Michael D Walsh

Summary

Affiliation: Queensland Institute of Medical Research
Country: Australia

Publications

  1. pmc Analysis of families with Lynch syndrome complicated by advanced serrated neoplasia: the importance of pathology review and pedigree analysis
    Michael D Walsh
    Familial Cancer Laboratory, QIMR, Herston, QLD 4006, Australia
    Fam Cancer 8:313-23. 2009
  2. doi request reprint Lynch syndrome-associated breast cancers do not overexpress chromosome 11-encoded mucins
    Michael D Walsh
    Cancer and Population Studies Group, Queensland Institute of Medical Research, Herston, QLD 4006, Australia
    Mod Pathol 26:944-54. 2013
  3. pmc SnoN expression is differently regulated in microsatellite unstable compared with microsatellite stable colorectal cancers
    June A Chia
    The Conjoint Gastroenterology Laboratory, Royal Brisbane and Women s Hospital Foundation Clinical Research Centre and the Queensland Institute of Medical Research, Brisbane, 4029, Australia
    BMC Cancer 6:252. 2006
  4. pmc Lynch syndrome-associated breast cancers: clinicopathologic characteristics of a case series from the colon cancer family registry
    Michael D Walsh
    Familial Cancer Laboratory, I Floor, Bancroft Centre, Queensland Institute of Medical Research, Herston Road, Herston, Queensland 4006, Australia
    Clin Cancer Res 16:2214-24. 2010
  5. doi request reprint Colorectal carcinomas with KRAS mutation are associated with distinctive morphological and molecular features
    Christophe Rosty
    Cancer and Population Studies Group, Queensland Institute of Medical Research, Herston, Queensland, Australia
    Mod Pathol 26:825-34. 2013
  6. pmc Phenotype and polyp landscape in serrated polyposis syndrome: a series of 100 patients from genetics clinics
    Christophe Rosty
    Pathology Queensland, Royal Brisbane and Women s Hospital, Herston, QLD 4006, Australia
    Am J Surg Pathol 36:876-82. 2012
  7. pmc PIK3CA activating mutation in colorectal carcinoma: associations with molecular features and survival
    Christophe Rosty
    Cancer and Population Studies Group, Queensland Institute of Medical Research, Herston, Australia
    PLoS ONE 8:e65479. 2013
  8. pmc Immunohistochemical testing of conventional adenomas for loss of expression of mismatch repair proteins in Lynch syndrome mutation carriers: a case series from the Australasian site of the colon cancer family registry
    Michael D Walsh
    Familial Cancer Laboratory, QIMR, Herston, QLD, Australia
    Mod Pathol 25:722-30. 2012
  9. pmc Multiplicity and molecular heterogeneity of colorectal carcinomas in individuals with serrated polyposis
    Christophe Rosty
    Cancer and Population Studies Group, Queensland Institute of Medical Research, Bancroft Centre, Herston, QLD, Australia
    Am J Surg Pathol 37:434-42. 2013
  10. pmc Risk factors for colorectal cancer in patients with multiple serrated polyps: a cross-sectional case series from genetics clinics
    Daniel D Buchanan
    Familial Cancer Laboratory, QIMR, Herston, Queensland, Australia
    PLoS ONE 5:e11636. 2010

