Research Topics
Genomes and Genes
| Dale R NyholtSummaryAffiliation: Queensland Institute of Medical Research Country: Australia Publications
| Collaborators
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Detail Information
Publications
Genome-wide association meta-analysis identifies new endometriosis risk lociDale R Nyholt
Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Nat Genet 44:1355-9. 2012..8 × 10(-11)), indicating that many weakly associated SNPs represent true endometriosis risk loci and that risk prediction and future targeted disease therapy may be transferred across these populations...
Using genomic data to make indirect (and unauthorized) estimates of disease riskD R Nyholt
Queensland Institute of Medical Research, Brisbane, QLD, Australia
Public Health Genomics 15:303-11. 2012....- A high-density association screen of 155 ion transport genes for involvement with common migraineDale R Nyholt
Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane4029, Queensland, Australia
Hum Mol Genet 17:3318-31. 2008..Multiple rare variants or trans-regulatory elements of these genes are not ruled out... 
On the probability of dizygotic twins being concordant for two alleles at multiple polymorphic lociDale R Nyholt
Queensland Institute of Medical Research, Brisbane, Australia
Twin Res Hum Genet 9:194-7. 2006..Numerous tools enabling convenient and accurate zygosity probability calculation may be accessed via the ZygProb homepage at http://genepi.qimr.edu.au/general/daleN/ZygProb/..- Sequence variants in three loci influence monocyte counts and erythrocyte volumeManuel A R Ferreira
Queensland Institute of Medical Research QIMR, Brisbane, QLD 4029, Australia
Am J Hum Genet 85:745-9. 2009..001, 9.9x10(-5), and 7x10(-5), respectively). The identification of these QTL provides new opportunities for furthering our understanding of the mechanisms regulating hemopoietic cell fate... - Common variants in the trichohyalin gene are associated with straight hair in EuropeansSarah E Medland
Queensland Institute of Medical Research, Brisbane 4029, Australia
Am J Hum Genet 85:750-5. 2009..5x10(-31)). These variants are at their highest frequency in Northern Europeans, paralleling the distribution of the straight-hair EDAR variant in Asian populations... - Common SNPs explain a large proportion of the heritability for human heightJian Yang
Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Nat Genet 42:565-9. 2010.... - High-density fine-mapping of a chromosome 10q26 linkage peak suggests association between endometriosis and variants close to CYP2C19Jodie N Painter
Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Fertil Steril 95:2236-40. 2011..To refine a previously reported linkage peak for endometriosis on chromosome 10q26, and conduct follow-up analyses and a fine-mapping association study across the region to identify new candidate genes for endometriosis... - Polymorphisms in the vascular endothelial growth factor gene and the risk of familial endometriosisZhen Zhen Zhao
Molecular Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
Mol Hum Reprod 14:531-8. 2008..Our detailed review and meta-analysis of the VEGF polymorphisms suggests that genotyping assay problems may underlie the previously reported associations between VEGF variants and endometriosis... - KRAS variation and risk of endometriosisZhen Zhen Zhao
Molecular Epidemiology Laboratory and Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Mol Hum Reprod 12:671-6. 2006..No germline variants for KRAS or BRAF were detected. Our results demonstrate that any risk of endometriosis in women because of common variation in KRAS must be very small... - The search for genes contributing to endometriosis riskGrant W Montgomery
Genetic and Molecular Epidemiology Laboratories, Queensland Institute of Medical Research, Royal Brisbane Hospital, 300 Herston Road, Brisbane, QLD 4029, Australia
Hum Reprod Update 14:447-57. 2008..Genetic variation contributes to the risk of developing endometriosis. This review summarizes gene mapping studies in endometriosis and the prospects of finding gene pathways contributing to disease using the latest genome-wide strategies... - Common variants in TMPRSS6 are associated with iron status and erythrocyte volumeBeben Benyamin
Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Nat Genet 41:1173-5. 2009..1 x 10(-10)). We also find suggestive evidence of association with blood hemoglobin levels (combined P = 5.3 x 10(-7)). These findings demonstrate the involvement of TMPRSS6 in control of iron homeostasis and in normal erythropoiesis... - Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in AustraliaManuel A R Ferreira
