Susan A Treloar

Summary

Affiliation: Queensland Institute of Medical Research
Country: Australia

Publications

  1. ncbi request reprint Association between polymorphisms in the progesterone receptor gene and endometriosis
    Susan A Treloar
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Mol Hum Reprod 11:641-7. 2005
  2. pmc Genomewide linkage study in 1,176 affected sister pair families identifies a significant susceptibility locus for endometriosis on chromosome 10q26
    Susan A Treloar
    Cooperative Research Centre for Discovery of Genes for Common Human Diseases, Melbourne, Australia
    Am J Hum Genet 77:365-76. 2005
  3. doi request reprint Polymorphisms in the vascular endothelial growth factor gene and the risk of familial endometriosis
    Zhen Zhen Zhao
    Molecular Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
    Mol Hum Reprod 14:531-8. 2008
  4. ncbi request reprint KRAS variation and risk of endometriosis
    Zhen Zhen Zhao
    Molecular Epidemiology Laboratory and Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Mol Hum Reprod 12:671-6. 2006
  5. pmc High-density fine-mapping of a chromosome 10q26 linkage peak suggests association between endometriosis and variants close to CYP2C19
    Jodie N Painter
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Fertil Steril 95:2236-40. 2011
  6. pmc A genome-wide linkage scan for age at menarche in three populations of European descent
    Carl A Anderson
    Queensland Institute of Medical Research, Royal Brisbane Hospital, Queensland 4029, Australia
    J Clin Endocrinol Metab 93:3965-70. 2008
  7. ncbi request reprint A deletion mutation in GDF9 in sisters with spontaneous DZ twins
    Grant W Montgomery
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res 7:548-55. 2004
  8. pmc No evidence for genetic association with the let-7 microRNA-binding site or other common KRAS variants in risk of endometriosis
    Hien T T Luong
    Genetics and Computational Biology Division, Queensland Institute of Medical Research, Royal Brisbane Hospital, Locked Bag 2000, Brisbane, QLD 4029 Australia
    Hum Reprod 27:3616-21. 2012
  9. pmc Genome-wide association meta-analysis identifies new endometriosis risk loci
    Dale R Nyholt
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Nat Genet 44:1355-9. 2012
  10. ncbi request reprint Variants in EMX2 and PTEN do not contribute to risk of endometriosis
    Susan A Treloar
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia, and Nuffield Department of Obstetrics and Gynaecology, University of Oxford, UK
    Mol Hum Reprod 13:587-94. 2007

