Dale R Nyholt

Summary

Affiliation: Queensland Institute of Medical Research
Country: Australia

Publications

  1. ncbi request reprint GENEHUNTER: your 'one-stop shop' for statistical genetic analysis?
    Dale R Nyholt
    Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, Brisbane, Australia
    Hum Hered 53:2-7. 2002
  2. pmc Common genetic influences underlie comorbidity of migraine and endometriosis
    Dale R Nyholt
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, QLD, Australia
    Genet Epidemiol 33:105-13. 2009
  3. pmc Genomewide significant linkage to migrainous headache on chromosome 5q21
    Dale R Nyholt
    Queensland Institute of Medical Research, Brisbane, Australia
    Am J Hum Genet 77:500-12. 2005
  4. ncbi request reprint ssSNPer: identifying statistically similar SNPs to aid interpretation of genetic association studies
    Dale R Nyholt
    Genetic Epidemiology Laboratory, QIMR 300 Herston Road, Brisbane, Queensland, 4006, Australia
    Bioinformatics 22:2960-1. 2006
  5. ncbi request reprint Latent class and genetic analysis does not support migraine with aura and migraine without aura as separate entities
    Dale R Nyholt
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Genet Epidemiol 26:231-44. 2004
  6. pmc A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other
    Dale R Nyholt
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Am J Hum Genet 74:765-9. 2004
  7. pmc Sequence variants in three loci influence monocyte counts and erythrocyte volume
    Manuel A R Ferreira
    Queensland Institute of Medical Research QIMR, Brisbane, QLD 4029, Australia
    Am J Hum Genet 85:745-9. 2009
  8. pmc Common variants in the trichohyalin gene are associated with straight hair in Europeans
    Sarah E Medland
    Queensland Institute of Medical Research, Brisbane 4029, Australia
    Am J Hum Genet 85:750-5. 2009
  9. pmc Common SNPs explain a large proportion of the heritability for human height
    Jian Yang
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Nat Genet 42:565-9. 2010
  10. pmc Genome-wide association meta-analysis identifies new endometriosis risk loci
    Dale R Nyholt
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Nat Genet 44:1355-9. 2012

Collaborators

Detail Information

Publications66

  1. ncbi request reprint GENEHUNTER: your 'one-stop shop' for statistical genetic analysis?
    Dale R Nyholt
    Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, Brisbane, Australia
    Hum Hered 53:2-7. 2002
    ..To help researchers answer this question, the following software review aims to summarize the main advantages and disadvantages of the popular GENEHUNTER package...
  2. pmc Common genetic influences underlie comorbidity of migraine and endometriosis
    Dale R Nyholt
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, QLD, Australia
    Genet Epidemiol 33:105-13. 2009
    ..Finally, we propose that the analysis of such genetically correlated comorbid traits can increase power to detect genetic risk loci through the use of more specific, homogenous and heritable phenotypes...
  3. pmc Genomewide significant linkage to migrainous headache on chromosome 5q21
    Dale R Nyholt
    Queensland Institute of Medical Research, Brisbane, Australia
    Am J Hum Genet 77:500-12. 2005
    ..These results will prove to be invaluable in the design and analysis of future linkage and linkage disequilibrium studies of migraine...
  4. ncbi request reprint ssSNPer: identifying statistically similar SNPs to aid interpretation of genetic association studies
    Dale R Nyholt
    Genetic Epidemiology Laboratory, QIMR 300 Herston Road, Brisbane, Queensland, 4006, Australia
    Bioinformatics 22:2960-1. 2006
    ..Identification of ssSNPs can have crucial implications for the interpretation of the initial association results and the design of follow-up studies...
  5. ncbi request reprint Latent class and genetic analysis does not support migraine with aura and migraine without aura as separate entities
    Dale R Nyholt
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Genet Epidemiol 26:231-44. 2004
    ....
  6. pmc A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other
    Dale R Nyholt
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Am J Hum Genet 74:765-9. 2004
    ..Additionally, output from SNPSpD includes eigenvalues, principal-component coefficients, and factor "loadings" after varimax rotation, enabling the selection of a subset of SNPs that optimize the information in a genomic region...