Detail Information

Publications29

  1. pmc Analysis of families with Lynch syndrome complicated by advanced serrated neoplasia: the importance of pathology review and pedigree analysis
    Michael D Walsh
    Familial Cancer Laboratory, QIMR, Herston, QLD 4006, Australia
    Fam Cancer 8:313-23. 2009
    ....
  2. doi request reprint Lynch syndrome-associated breast cancers do not overexpress chromosome 11-encoded mucins
    Michael D Walsh
    Cancer and Population Studies Group, Queensland Institute of Medical Research, Herston, QLD 4006, Australia
    Mod Pathol 26:944-54. 2013
    ..In addition, ectopic CDX2 expression is positively associated with de novo MUC2 expression. ..
  3. pmc SnoN expression is differently regulated in microsatellite unstable compared with microsatellite stable colorectal cancers
    June A Chia
    The Conjoint Gastroenterology Laboratory, Royal Brisbane and Women s Hospital Foundation Clinical Research Centre and the Queensland Institute of Medical Research, Brisbane, 4029, Australia
    BMC Cancer 6:252. 2006
    ..SnoN is an important regulator of the transforming growth factor beta (TGFbeta) signalling pathway and has been shown to exhibit both tumour promotion and suppression activity...
  4. pmc Lynch syndrome-associated breast cancers: clinicopathologic characteristics of a case series from the colon cancer family registry
    Michael D Walsh
    Familial Cancer Laboratory, I Floor, Bancroft Centre, Queensland Institute of Medical Research, Herston Road, Herston, Queensland 4006, Australia
    Clin Cancer Res 16:2214-24. 2010
    ..The recognition of breast cancer as a spectrum tumor in Lynch syndrome remains controversial. The aim of this study was to explore features of breast cancers arising in Lynch syndrome families...
  5. doi request reprint Colorectal carcinomas with KRAS mutation are associated with distinctive morphological and molecular features
    Christophe Rosty
    Cancer and Population Studies Group, Queensland Institute of Medical Research, Herston, Queensland, Australia
    Mod Pathol 26:825-34. 2013
    ..In summary, KRAS-mutated carcinomas frequently develop in contiguity with a residual polyp and show molecular features distinct from other colorectal carcinomas, in particular from tumors with neither BRAF nor KRAS mutation...
  6. pmc Phenotype and polyp landscape in serrated polyposis syndrome: a series of 100 patients from genetics clinics
    Christophe Rosty
    Pathology Queensland, Royal Brisbane and Women s Hospital, Herston, QLD 4006, Australia
    Am J Surg Pathol 36:876-82. 2012
    ..003). Patients with SPS referred to genetics clinics had a pancolonic disease with a high polyp burden and a high rate of BRAF mutation. The occurrence of CRC was associated with the presence of conventional adenoma...
  7. pmc PIK3CA activating mutation in colorectal carcinoma: associations with molecular features and survival
    Christophe Rosty
    Cancer and Population Studies Group, Queensland Institute of Medical Research, Herston, Australia
    PLoS ONE 8:e65479. 2013
    ..PIK3CA mutation also contributes to significantly decreased survival for patients with wild-type BRAF tumors...
  8. pmc Immunohistochemical testing of conventional adenomas for loss of expression of mismatch repair proteins in Lynch syndrome mutation carriers: a case series from the Australasian site of the colon cancer family registry
    Michael D Walsh
    Familial Cancer Laboratory, QIMR, Herston, QLD, Australia
    Mod Pathol 25:722-30. 2012
    ..The overwhelming majority of conventional adenomas from mutation carriers show loss of mismatch repair protein expression concordant with the underlying germline mutation...
  9. pmc Multiplicity and molecular heterogeneity of colorectal carcinomas in individuals with serrated polyposis
    Christophe Rosty
    Cancer and Population Studies Group, Queensland Institute of Medical Research, Bancroft Centre, Herston, QLD, Australia
    Am J Surg Pathol 37:434-42. 2013
    ..The high proportion of multiple CRCs suggests that individuals with SP would benefit from frequent colonoscopic surveillance and from a consideration of a more extensive colectomy at the time of CRC diagnosis...
  10. pmc Risk factors for colorectal cancer in patients with multiple serrated polyps: a cross-sectional case series from genetics clinics
    Daniel D Buchanan
    Familial Cancer Laboratory, QIMR, Herston, Queensland, Australia
    PLoS ONE 5:e11636. 2010
    ..The aim of this work therefore was to investigate the association between smoking and the risk of CRC in high-risk genetics clinic patients presenting with multiple serrated polyps...
