D Watters

Summary

Affiliation: Queensland Institute of Medical Research
Country: Australia

Publications

  1. ncbi request reprint Heteronuclear ribonucleoproteins C1 and C2, components of the spliceosome, are specific targets of interleukin 1beta-converting enzyme-like proteases in apoptosis
    N Waterhouse
    Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Herston, Brisbane, Queensland 4029, Australia
    J Biol Chem 271:29335-41. 1996
  2. ncbi request reprint Localization of a portion of extranuclear ATM to peroxisomes
    D Watters
    Cancer Research Unit, Queensland Institute of Medical Research, Royal Brisbane Hospital, Herston, Brisbane, Australia, 4029
    J Biol Chem 274:34277-82. 1999
  3. ncbi request reprint Critical targets of protein kinase C in differentiation of tumour cells
    D J Watters
    Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Herston, Australia
    Biochem Pharmacol 58:383-8. 1999
  4. ncbi request reprint Molecular mechanisms of ionizing radiation-induced apoptosis
    D Watters
    Cancer Research Unit, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Immunol Cell Biol 77:263-71. 1999
  5. ncbi request reprint Stimulation of melanogenesis in a human melanoma cell line by bistratene A
    D Watters
    Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Australia
    Biochem Pharmacol 55:1691-9. 1998
  6. ncbi request reprint Bistratene A causes phosphorylation of talin and redistribution of actin microfilaments in fibroblasts: possible role for PKC-delta
    D Watters
    Queensland Cancer Fund Research Unit, Royal Brisbane Hospital, Herston, 4029, Australia
    Exp Cell Res 229:327-35. 1996
  7. ncbi request reprint Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms
    D Watters
    Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Herston, Australia
    Oncogene 14:1911-21. 1997
  8. ncbi request reprint Defective signaling through the B cell antigen receptor in Epstein-Barr virus-transformed ataxia-telangiectasia cells
    K K Khanna
    Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Herston, Brisbane 4029, Australia
    J Biol Chem 272:9489-95. 1997
  9. ncbi request reprint Atm knock-in mice harboring an in-frame deletion corresponding to the human ATM 7636del9 common mutation exhibit a variant phenotype
    K Spring
    Queensland Cancer Fund Research Laboratories, The Queensland Institute of Medical Research, P O Box Royal Brisbane Hospital, Herston, Brisbane, Queensland 4029, Australia
    Cancer Res 61:4561-8. 2001
  10. pmc Resistance of actin to cleavage during apoptosis
    Q Song
    Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, Bancroft Centre, Herston, Brisbane, Australia
    Proc Natl Acad Sci U S A 94:157-62. 1997