Queensland Institute of Medical Research, Brisbane, QLD, Australia
Eur J Hum Genet 19:458-64. 2011..In conclusion, we confirm the association between asthma risk and variants in ORMDL3 and identify a novel risk variant in IL1RL1. Follow-up of the 17q21 deletion in larger cohorts is warranted... - GWAS of butyrylcholinesterase activity identifies four novel loci, independent effects within BCHE and secondary associations with metabolic risk factorsBeben Benyamin
Queensland Institute of Medical Research, Brisbane 4006, Australia
Hum Mol Genet 20:4504-14. 2011..We conclude that variation in BCHE activity is due to multiple variants across the spectrum from uncommon/large effect to common/small effect, and partly results from (rather than causes) metabolic abnormalities... - A versatile gene-based test for genome-wide association studiesJimmy Z Liu
Genetics and Population Health Division, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia
Am J Hum Genet 87:139-45. 2010..We have implemented the approach in both an easy-to-use web interface, which only requires the uploading of markers with their association p-values, and a separate downloadable application... - Common genetic influences underlie comorbidity of migraine and endometriosisDale R Nyholt
Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, QLD, Australia
Genet Epidemiol 33:105-13. 2009..Finally, we propose that the analysis of such genetically correlated comorbid traits can increase power to detect genetic risk loci through the use of more specific, homogenous and heritable phenotypes... - Variants in EMX2 and PTEN do not contribute to risk of endometriosisSusan A Treloar
Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia, and Nuffield Department of Obstetrics and Gynaecology, University of Oxford, UK
Mol Hum Reprod 13:587-94. 2007..It is unlikely that the EMX2 or PTEN gene variants investigated contribute to risk for initiation and/or development of endometriosis... - Loci affecting gamma-glutamyl transferase in adults and adolescents show age × SNP interaction and cardiometabolic disease associationsRita P Middelberg
Queensland Institute of Medical Research, Brisbane, Australia
Hum Mol Genet 21:446-55. 2012..Our results reinforce the disease associations of GGT and demonstrate that control by the GGT1 locus varies with age... - Educational attainment: a genome wide association study in 9538 AustraliansNicolas W Martin
Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
PLoS ONE 6:e20128. 2011..8. This makes EA an attractive alternative phenotype for studies wishing to map genes affecting cognition due to the ease of collecting EA data compared to other cognitive phenotypes such as IQ... - Genetic influences on handedness: data from 25,732 Australian and Dutch twin familiesSarah E Medland
Queensland Institute of Medical Research, Australia
Neuropsychologia 47:330-7. 2009..17, 27.09%) with the remainder accounted for by non-shared environmental influences. The implications of these findings for handedness both as a primary phenotype and as a covariate in linkage and association analyses are discussed... - A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personalityKarin J H Verweij
Genetic Epidemiology, Molecular Epidemiology, and Queensland Statistical Genetics Laboratories, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Biol Psychol 85:306-17. 2010.... - Association study of the dystrobrevin-binding gene with schizophrenia in Australian and Indian samplesElizabeth G Holliday
Queensland Centre for Mental Health Research, The Park, Centre for Mental Health, Wacol, Queensland, Australia
Twin Res Hum Genet 9:531-9. 2006..More comprehensive studies in multiple samples will be required to determine whether specific DTNBP1 variants function as risk factors for schizophrenia... - Genome-wide association study identifies a locus at 7p15.2 associated with endometriosisJodie N Painter
Molecular Epidemiology, Queensland Institute of Medical Research, Herston, Queensland, Australia
Nat Genet 43:51-4. 2011..4 × 10⁻⁹ (OR = 1.20, 95% CI 1.13-1.27) for 'all' endometriosis in our combined datasets of 5,586 cases and 9,331 controls. rs12700667 is located in an intergenic region upstream of the plausible candidate genes NFE2L3 and HOXA10... - Linkage and heritability analysis of migraine symptom groupings: a comparison of three different clustering methods on twin dataCarla C M Chen