  11. doi request reprint HLA-DR expression is associated with better prognosis in sporadic Australian clinicopathological Stage C colorectal cancers
    Michael D Walsh
    Queensland Institute of Medical Research, Herston, Australia
    Int J Cancer 125:1231-7. 2009
    ..0005) and peritumoral lymphocytes (p = 0.003), but not other clinicopathological features or MSI status. HLA-DR-positive CRCs were strongly associated with better patient outcome (p < 0.0001)...
  12. doi request reprint Family history of colorectal cancer in BRAF p.V600E-mutated colorectal cancer cases
    Daniel D Buchanan
    Cancer and Population Studies Group, Queensland Institute of Medical Research, 300 Herston Rd, Herston QLD 4006, Australia
    Cancer Epidemiol Biomarkers Prev 22:917-26. 2013
    ..V600E mutation are at an increased risk of CRC and extracolonic cancers (ECC). In this study, we estimated the association between a family history of either CRC or ECC and risk of CRC with a BRAF p.V600E mutation...
  13. doi request reprint Mutation deep within an intron of MSH2 causes Lynch syndrome
    Mark Clendenning
    Familial Cancer Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Herston, QLD, Australia
    Fam Cancer 10:297-301. 2011
    ....
  14. doi request reprint Molecular, pathologic, and clinical features of early-onset endometrial cancer: identifying presumptive Lynch syndrome patients
    Michael D Walsh
    Familial Cancer Laboratory and Molecular Cancer Epidemiology Laboratory, Queensland Institute of Medical Research, Herston, Australia
    Clin Cancer Res 14:1692-700. 2008
    ..The aim of this study was to determine the incidence of Lynch syndrome in a series of young-onset EC, and to identify molecular, clinical, and pathologic features that may alert clinicians to the presence of this disorder...
  15. pmc Classifying MLH1 and MSH2 variants using bioinformatic prediction, splicing assays, segregation, and tumor characteristics
    Sven Arnold
    Genetics and Population Health Division, Queensland Institute of Medical Research, Brisbane, Australia
    Hum Mutat 30:757-70. 2009
    ..Classification of mismatch repair gene variants is assisted by a comprehensive approach that includes in vitro, tumor pathology, clinical, and evolutionary conservation data...
  16. pmc Linkage to chromosome 2q32.2-q33.3 in familial serrated neoplasia (Jass syndrome)
    Aedan Roberts
    Familial Cancer Laboratory, Queensland Institute of Medical Research, Herston, QLD 4006, Australia
    Fam Cancer 10:245-54. 2011
    ..36 (P = 0.004). Five primary candidate genes (CFLAR, CASP10, CASP8, FZD7 and BMPR2) were sequenced and no segregating variants identified. There was no evidence of linkage to previously reported loci on chromosomes 3, 7 and 9...
  17. doi request reprint Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype
    Michael D Walsh
    1 Cancer and Population Studies Group, Queensland Institute of Medical Research, Herston, QLD, Australia 2 Department of Histopathology, Sullivan Nicolaides Pathology, Taringa, QLD, Australia
    Mod Pathol 26:1642-56. 2013
    ..Our results suggest that, in methylator-positive tumors, mucin genes on chromosome 11p15.5 region undergo increased expression via mechanisms other than direct regulation by CDX2. ..
  18. pmc Phenotypic diversity in patients with multiple serrated polyps: a genetics clinic study
    Daniel D Buchanan
    Familial Cancer Laboratory, QIMR, Herston, Brisbane Q 4006, Australia
    Int J Colorectal Dis 25:703-12. 2010
    ..Hyperplastic polyposis is a colonic polyposis condition of unknown aetiology. The purpose of this study was to examine the spectrum of phenotypic variation in patients with multiple serrated polyps as a basis for gene discovery...
  19. pmc Lessons from Lynch syndrome: a tumor biology-based approach to familial colorectal cancer
    Daniel D Buchanan
    Familial Cancer Laboratory, QIMR, Herston Q 4006, Australia
    Future Oncol 6:539-49. 2010
    ..Finally, rare families exist in which both conditions segregate independently, producing a difficult diagnostic picture...
  20. ncbi request reprint The MUC13 cell surface mucin is highly expressed by human colorectal carcinomas
    Michael D Walsh
    Molecular Cancer Epidemiology Laboratory, Bancroft Centre, Queensland Institute of Medical Research, Herston, QLD, Australia
    Hum Pathol 38:883-92. 2007
    ..In summary, MUC13 was expressed abundantly by all colorectal cancers, with the highest expression in more poorly differentiated tumors...
  21. ncbi request reprint High prevalence of sessile serrated adenomas with BRAF mutations: a prospective study of patients undergoing colonoscopy
    Kevin J Spring
