Peter Timms

Summary

Affiliation: Queensland University of Technology
Country: Australia

Publications

  1. ncbi request reprint Differential transcriptional responses between the interferon-gamma-induction and iron-limitation models of persistence for Chlamydia pneumoniae
    Peter Timms
    School of Life Sciences, Queensland University of Technology, Institute of Health and Biomedical Innovation, Brisbane, Australia
    J Microbiol Immunol Infect 42:27-37. 2009
  2. pmc Vaccination of Koalas with a Recombinant Chlamydia pecorum Major Outer Membrane Protein Induces Antibodies of Different Specificity Compared to Those Following a Natural Live Infection
    Avinash Kollipara
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia
    PLoS ONE 8:e74808. 2013
  3. pmc Spatial constraints within the chlamydial host cell inclusion predict interrupted development and persistence
    Alexander Hoare
    National Centre in HIV Epidemiology and Clinical Research, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia
    BMC Microbiol 8:5. 2008
  4. pmc Tissue MicroArray (TMA) analysis of normal and persistent Chlamydophila pneumoniae infection
    Nicole Borel
    Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
    BMC Infect Dis 6:152. 2006
  5. pmc The duration of Chlamydia muridarum genital tract infection and associated chronic pathological changes are reduced in IL-17 knockout mice but protection is not increased further by immunization
    Dean W Andrew
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia
    PLoS ONE 8:e76664. 2013
  6. ncbi request reprint CD4+ T cells reduce the tissue burden of Chlamydia muridarum in male BALB/c mice
    Kelly A Cunningham
    Institute of Health and Biomedical Innovation, Cell and Molecular Biosciences, Faculty of Science, Queensland University of Technology, 60 Musk Ave, Kelvin Grove, Brisbane, QLD 4059, Australia
    Vaccine 28:4861-3. 2010
  7. ncbi request reprint Genetic diversity of Chlamydia pecorum strains in wild koala locations across Australia and the implications for a recombinant C. pecorum major outer membrane protein based vaccine
    Avinash Kollipara
    Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove 4059, Australia
    Vet Microbiol 167:513-22. 2013
  8. pmc Chlamydia pneumoniae is genetically diverse in animals and appears to have crossed the host barrier to humans on (at least) two occasions
    Candice M Mitchell
    Institute of Health and Biomedical Innovation, School of Life Sciences, Queensland University of Technology, Kelvin Grove, Queensland, Australia
    PLoS Pathog 6:e1000903. 2010
  9. doi request reprint Antigenic specificity of a monovalent versus polyvalent MOMP based Chlamydia pecorum vaccine in koalas (Phascolarctos cinereus)
    Avinash Kollipara
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia
    Vaccine 31:1217-23. 2013
  10. doi request reprint Characterization of in vitro Chlamydia muridarum persistence and utilization in an in vivo mouse model of Chlamydia vaccine
    Alison J Carey
    Institute of Health and Biomedical Innovation, School of Biomedical Science, Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia
    Am J Reprod Immunol 69:475-85. 2013

Collaborators

Detail Information

Publications66

  1. ncbi request reprint Differential transcriptional responses between the interferon-gamma-induction and iron-limitation models of persistence for Chlamydia pneumoniae
    Peter Timms
    School of Life Sciences, Queensland University of Technology, Institute of Health and Biomedical Innovation, Brisbane, Australia
    J Microbiol Immunol Infect 42:27-37. 2009
    ..This study was performed to compare the interferon-gamma (IFN-gamma) induction and iron-limitation models of persistence for Chlamydia spp. to investigate the common and unique transcriptional pathways involved...
  2. pmc Vaccination of Koalas with a Recombinant Chlamydia pecorum Major Outer Membrane Protein Induces Antibodies of Different Specificity Compared to Those Following a Natural Live Infection
    Avinash Kollipara
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia
    PLoS ONE 8:e74808. 2013
    ..This work paves the way for further refinement of a MOMP-based Chlamydia vaccine that will offer wide cross-protection against the variety of chlamydial infections circulating in wild koala populations. ..
  3. pmc Spatial constraints within the chlamydial host cell inclusion predict interrupted development and persistence
    Alexander Hoare
    National Centre in HIV Epidemiology and Clinical Research, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia
    BMC Microbiol 8:5. 2008
    ..The triggers that mediate the interchange between these particle types are unknown and yet this is crucial for understanding basic Chlamydia biology...