School of Mathematical Sciences, Queensland University of Technology, QLD, Australia
Hum Genet 125:591-604. 2009..We therefore urge caution in the use of any single approach and suggest that multiple phenotyping methods be used... - Genetic variation in tumour necrosis factor and lymphotoxin is not associated with endometriosis in an Australian sampleZhen Zhen Zhao
Molecular Epidemiology, Queensland Institute of Medical Research, 300 Herston Road, Herston, Brisbane, Queensland 4029, Australia
Hum Reprod 22:2389-97. 2007..Tumour necrosis factor (TNF) is a pleiotropic cytokine with a wide range of immunoregulatory effects. Variation in the promoter region of TNF and the neighbouring lymphotoxin alpha (LTA) gene might be associated with endometriosis... - Variation in BMPR1B, TGFRB1 and BMPR2 and control of dizygotic twinningHien T T Luong
Queensland Institute of Medical Research, Brisbane, Australia
Twin Res Hum Genet 14:408-16. 2011..Our results suggest that variation in the TGF9 signaling pathway type II receptors has limited effects on DZ twinning rates in humans... - Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune controlManuel A R Ferreira
Queensland Institute of Medical Research, Brisbane, QLD, Australia
Am J Hum Genet 86:88-92. 2010.... - Common variation in the fibroblast growth factor receptor 2 gene is not associated with endometriosis riskZhen Zhen Zhao
Molecular Epidemiology Laboratory, Queensland Institute of Medical Research, 300 Herston Rd, Herston, Brisbane, QLD 4029, Australia
Hum Reprod 23:1661-8. 2008..We therefore hypothesized that variation in FGFR2 may contribute to the risk of endometriosis... - A variant in LIN28B is associated with 2D:4D finger-length ratio, a putative retrospective biomarker of prenatal testosterone exposureSarah E Medland
Genetic Epidemiology, Queensland Institute of Medical Research, Australia
Am J Hum Genet 86:519-25. 2010..Our findings call into question the validity of 2D:4D as a simplistic retrospective biomarker for prenatal testosterone exposure... - Within-family outliers: segregating alleles or environmental effects? A linkage analysis of height from 5815 sibling pairsBeben Benyamin
Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
Eur J Hum Genet 16:516-24. 2008..We suggest that the effect of within-family outliers deserves further investigation via theoretical and simulation studies... - Evaluation of polymorphisms in predicted target sites for micro RNAs differentially expressed in endometriosisZhen Zhen Zhao
Queensland Institute of Medical Research, Herston, Brisbane, Queensland, Australia
Mol Hum Reprod 17:92-103. 2011..Replication studies in independent large sample sets to confirm and characterize the involvement of the gene variation in the pathogenesis of endometriosis are needed... - Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the NetherlandsNaomi R Wray
Department of Genetic Epidemiology, Queensland Institute of Medical Research, 300 Herston Rd, Brisbane, Australia 4029
Arch Gen Psychiatry 65:649-58. 2008..Studying this personality dimension can give insights into the etiology of these important psychiatric disorders... - A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptorEnda M Byrne
Queensland Institute of Medical Research, Brisbane, Australia
Sleep 35:967-75. 2012..To identify common genetic variants that predispose to caffeine-induced insomnia and to test whether genes whose expression changes in the presence of caffeine are enriched for association with caffeine-induced insomnia... - No evidence for genetic association with the let-7 microRNA-binding site or other common KRAS variants in risk of endometriosisHien T T Luong
Genetics and Computational Biology Division, Queensland Institute of Medical Research, Royal Brisbane Hospital, Locked Bag 2000, Brisbane, QLD 4029 Australia
Hum Reprod 27:3616-21. 2012..STUDY FUNDING/COMPETING INTEREST(S): The research was funded by grants from the Australian National Health and Medical Research Council and Wellcome Trust. None of the authors has competing interests for the study... - A simple and fast two-locus quality control test to detect false positives due to batch effects in genome-wide association studiesSang Hong Lee
Queensland Institute of Medical Research, Herston, Queensland, Australia
Genet Epidemiol 34:854-62. 2010..This novel QC approach is easy to implement and computationally efficient, and can lead to a better quality of genotypes for subsequent genotype-phenotype investigations... - Association mappingJodie N Painter
