Inge Seim

Summary

Affiliation: Queensland University of Technology
Country: Australia

Publications

  1. pmc The proximal first exon architecture of the murine ghrelin gene is highly similar to its human orthologue
    Inge Seim
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia
    BMC Res Notes 2:85. 2009
  2. pmc Revised genomic structure of the human ghrelin gene and identification of novel exons, alternative splice variants and natural antisense transcripts
    Inge Seim
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia
    BMC Genomics 8:298. 2007
  3. pmc Complex organisation and structure of the ghrelin antisense strand gene GHRLOS, a candidate non-coding RNA gene
    Inge Seim
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia
    BMC Mol Biol 9:95. 2008
  4. doi request reprint Ghrelin and cancer
    Lisa Chopin
    Queensland University of Technology, Brisbane, Australia
    Mol Cell Endocrinol 340:65-9. 2011
  5. doi request reprint Identification of a long non-coding RNA gene, growth hormone secretagogue receptor opposite strand, which stimulates cell migration in non-small cell lung cancer cell lines
    Eliza J Whiteside
    Ghrelin Research Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia
    Int J Oncol 43:566-74. 2013
  6. pmc Ghrelin O-acyltransferase (GOAT) is expressed in prostate cancer tissues and cell lines and expression is differentially regulated in vitro by ghrelin
    Inge Seim
    Ghrelin Research Group, Translational Research Institute Institute of Health and Biomedical Innovation, Queensland University of Technology, 37 Kent St, Woolloongabba, Queensland, 4102, Australia
    Reprod Biol Endocrinol 11:70. 2013
  7. doi request reprint Ghrelin gene-related peptides: multifunctional endocrine / autocrine modulators in health and disease
    Inge Seim
    Institute of Health and Biomedical Innovation and School of Life Sciences, Queensland University of Technology, Brisbane, Queensland, Australia
    Clin Exp Pharmacol Physiol 37:125-31. 2010
  8. doi request reprint Ghrelin axis genes, peptides and receptors: recent findings and future challenges
    Inge Seim
    Queensland University of Technology, Brisbane, Queensland, Australia
    Mol Cell Endocrinol 340:3-9. 2011
  9. doi request reprint Cloning of a novel insulin-regulated ghrelin transcript in prostate cancer
    Inge Seim
    Institute of Health and Biomedical Innovation IHBI, Queensland University of Technology, Kelvin Grove, Brisbane, Queensland 4059, Australia
    J Mol Endocrinol 50:179-91. 2013
  10. doi request reprint New insights into the molecular complexity of the ghrelin gene locus
    Inge Seim
    Institute of Health and Biomedical Innovation and School of Life Sciences, Queensland University of Technology, Brisbane, QLD 4000, Australia
    Cytokine Growth Factor Rev 20:297-304. 2009

Collaborators

  • Lisa K Chopin
  • Penny L Jeffery
  • Magdy El-Salhy
  • Jenny N T Fung
  • Eliza J Whiteside
  • Adrian C Herington
  • John D Lee
  • Deborah Roche
  • Andreas Obermair
  • Angela J O'Keeffe
  • Shea L Carter
  • Carina M Walpole
  • Peter Josh
  • Jana P Pauli
  • Chen Chen
  • Patrick B Thomas