  7. pmc Sequence variants in three loci influence monocyte counts and erythrocyte volume
    Manuel A R Ferreira
    Queensland Institute of Medical Research QIMR, Brisbane, QLD 4029, Australia
    Am J Hum Genet 85:745-9. 2009
    ..001, 9.9x10(-5), and 7x10(-5), respectively). The identification of these QTL provides new opportunities for furthering our understanding of the mechanisms regulating hemopoietic cell fate...
  8. pmc Common variants in the trichohyalin gene are associated with straight hair in Europeans
    Sarah E Medland
    Queensland Institute of Medical Research, Brisbane 4029, Australia
    Am J Hum Genet 85:750-5. 2009
    ..5x10(-31)). These variants are at their highest frequency in Northern Europeans, paralleling the distribution of the straight-hair EDAR variant in Asian populations...
  9. pmc Common SNPs explain a large proportion of the heritability for human height
    Jian Yang
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Nat Genet 42:565-9. 2010
    ....
  10. pmc Genome-wide association meta-analysis identifies new endometriosis risk loci
    Dale R Nyholt
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Nat Genet 44:1355-9. 2012
    ..8 × 10(-11)), indicating that many weakly associated SNPs represent true endometriosis risk loci and that risk prediction and future targeted disease therapy may be transferred across these populations...
  11. pmc High-density fine-mapping of a chromosome 10q26 linkage peak suggests association between endometriosis and variants close to CYP2C19
    Jodie N Painter
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Fertil Steril 95:2236-40. 2011
    ..To refine a previously reported linkage peak for endometriosis on chromosome 10q26, and conduct follow-up analyses and a fine-mapping association study across the region to identify new candidate genes for endometriosis...
  12. doi request reprint Polymorphisms in the vascular endothelial growth factor gene and the risk of familial endometriosis
    Zhen Zhen Zhao
    Molecular Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
    Mol Hum Reprod 14:531-8. 2008
    ..Our detailed review and meta-analysis of the VEGF polymorphisms suggests that genotyping assay problems may underlie the previously reported associations between VEGF variants and endometriosis...
  13. pmc Inference of the genetic architecture underlying BMI and height with the use of 20,240 sibling pairs
    Gibran Hemani
    The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD 4102, Australia The University of Queensland, Queensland Brain Institute, Brisbane, QLD 4027, Australia
    Am J Hum Genet 93:865-75. 2013
    ....
  14. ncbi request reprint KRAS variation and risk of endometriosis
    Zhen Zhen Zhao
    Molecular Epidemiology Laboratory and Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Mol Hum Reprod 12:671-6. 2006
    ..No germline variants for KRAS or BRAF were detected. Our results demonstrate that any risk of endometriosis in women because of common variation in KRAS must be very small...
  15. pmc No evidence for genetic association with the let-7 microRNA-binding site or other common KRAS variants in risk of endometriosis
    Hien T T Luong
    Genetics and Computational Biology Division, Queensland Institute of Medical Research, Royal Brisbane Hospital, Locked Bag 2000, Brisbane, QLD 4029 Australia
    Hum Reprod 27:3616-21. 2012
    ..Is there a contribution of the minor allele at the KRAS single nucleotide polymorphism (SNP) rs61764370 in the let-7 microRNA-binding site to endometriosis risk?..
  16. pmc Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia
    Manuel A R Ferreira
    Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Eur J Hum Genet 19:458-64. 2011
    ..In conclusion, we confirm the association between asthma risk and variants in ORMDL3 and identify a novel risk variant in IL1RL1. Follow-up of the 17q21 deletion in larger cohorts is warranted...
  17. pmc GWAS of butyrylcholinesterase activity identifies four novel loci, independent effects within BCHE and secondary associations with metabolic risk factors
    Beben Benyamin
    Queensland Institute of Medical Research, Brisbane 4006, Australia
    Hum Mol Genet 20:4504-14. 2011
    ..We conclude that variation in BCHE activity is due to multiple variants across the spectrum from uncommon/large effect to common/small effect, and partly results from (rather than causes) metabolic abnormalities...