  4. pmc Tissue MicroArray (TMA) analysis of normal and persistent Chlamydophila pneumoniae infection
    Nicole Borel
    Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
    BMC Infect Dis 6:152. 2006
    ..Chlamydophila pneumoniae infection has been implicated as a potential risk factor for atherosclerosis, however the mechanism leading to persistent infection and its role in the disease process remains to be elucidated...
  5. pmc The duration of Chlamydia muridarum genital tract infection and associated chronic pathological changes are reduced in IL-17 knockout mice but protection is not increased further by immunization
    Dean W Andrew
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia
    PLoS ONE 8:e76664. 2013
    ..muridarum genital infection and associated oviduct pathology are significantly attenuated, however neither infection or pathology can be reduced further by vaccination protocols that effectively protect WT mice. ..
  6. ncbi request reprint CD4+ T cells reduce the tissue burden of Chlamydia muridarum in male BALB/c mice
    Kelly A Cunningham
    Institute of Health and Biomedical Innovation, Cell and Molecular Biosciences, Faculty of Science, Queensland University of Technology, 60 Musk Ave, Kelvin Grove, Brisbane, QLD 4059, Australia
    Vaccine 28:4861-3. 2010
    ..Here we report that adoptive transfer of MOMP-specific CD4+ T cells into naïve mice confers partial protective immunity, which significantly reduces the tissue burden of Chlamydia...
  7. ncbi request reprint Genetic diversity of Chlamydia pecorum strains in wild koala locations across Australia and the implications for a recombinant C. pecorum major outer membrane protein based vaccine
    Avinash Kollipara
    Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove 4059, Australia
    Vet Microbiol 167:513-22. 2013
    ..pecorum strains. ..
  8. pmc Chlamydia pneumoniae is genetically diverse in animals and appears to have crossed the host barrier to humans on (at least) two occasions
    Candice M Mitchell
    Institute of Health and Biomedical Innovation, School of Life Sciences, Queensland University of Technology, Kelvin Grove, Queensland, Australia
    PLoS Pathog 6:e1000903. 2010
    ..We identified a separate human lineage present in two Australian Indigenous isolates (independent geographical locations). This lineage is distinct and is present in Australian amphibians as well as a range of Australian marsupials...
  9. doi request reprint Antigenic specificity of a monovalent versus polyvalent MOMP based Chlamydia pecorum vaccine in koalas (Phascolarctos cinereus)
    Avinash Kollipara
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia
    Vaccine 31:1217-23. 2013
    ..pecorum vaccine that could protect against a range of strains...
  10. doi request reprint Characterization of in vitro Chlamydia muridarum persistence and utilization in an in vivo mouse model of Chlamydia vaccine
    Alison J Carey
    Institute of Health and Biomedical Innovation, School of Biomedical Science, Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia
    Am J Reprod Immunol 69:475-85. 2013
    ..In vitro chlamydial persistence has been well characterized in various strains; however, there have been no reported studies in C. muridarum...
  11. doi request reprint Effects of inoculating dose on the kinetics of Chlamydia muridarum genital infection in female mice
    Alison J Carey
    School of Life Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia
    Immunol Cell Biol 87:337-43. 2009
    ..Overall, this data show the effects of infectious dose on the kinetics of ascending chlamydial infection and associated inflammatory infiltration in BALB/c mice...
  12. doi request reprint A multi-subunit chlamydial vaccine induces antibody and cell-mediated immunity in immunized koalas (Phascolarctos cinereus): comparison of three different adjuvants
    Alison J Carey
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia
    Am J Reprod Immunol 63:161-72. 2010
    ..Little is known about the immune response in koalas, or the safety of commonly used adjuvants for induction of protective systemic and mucosal immunity...
  13. ncbi request reprint HtrA, RseP, and Tsp proteins do not elicit a pathology-related serum IgG response during sexually transmitted infection with Chlamydia trachomatis
    Wilhelmina M Huston
    Institute of Health and Biomedical Innovation and School of Life Sciences, Queensland University of Technology, Kelvin Grove, Qld 4053, Australia
    J Reprod Immunol 85:168-71. 2010
    ..Serum IgG(1-4) antibody subclasses reactive with these antigens was not significantly different between cohorts, although different responses to each antigen were detected...
