Affiliation: Queensland Institute of Medical Research
- Heteronuclear ribonucleoproteins C1 and C2, components of the spliceosome, are specific targets of interleukin 1beta-converting enzyme-like proteases in apoptosisN Waterhouse
Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Herston, Brisbane, Queensland 4029, Australia
J Biol Chem 271:29335-41. 1996..The results described here demonstrate that the hnRNP C proteins, abundant nuclear proteins thought to be involved in RNA splicing, belong to a critical set of protein substrates that are cleaved by ICE-like proteases during apoptosis...
- Localization of a portion of extranuclear ATM to peroxisomesD Watters
Cancer Research Unit, Queensland Institute of Medical Research, Royal Brisbane Hospital, Herston, Brisbane, Australia, 4029
J Biol Chem 274:34277-82. 1999..Significantly decreased catalase activity and increased lipid peroxidation was observed in several A-T cell lines. The localization of ATM to peroxisomes may contribute to the pleiotropic nature of A-T...
- Critical targets of protein kinase C in differentiation of tumour cellsD J Watters
Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Herston, Australia
Biochem Pharmacol 58:383-8. 1999..The central role that PKC plays in these processes points to the need for a greater understanding of the signalling pathways utilized by individual isoforms of this family of enzymes...
- Molecular mechanisms of ionizing radiation-induced apoptosisD Watters
Cancer Research Unit, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Immunol Cell Biol 77:263-71. 1999..How these signalling pathways converge to activate the caspases is presently unknown, although in some cell types a role for calpain has been suggested...
- Stimulation of melanogenesis in a human melanoma cell line by bistratene AD Watters
Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Australia
Biochem Pharmacol 55:1691-9. 1998..These results implicate a role for protein kinase Cdelta in the induction of differentiation of this human melanoma cell line...
- Bistratene A causes phosphorylation of talin and redistribution of actin microfilaments in fibroblasts: possible role for PKC-deltaD Watters
Queensland Cancer Fund Research Unit, Royal Brisbane Hospital, Herston, 4029, Australia
Exp Cell Res 229:327-35. 1996..These results demonstrate that phosphorylation of talin is implicated in the disruption of actin microfilaments in fibroblasts by bistratene A and that this is most likely mediated by PKC-delta...
- Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal formsD Watters
Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Herston, Australia
Oncogene 14:1911-21. 1997..These results provide further support for a role for the ATM protein as a sensor of DNA damage and in a more general role in cell signalling, compatible with the broader phenotype of the syndrome...
- Defective signaling through the B cell antigen receptor in Epstein-Barr virus-transformed ataxia-telangiectasia cellsK K Khanna
Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Herston, Brisbane 4029, Australia
J Biol Chem 272:9489-95. 1997..Our results provide evidence for a role for the ATM gene product in intracellular signaling which may account at least in part for the abnormalities in B cell function in A-T...
- Atm knock-in mice harboring an in-frame deletion corresponding to the human ATM 7636del9 common mutation exhibit a variant phenotypeK Spring
Queensland Cancer Fund Research Laboratories, The Queensland Institute of Medical Research, P O Box Royal Brisbane Hospital, Herston, Brisbane, Queensland 4029, Australia
Cancer Res 61:4561-8. 2001..Thus, expression of mutant protein in Atm-DeltaSRI knock-in mice gives rise to a discernibly different phenotype to Atm(-/-) mice, which may account for the heterogeneity seen in A-T patients with different mutations...
- Resistance of actin to cleavage during apoptosisQ Song
Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, Bancroft Centre, Herston, Brisbane, Australia
Proc Natl Acad Sci U S A 94:157-62. 1997....
- Transcriptional downregulation of ATM by EGF is defective in ataxia-telangiectasia cells expressing mutant proteinK E Keating
The Queensland Cancer Fund Research Laboratory, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Qld. 4029, Australia
Oncogene 20:4281-90. 2001..The results demonstrate that EGF-induced downregulation of ATM (mutant) protein in A-T cells is defective and this appears to be due to less efficient EGFR activation and abnormal Sp1 regulation...
- Interaction between ATM protein and c-Abl in response to DNA damageT Shafman
Joint Center for Radiation Therapy, Dana Farber Cancer Institutes, Boston, Massachusetts 02115, USA
Nature 387:520-3. 1997..These findings indicate that ATM is involved in the activation of c-Abl by DNA damage and this interaction may in part mediate radiation-induced G1 arrest...
- Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasiaN Gueven
Section for Radiobiology and Molecular Environmental Research, , , Germany
J Biol Chem 276:8884-91. 2001..Taken together these data support complex control of ATM function that has important repercussions for targeting ATM to improve radiotherapeutic benefit...