Detail Information

Publications29

  1. ncbi request reprint Association between polymorphisms in the progesterone receptor gene and endometriosis
    Susan A Treloar
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Mol Hum Reprod 11:641-7. 2005
    ..Further, analysis of our results pooled with those from two previous studies suggested that neither the T2 allele of the AluIns nor the T1/T2 genotype was associated with endometriosis...
  2. pmc Genomewide linkage study in 1,176 affected sister pair families identifies a significant susceptibility locus for endometriosis on chromosome 10q26
    Susan A Treloar
    Cooperative Research Centre for Discovery of Genes for Common Human Diseases, Melbourne, Australia
    Am J Hum Genet 77:365-76. 2005
    ..Greater understanding of the aberrant cellular and molecular mechanisms involved in the etiology and pathophysiology of endometriosis should lead to better diagnostic methods and targeted treatments...
  3. doi request reprint Polymorphisms in the vascular endothelial growth factor gene and the risk of familial endometriosis
    Zhen Zhen Zhao
    Molecular Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
    Mol Hum Reprod 14:531-8. 2008
    ..Our detailed review and meta-analysis of the VEGF polymorphisms suggests that genotyping assay problems may underlie the previously reported associations between VEGF variants and endometriosis...
  4. ncbi request reprint KRAS variation and risk of endometriosis
    Zhen Zhen Zhao
    Molecular Epidemiology Laboratory and Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Mol Hum Reprod 12:671-6. 2006
    ..No germline variants for KRAS or BRAF were detected. Our results demonstrate that any risk of endometriosis in women because of common variation in KRAS must be very small...
  5. pmc High-density fine-mapping of a chromosome 10q26 linkage peak suggests association between endometriosis and variants close to CYP2C19
    Jodie N Painter
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Fertil Steril 95:2236-40. 2011
    ..To refine a previously reported linkage peak for endometriosis on chromosome 10q26, and conduct follow-up analyses and a fine-mapping association study across the region to identify new candidate genes for endometriosis...
  6. pmc A genome-wide linkage scan for age at menarche in three populations of European descent
    Carl A Anderson
    Queensland Institute of Medical Research, Royal Brisbane Hospital, Queensland 4029, Australia
    J Clin Endocrinol Metab 93:3965-70. 2008
    ..Age at menarche (AAM) is an important trait both biologically and socially, a clearly defined event in female pubertal development, and has been associated with many clinically significant phenotypes...
  7. ncbi request reprint A deletion mutation in GDF9 in sisters with spontaneous DZ twins
    Grant W Montgomery
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res 7:548-55. 2004
    ..We conclude that rare mutations in GDF9 may influence twinning, but twinning frequency is not associated with common variation in GDF9...
  8. pmc No evidence for genetic association with the let-7 microRNA-binding site or other common KRAS variants in risk of endometriosis
    Hien T T Luong
    Genetics and Computational Biology Division, Queensland Institute of Medical Research, Royal Brisbane Hospital, Locked Bag 2000, Brisbane, QLD 4029 Australia
    Hum Reprod 27:3616-21. 2012
    ..Is there a contribution of the minor allele at the KRAS single nucleotide polymorphism (SNP) rs61764370 in the let-7 microRNA-binding site to endometriosis risk?..
  9. pmc Genome-wide association meta-analysis identifies new endometriosis risk loci
    Dale R Nyholt
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Nat Genet 44:1355-9. 2012
    ..8 × 10(-11)), indicating that many weakly associated SNPs represent true endometriosis risk loci and that risk prediction and future targeted disease therapy may be transferred across these populations...
  10. ncbi request reprint Variants in EMX2 and PTEN do not contribute to risk of endometriosis
    Susan A Treloar
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia, and Nuffield Department of Obstetrics and Gynaecology, University of Oxford, UK
    Mol Hum Reprod 13:587-94. 2007
    ..It is unlikely that the EMX2 or PTEN gene variants investigated contribute to risk for initiation and/or development of endometriosis...
  11. ncbi request reprint New concepts for distinguishing the hidden patterns of linkage disequilibrium which underlie association between genotypes and complex phenotypes
    Jacqueline Wicks
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 8:95-100. 2005
    ..This provides a basis for distinguishing the hidden LD patterns and might help to locate the functional variants responsible for the association...
  12. pmc The search for genes contributing to endometriosis risk
    Grant W Montgomery
    Genetic and Molecular Epidemiology Laboratories, Queensland Institute of Medical Research, Royal Brisbane Hospital, 300 Herston Road, Brisbane, QLD 4029, Australia
    Hum Reprod Update 14:447-57. 2008
    ..Genetic variation contributes to the risk of developing endometriosis. This review summarizes gene mapping studies in endometriosis and the prospects of finding gene pathways contributing to disease using the latest genome-wide strategies...
  13. pmc Evaluation of polymorphisms in predicted target sites for micro RNAs differentially expressed in endometriosis
    Zhen Zhen Zhao
    Queensland Institute of Medical Research, Herston, Brisbane, Queensland, Australia
    Mol Hum Reprod 17:92-103. 2011
    ..Replication studies in independent large sample sets to confirm and characterize the involvement of the gene variation in the pathogenesis of endometriosis are needed...
  14. ncbi request reprint A comparison of DNA pools constructed following whole genome amplification for two-stage SNP genotyping designs
    Zhen Zhen Zhao
    Molecular Epidemiology and Genetic Epidemiology Laboratories, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 8:353-61. 2005
    ..With current levels of accuracy, pooling is best suited to an initial screen in the SNP validation process that can provide high-throughput comparisons between cases and controls to prioritize SNPs for subsequent individual genotyping...
  15. pmc Common variation in the fibroblast growth factor receptor 2 gene is not associated with endometriosis risk
