L W Powell

Summary

Affiliation: Queensland Institute of Medical Research
Country: Australia

Publications

  1. ncbi request reprint The Queensland Institute of Medical Research. Excellence from the interplay of medicine and science
    L W Powell
    Queensland Institute of Medical Research, Brisbane
    Med J Aust 165:645-8. 1996
  2. ncbi request reprint Role of early case detection by screening relatives of patients with HFE-associated hereditary haemochromatosis
    Lawrie W Powell
    The Queensland Institute of Medical Research, Brisbane, Australia
    Best Pract Res Clin Haematol 18:221-34. 2005
  3. ncbi request reprint Bridging the gap between basic science and clinical medicine: mentors and memories
    Lawrie W Powell
    Teaching and Research Unit, Royal Brisbane and Women s Hospitals, QLD
    Med J Aust 177:657-60. 2002
  4. ncbi request reprint Diagnosis of hemochromatosis
    Lawrie W Powell
    Queensland Institute of Medical Research and the University of Queensland, Brisbane, Australia
    Semin Gastrointest Dis 13:80-8. 2002
  5. ncbi request reprint Hereditary hemochromatosis and iron overload diseases
    Lawrie W Powell
    The Queensland Institute of Medical Research and the Royal Brisbane Hospital, Australia
    J Gastroenterol Hepatol 17:S191-5. 2002
  6. ncbi request reprint Hemochromatosis
    L W Powell
    Department of Medicine, University of Queensland, Brisbane, Australia
    Clin Liver Dis 4:211-28, viii. 2000
  7. ncbi request reprint Haemochromatosis in the new millennium
    L W Powell
    The Queensland Institute of Medical Research and the Joint Clinical Sciences Program, The University of Queensland, Brisbane, Australia
    J Hepatol 32:48-62. 2000
  8. ncbi request reprint A population-based study of the clinical expression of the hemochromatosis gene
    J K Olynyk
    Department of Medicine, University of Western Australia, Fremantle, Australia
    N Engl J Med 341:718-24. 1999
  9. ncbi request reprint HFE gene and hemochromatosis
    G J Anderson
    The Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    J Gastroenterol Hepatol 19:712. 2004
  10. ncbi request reprint Lipid peroxidation in hepatic steatosis in humans is associated with hepatic fibrosis and occurs predominately in acinar zone 3
    G A Macdonald
    Population and Clinical Sciences Division, The Queensland Institute of Medical Research, Departments of Medicine, The University of Queensland, Australia
    J Gastroenterol Hepatol 16:599-606. 2001

