D P McManus

Summary

Affiliation: Queensland Institute of Medical Research
Country: Australia

Publications

  1. pmc Echinococcus granulosus infection and options for control of cystic echinococcosis in Tibetan communities of Western Sichuan Province, China
    Yu Rong Yang
    Molecular Parasitology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    PLoS Negl Trop Dis 3:e426. 2009
  2. pmc A cluster-randomised intervention trial against Schistosoma japonicum in the Peoples' Republic of China: bovine and human transmission
    Darren J Gray
    Molecular Parasitology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    PLoS ONE 4:e5900. 2009
  3. pmc Transmission dynamics of Schistosoma japonicum in the lakes and marshlands of China
    Darren J Gray
    Molecular Parasitology Laboratory, Queensland Institute of Medical Research, Herston, Brisbane, Queensland, Australia
    PLoS ONE 3:e4058. 2008
  4. pmc Recombinant antigens for immunodiagnosis of cystic echinococcosis
    Jun Li
    Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research 300 Herston Road, Herston, Brisbane, Queensland 4029 Australia
    Biol Proced Online 6:67-77. 2004
  5. pmc Cloning and characterisation of Schistosoma japonicum insulin receptors
    Hong You
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    PLoS ONE 5:e9868. 2010
  6. pmc Inconsistent protective efficacy and marked polymorphism limits the value of Schistosoma japonicum tetraspanin-2 as a vaccine target
    Wenbao Zhang
    Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    PLoS Negl Trop Dis 5:e1166. 2011
  7. pmc Echinococcosis, Ningxia, China
    Yu Rong Yang
    Emerg Infect Dis 11:1314-6. 2005
  8. pmc Impact of anthropogenic and natural environmental changes on Echinococcus transmission in Ningxia Hui Autonomous Region, the People's Republic of China
    Yu Rong Yang
    Molecular Parasitology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Parasit Vectors 5:146. 2012
  9. pmc Case studies emphasising the difficulties in the diagnosis and management of alveolar echinococcosis in rural China
    Donald P McManus
    Queensland Institute of Medical Research, Herston, Brisbane, Australia
    Parasit Vectors 4:196. 2011
  10. pmc Hepatic stellate cells and parasite-induced liver fibrosis
    Barrie Anthony
    Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, Brisbane, Q 4029, Australia
    Parasit Vectors 3:60. 2010

Collaborators

Detail Information

Publications156 found, 100 shown here

  1. pmc Echinococcus granulosus infection and options for control of cystic echinococcosis in Tibetan communities of Western Sichuan Province, China
    Yu Rong Yang
    Molecular Parasitology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    PLoS Negl Trop Dis 3:e426. 2009
    ..The poor sanitation and hygiene, the Buddhist doctrine of allowing old livestock to die naturally, plus the unrestricted disposal of animal viscera post-slaughter may be responsible for the high prevalence of human CE in this setting...
  2. pmc A cluster-randomised intervention trial against Schistosoma japonicum in the Peoples' Republic of China: bovine and human transmission
    Darren J Gray
    Molecular Parasitology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    PLoS ONE 4:e5900. 2009
    ..Preliminary results (1998-2003) of a praziquantel (PZQ)-based pilot intervention study we undertook provided proof of principle that water buffaloes are major reservoir hosts for S. japonicum in the Poyang Lake region, Jiangxi Province...
  3. pmc Transmission dynamics of Schistosoma japonicum in the lakes and marshlands of China
    Darren J Gray
    Molecular Parasitology Laboratory, Queensland Institute of Medical Research, Herston, Brisbane, Queensland, Australia
    PLoS ONE 3:e4058. 2008
    ..japonicum transmission there, and a drug-based intervention study (1998-2003) around the Poyang Lake in Jiangxi Province provided proof of concept that water buffaloes are, indeed, major reservoirs of human infection in this setting...