    Conjoint Gastroenterology Laboratory, Queensland Institute of Medical Research, Herston, Brisbane, Australia
    Gastroenterology 131:1400-7. 2006
    ..This prospective study examined the prevalence of sessile serrated adenomas and determined the incidence of BRAF and K-ras mutations in different types of polyps...
  22. doi request reprint Improving identification of lynch syndrome patients: a comparison of research data with clinical records
    Yen Y Tan
    School of Medicine, The University of Queensland, 288 Herston Road, Herston, Queensland 4006, Australia
    Int J Cancer 132:2876-83. 2013
    ..Hospital records indicate poor recognition of family history. Application of research methods show improved identification and may facilitate appropriate referrals of endometrial cancer patients with possible Lynch syndrome...
  23. ncbi request reprint Silencing of O6-methylguanine DNA methyltransferase in the absence of promoter hypermethylation in hepatocellular carcinomas from Australia and South Africa
    Nirmitha I Herath
    Leukaemia Foundation of Queensland, Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia
    Oncol Rep 17:817-22. 2007
    ..This suggests that epigenetic silencing of MGMT and microsatellite instability does not play an important role in this series of HCCs derived from different populations...
  24. ncbi request reprint Cadherin/catenin complex appears to be intact in hepatocellular carcinomas from Australia and South Africa
    Nirmitha I Herath
    Conjoint Gastroenterology Laboratory, Clinical Research Center, Royal Brisbane Hospital Research Foundation, Brisbane, Australia
    J Gastroenterol Hepatol 19:676-82. 2004
    ..The aim of the present study was to assess the role of E-cadherin and beta-catenin in Australian and South African patients with HCC...
  25. ncbi request reprint Morphological and molecular heterogeneity within nonmicrosatellite instability-high colorectal cancer
    Vicki L J Whitehall
    Conjoint Gastroenterology Laboratory, Clinical Research Centre, Royal Brisbane Hospital Research Foundation, Queensland 4029, Australia
    Cancer Res 62:6011-4. 2002
    ..004) and lower frequency of hMLH1 methylation (P < 0.001) in the latter. These data demonstrate that the separation of CRC into two nonoverlapping groups (MSI-H versus MSS/MSI-L) is a misleading oversimplification...
  26. ncbi request reprint Reciprocal relationship between methylation status and loss of heterozygosity at the p14(ARF) locus in Australian and South African hepatocellular carcinomas
    Nirmitha I Herath
    Conjoint Gastroenterology Laboratory, Clinical Research Center, Royal Brisbane Hospital Research Foundation, The Queensland Institute of Medical Research, Queesland, Australia
    J Gastroenterol Hepatol 17:301-7. 2002
    ..05). No significant association between p14 and p53 was seen in this study. The reciprocal relationship identified indicates different pathways of tumorigenesis and likely reflects different etiologies of HCC in the two countries...
  27. ncbi request reprint Evidence for BRAF mutation and variable levels of microsatellite instability in a syndrome of familial colorectal cancer
    Joanne Young
    Conjoint Gastroenterology Laboratory, Queensland Institute of Medical Research, Herston, Australia
    Clin Gastroenterol Hepatol 3:254-63. 2005
    ..Here, we discuss their role in the development of other familial colorectal cancers (CRC). We studied non-FAP, non-HNPCC CRC families characterized by tumors that varied in their level of MSI between individual members...
  28. pmc Detection of large scale 3' deletions in the PMS2 gene amongst Colon-CFR participants: have we been missing anything?
    Mark Clendenning
    Cancer and Population Studies, Queensland Institute of Medical Research, 300 Herston Road, Herston, QLD, 4006, Australia
    Fam Cancer 12:563-6. 2013
    ..No deletions encompassing any or all of exons 12 through 15 were identified; therefore, our results suggest that 3' deletions in PMS2 are not a frequent occurrence in such families...
  29. ncbi request reprint Mutation searching in colorectal cancer studies: experience with a denaturing high-pressure liquid chromatography system for exon-by-exon scanning of tumour suppressor genes
    Joanne Young
    Conjoint Gastroenterology Laboratory, Royal Brisbane Hospital Foundation Clinical Research Centre, Bancroft Centre, Herston, Queensland, Australia
    Pathology 34:529-33. 2002
    ..Here we report our progress using denaturing gradient high-pressure liquid chromatography (DHPLC) in the screening of the mismatch repair genes MLH1 and MSH2 and in screening the APC and HPP1 tumour suppressor genes for mutations...