queensland Institute of Medical Research, Brisbane, Australia
    Clin Gastroenterol Hepatol 7:840-8. 2009
    ..However, few population-based studies of BE have been conducted, so little is known about potentially modifiable causes of this disease...
  41. doi request reprint Alcohol consumption and the risks of adenocarcinoma and squamous cell carcinoma of the esophagus
    Nirmala Pandeya
    Queensland Institute of Medical Research, Brisbane, Australia School of Population Health, The University of Queensland, Brisbane, Australia
    Gastroenterology 136:1215-24, e1-2. 2009
    ..Alcohol has been declared a carcinogen for cancers of the esophagus, although the evidence relates largely to the squamous subtype. Evidence for an effect on adenocarcinomas is scant and inconsistent...
  42. doi request reprint Tea consumption and risk of ovarian cancer
    Christina M Nagle
    Genetics and Population Health, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, QLD, Australia
    Cancer Causes Control 21:1485-91. 2010
    ..Although the growth inhibitory effects of tea, particularly green tea, and tea polyphenols have been demonstrated in animal models of ovarian cancer, the results of epidemiological studies have been inconclusive...
  43. pmc Nevus density and melanoma risk in women: a pooled analysis to test the divergent pathway hypothesis
    Catherine M Olsen
    Cancer and Population Studies Group, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Int J Cancer 124:937-44. 2009
    ..This finding supports different etiologic pathways of melanoma development by anatomic site...
  44. doi request reprint Histologic and epidemiologic correlates of P-MAPK, Brn-2, pRb, p53, and p16 immunostaining in cutaneous melanomas
    Naomi M Richmond-Sinclair
    Queensland Institute of Medical Research, The School of Life Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia
    Melanoma Res 18:336-45. 2008
    ..Exactly how the expression of each protein relates to the causal pathways needs to be further explored...
  45. doi request reprint Epithelial ovarian cancer: testing the 'androgens hypothesis'
    Catherine M Olsen
    Cancer and Population Studies Group, Queensland Institute of Medical Research, Brisbane, 4029, Australia
    Endocr Relat Cancer 15:1061-8. 2008
    ..7; 95% CI 1.1-12.0); however, use of the androgenic medication Danazol did not increase risk (OR 1.0; 95% CI 0.4-2.9). Overall, our results do not support the hypothesis that androgen-related disorders increase the risk of ovarian cancer...
  46. doi request reprint Familial melanoma: a meta-analysis and estimates of attributable fraction
    Catherine M Olsen
    Cancer Control Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Queensland 4029, Australia
    Cancer Epidemiol Biomarkers Prev 19:65-73. 2010
    ..040 for all regions combined). Our findings suggest that only a small percentage of melanoma cases (always <7%) are attributable to familial risk; the majority of melanomas are presumably attributable to other factors...
  47. doi request reprint webFOG: A web tool to map genomic features onto genes
    Sonika Tyagi
    Oncogenomics Laboratory, Queensland Institute of Medical Research, Herston, Brisbane, QLD 4029, Australia
    Biochem Biophys Res Commun 401:447-50. 2010
    ..A standalone version and web interface for the tool can be accessed through: http://populationhealth.qimr.edu.au/cgi-bin/webFOG/index.cgi. The project details and source code is also available at http://www.bioinformatics.org/webfog...
  48. doi request reprint Estimating the attributable fraction for melanoma: a meta-analysis of pigmentary characteristics and freckling
    Catherine M Olsen
    Cancer Control Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, QLD 4029, Australia
    Int J Cancer 127:2430-45. 2010
    ..18 vs. 0.13). The PAF of melanoma associated with red hair colour was 0.10. These estimates of melanoma burden attributable to pigmentary characteristics provide a basis for designing prevention strategies for melanoma...