  4. pmc Recombinant antigens for immunodiagnosis of cystic echinococcosis
    Jun Li
    Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research 300 Herston Road, Herston, Brisbane, Queensland 4029 Australia
    Biol Proced Online 6:67-77. 2004
    ..2% and specificity of 95.6%, levels unprecedented taking into account the large panel of 896 human sera that were tested. The strategy used may also prove suitable for improved immunodiagnosis of other parasitic infections...
  5. pmc Cloning and characterisation of Schistosoma japonicum insulin receptors
    Hong You
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    PLoS ONE 5:e9868. 2010
    ..We cloned and assessed the function of two insulin receptors from Schistosoma japonicum in order to shed light on their role in schistosome biology...
  6. pmc Inconsistent protective efficacy and marked polymorphism limits the value of Schistosoma japonicum tetraspanin-2 as a vaccine target
    Wenbao Zhang
    Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    PLoS Negl Trop Dis 5:e1166. 2011
    ..Amplification by PCR of homologous sequences from male and female S. japonicum worms showed the presence of 7 different clusters or subclasses of S. japonicum TSP-2. We determined the protective efficacy of one subclass - Sj-TSP-2e...
  7. pmc Echinococcosis, Ningxia, China
    Yu Rong Yang
    Emerg Infect Dis 11:1314-6. 2005
  8. pmc Impact of anthropogenic and natural environmental changes on Echinococcus transmission in Ningxia Hui Autonomous Region, the People's Republic of China
    Yu Rong Yang
    Molecular Parasitology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Parasit Vectors 5:146. 2012
    ..and their impact on transmission to humans because such information is necessary to formulate reliable future public health policy for echinococcosis control programs and to prevent disease spread...
  9. pmc Case studies emphasising the difficulties in the diagnosis and management of alveolar echinococcosis in rural China
    Donald P McManus
    Queensland Institute of Medical Research, Herston, Brisbane, Australia
    Parasit Vectors 4:196. 2011
    ..AE occurs frequently in rural western China due to the poor levels of hygiene, the close contact of people with dogs, and the lack of appropriate facilities for the correct and rapid diagnosis of the disease...
  10. pmc Hepatic stellate cells and parasite-induced liver fibrosis
    Barrie Anthony
    Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, Brisbane, Q 4029, Australia
    Parasit Vectors 3:60. 2010
    ....
  11. pmc Comparison of two approaches for measuring household wealth via an asset-based index in rural and peri-urban settings of Hunan province, China
    Julie Balen
    Queensland Institute of Medical Research, P, O, Royal Brisbane Hospital, Brisbane 4029, Queensland, Australia
    Emerg Themes Epidemiol 7:7. 2010
    ..Our aim was to compare direct and proxy methods of estimating household wealth in a rural and a peri-urban setting of Hunan province, P.R. China...
  12. pmc Developmental gene expression profiles of the human pathogen Schistosoma japonicum
    Geoffrey N Gobert
    Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    BMC Genomics 10:128. 2009
    ..Advanced analyses including ANOVA, principal component analysis, and hierarchal clustering provided a global synopsis of gene expression relationships among the different developmental stages of the schistosome parasite...
  13. ncbi request reprint Reflections on the biochemistry of Echinococcus: past, present and future
    D P McManus
    Molecular Parasitology Laboratory, Division of Infectious Diseases, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, QLD 4006, Australia
    Parasitology 136:1643-52. 2009
    ..As well, I provide brief insight on new research directions, emphasizing the impact of molecular biology and associated techniques on future studies of Echinococcus and hydatid disease...
  14. ncbi request reprint HLA class II antigens positively and negatively associated with hepatosplenic schistosomiasis in a Chinese population
    D P McManus
    Molecular Parasitology Unit, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, QLD 4029, Australia
    Int J Parasitol 31:674-80. 2001
    ..The study has thus identified both positive and negative associations between HLA class II alleles and the risk of individuals developing moderate to severe liver fibrosis following schistosome infection...