  14. doi request reprint Vaccination of healthy and diseased koalas (Phascolarctos cinereus) with a Chlamydia pecorum multi-subunit vaccine: evaluation of immunity and pathology
    Avinash Kollipara
    Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Ave, Kelvin Grove, QLD 4059, Australia
    Vaccine 30:1875-85. 2012
    ..Collectively, this work illustrates the feasibility of developing a safe and effective Chlamydia vaccine as a tool for management of disease in wild koalas...
  15. pmc Unique residues involved in activation of the multitasking protease/chaperone HtrA from Chlamydia trachomatis
    Wilhelmina M Huston
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia
    PLoS ONE 6:e24547. 2011
    ..Therefore, we have revealed novel residues involved in the activation of CtHtrA which are likely to have important in vivo implications for outer membrane protein assembly...
  16. pmc Chlamydia trachomatis responds to heat shock, penicillin induced persistence, and IFN-gamma persistence by altering levels of the extracytoplasmic stress response protease HtrA
    Wilhelmina M Huston
    Institute of Health and Biomedical Innovation, 60 Musk Ave, Queensland University of Technology, Kelvin Grove, QLD, 4059, Australia
    BMC Microbiol 8:190. 2008
    ..Recombinant purified C. trachomatis HtrA has been previously shown to have both activities. This investigation examined the physiological role of Chlamydia trachomatis HtrA...
  17. doi request reprint Chlamydia muridarum major outer membrane protein-specific antibodies inhibit in vitro infection but enhance pathology in vivo
    Kelly A Cunningham
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
    Am J Reprod Immunol 65:118-26. 2011
    ..To develop a successful vaccine, a complete understanding of the immune response to chlamydial infection and development of genital tract pathology is required...
  18. ncbi request reprint Discordant detection of Chlamydia pneumoniae in patients with carotid artery disease using polymerase chain reaction, immunofluorescence microscopy and serological methods
    Melanie Cochrane
    School of Life Sciences, Queensland University of Technology, Brisbane, Australia
    Pathology 37:69-75. 2005
    ....
  19. pmc Interaction of microbiology and pathology in women undergoing investigations for infertility
    Joseph Debattista
    Sexual Health and AIDS Service, Prince Charles Hospital, Health Service District, Brisbane, Australia
    Infect Dis Obstet Gynecol 12:135-45. 2004
    ....
  20. ncbi request reprint Wide range of Chlamydiales types detected in native Australian mammals
    Tracey J Bodetti
    Centre for Molecular Biotechnology, School of Life Sciences, Queensland University of Technology, Brisbane, Australia
    Vet Microbiol 96:177-87. 2003
    ..These findings provide further evidence that novel Chlamydiales infections occur in a wide range of hosts and that, in some of these, the chlamydial infections may contribute to clinical disease...
  21. ncbi request reprint Use of a commercial assay for detecting the 60 kDa chlamydial heat shock protein in a range of patient groups
    Caroline M Gazzard
    QML Pathology, West End, Queensland, Australia
    Sex Transm Dis 33:77-9. 2006
  22. doi request reprint Comparison of antigen detection and quantitative PCR in the detection of chlamydial infection in koalas (Phascolarctos cinereus)
    Jon Hanger
    Endeavour Veterinary Ecology, Toorbul, Queensland, Australia Australia Zoo Wildlife Hospital, Beerwah, Queensland, Australia
    Vet J 195:391-3. 2013
    ..2%). The immunoassay detection cut-off was determined as approximately 400 C. pecorum copies, indicating that the test was sufficiently sensitive to be used for the rapid diagnosis of active chlamydial infections...
  23. doi request reprint the active site residue V266 of Chlamydial HtrA is critical for substrate binding during both in vitro and in vivo conditions
    Sarina Gloeckl
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia
    J Mol Microbiol Biotechnol 22:10-6. 2012
    ..Notably, however, the interaction was significantly altered in 35 out of 69 clones when residue V266 was mutated, indicating that this residue has an important function during substrate binding...
  24. ncbi request reprint Multiple genotypes of Chlamydia pneumoniae identified in human carotid plaque
    Melanie Cochrane
    School of Life Sciences, Queensland University of Technology, GPO Box 2434, Brisbane, Australia
    Microbiology 151:2285-90. 2005
    ..While one genotype was identified that was the same as one reported previously in humans (respiratory and cardiovascular), another genotype was found that was identical to a genotype from non-human sources (frog/koala)...