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Heteronuclear ribonucleoproteins C1 and C2, components of the spliceosome, are specific targets of interleukin 1beta-converting enzyme-like proteases in apoptosis
    N Waterhouse
    Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Herston, Brisbane, Queensland 4029, Australia
    J Biol Chem 271:29335-41. 1996
    ..The results described here demonstrate that the hnRNP C proteins, abundant nuclear proteins thought to be involved in RNA splicing, belong to a critical set of protein substrates that are cleaved by ICE-like proteases during apoptosis...
  2. ncbi request reprint Localization of a portion of extranuclear ATM to peroxisomes
    D Watters
    Cancer Research Unit, Queensland Institute of Medical Research, Royal Brisbane Hospital, Herston, Brisbane, Australia, 4029
    J Biol Chem 274:34277-82. 1999
    ..Significantly decreased catalase activity and increased lipid peroxidation was observed in several A-T cell lines. The localization of ATM to peroxisomes may contribute to the pleiotropic nature of A-T...
  3. ncbi request reprint Critical targets of protein kinase C in differentiation of tumour cells
    D J Watters
    Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Herston, Australia
    Biochem Pharmacol 58:383-8. 1999
    ..The central role that PKC plays in these processes points to the need for a greater understanding of the signalling pathways utilized by individual isoforms of this family of enzymes...
  4. ncbi request reprint Molecular mechanisms of ionizing radiation-induced apoptosis
    D Watters
    Cancer Research Unit, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Immunol Cell Biol 77:263-71. 1999
    ..How these signalling pathways converge to activate the caspases is presently unknown, although in some cell types a role for calpain has been suggested...
  5. ncbi request reprint Stimulation of melanogenesis in a human melanoma cell line by bistratene A
    D Watters
    Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Australia
    Biochem Pharmacol 55:1691-9. 1998
    ..These results implicate a role for protein kinase Cdelta in the induction of differentiation of this human melanoma cell line...
  6. ncbi request reprint Bistratene A causes phosphorylation of talin and redistribution of actin microfilaments in fibroblasts: possible role for PKC-delta
    D Watters
    Queensland Cancer Fund Research Unit, Royal Brisbane Hospital, Herston, 4029, Australia
    Exp Cell Res 229:327-35. 1996
    ..These results demonstrate that phosphorylation of talin is implicated in the disruption of actin microfilaments in fibroblasts by bistratene A and that this is most likely mediated by PKC-delta...
  7. ncbi request reprint Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms
    D Watters
    Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Herston, Australia
    Oncogene 14:1911-21. 1997
    ..These results provide further support for a role for the ATM protein as a sensor of DNA damage and in a more general role in cell signalling, compatible with the broader phenotype of the syndrome...
  8. ncbi request reprint Defective signaling through the B cell antigen receptor in Epstein-Barr virus-transformed ataxia-telangiectasia cells
    K K Khanna
    Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Herston, Brisbane 4029, Australia
    J Biol Chem 272:9489-95. 1997
    ..Our results provide evidence for a role for the ATM gene product in intracellular signaling which may account at least in part for the abnormalities in B cell function in A-T...
  9. ncbi request reprint Atm knock-in mice harboring an in-frame deletion corresponding to the human ATM 7636del9 common mutation exhibit a variant phenotype
    K Spring
    Queensland Cancer Fund Research Laboratories, The Queensland Institute of Medical Research, P O Box Royal Brisbane Hospital, Herston, Brisbane, Queensland 4029, Australia
    Cancer Res 61:4561-8. 2001
    ..Thus, expression of mutant protein in Atm-DeltaSRI knock-in mice gives rise to a discernibly different phenotype to Atm(-/-) mice, which may account for the heterogeneity seen in A-T patients with different mutations...
  10. pmc Resistance of actin to cleavage during apoptosis
    Q Song
    Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, Bancroft Centre, Herston, Brisbane, Australia
    Proc Natl Acad Sci U S A 94:157-62. 1997
    ....
  11. ncbi request reprint Transcriptional downregulation of ATM by EGF is defective in ataxia-telangiectasia cells expressing mutant protein
    K E Keating
    The Queensland Cancer Fund Research Laboratory, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Qld. 4029, Australia
    Oncogene 20:4281-90. 2001
    ..The results demonstrate that EGF-induced downregulation of ATM (mutant) protein in A-T cells is defective and this appears to be due to less efficient EGFR activation and abnormal Sp1 regulation...
  12. ncbi request reprint Interaction between ATM protein and c-Abl in response to DNA damage
    T Shafman
    Joint Center for Radiation Therapy, Dana Farber Cancer Institutes, Boston, Massachusetts 02115, USA
    Nature 387:520-3. 1997
    ..These findings indicate that ATM is involved in the activation of c-Abl by DNA damage and this interaction may in part mediate radiation-induced G1 arrest...
  13. ncbi request reprint Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasia
    N Gueven
    Section for Radiobiology and Molecular Environmental Research, , , Germany
    J Biol Chem 276:8884-91. 2001
    ..Taken together these data support complex control of ATM function that has important repercussions for targeting ATM to improve radiotherapeutic benefit...