  49. doi request reprint Cancers of the esophagus and carbonated beverage consumption: a population-based case-control study
    Torukiri I Ibiebele
    Cancer and Population Studies Group, Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, Brisbane, QLD 4029, Australia
    Cancer Causes Control 19:577-84. 2008
    ..We analyzed data from a population-based case-control study to measure the association between carbonated beverage intake and risk of adenocarcinomas and squamous cell carcinoma (SCC) of the esophagus...
  50. ncbi request reprint A rapid method for determining recent sunscreen use in field studies
    David C Whiteman
    Division of Population and Clinical Sciences, Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Brisbane, Herston QLD 4029, Australia
    J Photochem Photobiol B 69:59-63. 2003
    ..We conclude that spectrophotometric analysis of skin swabs can reliably detect the presence of sunscreen on the skin for up to 2 h after application...
  51. ncbi request reprint Does smoking increase risk of ovarian cancer? A systematic review
    Susan J Jordan
    Cancer and Population Studies Group, Queensland Institute of Medical Research, School of Population Health, University of Queensland, Brisbane, Australia
    Gynecol Oncol 103:1122-9. 2006
    ..We sought to clarify the relationship between smoking and ovarian cancer by histological subtype...
  52. ncbi request reprint Melanocytic nevi, solar keratoses, and divergent pathways to cutaneous melanoma
    David C Whiteman
    Division of Population Studies and Human Genetics, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Queensland, Australia
    J Natl Cancer Inst 95:806-12. 2003
    ..We tested this hypothesis in a case-case comparative study of melanoma patients in Queensland, Australia...
  53. ncbi request reprint Prevalence and anatomical distribution of naevi in young Queensland children
    David C Whiteman
    Division of Population Studies and Human Genetics Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Queensland, Australia
    Int J Cancer 106:930-3. 2003
    ..These data support the concept that melanocytic neoplasia commences early in life and that naevus evolution is influenced by the anatomical site of the target cell...
  54. ncbi request reprint Repeatability of self-reported information for population-based studies of cancer
    Shamshad Karatela
    Division of Population Studies and Human Genetics, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Queensland 4029 Australia
    Asian Pac J Cancer Prev 7:303-8. 2006
    ..To measure the repeatability of a cancer risk factor questionnaire in a population-based case-control study...
  55. ncbi request reprint Temporal changes in the endoscopic frequency of new cases of Barrett's esophagus in an Australian health region
    Bradley J Kendall
    Department of Gastroenterology, Royal Brisbane and Women s Hospital, Brisbane, Queensland, Australia
    Am J Gastroenterol 101:1178-82. 2006
    ..This increase has significant implications for health resource utilization and costs. We sought to determine changes in the endoscopic frequency of new cases of BE in an Australian population during the period 1990-2002...
  56. ncbi request reprint Anatomical distribution of solar ultraviolet exposures among cyclists
    Michael G Kimlin
    Institute of Health and Biomedical Innovation, Faculty of Health, Queensland University of Technology, Brisbane, Qld 4001, Australia
    J Photochem Photobiol B 85:23-7. 2006
    ..Moreover, our observations suggest that even vertically-oriented, potentially shaded sites such as the lower leg typically receive doses of solar radiation no less than half of maximally exposed sites...
  57. ncbi request reprint Melanocytic nevi in very young children: the role of phenotype, sun exposure, and sun protection
    David C Whiteman
    Division of Population Studies and Human Genetics, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Queensland 4029 Australia
    J Am Acad Dermatol 52:40-7. 2005
    ..Melanocytic nevi are strongly associated with cutaneous melanoma, yet little is known about factors influencing nevus development in the first years of life...
  58. ncbi request reprint Timing of pregnancy and the risk of epithelial ovarian cancer
    David C Whiteman
    Population and Clinical Sciences Division, Queensland Institute of Medical Research, Queensland 4029, Australia
    Cancer Epidemiol Biomarkers Prev 12:42-6. 2003
    ....
