L A Simms

Summary

Affiliation: Queensland Institute of Medical Research
Country: Australia

Publications

  1. ncbi request reprint Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease
    L A Simms
    Inflammatory Bowel Disease Laboratory, Royal Brisbane and Women s Hospital Foundation, Brisbane, Australia
    Gut 57:903-10. 2008
  2. pmc SnoN expression is differently regulated in microsatellite unstable compared with microsatellite stable colorectal cancers
    June A Chia
    The Conjoint Gastroenterology Laboratory, Royal Brisbane and Women s Hospital Foundation Clinical Research Centre and the Queensland Institute of Medical Research, Brisbane, 4029, Australia
    BMC Cancer 6:252. 2006
  3. doi request reprint KCNN4 gene variant is associated with ileal Crohn's Disease in the Australian and New Zealand population
    Lisa A Simms
    Royal Brisbane and Women s Research Foundation, Brisbane, Queensland, Australia
    Am J Gastroenterol 105:2209-17. 2010
  4. ncbi request reprint A family with attenuated familial adenomatous polyposis due to a mutation in the alternatively spliced region of APC exon 9
    J Young
    Glaxo Conjoint Gastroenterology Laboratory, Royal Brisbane Hospital Foundation Clinical Research Centre, Australia
    Hum Mutat 11:450-5. 1998
  5. pmc Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic settings: parallel pathways of tumorigenesis
    J Young
    Conjoint Gastroenterology Laboratory, Royal Brisbane Hospital Foundation Clinical Research Centre, Bancroft Centre, Herston, Australia
    Am J Pathol 159:2107-16. 2001
  6. ncbi request reprint Angiogenic factor VEGF is decreased in human colorectal neoplasms showing DNA microsatellite instability
    C V Wynter
    Department of Surgery, Greenslopes Private Hospital, University of Queensland, Brisbane, Australia
    J Pathol 189:319-25. 1999
  7. ncbi request reprint Promoter hypermethylation frequency and BRAF mutations distinguish hereditary non-polyposis colon cancer from sporadic MSI-H colon cancer
    A McGivern
    Conjoint Gastroenterology Laboratory, Bancroft Centre, Herston, Brisbane, Queensland, Australia
    Fam Cancer 3:101-7. 2004

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease
    L A Simms
    Inflammatory Bowel Disease Laboratory, Royal Brisbane and Women s Hospital Foundation, Brisbane, Australia
    Gut 57:903-10. 2008
    ..The aim of this study was to independently assess whether NOD2, alpha-defensins and Crohn's disease are linked...
  2. pmc SnoN expression is differently regulated in microsatellite unstable compared with microsatellite stable colorectal cancers
    June A Chia
    The Conjoint Gastroenterology Laboratory, Royal Brisbane and Women s Hospital Foundation Clinical Research Centre and the Queensland Institute of Medical Research, Brisbane, 4029, Australia
    BMC Cancer 6:252. 2006
    ..SnoN is an important regulator of the transforming growth factor beta (TGFbeta) signalling pathway and has been shown to exhibit both tumour promotion and suppression activity...
  3. doi request reprint KCNN4 gene variant is associated with ileal Crohn's Disease in the Australian and New Zealand population
    Lisa A Simms
    Royal Brisbane and Women s Research Foundation, Brisbane, Queensland, Australia
    Am J Gastroenterol 105:2209-17. 2010
    ..Our aim was to determine whether a gene in the IBD linkage region on chromosome 19q13, with a role in Paneth cell secretion and T-cell activation, conferred genetic susceptibility to the development of CD...
  4. ncbi request reprint A family with attenuated familial adenomatous polyposis due to a mutation in the alternatively spliced region of APC exon 9
    J Young
    Glaxo Conjoint Gastroenterology Laboratory, Royal Brisbane Hospital Foundation Clinical Research Centre, Australia
    Hum Mutat 11:450-5. 1998
    ..Alternatively spliced transcripts that delete the mutation were readily amplified from normal colonic mucosa and therefore create a mechanism for the attenuated phenotype seen in this family...
  5. pmc Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic settings: parallel pathways of tumorigenesis
    J Young
    Conjoint Gastroenterology Laboratory, Royal Brisbane Hospital Foundation Clinical Research Centre, Bancroft Centre, Herston, Australia
    Am J Pathol 159:2107-16. 2001
    ....
  6. ncbi request reprint Angiogenic factor VEGF is decreased in human colorectal neoplasms showing DNA microsatellite instability
    C V Wynter
    Department of Surgery, Greenslopes Private Hospital, University of Queensland, Brisbane, Australia
    J Pathol 189:319-25. 1999
    ..The low frequency of VEGF expression amongst MSI-H cancers may partially explain why these cancers are less aggressive, with a better overall prognosis...
  7. ncbi request reprint Promoter hypermethylation frequency and BRAF mutations distinguish hereditary non-polyposis colon cancer from sporadic MSI-H colon cancer
    A McGivern
    Conjoint Gastroenterology Laboratory, Bancroft Centre, Herston, Brisbane, Queensland, Australia
    Fam Cancer 3:101-7. 2004
    ..However, significant differences can be demonstrated at the molecular level including widespread promoter hypermethylation and BRAF -activating mutations which occur significantly less often in HNPCC...