  18. pmc Common variants in TMPRSS6 are associated with iron status and erythrocyte volume
    Beben Benyamin
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Nat Genet 41:1173-5. 2009
    ..1 x 10(-10)). We also find suggestive evidence of association with blood hemoglobin levels (combined P = 5.3 x 10(-7)). These findings demonstrate the involvement of TMPRSS6 in control of iron homeostasis and in normal erythropoiesis...
  19. ncbi request reprint Variants in EMX2 and PTEN do not contribute to risk of endometriosis
    Susan A Treloar
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia, and Nuffield Department of Obstetrics and Gynaecology, University of Oxford, UK
    Mol Hum Reprod 13:587-94. 2007
    ..It is unlikely that the EMX2 or PTEN gene variants investigated contribute to risk for initiation and/or development of endometriosis...
  20. pmc A versatile gene-based test for genome-wide association studies
    Jimmy Z Liu
    Genetics and Population Health Division, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia
    Am J Hum Genet 87:139-45. 2010
    ..We have implemented the approach in both an easy-to-use web interface, which only requires the uploading of markers with their association p-values, and a separate downloadable application...
  21. pmc The search for genes contributing to endometriosis risk
    Grant W Montgomery
    Genetic and Molecular Epidemiology Laboratories, Queensland Institute of Medical Research, Royal Brisbane Hospital, 300 Herston Road, Brisbane, QLD 4029, Australia
    Hum Reprod Update 14:447-57. 2008
    ..Genetic variation contributes to the risk of developing endometriosis. This review summarizes gene mapping studies in endometriosis and the prospects of finding gene pathways contributing to disease using the latest genome-wide strategies...
  22. pmc Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis
    S Hong Lee
    The University of Queensland, Queensland Brain Institute, Brisbane, QLD 4072, Australia
    Hum Mol Genet 22:832-41. 2013
    ..We provide strong evidence that a substantial proportion of variation in liability is explained by common SNPs, and thereby give insights into the genetic architecture of the diseases...
  23. pmc Loci affecting gamma-glutamyl transferase in adults and adolescents show age × SNP interaction and cardiometabolic disease associations
    Rita P Middelberg
    Queensland Institute of Medical Research, Brisbane, Australia
    Hum Mol Genet 21:446-55. 2012
    ..Our results reinforce the disease associations of GGT and demonstrate that control by the GGT1 locus varies with age...
  24. doi request reprint Within-family outliers: segregating alleles or environmental effects? A linkage analysis of height from 5815 sibling pairs
    Beben Benyamin
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
    Eur J Hum Genet 16:516-24. 2008
    ..We suggest that the effect of within-family outliers deserves further investigation via theoretical and simulation studies...
  25. pmc Educational attainment: a genome wide association study in 9538 Australians
    Nicolas W Martin
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    PLoS ONE 6:e20128. 2011
    ..8. This makes EA an attractive alternative phenotype for studies wishing to map genes affecting cognition due to the ease of collecting EA data compared to other cognitive phenotypes such as IQ...
  26. pmc A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality
    Karin J H Verweij
    Genetic Epidemiology, Molecular Epidemiology, and Queensland Statistical Genetics Laboratories, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Biol Psychol 85:306-17. 2010
    ....
  27. pmc Genetic influences on handedness: data from 25,732 Australian and Dutch twin families
    Sarah E Medland
    Queensland Institute of Medical Research, Australia
    Neuropsychologia 47:330-7. 2009
    ..17, 27.09%) with the remainder accounted for by non-shared environmental influences. The implications of these findings for handedness both as a primary phenotype and as a covariate in linkage and association analyses are discussed...
  28. pmc A genome-wide association study of sleep habits and insomnia
    Enda M Byrne
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Am J Med Genet B Neuropsychiatr Genet 162:439-51. 2013
    ..We did not replicate the results from previous genome-wide analyses of self-reported sleep phenotypes after correction for multiple testing...
  29. pmc Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control
    Manuel A R Ferreira
    Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Am J Hum Genet 86:88-92. 2010
    ....
  30. pmc A variant in LIN28B is associated with 2D:4D finger-length ratio, a putative retrospective biomarker of prenatal testosterone exposure
    Sarah E Medland
    Genetic Epidemiology, Queensland Institute of Medical Research, Australia
    Am J Hum Genet 86:519-25. 2010
    ..Our findings call into question the validity of 2D:4D as a simplistic retrospective biomarker for prenatal testosterone exposure...