  25. doi request reprint The cross-species prediction of bacterial promoters using a support vector machine
    Michael Towsey
    School of Life Sciences, Faculty of Science, Queensland University of Queensland, Brisbane, Queensland, Australia
    Comput Biol Chem 32:359-66. 2008
    ..We found a strong -35 hexamer and TGN/-10 associated with a set of early expressed genes. Our analysis highlights the advantage of using TSS-PREDICT as a starting point for predicting promoters in species where few are known...
  26. doi request reprint Phylogenetic comparison of the known Chlamydia trachomatis sigma(66) promoters across to Chlamydia pneumoniae and Chlamydia caviae identifies seven poorly conserved promoters
    Brian Grech
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Corner Musk Avenue and Blamey Street, Kelvin Grove, Brisbane, Queensland 4059, Australia
    Res Microbiol 159:550-6. 2008
    ..trachomatis are poorly conserved across C. trachomatis, C. pneumoniae and C. caviae, we would like to suggest that many other chlamydial promoters are poorly conserved across these species...
  27. pmc Chlamydial persistence: beyond the biphasic paradigm
    Richard J Hogan
    Infectious Diseases Program and Cooperative Research Centre for Diagnostics, School of Life Sciences, Queensland University of Technology, Brisbane, Australia
    Infect Immun 72:1843-55. 2004
  28. ncbi request reprint Molecular evidence for novel chlamydial infections in the koala (Phascolarctos cinereus)
    Lisa N Devereaux
    Centre for Molecular Biotechnology, School of Life Sciences, Queensland University of Technology, Brisbane, Australia
    Syst Appl Microbiol 26:245-53. 2003
    ..UKC sequences were most commonly found as dual infections with C. pecorum. This report provides the first description of additional members of the order Chlamydiales infecting the koala...
  29. pmc Novel molecular markers of Chlamydia pecorum genetic diversity in the koala (Phascolarctos cinereus)
    James Marsh
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
    BMC Microbiol 11:77. 2011
    ..pecorum genome. Using the recently sequenced C. pecorum genome sequence (E58), we analysed 10 genes, including ompA, to evaluate the use of ompA as a molecular marker in the study of koala C. pecorum genetic diversity...
  30. pmc The protease inhibitor JO146 demonstrates a critical role for CtHtrA for Chlamydia trachomatis reversion from penicillin persistence
    Vanissa A Ong
    School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology Brisbane, QLD, Australia
    Front Cell Infect Microbiol 3:100. 2013
    ..Thus, CtHtrA is an essential protease with both replicative phase and stress condition functions for Chlamydia trachomatis. ..
  31. doi request reprint Poly-immunoglobulin receptor-mediated transport of IgA into the male genital tract is important for clearance of Chlamydia muridarum infection
    Kelly A Cunningham
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia
    Am J Reprod Immunol 60:405-14. 2008
    ..While infection in females requires a Th1 response for clearance, such a response in males may disrupt the immune privileged nature of the male reproductive tract, potentially contributing to infertility...
  32. doi request reprint Molecular characterisation and expression analysis of interferon gamma in response to natural Chlamydia infection in the koala, Phascolarctos cinereus
    Marina Mathew
    Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Australia
    Gene 527:570-7. 2013
    ..Description of the IFNγ sequence from the koala will not only assist in understanding this species' response to its most important pathogen but will also provide further insight into the evolution of the marsupial immune system. ..
  33. pmc Preliminary characterisation of tumor necrosis factor alpha and interleukin-10 responses to Chlamydia pecorum infection in the koala (Phascolarctos cinereus)
    Marina Mathew
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane, Australia
    PLoS ONE 8:e59958. 2013
    ....
  34. doi request reprint Vaccination to protect against infection of the female reproductive tract
    Wilhelmina M Huston
    Institute of Health and Biomedical Innovation, 60 Musk Avenue, Queensland University of Technology, Kelvin Grove, Queensland, Australia
    Expert Rev Clin Immunol 8:81-94. 2012
    ..Despite these difficulties, there are numerous ongoing efforts to develop effective vaccines against these infectious agents and it is likely that this important human health field will see further major developments in the next 5 years...
