Tina S Skinner-Adams

Summary

Affiliation: Queensland Institute of Medical Research
Country: Australia

Publications

  1. pmc The frequency of malaria is similar among women receiving either lopinavir/ritonavir or nevirapine-based antiretroviral treatment
    Tina S Skinner-Adams
    Infectious Diseases Division, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    PLoS ONE 7:e34399. 2012
  2. ncbi request reprint HIV and malaria co-infection: interactions and consequences of chemotherapy
    T S Skinner-Adams
    University of Queensland, Brisbane, Australia
    Trends Parasitol 24:264-71. 2008
  3. doi request reprint Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials
    Tina S Skinner-Adams
    Malaria Biology Laboratory, Queensland Institute of Medical Research, Herston, QLD 4006, Australia
    Trends Biochem Sci 35:53-61. 2010
  4. pmc Synergistic interactions of the antiretroviral protease inhibitors saquinavir and ritonavir with chloroquine and mefloquine against Plasmodium falciparum in vitro
    T S Skinner-Adams
    University of Queensland, Department of Medicine, Brisbane, Australia
    Antimicrob Agents Chemother 51:759-62. 2007
  5. pmc Comparison of Plasmodium falciparum transfection methods
    Tina S Skinner-Adams
    Malaria Biology Laboratory, The Australian Centre for International and Tropical Health and Nutrition, University of Queensland, Australia
    Malar J 2:19. 2003
  6. ncbi request reprint The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparum
    Franka Teuscher
    Malaria Biology Laboratory, The Queensland Institute of Medical Research, 300 Herston Rd, Herston, Brisbane, Queensland 4006, Australia
    J Biol Chem 282:30817-26. 2007
  7. ncbi request reprint CLAG 9 is located in the rhoptries of Plasmodium falciparum
    Donald L Gardiner
    Malaria Biology Laboratory, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, 300 Herston Road, 4006 Herston, Queensland, Australia
    Parasitol Res 93:64-7. 2004
  8. ncbi request reprint Plasmodium falciparum: new molecular targets with potential for antimalarial drug development
    Donald L Gardiner
    Malaria Biology Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Herston, QLD 4006, Australia
    Expert Rev Anti Infect Ther 7:1087-98. 2009
  9. ncbi request reprint Overexpression of leucyl aminopeptidase in Plasmodium falciparum parasites. Target for the antimalarial activity of bestatin
    Donald L Gardiner
    Malaria Biology Laboratory, The Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, 300 Herston Road, Herston, Brisbane QLD 4029, Australia
    J Biol Chem 281:1741-5. 2006
  10. pmc Antimalarial asexual stage-specific and gametocytocidal activities of HIV protease inhibitors
    Christopher L Peatey
    Queensland Institute of Medical Research, 300 Herston Rd, Herston, Queensland, Australia
    Antimicrob Agents Chemother 54:1334-7. 2010