Collaborators

Detail Information

Publications40

  1. ncbi request reprint The Queensland Institute of Medical Research. Excellence from the interplay of medicine and science
    L W Powell
    Queensland Institute of Medical Research, Brisbane
    Med J Aust 165:645-8. 1996
    ..Yet the clinical objectives of research still motivate and inform the research effort...
  2. ncbi request reprint Role of early case detection by screening relatives of patients with HFE-associated hereditary haemochromatosis
    Lawrie W Powell
    The Queensland Institute of Medical Research, Brisbane, Australia
    Best Pract Res Clin Haematol 18:221-34. 2005
    ..The most cost-effective methods of early case detection are family (cascade) screening and evaluation of potential cases by primary care physicians with a high index of clinical suspicion...
  3. ncbi request reprint Bridging the gap between basic science and clinical medicine: mentors and memories
    Lawrie W Powell
    Teaching and Research Unit, Royal Brisbane and Women s Hospitals, QLD
    Med J Aust 177:657-60. 2002
  4. ncbi request reprint Diagnosis of hemochromatosis
    Lawrie W Powell
    Queensland Institute of Medical Research and the University of Queensland, Brisbane, Australia
    Semin Gastrointest Dis 13:80-8. 2002
    ..Because of its familial occurrence all first-degree relatives of patients with hereditary hemochromatosis should be tested for the disease...
  5. ncbi request reprint Hereditary hemochromatosis and iron overload diseases
    Lawrie W Powell
    The Queensland Institute of Medical Research and the Royal Brisbane Hospital, Australia
    J Gastroenterol Hepatol 17:S191-5. 2002
  6. ncbi request reprint Hemochromatosis
    L W Powell
    Department of Medicine, University of Queensland, Brisbane, Australia
    Clin Liver Dis 4:211-28, viii. 2000
    ..In addition, it is now apparent that iron, even in the modest tissue concentrations, can act as a co-factor in potentiating cell injury in other liver diseases...
  7. ncbi request reprint Haemochromatosis in the new millennium
    L W Powell
    The Queensland Institute of Medical Research and the Joint Clinical Sciences Program, The University of Queensland, Brisbane, Australia
    J Hepatol 32:48-62. 2000
    ..In the future, population screening by genotype should be feasible once the relevant technical, legal and ethical issues are resolved...
  8. ncbi request reprint A population-based study of the clinical expression of the hemochromatosis gene
    J K Olynyk
    Department of Medicine, University of Western Australia, Fremantle, Australia
    N Engl J Med 341:718-24. 1999
    ..We recommended liver biopsy for subjects with serum ferritin levels of 300 ng per milliliter or higher. The subjects were followed for up to four years...
  9. ncbi request reprint HFE gene and hemochromatosis
    G J Anderson
    The Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    J Gastroenterol Hepatol 19:712. 2004
  10. ncbi request reprint Lipid peroxidation in hepatic steatosis in humans is associated with hepatic fibrosis and occurs predominately in acinar zone 3
    G A Macdonald
    Population and Clinical Sciences Division, The Queensland Institute of Medical Research, Departments of Medicine, The University of Queensland, Australia
    J Gastroenterol Hepatol 16:599-606. 2001
    ..The aim of this study was to assess the distribution of lipid peroxidation in association with these factors, and the relationship of this to the fibrogenic cascade...
  11. ncbi request reprint What's new in hemochromatosis
    P A Gochee
    Population and Clinical Sciences Division, The Queensland Institute of Medical Research, Brisbane, Australia
    Curr Opin Hematol 8:98-104. 2001
    ..In addition, mechanisms of iron transport and metabolism are unfolding and are providing clues to the enigma of iron homeostasis and the pathophysiology of iron overload...
  12. ncbi request reprint Interrelationships of alcohol and iron in liver disease with particular reference to the iron-binding proteins, ferritin and transferrin
    L M Fletcher
    The Clinical Sciences Unit, The Queensland Institute of Medical Research, Brisbane, Australia
    J Gastroenterol Hepatol 14:202-14. 1999
    ....
  13. doi request reprint Patient-focused outcomes following detection in a hospital-based screening programme for C282Y haemochromatosis
    M A McCullen
    Department of Gastroenterology and Hepatology, Royal Brisbane Hospital, Brisbane, QLD, Australia
    Intern Med J 38:651-6. 2008
    ..Haemochromatosis is a common genetic disease in populations of a northern European origin. However, there is uncertainty as to whether it is a condition that should be screened for...
  14. ncbi request reprint Identification of a novel Krueppel-related zinc finger gene (ZNF184) mapping to 6p21.3
    S Goldwurm
    The Queensland Institute of Medical Research, University of Queensland, Brisbane, Queensland, 4029, Australia
    Genomics 40:486-9. 1997
    ..This zinc finger gene maps to a region approximately 200 kb distal to the microsatellite marker D6S105 and approximately 300 kb proximal to D6S1260...
  15. ncbi request reprint Hepatic stellate cell activation in genetic haemochromatosis. Lobular distribution, effect of increasing hepatic iron and response to phlebotomy