Detail Information

Publications14

  1. pmc The proximal first exon architecture of the murine ghrelin gene is highly similar to its human orthologue
    Inge Seim
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia
    BMC Res Notes 2:85. 2009
    ....
  2. pmc Revised genomic structure of the human ghrelin gene and identification of novel exons, alternative splice variants and natural antisense transcripts
    Inge Seim
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia
    BMC Genomics 8:298. 2007
    ..The availability of bioinformatic tools enabling comparative analysis and the finalisation of the human genome prompted us to re-examine the genomic structure of the ghrelin locus...
  3. pmc Complex organisation and structure of the ghrelin antisense strand gene GHRLOS, a candidate non-coding RNA gene
    Inge Seim
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia
    BMC Mol Biol 9:95. 2008
    ..We previously identified a gene on the opposite strand of the ghrelin gene, ghrelinOS (GHRLOS), which spans the promoter and untranslated regions of the ghrelin gene (GHRL). Here we further characterise GHRLOS...
  4. doi request reprint Ghrelin and cancer
    Lisa Chopin
    Queensland University of Technology, Brisbane, Australia
    Mol Cell Endocrinol 340:65-9. 2011
    ..Ghrelin and its receptor are expressed in a number of cancers and cancer cell lines and may play a role in processes associated with cancer progression, including cell proliferation, apoptosis, and cell invasion and migration...
  5. doi request reprint Identification of a long non-coding RNA gene, growth hormone secretagogue receptor opposite strand, which stimulates cell migration in non-small cell lung cancer cell lines
    Eliza J Whiteside
    Ghrelin Research Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia
    Int J Oncol 43:566-74. 2013
    ....
  6. pmc Ghrelin O-acyltransferase (GOAT) is expressed in prostate cancer tissues and cell lines and expression is differentially regulated in vitro by ghrelin
    Inge Seim
    Ghrelin Research Group, Translational Research Institute Institute of Health and Biomedical Innovation, Queensland University of Technology, 37 Kent St, Woolloongabba, Queensland, 4102, Australia
    Reprod Biol Endocrinol 11:70. 2013
    ..Recently, the enzyme responsible for adding the fatty acid residue (octanoyl/acyl group) to the third amino acid of ghrelin, GOAT (ghrelin O-acyltransferase), was identified...
  7. doi request reprint Ghrelin gene-related peptides: multifunctional endocrine / autocrine modulators in health and disease
    Inge Seim
    Institute of Health and Biomedical Innovation and School of Life Sciences, Queensland University of Technology, Brisbane, Queensland, Australia
    Clin Exp Pharmacol Physiol 37:125-31. 2010
    ..6. The identification of these novel ghrelin-gene related transcripts and peptides raises critical questions regarding their physiological function and their potential role in obesity, diabetes and cancer...
  8. doi request reprint Ghrelin axis genes, peptides and receptors: recent findings and future challenges
    Inge Seim
    Queensland University of Technology, Brisbane, Queensland, Australia
    Mol Cell Endocrinol 340:3-9. 2011
    ..Studies of the role of ghrelin axis genes, peptides and receptors, therefore, promises to be a fruitful area of basic and clinical research in years to come...
  9. doi request reprint Cloning of a novel insulin-regulated ghrelin transcript in prostate cancer
    Inge Seim
    Institute of Health and Biomedical Innovation IHBI, Queensland University of Technology, Kelvin Grove, Brisbane, Queensland 4059, Australia
    J Mol Endocrinol 50:179-91. 2013
    ..This study is the first description of insulin regulation of a ghrelin transcript in cancer and should provide further impetus for studies into the expression, regulation and function of ghrelin gene products...
  10. doi request reprint New insights into the molecular complexity of the ghrelin gene locus
    Inge Seim
    Institute of Health and Biomedical Innovation and School of Life Sciences, Queensland University of Technology, Brisbane, QLD 4000, Australia
    Cytokine Growth Factor Rev 20:297-304. 2009
    ..Alternative splicing and the use of alternative post-translational cleavages sites may give rise to novel ghrelin gene-derived peptides that potentially act through different receptors and have novel biological functions...
  11. doi request reprint The ghrelin axis--does it have an appetite for cancer progression?
    Lisa K Chopin
    Ghrelin Research Group, Institute of Health and Biomedical Innovation, Queensland University of Technology and Australian Prostate Cancer Research Centre Queensland, Brisbane, Queensland 4001, Australia
    Endocr Rev 33:849-91. 2012
    ..Ghrelin and its analogs show promise as treatments for cancer-related cachexia. Further studies using in vivo models are required to determine whether ghrelin has a role in cancer progression...
  12. doi request reprint The expanding roles of the ghrelin-gene derived peptide obestatin in health and disease
    Inge Seim
    Queensland University of Technology, Queensland, Brisbane, Australia
    Mol Cell Endocrinol 340:111-7. 2011
    ..In this review we will discuss the controversies associated with the discovery of obestatin and explore emerging central and peripheral roles of obestatin, which includes adipogenesis, pancreatic homeostasis and cancer...
  13. doi request reprint Silencing of ghrelin receptor expression inhibits endometrial cancer cell growth in vitro and in vivo
    Jenny N T Fung
    School of Biomedical Sciences, University of Queensland, St Lucia, Queensland, Australia
    Am J Physiol Endocrinol Metab 305:E305-13. 2013
    ..This is the first preclinical evidence that downregulation of GHSR may be therapeutic in endometrial cancer. ..
  14. ncbi request reprint Ghrelin and the brain-gut axis as a pharmacological target for appetite control
    Inge Seim
    Ghrelin Research Group, Institute of Health and Biomedical Innovation, 60 Musk Avenue, Kelvin Grove, Queensland, 4059, Australia
    Curr Pharm Des 18:768-75. 2012
    ....