    Zhen Zhen Zhao
    Molecular Epidemiology Laboratory, Queensland Institute of Medical Research, 300 Herston Rd, Herston, Brisbane, QLD 4029, Australia
    Hum Reprod 23:1661-8. 2008
    ..We therefore hypothesized that variation in FGFR2 may contribute to the risk of endometriosis...
  16. pmc Common genetic influences underlie comorbidity of migraine and endometriosis
    Dale R Nyholt
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, QLD, Australia
    Genet Epidemiol 33:105-13. 2009
    ..Finally, we propose that the analysis of such genetically correlated comorbid traits can increase power to detect genetic risk loci through the use of more specific, homogenous and heritable phenotypes...
  17. ncbi request reprint Exploring the inter-relationship of smoking age-at-onset, cigarette consumption and smoking persistence: genes or environment?
    Katherine I Morley
    Genetic Epidemiology Group, Queensland Institute of Medical Research, Queensland, Australia
    Psychol Med 37:1357-67. 2007
    ..We investigated the genetic and environmental contributions to covariation between smoking age-at-onset, cigarette consumption and smoking persistence...
  18. pmc Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis
    Jodie N Painter
    Molecular Epidemiology, Queensland Institute of Medical Research, Herston, Queensland, Australia
    Nat Genet 43:51-4. 2011
    ..4 × 10⁻⁹ (OR = 1.20, 95% CI 1.13-1.27) for 'all' endometriosis in our combined datasets of 5,586 cases and 9,331 controls. rs12700667 is located in an intergenic region upstream of the plausible candidate genes NFE2L3 and HOXA10...
  19. ncbi request reprint Genetic variation in tumour necrosis factor and lymphotoxin is not associated with endometriosis in an Australian sample
    Zhen Zhen Zhao
    Molecular Epidemiology, Queensland Institute of Medical Research, 300 Herston Road, Herston, Brisbane, Queensland 4029, Australia
    Hum Reprod 22:2389-97. 2007
    ..Tumour necrosis factor (TNF) is a pleiotropic cytokine with a wide range of immunoregulatory effects. Variation in the promoter region of TNF and the neighbouring lymphotoxin alpha (LTA) gene might be associated with endometriosis...
  20. pmc Genetic influences on handedness: data from 25,732 Australian and Dutch twin families
    Sarah E Medland
    Queensland Institute of Medical Research, Australia
    Neuropsychologia 47:330-7. 2009
    ..17, 27.09%) with the remainder accounted for by non-shared environmental influences. The implications of these findings for handedness both as a primary phenotype and as a covariate in linkage and association analyses are discussed...
  21. ncbi request reprint Early menstrual characteristics associated with subsequent diagnosis of endometriosis
    Susan A Treloar
    Center for Military and Veterans Health, The University of Queensland, Brisbane, Australia
    Am J Obstet Gynecol 202:534.e1-6. 2010
    ..The aim of this study was to investigate the association between early menstrual characteristics, before symptom onset, and later diagnosis of endometriosis...
  22. ncbi request reprint Using identity-by-descent information in affected sib pairs to increase the efficiency of genetic association studies
    Jacqueline Wicks
    Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res 7:211-6. 2004
    ....
  23. ncbi request reprint Why do they do it? A pilot study towards understanding participant motivation and experience in a large genetic epidemiological study of endometriosis
    Susan A Treloar
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Community Genet 10:61-71. 2007
    ..We also aimed to explore understanding of complex genetic or multifactorial conditions in general...
  24. ncbi request reprint Genetic covariation of pelvic organ and elbow mobility in twins and their sisters
    Narelle K Hansell
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res 7:254-60. 2004
    ..06), with genes influencing latent elbow mobility accounting for 14% of the variation in latent bladder mobility. We speculate that genes influencing connective tissue structure may underlie this association...
  25. ncbi request reprint Multivariate genetic analysis of chronic pelvic pain and associated phenotypes
    Krina T Zondervan
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, United Kingdom
    Behav Genet 35:177-88. 2005
    ..CPP itself is unlikely to be a useful independent phenotype to conduct genetic aetiological studies; contributing conditions such as endometriosis and variation in nociception are likely to provide more useful phenotypes...
  26. ncbi request reprint Mammographic density and candidate gene variants: a twins and sisters study
    Jennifer Stone
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, 2 723 Swanston Street, Carlton, Victoria 3053, Australia
    Cancer Epidemiol Biomarkers Prev 16:1479-84. 2007
    ..Little is known about its genetic determinants...
  27. ncbi request reprint Significant evidence of one or more susceptibility loci for endometriosis with near-Mendelian inheritance on chromosome 7p13-15
    Krina T Zondervan
    Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Hum Reprod 22:717-28. 2007
    ..The aim was to investigate whether the apparent concentration of cases in a proportion of families could be explained by one or more rare variants with (near-)Mendelian autosomal inheritance...
  28. ncbi request reprint Australian Twin Registry: a nationally funded resource for medical and scientific research, incorporating match and WATCH
    John L Hopper
    Australian Twin Registry, Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, 723 Swanston Street, Carlton, Victoria 3053, Australia
    Twin Res Hum Genet 9:707-11. 2006
    ..Consistent with its mission statement, the long-term goal of the ATR is to make twin studies a standard component of medical and scientific research...
  29. ncbi request reprint Investigating genetic discrimination in Australia: opportunities and challenges in the early stages
    Sandra D Taylor
    School of Social Work and Applied Human Sciences, The University of Queensland, St Lucia, Q Australia 4072
    New Genet Soc 23:225-39. 2004
    ..Attempted verification of alleged accounts of genetic discrimination will be a novel feature of the research. This paper overviews the early stages of the research, including conceptual challenges and their methodological implications...