  15. doi request reprint Conquering 'snail fever': schistosomiasis and its control in China
    Donald P McManus
    Molecular Parasitology Laboratory, Infectious Diseases Division, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, QLD 4029, Australia
    Expert Rev Anti Infect Ther 7:473-85. 2009
    ..The threat posed by the Three Gorges Dam may undermine control efforts because it will change the local ecology and associated schistosomiasis transmission risks over the next decade and beyond...
  16. pmc Current status of vaccines for schistosomiasis
    Donald P McManus
    Molecular Parasitology Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Brisbane Q4006, Australia
    Clin Microbiol Rev 21:225-42. 2008
    ..haematobium) and Asian (S. japonicum) schistosomes is then discussed, as are new approaches that may improve the efficacy of available vaccines and aid in the identification of new targets for immune attack...
  17. ncbi request reprint Vaccines against the zoonotic trematodes Schistosoma japonicum, Fasciola hepatica and Fasciola gigantica
    D P McManus
    Molecular Parasitology Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Q 4006, Australia
    Parasitology 133:S43-61. 2006
    ..Approaches towards identifying and producing vaccines against these parasites are similar and are discussed in this review...
  18. ncbi request reprint Molecular discrimination of taeniid cestodes
    Donald P McManus
    Molecular Parasitology Laboratory, Division of Infectious Diseases and Immunology, Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital
    Parasitol Int 55:S31-7. 2006
    ..solium. This is important in public health terms as it predicts that cysticercosis in humans attributable to Asian Taenia does not occur, because cysticercosis is unknown in T. saginata...
  19. ncbi request reprint Immunoglobulin profiles in a murine intermediate host model of resistance for Echinococcus granulosus infection
    Wenbao Zhang
    Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research and The University of Queensland, Brisbane, Queensland 4029, Australia
    Parasite Immunol 25:161-8. 2003
    ..i. The results suggest that protection against secondary infection was not principally antibody-mediated during the initial phases of infection, when cellular immune responses may play a pivotal role in the protective mechanism...
  20. ncbi request reprint Echinococcosis
    Donald P McManus
    Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research and The University of Queensland, Queensland 4029, Brisbane, Australia
    Lancet 362:1295-304. 2003
    ..E multilocularis and alveolar echinococcosis are more problematic, since the primary transmission cycle is almost always sylvatic so that efficient and cost-effective methods for control are unavailable...
  21. ncbi request reprint Genomics of parasitic flatworms
    Donald P McManus
    Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research and The University of Queensland, Brisbane, QLD 4029, Australia
    Int J Parasitol 34:153-8. 2004
    ..We highlight the remarkable recent progress in gene discovery for schistosomes and the goal of sequencing complete schistosome genomes...
  22. ncbi request reprint Molecular epidemiology of cystic echinococcosis
    D P McManus
    Molecular Parasitology Laboratory, Division of Infectious Diseases, Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research and The University of Queensland, Australia
    Parasitology 127:S37-51. 2003
    ..granulosus remain to be identified...
  23. ncbi request reprint A vaccine against Asian schistosomiasis
    Donald P McManus
    Molecular Parasitology Laboratory, Australian Center for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, QLD 4029, Australia
    Parasitol Int 53:163-73. 2004
    ..japonicum genome project, the prospects for developing an effective vaccine are encouraging. The challenges that remain are many but it is crucial that the momentum towards developing effective anti-schistosome vaccines is maintained...
  24. ncbi request reprint Short report: molecular genetic characterization of an unusually severe case of hydatid disease in Alaska caused by the cervid strain of Echinococcus granulosus
    Donald P McManus
    Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, The University of Queensland, Brisbane
    Am J Trop Med Hyg 67:296-8. 2002
    ....
  25. ncbi request reprint Prospects for development of a transmission blocking vaccine against Schistosoma japonicum
    D P McManus
    Molecular Parasitology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Parasite Immunol 27:297-308. 2005
    ..If a transmission blocking veterinary vaccine developed for bovines can be put into practice in combination with other control strategies such as human chemotherapy, elimination of S. japonicum from China may be achievable...