  35. doi request reprint Partial protection against chlamydial reproductive tract infection by a recombinant major outer membrane protein/CpG/cholera toxin intranasal vaccine in the guinea pig Chlamydia caviae model
    Dean W Andrew
    Infectious Diseases Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane 4059, Australia
    J Reprod Immunol 91:9-16. 2011
    ..This data demonstrates the value of using the guinea pig model to evaluate potential chlamydial vaccines for protection against infection and disease pathology caused by C. trachomatis in the female reproductive tract...
  36. doi request reprint In vitro characterisation of koala Chlamydia pneumoniae: morphology, inclusion development and doubling time
    Candice M Mitchell
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland 4059, Australia
    Vet Microbiol 136:91-9. 2009
    ..Our findings have provided new insights and identified key differences in the in vitro doubling time, size and morphology of an animal C. pneumoniae isolate...
  37. ncbi request reprint Differential expression of chlamydial signal transduction genes in normal and interferon gamma-induced persistent Chlamydophila pneumoniae infections
    Adam Polkinghorne
    School of Life Sciences, Queensland University of Technology, GPO Box 2434, Brisbane 4001, Australia
    Microbes Infect 8:61-72. 2006
    ..pneumoniae persistence, likely as part of the IFN-gamma response stimulon as described for C. trachomatis, but with considerable differences in the transcriptional profile...
  38. doi request reprint In silico identification and in vivo analysis of a novel T-cell antigen from Chlamydia, NrdB
    Christopher J Barker
    Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Queensland 4059, Australia
    Vaccine 26:1285-96. 2008
    ..NrdB is a highly conserved chlamydial protein with an essential role in the replication of chlamydiae and could be a useful component of a multi-subunit vaccine against chlamydial genital tract infections...
  39. doi request reprint Immunity against a Chlamydia infection and disease may be determined by a balance of IL-17 signaling
    Connor P O'Meara
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia
    Immunol Cell Biol 92:287-97. 2014
    ....
  40. doi request reprint Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis
    Sarina Gloeckl
    Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Kelvin Grove, QLD, 4059, Australia
    Mol Microbiol 89:676-89. 2013
    ....
  41. pmc Multilocus sequence analysis provides insights into molecular epidemiology of Chlamydia pecorum infections in Australian sheep, cattle, and koalas
    Martina Jelocnik
    Institute for Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia
    J Clin Microbiol 51:2625-32. 2013
    ..pecorum strains and provide the first molecular epidemiological data on infections in Australian livestock hosts. ..
  42. pmc Comparison of koala LPCoLN and human strains of Chlamydia pneumoniae highlights extended genetic diversity in the species
    Candice M Mitchell
    Faculty of Science and Technology, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland 4059, Australia
    BMC Genomics 11:442. 2010
    ..pneumoniae human genomes (AR39, CWL029, J138 and TW183), providing relatively little insight into strain diversity and evolution of this species...
  43. ncbi request reprint Differential expression of genes encoding membrane proteins between acute and continuous Chlamydia pneumoniae infections
    Richard J Hogan
    Centre for Molecular Biotechnology Cooperative Research Centre for Diagnostics, School of Life Sciences, Level 5, Q Block, Queensland University of Technology, 2 George Street, Brisbane, Queensland 4000, Australia
    Microb Pathog 34:11-6. 2003
    ..These results show that Chlamydia in the long-term continuous model of persistence have a unique transcription profile, adding to our knowledge of regulation of this important stage of chlamydial growth...
  44. doi request reprint CTA1-DD is an effective adjuvant for targeting anti-chlamydial immunity to the murine genital mucosa
    Kelly A Cunningham
    Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Ave, Brisbane QLD 4059, Australia
    J Reprod Immunol 81:34-8. 2009
    ..Thus, CTA1-DD is an effective adjuvant for vaccine development against Chlamydia trachomatis, and possibly also a range of other genital pathogens...
  45. ncbi request reprint Recent advances in understanding the biology, epidemiology and control of chlamydial infections in koalas
    Adam Polkinghorne
    Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane 4059, Australia
    Vet Microbiol 165:214-23. 2013
    ....