  59. ncbi request reprint Obesity and the risk of epithelial ovarian cancer: a systematic review and meta-analysis
    Catherine M Olsen
    Cancer and Population Studies Group, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Herston, Brisbane, QLD 4029, Australia
    Eur J Cancer 43:690-709. 2007
    ..There was no evidence that the association varied for the different histological subtypes of ovarian cancer. Ovarian cancer should be added to the list of cancers likely to be related to obesity...
  60. ncbi request reprint Risk factors for benign serous and mucinous epithelial ovarian tumors
    Susan J Jordan
    Cancer and Population Studies Group, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Obstet Gynecol 109:647-54. 2007
    ..To investigate the risk factors for benign serous and mucinous epithelial ovarian tumors...
  61. pmc Hypothesis: hair cover can protect against invasive melanoma on the head and neck (Australia)
    Adele C Green
    Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland, Australia
    Cancer Causes Control 17:1263-6. 2006
    ..We conclude that hair cover can protect against invasive melanoma on the ear and may similarly protect on the scalp and neck. When discretionary, hair may be an important additional factor to be considered for melanoma prevention...
  62. pmc SiDCoN: a tool to aid scoring of DNA copy number changes in SNP chip data
    Derek J Nancarrow
    Oncogenomics, Queensland Institute of Medical Research, Herston, Queensland, Australia
    PLoS ONE 2:e1093. 2007
    ..We believe this tool will prove useful to others working in the area, both as a training tool, and to aid in the interpretation of complex copy number changes...
  63. doi request reprint Eating habits and risk of esophageal cancers: a population-based case-control study
    Torukiri I Ibiebele
    Clive Berghofer Cancer Research Centre, Queensland Institute of Medical Research, Herston, QLD, Australia
    Cancer Causes Control 21:1475-84. 2010
    ..We analyzed data from a population-based case-control study to examine whether eating behaviors are associated with risk of esophageal cancer...
  64. ncbi request reprint Serous ovarian, fallopian tube and primary peritoneal cancers: a comparative epidemiological analysis
    Susan J Jordan
    Cancer and Population Studies Group, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Int J Cancer 122:1598-603. 2008
    ..These results also call into question the role of the physical effects of ovulation in the development of serous ovarian cancer...
  65. ncbi request reprint Recreational physical activity and epithelial ovarian cancer: a case-control study, systematic review, and meta-analysis
    Catherine M Olsen
    Cancer and Population Studies Group, Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Herston 4029, Queensland, Australia
    Cancer Epidemiol Biomarkers Prev 16:2321-30. 2007
    ..Thus, pooled results from observational studies suggest that a modest inverse association exists between level of recreational physical activity and the risk of ovarian cancer...
  66. doi request reprint Body-site distribution of skin cancer, pre-malignant and common benign pigmented lesions excised in general practice
    P H Youl
    Viertel Centre for Research in Cancer Control, Cancer Council Queensland, Spring Hill, QLD, Australia
    Br J Dermatol 165:35-43. 2011
    ..Concern about skin cancer is a common reason for people from predominantly fair-skinned populations to present to primary care doctors...
  67. pmc Interactions among smoking, obesity, and symptoms of acid reflux in Barrett's esophagus
    Kylie J Smith
    Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, Queensland 4029, Australia
    Cancer Epidemiol Biomarkers Prev 14:2481-6. 2005
    ..Clinical studies suggest acid reflux causes Barrett's esophagus; however, no population-based estimates of risk have been reported, and the role of other health factors in modifying risk is unclear...
  68. pmc Variation in bone morphogenetic protein 15 is not associated with spontaneous human dizygotic twinning
    Zhen Zhen Zhao
    Molecular Epidemiology, Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, QLD, Australia
    Hum Reprod 23:2372-9. 2008
    ..Spontaneous dizygotic (DZ) twinning in humans is under genetic control. In sheep, heterozygous loss of function mutations in bone morphogenetic protein 15 (BMP15) increase ovulation and hence twinning rates...
  69. pmc A population-based study of Australian twins with melanoma suggests a strong genetic contribution to liability
    Sri N Shekar
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    J Invest Dermatol 129:2211-9. 2009
    ..Using these data and population prevalences, it was estimated that 55% of the variation in liability to melanoma is due to genetic influences...