    G A Ramm
    The University of Queensland Department of Medicine, Australia
    J Hepatol 26:584-92. 1997
    ..This study examined the relationship between hepatic iron concentration and hepatic stellate cell activation in genetic haemochromatosis...
  16. pmc A novel mutation in ferroportin1 is associated with haemochromatosis in a Solomon Islands patient
    K E Arden
    Membrane Transport Laboratory, The Queensland Institute of Medical Research, Brisbane, Australia
    Gut 52:1215-7. 2003
    ..The genetic basis of the disorder has not been identified. The disorder has similarities to type 4 haemochromatosis, which is caused by mutations in ferroportin1...
  17. ncbi request reprint Population screening for HFE-associated haemochromatosis: should we have to pay for our genes?
    T R Yapp
    Queensland Institute of Medical Research, University of Queensland, Brisbane, Australia
    Intern Med J 31:48-52. 2001
    ..The present paper summarizes the evidence in favour of population screening and analyses the relative advantages of genotypic (DNA test) versus phenotypic (transferrin saturation) testing...
  18. ncbi request reprint Patient and graft survival after liver transplantation for hereditary hemochromatosis: Implications for pathogenesis
    Darrell H G Crawford
    Queensland Liver Transplant Service and The University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
    Hepatology 39:1655-62. 2004
    ..Our data suggest that iron excess in HH does not wholly depend on intestinal iron absorption but is also influenced by liver factors that moderate iron metabolism...
  19. ncbi request reprint Hereditary hemochromatosis genetic testing of at-risk children: what is the appropriate age?
    Martin B Delatycki
    Bruce Lefroy Centre for Genetic Health Research, Murdoch Children s Research Institute, Department of Paediatrics, University of Melbourne, Victoria, Australia
    Genet Test 8:98-103. 2004
    ..In the cascade setting, genetic testing for hemochromatosis need not be offered until late teenage years...
  20. ncbi request reprint Hemojuvelin (HJV)-associated hemochromatosis: analysis of HJV and HFE mutations and iron overload in three families
    Daniel F Wallace
    Haematologica 90:254-5. 2005
    ..In this study we identified the molecular basis of juvenile hemochromatosis in three Australian families and assessed the role of potential modifying genes in individuals carrying HFE mutations...
  21. ncbi request reprint The clinical relevance of compound heterozygosity for the C282Y and H63D substitutions in hemochromatosis
    Alissa Walsh
    The Department of Gastroenterology and Hepatology, Royal Brisbane and Women s Hospital, Brisbane, Australia
    Clin Gastroenterol Hepatol 4:1403-10. 2006
    ..This study assessed the phenotypic expression in C282Y/H63D subjects as compared with C282Y homozygotes...
  22. ncbi request reprint Effects of HFE gene mutations and alcohol on iron status, liver biochemistry and morbidity
    John K Olynyk
    School of Medicine and Pharmacology, University of Western Australia, Crawley, Australia
    J Gastroenterol Hepatol 20:1435-41. 2005
    ....
  23. ncbi request reprint Steatosis is a cofactor in liver injury in hemochromatosis
    Elizabeth E Powell
    School of Medicine, The University of Queensland, Brisbane, Australia
    Gastroenterology 129:1937-43. 2005
    ....
  24. doi request reprint Iron-overload-related disease in HFE hereditary hemochromatosis
    Katrina J Allen
    Murdoch Children s Research Institute, University of Melbourne, Melbourne, Australia
    N Engl J Med 358:221-30. 2008
    ..Diseases related to iron overload develop in some C282Y homozygotes, but the extent of the risk is controversial...
  25. ncbi request reprint Screening for hemochromatosis in asymptomatic subjects with or without a family history
    Lawrie W Powell
    Centre for the Advancement of Clinical Research, Royal Brisbane and Women s Hospital, Brisbane, Queensland 4029, Australia
    Arch Intern Med 166:294-301. 2006
    ..This study compared screening for hemochromatosis in subjects with or without a family history...
  26. ncbi request reprint Psychological adjustment and knowledge about hereditary hemochromatosis in a clinic-based sample: a prospective study
    Bettina Meiser
    Hereditary Cancer Clinic, Department of Medical Oncology, Prince of Wales Hospital, Sydney, Australia
    J Genet Couns 14:453-63. 2005
    ..Results also show that patients may benefit from strategies aimed at improving recall of genetic testing results...
  27. ncbi request reprint Hemochromatosis and alcoholic liver disease
    Linda M Fletcher
    Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia
    Alcohol 30:131-6. 2003
    ..In addition, the cumulative effects of other forms of liver injury may result when iron and alcohol are present concurrently. Clearly, the addition of dietary iron in subjects homozygous for hemochromatosis would be unwise...
  28. ncbi request reprint Excess alcohol greatly increases the prevalence of cirrhosis in hereditary hemochromatosis
    Linda M Fletcher
    Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Queensland, Australia
    Gastroenterology 122:281-9. 2002
    ....