  26. ncbi request reprint The molecular epidemiology of Echinococcus granulosus and cystic hydatid disease
    D P McManus
    Division of Infectious Disease and Immunity, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, University of Queensland, Brisbane, Queensland, Australia
    Trans R Soc Trop Med Hyg 96:S151-7. 2002
    ....
  27. ncbi request reprint Production of interleukin-10 by peripheral blood mononuclear cells from residents of a marshland area in China endemic for Schistosoma japonicum
    D P McManus
    Molecular Parasitology Unit, The Bancroft Centre, The Queensland Institute of Medical Research, Brisbane, Australia
    Parasitol Int 48:169-77. 1999
    ..These results suggest an association between IL-10 production and resistance to S. japonicum in subjects from this Chinese population exposed to infection...
  28. pmc Human cases of simultaneous echinococcosis and tuberculosis - significance and extent in China
    Yu Rong Yang
    Molecular Parasitology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Parasit Vectors 2:53. 2009
    ....
  29. ncbi request reprint The vaccine efficacy of native paramyosin (Sj-97) against Chinese Schistosoma japonicum
    D P McManus
    Molecular Parasitology Unit, Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital
    Int J Parasitol 28:1739-42. 1998
    ..These data contrast with the impressive protection figures reported by another group who used a similar intraperitoneal vaccination protocol with native paramyosin extracted from Philippine strain S. japonicum...
  30. ncbi request reprint Recombinant paramyosin (rec-Sj-97) tested for immunogenicity and vaccine efficacy against Schistosoma japonicum in mice and water buffaloes
    D P McManus
    Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research, 300 Herston Road, Queensland 4029, Brisbane, Australia
    Vaccine 20:870-8. 2001
    ....
  31. ncbi request reprint The search for a vaccine against schistosomiasis--a difficult path but an achievable goal
    D P McManus
    Molecular Parasitology Unit, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, Australia
    Immunol Rev 171:149-61. 1999
    ....
  32. ncbi request reprint Schistosome transcriptome analysis at the cutting edge
    Donald P McManus
    Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research and The University of Queensland, Brisbane, QLD 4029, Australia
    Trends Parasitol 20:301-4. 2004
    ..Remarkable recent progress has also been achieved in genomic sequencing, and completed genomes for both species can be expected shortly...
  33. ncbi request reprint Molecular study of Echinococcus in west-central China
    Y R Yang
    Molecular Parasitology Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Q 4006, Australia
    Parasitology 131:547-55. 2005
    ..Such adaptations may also result in different sensitivity to drugs or increased virulence for hosts that will impede control efforts and even affect vaccination strategies against Echinococcus...
  34. ncbi request reprint Antibody isotype responses, infection and re-infection for Schistosoma japonicum in a marshland area of China
    Y S Li
    Australian Centre for International and Tropical Health and Nutrition, The University of Queensland and The Queensland Institute of Medical Research, Brisbane
    Acta Trop 73:79-92. 1999
    ..8% and 7.3% of the study population were IgE responders to AWA, PMY and TEG. A longer follow-up period is required before we can more fully understand the role of IgE, if any, in protective immunity against schistosomiasis japonica...
  35. ncbi request reprint Epidemiological identification of Chinese individuals putatively susceptible or insusceptible to Schistosoma japonicum: a prelude to immunogenetic study of human resistance to Asian schistosomiasis
    A G Ross
    Tropical Health Program, Australian Centre for International and Tropical Health and Nutrition, University of Queensland, Australia
    Ann Trop Med Parasitol 92:765-74. 1998
    ....