  70. doi request reprint Breastfeeding and risk of epithelial ovarian cancer
    Susan J Jordan
    School of Population Health, The University of Queensland, Public Health Building, Herston, Brisbane, Australia
    Cancer Causes Control 21:109-16. 2010
    ..The relationship with breastfeeding duration is unclear, and it is uncertain whether the association varies according to histological subtype of ovarian cancer. We sought to clarify these issues...
  71. ncbi request reprint Twinning and the incidence of breast and gynecological cancers (United States)
    Rachel E Neale
    Queensland Institute of Medical Research, Brisbane, Australia
    Cancer Causes Control 15:829-35. 2004
    ..21). Conversely the risk of cervical cancer was higher among twin mothers (RR = 1.78, 95% CI 0.88-3.52). This latter finding supports previous data suggesting that reproductive hormones act as cofactors in the etiology of cervical cancer...
  72. ncbi request reprint Nonsteroidal anti-inflammatory drugs and the risk of actinic keratoses and squamous cell cancers of the skin
    Gregory J Butler
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    J Am Acad Dermatol 53:966-72. 2005
    ....
  73. ncbi request reprint Loss of p16 expression is associated with histological features of melanoma invasion
    S J Pavey
    Joint Experimental Oncology Programme of the Queensland Institute of Medical Research, the University of Queensland and the Queensland Cancer Fund, Post Office Royal Brisbane Hospital, Australia
    Melanoma Res 12:539-47. 2002
    ..084) and a high mitotic index (P = 0.013). Taken together, these findings are consistent with loss of p16 being a late event in the progression of sporadic primary melanomas, being associated with tumours of a more aggressive nature...
  74. ncbi request reprint Determinants of melanocyte density in adult human skin
    D C Whiteman
    Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    Arch Dermatol Res 291:511-6. 1999
    ..We speculate that the unequal distribution of melanocytes may partially explain the site-specific incidence of melanoma, offering fresh perspectives on the aetiology of this cancer...
  75. ncbi request reprint Symptoms, investigations and management of patients with cancer of the oesophagus and gastro-oesophageal junction in Australia
    Bernard M Smithers
    Upper GI and Soft Tissue Unit, Division of Surgery, Princess Alexandra Hospital, Brisbane, QLD, Australia
    Med J Aust 193:572-7. 2010
    ..To document presenting symptoms, investigations and management for Australian patients with oesophageal adenocarcinoma (OAC), gastro-oesophageal junction adenocarcinoma (GOJAC) and oesophageal squamous cell carcinoma (OSCC)...
  76. ncbi request reprint Induction of metallothionein in human skin by routine exposure to sunlight: evidence for a systemic response and enhanced induction at certain body sites
    Effie Ablett
    Centre for Plant Conservation Genetics, Southern Cross University, Lismore, New South Wales, Australia
    J Invest Dermatol 120:318-24. 2003
    ..Leukocytes may therefore contribute to and amplify the systemic effects of ultraviolet-induced interleukin-6 and metallothionein expression...
  77. ncbi request reprint Basal cell carcinoma on the trunk is associated with excessive sun exposure
    Rachel E Neale
    Viertel Centre for Research in Cancer Control, Queensland Cancer Fund, Spring Hill, Queensland, Australia
    J Am Acad Dermatol 56:380-6. 2007
    ..We tested the hypothesis that the phenotypic determinants and patterns of sun exposure that give rise to BCC on the head and trunk vary in a way that explains the anomalous site distribution...
  78. pmc Similarity of aberrant DNA methylation in Barrett's esophagus and esophageal adenocarcinoma
    Eric Smith
    School of Nursing and Midwifery, Flinders University, Bedford Park, South Australia 5042, Australia
    Mol Cancer 7:75. 2008
    ..This study was designed to determine at what stage, in the progression from BE to EAC, methylation of key genes occurs...