Collaborators

Detail Information

Publications21

  1. pmc The frequency of malaria is similar among women receiving either lopinavir/ritonavir or nevirapine-based antiretroviral treatment
    Tina S Skinner-Adams
    Infectious Diseases Division, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    PLoS ONE 7:e34399. 2012
    ..PI-sparing ART, and were followed prospectively for ≥48 weeks; 73% also received cotrimoxazole prophylaxis. PI-containing treatment was not associated with protection against malaria in this study population...
  2. ncbi request reprint HIV and malaria co-infection: interactions and consequences of chemotherapy
    T S Skinner-Adams
    University of Queensland, Brisbane, Australia
    Trends Parasitol 24:264-71. 2008
    ..Here, we discuss recent findings on the impact of HIV/AIDS and malaria co-infection and the possible roles of chemotherapy in improving the treatment of these diseases...
  3. doi request reprint Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials
    Tina S Skinner-Adams
    Malaria Biology Laboratory, Queensland Institute of Medical Research, Herston, QLD 4006, Australia
    Trends Biochem Sci 35:53-61. 2010
    ..Together with biological studies, these data form the rationale for choosing PfM1AAP and PfM17LAP as targets for anti-malarial development...
  4. pmc Synergistic interactions of the antiretroviral protease inhibitors saquinavir and ritonavir with chloroquine and mefloquine against Plasmodium falciparum in vitro
    T S Skinner-Adams
    University of Queensland, Department of Medicine, Brisbane, Australia
    Antimicrob Agents Chemother 51:759-62. 2007
    ..These data, and interactions with pepstatin-A, E-64, and bestatin, suggest that human immunodeficiency virus protease inhibitors do not target digestive-vacuole plasmepsins...
  5. pmc Comparison of Plasmodium falciparum transfection methods
    Tina S Skinner-Adams
    Malaria Biology Laboratory, The Australian Centre for International and Tropical Health and Nutrition, University of Queensland, Australia
    Malar J 2:19. 2003
    ..falciparum. In this paper we compare four published transfection techniques in their ability to achieve stable transfections...
  6. ncbi request reprint The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparum
    Franka Teuscher
    Malaria Biology Laboratory, The Queensland Institute of Medical Research, 300 Herston Rd, Herston, Brisbane, Queensland 4006, Australia
    J Biol Chem 282:30817-26. 2007
    ..However, we were able to draw valuable observations concerning the structure-activity relationship of these inhibitors that can be employed in future inhibitor optimization studies...
  7. ncbi request reprint CLAG 9 is located in the rhoptries of Plasmodium falciparum
    Donald L Gardiner
    Malaria Biology Laboratory, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, 300 Herston Road, 4006 Herston, Queensland, Australia
    Parasitol Res 93:64-7. 2004
    ..Co-localization using immunofluorescence of wildtype and knockout parasites unequivocally shows that CLAG 9 is localized to the rhoptry organelles of P. falciparum...
  8. ncbi request reprint Plasmodium falciparum: new molecular targets with potential for antimalarial drug development
    Donald L Gardiner
    Malaria Biology Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Herston, QLD 4006, Australia
    Expert Rev Anti Infect Ther 7:1087-98. 2009
    ..These targets include histone deacetylase, the aspartic proteases or plasmepsins, aminopeptidases and the purine salvage enzyme hypoxanthine-xanthine-guanine phosphoribosyltransferase...
  9. ncbi request reprint Overexpression of leucyl aminopeptidase in Plasmodium falciparum parasites. Target for the antimalarial activity of bestatin
    Donald L Gardiner
    Malaria Biology Laboratory, The Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, 300 Herston Road, Herston, Brisbane QLD 4029, Australia
    J Biol Chem 281:1741-5. 2006
    ..Overexpression of genes in malaria parasites would have general application in the identification and validation of targets for antimalarial drugs...
  10. pmc Antimalarial asexual stage-specific and gametocytocidal activities of HIV protease inhibitors
    Christopher L Peatey
    Queensland Institute of Medical Research, 300 Herston Rd, Herston, Queensland, Australia
    Antimicrob Agents Chemother 54:1334-7. 2010
    ..While all of the PIs tested inhibited gametocytogenesis, tipranavir was the only one to exhibit gametocytocidal activity...
  11. ncbi request reprint Aminopeptidases of malaria parasites: new targets for chemotherapy
    Katharine R Trenholme
    Malaria Biology Laboratory, Queensland Institute of Medical Research, 300 Herston Rd, Herston, QLD, 4006, Australia
    Infect Disord Drug Targets 10:217-25. 2010
    ..Recent advances in our understanding of these genes and their protein products are outlined in this review, including their potential for antimalarial drug development...
  12. ncbi request reprint Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compounds
    Tina S Skinner-Adams
    Malaria Biology Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Herston, Queensland 4029, Australia
    J Med Chem 50:6024-31. 2007
    ..These studies establish the PfLAP as a prime target for the development of antimalarial drugs and provide important new lead compounds...
  13. pmc The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria
    Tina S Skinner-Adams
    Malaria Biology Laboratory, Queensland Institute of Medical Research, Herston, Brisbane, Australia
    Antimicrob Agents Chemother 56:3244-9. 2012
    ..Here, we show that an orally bioavailable aminopeptidase inhibitor, CHR-2863, is efficacious against murine malaria...
  14. ncbi request reprint Malaria transfection and transfection vectors
    Donald L Gardiner
    Malaria Biology Laboratory, The Australian Centre for International and Tropical Health and Nutrition, a joint program of the Queensland Institute of Medical Research and the School of Population Health, University of Queensland, Herston
    Trends Parasitol 19:381-3. 2003
    ..The genetic manipulation of specific genes via the use of plasmid constructs and transfection represents one such tool...
  15. ncbi request reprint Implication of a Plasmodium falciparum gene in the switch between asexual reproduction and gametocytogenesis
    Donald L Gardiner
    Malaria Biology Laboratory, The Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research, 300 Herston Road, Herston, QLD 4006, Australia
    Mol Biochem Parasitol 140:153-60. 2005
    ..Here we identify a novel gene in P. falciparum that when genetically silenced reduces gametocyte production by a factor of 6, and when complemented up-regulates gametocyte-specific gene transcription...
  16. ncbi request reprint Antiretrovirals as antimalarial agents
    Tina S Skinner-Adams
    Malaria Biology Laboratory, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research and School of Population Health, University of Queensland, St Lucia, Queensland, Australia
    J Infect Dis 190:1998-2000. 2004
    ..These findings are particularly important in light of both the high rate of malaria and HIV-1 coinfection in sub-Saharan Africa and the effort to employ highly active antiretroviral therapy in these regions...
  17. ncbi request reprint Effect of antimalarial drugs on Plasmodium falciparum gametocytes
    Christopher L Peatey
    Malaria Biology Laboratory, Queensland Institute of Medical Research, Herston, 4006 Victoria, Australia
    J Infect Dis 200:1518-21. 2009
    ..Although a dose-dependent reduction in late-stage gametocyte viability was observed, none of the drugs tested statistically significantly reduced gametocyte numbers...
  18. ncbi request reprint The activity of protease inhibitors against Giardia duodenalis and metronidazole-resistant Trichomonas vaginalis
    Linda A Dunn
    Molecular Genetics Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, QLD 4006, Australia
    Int J Antimicrob Agents 29:98-102. 2007
    ..duodenalis trophozoites. Saquinavir was not effective. These findings are significant considering the association between human immunodeficiency virus and T. vaginalis, and between G. duodenalis and homosexual behaviour...
  19. ncbi request reprint A novel Plasmodium falciparum ring stage protein, REX, is located in Maurer's clefts
    Paula L Hawthorne
    University of Queensland, Herston, 4006 QLD, Australia
    Mol Biochem Parasitol 136:181-9. 2004
    ..REX persists in Maurer's clefts throughout the infection of the erythrocyte, where it may play a role in the biogenesis and/or function of this organelle...
  20. ncbi request reprint Plasmodium falciparum gametocytes: with a view to a kill
    Alice S Butterworth
    Queensland Institute of Medical Research, Brisbane, Australia
    Parasitology 140:1718-34. 2013
    ..This review examines the gametocytocidal properties of currently available drugs as well as those in the development pipeline and examines the prospects for discovery of new anti-gametocyte compounds...
  21. doi request reprint Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics
    Dianne T Keough
    The School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, 4072 QLD, Australia
    J Med Chem 52:4391-9. 2009
    ..These results provide a basis for the design of potent and selective ANP inhibitors of Pf HGXPRT as antimalarial drug leads...