  36. ncbi request reprint Human susceptibility to Schistosoma japonicum in China correlates with antibody isotypes to native antigens
    Y Li
    Molecular Parasitology Unit, Tropical Health Programme, Australian Centre for International and Tropical Health and Nutrition, University of Queensland, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4029, Australia
    Trans R Soc Trop Med Hyg 95:441-8. 2001
    ..These and earlier findings provide evidence that immunity develops against schistosomiasis japonica in China and that susceptibility/resistance correlates with antibody isotypes against native schistosome antigens...
  37. ncbi request reprint A 2-year prospective study in China provides epidemiological evidence for resistance in humans to re-infection with Schistosoma japonicum
    Y S Li
    Molecular Parasitology Unit, Australian Centre for International and Tropical Health and Nutrition, University of Queensland, Brisbane, Australia
    Ann Trop Med Parasitol 93:629-42. 1999
    ..Further investigation of these individuals should help to shed some light on the role of immunogenetic status in human immunity to Schistosoma japonicum...
  38. ncbi request reprint Two-year impact of praziquantel treatment for Schistosoma japonicum infection in China: re-infection, subclinical disease and fibrosis marker measurements
    Y S Li
    Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, Herston, Brisbane, Australia
    Trans R Soc Trop Med Hyg 94:191-7. 2000
    ..05). Chemotherapy focused on at-risk residents controls prevalent subclinical hepatic fibrosis but re-infection indicates the need for complementary control strategies...
  39. ncbi request reprint Mitochondrial gene content, arrangement and composition compared in African and Asian schistosomes
    T H Le
    Molecular Parasitology Unit, Australian Centre for International and Tropical Health and Nutrition, The University of Queensland and The Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Mol Biochem Parasitol 117:61-71. 2001
    ..mansoni and the Asian schistosomes is far less (33-66% for amino acids and 54-68% for nucleotides), an observation consistent with the known phylogenetic distance between S. mansoni and the other species...
  40. ncbi request reprint Epidemiology of Schistosoma japonicum in China: morbidity and strategies for control in the Dongting Lake region
    Y S Li
    Tropical Health Program, Australian Centre for International and Tropical Health and Nutrition, The University of Queensland, Brisbane, Australia
    Int J Parasitol 30:273-81. 2000
    ....
  41. ncbi request reprint Measuring exposure to Schistosoma japonicum in China. III. Activity diaries, snail and human infection, transmission ecology and options for control
    Y Li
    Tropical Health Program, Australian Centre for International and Tropical Health and Nutrition, The University of Queensland and The Queensland Institute of Medical Research, 300 Herston Road, Herston, QLD 4029, Brisbane, Australia
    Acta Trop 75:279-89. 2000
    ..Potential strategies for migrating buffaloes and families living on visiting fishing boats are explored...
  42. ncbi request reprint Vaccine efficacy of recombinant cathepsin D aspartic protease from Schistosoma japonicum
    C K Verity
    Division of Infectious Diseases and Immunology and The CRC for Vaccine Technology, The Queensland Institute of Medical Research, Royal Brisbane Hospital, Queensland, Australia
    Parasite Immunol 23:153-62. 2001
    ..These results suggest that antibodies may not play a key role in the protective effect elicited, and that protection may be due to a combination of humoral and cell-mediated responses..
  43. ncbi request reprint Developmental expression of cathepsin D aspartic protease in Schistosoma japonicum
    C K Verity
    The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Herston, Australia
    Int J Parasitol 29:1819-24. 1999
    ..japonicum, express an aspartic protease. Moreover, they are consistent with the hypothesis that this enzyme plays a key role in maturing and adult schistosomes in the proteolysis of host haemoglobin from ingested erythrocytes...
  44. ncbi request reprint Faecal egg aggregation in humans infected with Schistosoma japonicum in China
    A G Ross
    Tropical Health Program, Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research, Brisbane
    Acta Trop 70:205-10. 1998
    ..However, for estimating the true prevalence of infection in a community, or for obtaining an accurate estimate of egg excretion for research studies, multiple KK smears are warranted...