  46. pmc Evolution to a chronic disease niche correlates with increased sensitivity to tryptophan availability for the obligate intracellular bacterium Chlamydia pneumoniae
    Wilhelmina M Huston
    Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Kelvin Grove, Queensland, Australia
    J Bacteriol 196:1915-24. 2014
    ..During persistence, they reduce their metabolic levels, halting progression of their developmental cycle, waiting until the hostile external conditions have passed before they reemerge. ..
  47. doi request reprint Progesterone activates multiple innate immune pathways in Chlamydia trachomatis-infected endocervical cells
    Charles Wan
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia
    Am J Reprod Immunol 71:165-77. 2014
    ..We therefore sought to determine the effects of female sex hormones on the innate immune response to C. trachomatis infection...
  48. pmc Immunization with a MOMP-based vaccine protects mice against a pulmonary Chlamydia challenge and identifies a disconnection between infection and pathology
    Connor P O'Meara
    Institute of Health and Biomedical Innovation IHBI, Queensland University of Technology QUT, Brisbane, Queensland, Australia
    PLoS ONE 8:e61962. 2013
    ..This identifies a disconnection between the control of infection and the development of pathology, which may influence the design of future vaccines...
  49. pmc The role of the multiple banded antigen of Ureaplasma parvum in intra-amniotic infection: major virulence factor or decoy?
    Samantha J Dando
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia
    PLoS ONE 7:e29856. 2012
    ..This host response may be important in the pathogenesis of inflammation-mediated adverse pregnancy outcomes...
  50. ncbi request reprint A comparison of the effects of a chlamydial vaccine administered during or after a C. muridarum urogenital infection of female mice
    Alison Carey
    Institute of Health and Biomedical Innovation, Cell and Molecular Biosciences, Faculty of Science, Queensland University of Technology, 60 Musk Ave, Kelvin Grove, QLD 4059, Australia
    Vaccine 29:6505-13. 2011
    ..This demonstrates that vaccination may not be protective in individuals who are seropositive for an acute or previous chlamydial infection...
  51. doi request reprint Apoptosis is induced in Chlamydia trachomatis-infected HEp-2 cells by the addition of a combination innate immune activation compounds and the inhibitor wedelolactone
    Wilhelmina M Huston
    Institute of Health and Biomedical Innovation and School of Life Sciences, Queensland University of Technology, Kelvin Grove, QLD, Australia
    Am J Reprod Immunol 65:460-5. 2011
    ..Innate immune activation of human cells, for some intracellular pathogens, is advantageous for vacuole morphology and pathogenic viability. It is unknown whether innate immune activation is advantageous to Chlamydia trachomatis viability...
  52. pmc Divergent outcomes following transcytosis of IgG targeting intracellular and extracellular chlamydial antigens
    Charles W Armitage
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia
    Immunol Cell Biol 92:417-26. 2014
    ..Together these data show that the protective and pathological effects of IgG are dependent on FcRn-mediated transport as well as the specificity of IgG for intracellular or extracellular antigens. ..
  53. pmc Modulation of the Chlamydia trachomatis in vitro transcriptome response by the sex hormones estradiol and progesterone
    Ashkan Amirshahi
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland 4059, Australia
    BMC Microbiol 11:150. 2011
    ..We performed a whole genome transcriptional profiling study of C. trachomatis infection in ECC-1 cells under progesterone or estradiol treatment...
  54. ncbi request reprint Chlamydial infection of immune cells: altered function and implications for disease
    Kenneth W Beagley
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Australia
    Crit Rev Immunol 29:275-305. 2009
    ..In this paper, we review the evidence for the growth of Chlamydia in immune cells, particularly monocytes/macrophages and dendritic cells, and describe how infection may affect the function of these cells...
  55. doi request reprint Identification of novel markers for uncomplicated lower genital tract infections and upper genital tract pathology due to Chlamydia trachomatis
    Trudi Collet
    CRC for Diagnostics, Queensland University of Technology, 2 George Street, Brisbane, Queensland, Australia 4000
    Int J Infect Dis 15:e257-66. 2011
    ..As a consequence, this study aimed to identify serological markers that can, with a high degree of sensitivity and specificity, discriminate between LGT infections and UGT pathology...
  56. pmc Distribution of Chlamydia pneumoniae DNA in atherosclerotic carotid arteries: significance for sampling procedures
    Melanie Cochrane
    Center for Molecular Biotechnology, Queensland University of Technology, Brisbane, Australia
    J Clin Microbiol 41:1454-7. 2003
    ..The low concentration and patchy distribution of C. pneumoniae DNA in atherosclerotic plaque appear to be among the reasons for inconsistency between laboratories in the results reported...