Queensland Institute of Medical Research, Brisbane, QLD, Australia
Methods Mol Biol 760:35-52. 2011.... - Identification of IL6R and chromosome 11q13.5 as risk loci for asthmaManuel A R Ferreira
The Queensland Institute of Medical Research, Brisbane, QLD, Australia
Lancet 378:1006-14. 2011..We aimed to identify novel genetic variants affecting asthma risk, since these might provide novel insights into molecular mechanisms underlying the disease... - Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3Stuart Macgregor
Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Nat Genet 43:1114-8. 2011..3 locus span a region with ten genes, and plausible candidate genes for melanoma susceptibility include ARNT and SETDB1. Variants at the 1q21.3 locus do not seem to be associated with human pigmentation or measures of nevus density... - ssSNPer: identifying statistically similar SNPs to aid interpretation of genetic association studiesDale R Nyholt
Genetic Epidemiology Laboratory, QIMR 300 Herston Road, Brisbane, Queensland, 4006, Australia
Bioinformatics 22:2960-1. 2006..Identification of ssSNPs can have crucial implications for the interpretation of the initial association results and the design of follow-up studies. AVAILABILITY: http://fraser.qimr.edu.au/general/daleN/ssSNPer/.. - Genomewide significant linkage to migrainous headache on chromosome 5q21Dale R Nyholt
Queensland Institute of Medical Research, Brisbane, Australia
Am J Hum Genet 77:500-12. 2005..These results will prove to be invaluable in the design and analysis of future linkage and linkage disequilibrium studies of migraine... - FTO genotype is associated with phenotypic variability of body mass indexJian Yang
University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia
Nature 490:267-72. 2012.... - Evaluation of Nyholt's procedure for multiple testing correction - author's replyDale R Nyholt
Queensland Institute of Medical Research, Brisbane, Australia
Hum Hered 60:61-2. 2005 - Latent class and genetic analysis does not support migraine with aura and migraine without aura as separate entitiesDale R Nyholt
Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Genet Epidemiol 26:231-44. 2004.... - Bayesian latent trait modeling of migraine symptom dataCarla Chia Ming Chen
School of Mathematical Sciences, Queensland University of Technology, QLD, Australia
Hum Genet 126:277-88. 2009..We argue that such continuous measures are a powerful tool for identifying genes contributing to migraine susceptibility... - A comparison of DNA pools constructed following whole genome amplification for two-stage SNP genotyping designsZhen Zhen Zhao
Molecular Epidemiology and Genetic Epidemiology Laboratories, Queensland Institute of Medical Research, Brisbane, Australia
Twin Res Hum Genet 8:353-61. 2005..With current levels of accuracy, pooling is best suited to an initial screen in the SNP validation process that can provide high-throughput comparisons between cases and controls to prioritize SNPs for subsequent individual genotyping... - A typical migraine susceptibility region localizes to chromosome 1q31Rod A Lea
Genomics Research Centre, School of Health Sciences, Griffith University, Southport, Queensland, Australia
Neurogenetics 4:17-22. 2002.... - GENEHUNTER: your 'one-stop shop' for statistical genetic analysis?Dale R Nyholt
Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, Brisbane, Australia
Hum Hered 53:2-7. 2002..To help researchers answer this question, the following software review aims to summarize the main advantages and disadvantages of the popular GENEHUNTER package... - Genomewide linkage study in 1,176 affected sister pair families identifies a significant susceptibility locus for endometriosis on chromosome 10q26Susan A Treloar
Cooperative Research Centre for Discovery of Genes for Common Human Diseases, Melbourne, Australia
Am J Hum Genet 77:365-76. 2005..Greater understanding of the aberrant cellular and molecular mechanisms involved in the etiology and pathophysiology of endometriosis should lead to better diagnostic methods and targeted treatments... - Genomic inflation factors under polygenic inheritanceJian Yang
Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Eur J Hum Genet 19:807-12. 2011..Our predictions are consistent with empirical observations on height in independent samples of ~4000 and ~133,000 individuals... - A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each otherDale R Nyholt
Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Am J Hum Genet 74:765-9. 2004.... - Heritability and genome-wide linkage analysis of migraine in the genetic isolate of Norfolk IslandHannah C Cox
Genomics Research Centre, Griffith Health Institute, Gold Coast Campus, Griffith University, Queensland, Australia
Gene 494:119-23. 2012..05). In conclusion, a genome-wide linkage analysis and follow-up association analysis of migraine in the genetic isolate of Norfolk Island provided evidence for migraine susceptibility loci on chromosomes 9q22.22 and 13q33.1... - Genome-wide association studies of quantitative traits with related individuals: little (power) lost but much to be gainedPeter M Visscher
Genetic Epidemiology, Queensland Institute of Medical Research, Herston, Brisbane, Australia
Eur J Hum Genet 16:387-90. 2008..Therefore, the advantages of using relatives in GWAS for quantitative traits may well outweigh the small disadvantage in terms of statistical power... - Zygosity diagnosis in the absence of genotypic data: an approach using latent class analysisAndrew C Heath
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63108, USA
Twin Res 6:22-6. 2003..In the absence of genotypic data, or as a safeguard against sample duplication, application of LCA for zygosity assignment or confirmation is strongly recommended... - Consistently replicating locus linked to migraine on 10q22-q23Verneri Anttila
Biomedicum Helsinki, Research Program in Molecular Medicine, University of Helsinki, 00290 Helsinki, Finland
Am J Hum Genet 82:1051-63. 2008..These results support the use of symptomology-based phenotyping in migraine and suggest that the 10q22-q23 locus probably contains one or more migraine susceptibility variants... - Genetic and environmental influences on migraine: a twin study across six countriesElles J Mulder
Dept of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
Twin Res 6:422-31. 2003..After migraine definitions are homogenized among the participating countries, the GenomEUtwin project will provide a powerful resource to identify the genes involved in migraine... - A genome-wide linkage scan provides evidence for both new and previously reported loci influencing common migraineLannie Ligthart
Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
Am J Med Genet B Neuropsychiatr Genet 147:1186-95. 2008..Additionally, our novel "2-step" analysis and simulation approach provides a powerful means to investigate linkage to individual trait components... - Significant evidence of one or more susceptibility loci for endometriosis with near-Mendelian inheritance on chromosome 7p13-15Krina T Zondervan
Wellcome Trust Centre for Human Genetics, University of Oxford, UK
Hum Reprod 22:717-28. 2007..The aim was to investigate whether the apparent concentration of cases in a proportion of families could be explained by one or more rare variants with (near-)Mendelian autosomal inheritance... - Personality, health and lifestyle in a questionnaire family study: a comparison between highly cooperative and less cooperative familiesMarijn A Distel
Department of Biological Psychology, VU University, Amsterdam, The Netherlands
Twin Res Hum Genet 10:348-53. 2007..001). However, the absolute difference in mean scores is very small, less than 1 point for a scale ranging from 0 to 72. In conclusion, survey data on personality, health and lifestyle are relatively unbiased with respect to nonresponse... - Migraine with aura and migraine without aura are not distinct entities: further evidence from a large Dutch population studyLannie Ligthart
Department of Biological Psychology, Vrije Universiteit, Amsterdam, Netherlands
Twin Res Hum Genet 9:54-63. 2006..The heritability of the screening question was similar to more detailed LCA and IHS classifications, suggesting that the screening procedure is an important determining factor in genetic studies of migraine... - A report of dizygous monochorionic twinsVivienne L Souter
Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, USA
N Engl J Med 349:154-8. 2003 - A case of true hermaphroditism reveals an unusual mechanism of twinningVivienne L Souter
Department of Obstetrics and Gynecology, Banner Good Samaritan Medical Center, Phoenix, AZ 85006, USA
Hum Genet 121:179-85. 2007..The twins are chimeric and share a single genetic contribution from their mother but have two genetic contributions from their father thus supporting the existence of a third, previously unreported type of twinning... - Genetic basis of male pattern baldnessDale R Nyholt
J Invest Dermatol 121:1561-4. 2003