  31. doi request reprint Variation in BMPR1B, TGFRB1 and BMPR2 and control of dizygotic twinning
    Hien T T Luong
    Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 14:408-16. 2011
    ..Our results suggest that variation in the TGF9 signaling pathway type II receptors has limited effects on DZ twinning rates in humans...
  32. pmc Common variation in the fibroblast growth factor receptor 2 gene is not associated with endometriosis risk
    Zhen Zhen Zhao
    Molecular Epidemiology Laboratory, Queensland Institute of Medical Research, 300 Herston Rd, Herston, Brisbane, QLD 4029, Australia
    Hum Reprod 23:1661-8. 2008
    ..We therefore hypothesized that variation in FGFR2 may contribute to the risk of endometriosis...
  33. pmc Evaluation of polymorphisms in predicted target sites for micro RNAs differentially expressed in endometriosis
    Zhen Zhen Zhao
    Queensland Institute of Medical Research, Herston, Brisbane, Queensland, Australia
    Mol Hum Reprod 17:92-103. 2011
    ..Replication studies in independent large sample sets to confirm and characterize the involvement of the gene variation in the pathogenesis of endometriosis are needed...
  34. ncbi request reprint Genetic variation in tumour necrosis factor and lymphotoxin is not associated with endometriosis in an Australian sample
    Zhen Zhen Zhao
    Molecular Epidemiology, Queensland Institute of Medical Research, 300 Herston Road, Herston, Brisbane, Queensland 4029, Australia
    Hum Reprod 22:2389-97. 2007
    ..Tumour necrosis factor (TNF) is a pleiotropic cytokine with a wide range of immunoregulatory effects. Variation in the promoter region of TNF and the neighbouring lymphotoxin alpha (LTA) gene might be associated with endometriosis...
  35. doi request reprint Linkage and heritability analysis of migraine symptom groupings: a comparison of three different clustering methods on twin data
    Carla C M Chen
    School of Mathematical Sciences, Queensland University of Technology, QLD, Australia
    Hum Genet 125:591-604. 2009
    ..We therefore urge caution in the use of any single approach and suggest that multiple phenotyping methods be used...
  36. pmc A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor
    Enda M Byrne
    Queensland Institute of Medical Research, Brisbane, Australia
    Sleep 35:967-75. 2012
    ..To identify common genetic variants that predispose to caffeine-induced insomnia and to test whether genes whose expression changes in the presence of caffeine are enriched for association with caffeine-induced insomnia...
  37. doi request reprint Association mapping
    Jodie N Painter
    Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Methods Mol Biol 760:35-52. 2011
    ....
  38. pmc Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the Netherlands
    Naomi R Wray
    Department of Genetic Epidemiology, Queensland Institute of Medical Research, 300 Herston Rd, Brisbane, Australia 4029
    Arch Gen Psychiatry 65:649-58. 2008
    ..Studying this personality dimension can give insights into the etiology of these important psychiatric disorders...
  39. pmc Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis
    Jodie N Painter
    Molecular Epidemiology, Queensland Institute of Medical Research, Herston, Queensland, Australia
    Nat Genet 43:51-4. 2011
    ..4 × 10⁻⁹ (OR = 1.20, 95% CI 1.13-1.27) for 'all' endometriosis in our combined datasets of 5,586 cases and 9,331 controls. rs12700667 is located in an intergenic region upstream of the plausible candidate genes NFE2L3 and HOXA10...
  40. pmc Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
    S Hong Lee
    The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, Australia
    Nat Genet 45:984-94. 2013
    ..This empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders. ..
  41. ncbi request reprint Association study of the dystrobrevin-binding gene with schizophrenia in Australian and Indian samples
    Elizabeth G Holliday
    Queensland Centre for Mental Health Research, The Park, Centre for Mental Health, Wacol, Queensland, Australia
    Twin Res Hum Genet 9:531-9. 2006
    ..More comprehensive studies in multiple samples will be required to determine whether specific DTNBP1 variants function as risk factors for schizophrenia...