  29. ncbi request reprint A population-based study of the biochemical and clinical expression of the H63D hemochromatosis mutation
    Peter A Gochee
    Queensland Institute of Medical Research and the University of Queensland, Brisbane, Western Australia
    Gastroenterology 122:646-51. 2002
    ..We accessed a well-defined population in Busselton, Australia, and determined the frequency of the H63D mutation and its influence on total body iron stores...
  30. ncbi request reprint Frequency of the S65C mutation of HFE and iron overload in 309 subjects heterozygous for C282Y
    Daniel F Wallace
    Centre for Hepatology, Department of Medicine, Royal Free and University College Medical School, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
    J Hepatol 36:474-9. 2002
    ..Some are compound heterozygotes for C282Y/H63D. A small proportion have neither of these genotypes. We have investigated the phenotype of compound heterozygotes for C282Y and another missense mutation S65C...
  31. ncbi request reprint Reciprocal relationship between methylation status and loss of heterozygosity at the p14(ARF) locus in Australian and South African hepatocellular carcinomas
    Nirmitha I Herath
    Conjoint Gastroenterology Laboratory, Clinical Research Center, Royal Brisbane Hospital Research Foundation, The Queensland Institute of Medical Research, Queesland, Australia
    J Gastroenterol Hepatol 17:301-7. 2002
    ..05). No significant association between p14 and p53 was seen in this study. The reciprocal relationship identified indicates different pathways of tumorigenesis and likely reflects different etiologies of HCC in the two countries...
  32. ncbi request reprint Novel mutation in ferroportin1 is associated with autosomal dominant hemochromatosis
    Daniel F Wallace
    Queensland Institute of Medical Research, the Digestive Health Clinics, and the Department of Pathology, Royal Brisbane Hospital, Brisbane, Australia
    Blood 100:692-4. 2002
    ..We propose that this mutation disrupts the function of the ferroportin1 protein, leading to impaired iron homeostasis and iron overload...
  33. ncbi request reprint Concordance of iron indices in homozygote and heterozygote sibling pairs in hemochromatosis families: implications for family screening
    Peter W Whiting
    Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Brisbane, Australia
    J Hepatol 37:309-14. 2002
    ....
  34. ncbi request reprint Effects of body iron stores and haemochromatosis genotypes on coronary heart disease outcomes in the Busselton health study
    Christopher J Fox
    Department of Gastroenterology, Fremantle Hospital, Fremantle, Western Australia, Australia
    J Cardiovasc Risk 9:287-93. 2002
    ..The aims of this study were to determine in a stable community population whether increased iron stores or haemochromatosis gene mutations were risk factors for coronary heart disease...
  35. ncbi request reprint HFE and non-HFE hemochromatosis
    Gregory J Anderson
    The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Australia
    Int J Hematol 76:203-7. 2002
    ..Recently, other forms of HH have been described that are not related to HFE but are due to mutations in genes coding iron transport proteins...
  36. ncbi request reprint Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis
    Kim R Bridle
    Hepatic Fibrosis Group, Queensland Institute of Medical Research, Royal Brisbane Hospital, Queensland, Herston, Australia
    Lancet 361:669-73. 2003
    ..To investigate this possible association, we studied the hepatic expression of the gene for hepcidin (HAMP) and a gene important in iron transport (IREG1) in patients with haemochromatosis, in normal controls, and in Hfe-knockout mice...
  37. ncbi request reprint Relative importance of female-specific and non-female-specific effects on variation in iron stores between women
    John B Whitfield
    Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Sydney, Australia
    Br J Haematol 120:860-6. 2003
    ....
  38. ncbi request reprint Evidence for a sub-morphological inflammatory process in the liver in haemochromatosis
    Kim R Bridle
    Hepatic Fibrosis Group, Population Health and Clinical Sciences Division, The Queensland Institute of Medical Research, Post Office, Royal Brisbane Hospital, Herston, QLD 4029, Australia
    J Hepatol 38:426-33. 2003
    ..The aim of the current study was to examine the hepatic gene expression of potential proinflammatory and profibrogenic cytokines in haemochromatosis...
  39. ncbi request reprint A novel mutation in ferroportin implicated in iron overload
    Daniel F Wallace
    Membrane Transport Laboratory, The Queensland Institute of Medical Research, Brisbane, QLD, Australia
    J Hepatol 46:921-6. 2007
    ..In this study we examined the molecular basis of iron overload in an individual from New Zealand and characterised the molecular and cellular defect...
  40. doi request reprint Environmental and genetic modifiers of the progression to fibrosis and cirrhosis in hemochromatosis
    Marnie J Wood
    Hepatic Fibrosis Group, The Queensland Institute of Medical Research, Brisbane, Australia
    Blood 111:4456-62. 2008
    ..This review explores recent developments in knowledge of environmental and genetic modifiers of this process...