  45. ncbi request reprint Schistosoma japonicum: immunolocalization of paramyosin during development
    G N Gobert
    Analytical Electron Microscopy Facility, Queensland University of Technology, Brisbane, Australia
    Parasitology 114:45-52. 1997
    ..The possible functions of paramyosin within S. japonicum and the relevance of these findings in relation to the reported protective properties of paramyosin as an anti-schistosome vaccine target molecule are discussed...
  46. ncbi request reprint Gulliver, a long terminal repeat retrotransposon from the genome of the oriental blood fluke Schistosoma japonicum
    T Laha
    Molecular Parasitology Laboratory, Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Queensland, Brisbane, Australia
    Gene 264:59-68. 2001
    ..This is the first report of the sequence and structure of an LTR retrotransposon from any schistosome or indeed from any species belonging to the phylum Platyhelminthes...
  47. ncbi request reprint Dam worms
    A G Ross
    Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Reseach, and The University of Queensland, PO Royal Brisbane Hospital, QLD 4029, Australia
    Biologist (London) 48:121-4. 2001
    ....
  48. ncbi request reprint Five-year impact of repeated praziquantel treatment on subclinical morbidity due to Schistosoma japonicum in China
    Y S Li
    Tropical Health Programme, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, University of Queensland, 300 Herston Road, Herston, Brisbane, Queensland 4029, Australia
    Trans R Soc Trop Med Hyg 96:438-43. 2002
    ....
  49. pmc Schistosomiasis in the People's Republic of China: prospects and challenges for the 21st century
    A G Ross
    Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research, and The University of Queensland, Brisbane, Queensland 4029, Australia
    Clin Microbiol Rev 14:270-95. 2001
    ..In this article, we provide an overview of the biology, epidemiology, clinical features, and prospects for control of oriental schistosomiasis in the People's Republic of China...
  50. ncbi request reprint Immunolocalization of the fatty acid-binding protein Sj-FABPc within adult Schistosoma japonicum
    G N Gobert
    Analytical Electron Microscopy Facility, Queensland University of Technology, Brisbane, Australia
    Parasitology 115:33-9. 1997
    ..japonicum and the relevance of these immunolocalization findings in light of the recent reports that the homologue Sm-FABPc is an important anti-S. mansoni vaccine target molecule are also discussed...
  51. pmc Receptor for Fc on the surfaces of schistosomes
    A Loukas
    Molecular Parasitology Laboratory, Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Queensland 4006, The University of Queensland, Queensland 4072, Australia
    Infect Immun 69:3646-51. 2001
    ..This is the first report of the molecular identity of a schistosome Fc receptor; moreover it demonstrates an additional aspect of the unusual and multifunctional properties of Pmy from schistosomes and other parasitic flatworms...
  52. ncbi request reprint Cloning and characterization of a ribosomal P protein from Taenia solium, the aetiological agent of human cysticercosis
    B H Kalinna
    Molecular Parasitology Unit, Queensland Institute of Medical Research, Bancroft Centre, Brisbane, Australia
    Biochem Biophys Res Commun 219:231-7. 1996
    ..5 kDa arpP2 plus an additional 2 kDa for the N-terminal fusion peptide incorporating the six histidine residues required for purification...
  53. pmc Differential antigen-stimulated proliferation of human mononuclear cells by recombinant Schistosoma japonicum antigens in a Chinese population
    G J Waine
    Molecular Parasitology Unit, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Australia
    Clin Exp Immunol 112:69-73. 1998
    ..The identification of differential cellular proliferative responses to specific schistosome antigens within an infected human population may have important practical implications for vaccine development against schistosomiasis japonica...
  54. ncbi request reprint Complete DNA sequence and gene organization of the mitochondrial genome of the liverfluke, Fasciola hepatica L. (Platyhelminthes; Trematoda)
    T H Le
    Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research and The University of Queensland, Brisbane
    Parasitology 123:609-21. 2001
    ..Transfer RNA genes range in length from 58 to 70 nt, their products producing characteristic 'clover leaf' structures, except for tRNA(S(UNC)) and tRNA(S(AGN)) lacking the DHU arm...