  42. ncbi request reprint On the probability of dizygotic twins being concordant for two alleles at multiple polymorphic loci
    Dale R Nyholt
    Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 9:194-7. 2006
    ..Numerous tools enabling convenient and accurate zygosity probability calculation may be accessed via the ZygProb homepage at http://genepi.qimr.edu.au/general/daleN/ZygProb/..
  43. pmc A high-density association screen of 155 ion transport genes for involvement with common migraine
    Dale R Nyholt
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane4029, Queensland, Australia
    Hum Mol Genet 17:3318-31. 2008
    ..Multiple rare variants or trans-regulatory elements of these genes are not ruled out...
  44. pmc Identification of IL6R and chromosome 11q13.5 as risk loci for asthma
    Manuel A R Ferreira
    The Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Lancet 378:1006-14. 2011
    ..We aimed to identify novel genetic variants affecting asthma risk, since these might provide novel insights into molecular mechanisms underlying the disease...
  45. pmc Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3
    Stuart Macgregor
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Nat Genet 43:1114-8. 2011
    ..3 locus span a region with ten genes, and plausible candidate genes for melanoma susceptibility include ARNT and SETDB1. Variants at the 1q21.3 locus do not seem to be associated with human pigmentation or measures of nevus density...
  46. pmc FTO genotype is associated with phenotypic variability of body mass index
    Jian Yang
    University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia
    Nature 490:267-72. 2012
    ....
  47. ncbi request reprint A comparison of DNA pools constructed following whole genome amplification for two-stage SNP genotyping designs
    Zhen Zhen Zhao
    Molecular Epidemiology and Genetic Epidemiology Laboratories, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 8:353-61. 2005
    ..With current levels of accuracy, pooling is best suited to an initial screen in the SNP validation process that can provide high-throughput comparisons between cases and controls to prioritize SNPs for subsequent individual genotyping...
  48. pmc A simple and fast two-locus quality control test to detect false positives due to batch effects in genome-wide association studies
    Sang Hong Lee
    Queensland Institute of Medical Research, Herston, Queensland, Australia
    Genet Epidemiol 34:854-62. 2010
    ..This novel QC approach is easy to implement and computationally efficient, and can lead to a better quality of genotypes for subsequent genotype-phenotype investigations...
  49. pmc Heritability and genome-wide linkage analysis of migraine in the genetic isolate of Norfolk Island
    Hannah C Cox
    Genomics Research Centre, Griffith Health Institute, Gold Coast Campus, Griffith University, Queensland, Australia
    Gene 494:119-23. 2012
    ..05). In conclusion, a genome-wide linkage analysis and follow-up association analysis of migraine in the genetic isolate of Norfolk Island provided evidence for migraine susceptibility loci on chromosomes 9q22.22 and 13q33.1...
  50. ncbi request reprint Evaluation of Nyholt's procedure for multiple testing correction - author's reply
    Dale R Nyholt
    Queensland Institute of Medical Research, Brisbane, Australia
    Hum Hered 60:61-2. 2005
  51. doi request reprint Bayesian latent trait modeling of migraine symptom data
    Carla Chia Ming Chen
    School of Mathematical Sciences, Queensland University of Technology, QLD, Australia
    Hum Genet 126:277-88. 2009
    ..We argue that such continuous measures are a powerful tool for identifying genes contributing to migraine susceptibility...
  52. pmc Genomewide linkage study in 1,176 affected sister pair families identifies a significant susceptibility locus for endometriosis on chromosome 10q26
    Susan A Treloar
    Cooperative Research Centre for Discovery of Genes for Common Human Diseases, Melbourne, Australia
    Am J Hum Genet 77:365-76. 2005
    ..Greater understanding of the aberrant cellular and molecular mechanisms involved in the etiology and pathophysiology of endometriosis should lead to better diagnostic methods and targeted treatments...
  53. pmc Genomic inflation factors under polygenic inheritance
    Jian Yang
    Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Eur J Hum Genet 19:807-12. 2011
    ..Our predictions are consistent with empirical observations on height in independent samples of ~4000 and ~133,000 individuals...