  79. ncbi request reprint Sun protection messages, vitamin D and skin cancer: out of the frying pan and into the fire?
    Monika Janda
    Med J Aust 186:52-4. 2007
  80. ncbi request reprint Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer
    Simon A Gayther
    Translational Research Laboratories, University College London, London, United Kingdom
    Cancer Res 67:3027-35. 2007
    ..This study highlights the need for multicenter collaborations for genetic association studies...
  81. ncbi request reprint Expression of p53 tumor suppressor protein in sun-exposed skin and associations with sunscreen use and time spent outdoors: a community-based study
    Jolieke C van der Pols
    School of Population Health, University of Queensland, Herston, Australia
    Am J Epidemiol 163:982-8. 2006
    ..7, 95% confidence interval: 0.9, 3.1). The authors conclude that p53 immunoreactivity in the skin is a marker of exposure to ultraviolet light in the past 6 months, but this may be mitigated by regular application of sunscreen...
  82. ncbi request reprint Childhood and adult cancer in twins: evidence from the Utah genealogy
    Rachel E Neale
    Childhood Cancer Research Group, 57 Woodstock Road, Oxford OX2 6HJ, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:1236-40. 2005
    ..Mothers of twins have higher estrogen levels during pregnancy than mothers of singletons, therefore, assessment of cancer risk in twins may be informative...
  83. ncbi request reprint Diagnostic accuracy in skin cancer clinics: the Australian experience
    Cameron R M Moffatt
    Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Int J Dermatol 45:656-60. 2006
    ..We sought to measure the accuracy of clinical diagnosis in this setting...
  84. ncbi request reprint Diagnosing skin cancer in primary care: how do mainstream general practitioners compare with primary care skin cancer clinic doctors?
    Philippa H Youl
    Viertel Centre for Research in Cancer Control, The Cancer Council Queensland, Brisbane, QLD, Australia
    Med J Aust 187:215-20. 2007
    ..To measure and compare the casemix and diagnostic accuracy of excised or biopsied skin lesions managed by mainstream general practitioners and doctors within primary care skin cancer clinics...
  85. ncbi request reprint Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma
    David C Whiteman
    Population and Clinical Sciences Division, Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, Australia
    Int J Cancer 99:63-7. 2002
    ..Taken together with our previous observations in thyroid and islet cell tumors, our data suggest that nuclear-cytoplasmic partitioning of PTEN might also play a role in melanoma progression...
  86. ncbi request reprint National ethics committee urgently needed
    David C Whiteman
    Med J Aust 178:187. 2003
  87. ncbi request reprint Novel variants in growth differentiation factor 9 in mothers of dizygotic twins
    James S Palmer
    Molecular Epidemiology, Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia
    J Clin Endocrinol Metab 91:4713-6. 2006
    ..We previously identified a deletion mutation in GDF9 in sisters with spontaneous dizygotic (DZ) twins, but the prevalence of rare GDF9 variants in twinning families is unknown...
  88. pmc Australian public's views on privacy and health research
    David C Whiteman
    BMJ 332:1274. 2006
  89. ncbi request reprint A risk prediction tool for melanoma?
    David C Whiteman
    Cancer Epidemiol Biomarkers Prev 14:761-3. 2005
  90. ncbi request reprint Isoflavonoid photoprotection in mouse and human skin is dependent on metallothionein
    Sitarina Widyarini
    Faculty of Veterinary Science, University of Sydney, New South Wales, Australia
    J Invest Dermatol 126:198-204. 2006
    ..We speculate that equol and its related derivative NV-07alpha may activate the MT gene synergistically with SSUV, to produce the enhanced immunoprotective effect...

Research Grants6

  1. Molecular epidemiology of Barretts esophagus and cancer
    David Whiteman; Fiscal Year: 2006
    ..Epidemiologic analyses will then be performed comparing risks of exposure among the major disease groupings (RE, BE, AC), as well as for the molecular subtypes of RE, BE and AC. ..