  57. ncbi request reprint Molecular evidence to support the expansion of the hostrange of Chlamydophila pneumoniae to include reptiles as well as humans, horses, koalas and amphibians
    Tracey J Bodetti
    Centre for Molecular Biotechnology, School of Life Sciences, Queensland University of Technology, Brisbane, Australia
    Syst Appl Microbiol 25:146-52. 2002
    ..pneumoniae are still capable of infecting humans, or crossed the host barrier some time ago, remains to be determined but may provide further insights into the relationship of this common respiratory infection with its human host...
  58. ncbi request reprint Investigation of the koala (Phascolarctos cinereus) hindgut microbiome via 16S pyrosequencing
    Christopher J Barker
    Institute of Health and Biomedical Innovation IHBI, 60 Musk Avenue, Kelvin Grove, Queensland 4059, Australia
    Vet Microbiol 167:554-64. 2013
    ..This study is the first non-culture based microbiota analysis, using 454-amplicon pyrosequencing, and provides preliminary data to expand our understanding of the koala hindgut. ..
  59. doi request reprint Chlamydia pneumoniae: modern insights into an ancient pathogen
    Eileen Roulis
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane 4059, Australia
    Trends Microbiol 21:120-8. 2013
    ..Here, we examine the characteristic facets of C. pneumoniae biology, offering insights into the diversity and evolution of this silent and ancient pathogen...
  60. ncbi request reprint The in silico prediction of promoters in bacterial genomes
    Michael Towsey
    Institute for Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia
    Genome Inform 19:178-89. 2007
    ..We also demonstrate for the first time, that sigma-54 promoters have a stronger association with SIDD than do other promoter types...
  61. ncbi request reprint The temperature activated HtrA protease from pathogen Chlamydia trachomatis acts as both a chaperone and protease at 37 degrees C
    Wilhelmina M Huston
    Institute of Health and Biomedical Innovation and School of Life Sciences, Faculty of Science, Queensland University of Technology, Brisbane, Australia
    FEBS Lett 581:3382-6. 2007
    ..trachomatis HtrA functions as both a chaperone and protease at 37 degrees C. These properties are consistent with the developmental cycle of this obligate intracellular bacterium...
  62. ncbi request reprint Genome-wide analysis of chlamydiae for promoters that phylogenetically footprint
    Brian Grech
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Corner Musk Avenue and Blamey Street, Kelvin Grove, Brisbane, Queensland, 4059, Australia
    Res Microbiol 158:685-93. 2007
    ..This paper, therefore, shows the value of a bioinformatics programme able to perform genome-wide analysis of bacteria for promoters that phylogenetically footprint...
  63. pmc Molecular and pathological insights into Chlamydia pecorum-associated sporadic bovine encephalomyelitis (SBE) in Western Australia
    Martina Jelocnik
    Institute for Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland 4059, Australia
    BMC Vet Res 10:121. 2014
    ..This report provides the first molecular evidence for the presence of mixed infections of C. pecorum strains in Australian cattle...
  64. doi request reprint Development status and future prospects for a vaccine against Chlamydia trachomatis infection
    Louise M Hafner
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
    Vaccine 32:1563-71. 2014
    ..While still remaining a major challenge, the development of a successful C. trachomatis vaccine is starting to look more likely. ..
  65. ncbi request reprint Immunopathogenesis of chlamydia trachomatis infections in women
    Joseph Debattista
    Centre for Molecular Biotechnology, Queensland University of Technology, Queensland, Australia
    Fertil Steril 79:1273-87. 2003
    ..To develop a model of pathogenesis by which Chlamydia trachomatis progresses from acute to chronic infection, and finally serious disease (salpingitis, tubal occlusion)...
  66. ncbi request reprint Ureaplasma parvum and Ureaplasma urealyticum are detected in semen after washing before assisted reproductive technology procedures
    Christine L Knox
    Centre for Molecular Biotechnology, Queensland University of Technology, Brisbane, Queensland, Australia
    Fertil Steril 80:921-9. 2003
    ..To investigate the prevalence of ureaplasmas in semen and washed semen and to explore their effect on semen andrology variables...