  54. doi request reprint Genome-wide association studies of quantitative traits with related individuals: little (power) lost but much to be gained
    Peter M Visscher
    Genetic Epidemiology, Queensland Institute of Medical Research, Herston, Brisbane, Australia
    Eur J Hum Genet 16:387-90. 2008
    ..Therefore, the advantages of using relatives in GWAS for quantitative traits may well outweigh the small disadvantage in terms of statistical power...
  55. ncbi request reprint A typical migraine susceptibility region localizes to chromosome 1q31
    Rod A Lea
    Genomics Research Centre, School of Health Sciences, Griffith University, Southport, Queensland, Australia
    Neurogenetics 4:17-22. 2002
    ....
  56. doi request reprint The shared genetics of migraine and anxious depression
    Lannie Ligthart
    Department of Biological Psychology, VU University, Van der Boechorststraat 1, Amsterdam, The Netherlands
    Headache 50:1549-60. 2010
    ....
  57. ncbi request reprint Significant evidence of one or more susceptibility loci for endometriosis with near-Mendelian inheritance on chromosome 7p13-15
    Krina T Zondervan
    Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Hum Reprod 22:717-28. 2007
    ..The aim was to investigate whether the apparent concentration of cases in a proportion of families could be explained by one or more rare variants with (near-)Mendelian autosomal inheritance...
  58. ncbi request reprint Personality, health and lifestyle in a questionnaire family study: a comparison between highly cooperative and less cooperative families
    Marijn A Distel
    Department of Biological Psychology, VU University, Amsterdam, The Netherlands
    Twin Res Hum Genet 10:348-53. 2007
    ..001). However, the absolute difference in mean scores is very small, less than 1 point for a scale ranging from 0 to 72. In conclusion, survey data on personality, health and lifestyle are relatively unbiased with respect to nonresponse...
  59. ncbi request reprint Zygosity diagnosis in the absence of genotypic data: an approach using latent class analysis
    Andrew C Heath
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63108, USA
    Twin Res 6:22-6. 2003
    ..In the absence of genotypic data, or as a safeguard against sample duplication, application of LCA for zygosity assignment or confirmation is strongly recommended...
  60. doi request reprint A genome-wide linkage scan provides evidence for both new and previously reported loci influencing common migraine
    Lannie Ligthart
    Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 147:1186-95. 2008
    ..Additionally, our novel "2-step" analysis and simulation approach provides a powerful means to investigate linkage to individual trait components...
  61. ncbi request reprint Migraine with aura and migraine without aura are not distinct entities: further evidence from a large Dutch population study
    Lannie Ligthart
    Department of Biological Psychology, Vrije Universiteit, Amsterdam, Netherlands
    Twin Res Hum Genet 9:54-63. 2006
    ..The heritability of the screening question was similar to more detailed LCA and IHS classifications, suggesting that the screening procedure is an important determining factor in genetic studies of migraine...
  62. pmc Consistently replicating locus linked to migraine on 10q22-q23
    Verneri Anttila
    Biomedicum Helsinki, Research Program in Molecular Medicine, University of Helsinki, 00290 Helsinki, Finland
    Am J Hum Genet 82:1051-63. 2008
    ..These results support the use of symptomology-based phenotyping in migraine and suggest that the 10q22-q23 locus probably contains one or more migraine susceptibility variants...
  63. ncbi request reprint Genetic and environmental influences on migraine: a twin study across six countries
    Elles J Mulder
    Dept of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
    Twin Res 6:422-31. 2003
    ..After migraine definitions are homogenized among the participating countries, the GenomEUtwin project will provide a powerful resource to identify the genes involved in migraine...
  64. ncbi request reprint A case of true hermaphroditism reveals an unusual mechanism of twinning
    Vivienne L Souter
    Department of Obstetrics and Gynecology, Banner Good Samaritan Medical Center, Phoenix, AZ 85006, USA
    Hum Genet 121:179-85. 2007
    ..The twins are chimeric and share a single genetic contribution from their mother but have two genetic contributions from their father thus supporting the existence of a third, previously unreported type of twinning...
  65. ncbi request reprint A report of dizygous monochorionic twins
    Vivienne L Souter
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, USA
    N Engl J Med 349:154-8. 2003
  66. ncbi request reprint Genetic basis of male pattern baldness
    Dale R Nyholt
    J Invest Dermatol 121:1561-4. 2003