Derek J Richard

Summary

Affiliation: Queensland Institute of Medical Research
Country: Australia

Publications

  1. pmc ATM mediated phosphorylation of CHD4 contributes to genome maintenance
    Aaron J Urquhart
    Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia
    Genome Integr 2:1. 2011
  2. pmc hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity
    Derek J Richard
    Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia
    Nucleic Acids Res 39:3643-51. 2011
  3. pmc Kruppel-associated Box (KRAB)-associated co-repressor (KAP-1) Ser-473 phosphorylation regulates heterochromatin protein 1β (HP1-β) mobilization and DNA repair in heterochromatin
    Emma Bolderson
    Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
    J Biol Chem 287:28122-31. 2012
  4. pmc hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex
    Derek J Richard
    Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
    Nucleic Acids Res 39:1692-702. 2011
  5. pmc Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks
    Emma Bolderson
    Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
    Nucleic Acids Res 38:1821-31. 2010

Collaborators

Detail Information

Publications5

  1. pmc ATM mediated phosphorylation of CHD4 contributes to genome maintenance
    Aaron J Urquhart
    Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia
    Genome Integr 2:1. 2011
    ..abstract:..
  2. pmc hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity
    Derek J Richard
    Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia
    Nucleic Acids Res 39:3643-51. 2011
    ..Interestingly, analysis of two point mutations in NBS1, associated with Nijmegen breakage syndrome, revealed weaker binding to hSSB1, suggesting a possible disease mechanism...
  3. pmc Kruppel-associated Box (KRAB)-associated co-repressor (KAP-1) Ser-473 phosphorylation regulates heterochromatin protein 1β (HP1-β) mobilization and DNA repair in heterochromatin
    Emma Bolderson
    Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
    J Biol Chem 287:28122-31. 2012
    ..These results suggest a novel mechanism of KAP-1-mediated chromatin restructuring via Chk2-regulated HP1-β exchange from heterochromatin, promoting DNA repair...
  4. pmc hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex
    Derek J Richard
    Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
    Nucleic Acids Res 39:1692-702. 2011
    ..These findings, together with previous work establish essential roles of hSSB1 in controlling ATM activation and activity, and subsequent DSB resection and homologous recombination (HR)...
  5. pmc Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks
    Emma Bolderson
    Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
    Nucleic Acids Res 38:1821-31. 2010
    ..These data establish a role for Exo1 in resection of DSBs in human cells, highlighting the critical requirement of Exo1 for DSB repair via HR and thus the maintenance of genomic stability...