  55. ncbi request reprint HLA class II antigens are associated with resistance or susceptibility to hepatosplenic disease in a Chinese population infected with Schistosoma japonicum
    G J Waine
    Molecular Parasitology Unit, PO Royal Brisbane Hospital, QLD, Australia
    Int J Parasitol 28:537-42. 1998
    ..In contrast, alleles DQA1*0601 and DQB1*05031 never co-occurred and had opposite and significant effects on the occurrence of disease...
  56. pmc Comparative real-time PCR and enzyme analysis of selected gender-associated molecules in Schistosoma japonicum
    L Moertel
    Queensland Institute of Medical Research, and Australian Centre for International Health and Nutrition, Herston, QLD 4029, Australia
    Parasitology 135:575-83. 2008
    ..Continual refinement and annotation of the microarray used in the current study should support future work on these aspects...
  57. ncbi request reprint Short report: Echinococcus granulosus from Xinjiang, PR China: cDNAS encoding the EG95 vaccine antigen are expressed in different life cycle stages and are conserved in the oncosphere
    Wenbao Zhang
    Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research and University of Queensland, Brisbane, Queensland, Australia
    Am J Trop Med Hyg 68:40-3. 2003
    ..Very limited sequence variation was evident in the EG95 protein from oncospheres. This high degree of sequence conservation predicts that the vaccine will continue to be effective in China and elsewhere...
  58. pmc A cluster-randomized bovine intervention trial against Schistosoma japonicum in the People's Republic of China: design and baseline results
    Darren J Gray
    Australian Centre for International and Tropical Health and Nutrition, The University of Queensland and The Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Am J Trop Med Hyg 77:866-74. 2007
    ..japonicum. The combination of such a vaccine with other control strategies could potentially eliminate S. japonicum from southern China...
  59. ncbi request reprint Mitochondrial genes of Schistosoma mansoni
    D Blair
    Department of Zoology and Tropical Ecology, James Cook University, Townsville, Queensland, Australia
    Parasitology 119:303-13. 1999
    ..The gene order of S. mansoni is unique and differs from that of Fasciola hepatica, the only other trematode for which any information is available...
  60. ncbi request reprint An examination of current control strategies for Asian schistosomiasis in the Dongting lake region of China. II. A five year follow-up survey on Qingshan island
    A G Ross
    Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, Brisbane, Australia
    Acta Trop 68:93-104. 1997
    ..Chemotherapy for bovines and humans, mollusciding for Oncomelania control and health education should be initiated and upgraded if the health and well being of these island communities is to further improve...
  61. ncbi request reprint A vaccine against the Asian schistosome, Schistosoma japonicum: an update on paramyosin as a target of protective immunity
    B H Kalinna
    Molecular Parasitology Unit, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, Bancroft Centre, Royal Brisbane Hospital, Australia
    Int J Parasitol 27:1213-9. 1997
    ..Here we discuss the literature of the past decade and report on different recombinant paramyosin constructs we are using in our laboratory to develop a vaccine against the Asian schistosoma, Schistosoma japonicum...
  62. ncbi request reprint Revisiting the question of limited genetic variation within Schistosoma japonicum
    T H Le
    Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research, Brisbane
    Ann Trop Med Parasitol 96:155-64. 2002
    ..The results thus indicate no significant intra-specific genetic variation among S. japonicum samples collected from different geographical areas and do not support the idea of a distinct form in Sichuan...
  63. ncbi request reprint Current status of the genetics and molecular taxonomy of Echinococcus species
    D P McManus
    Molecular Parasitology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia
    Parasitology 140:1617-23. 2013
    ..A revised taxonomy for species in the Echinococcus genus has been proposed that is generally accepted, and is based on the new molecular data and the biological and epidemiological characteristics of host-adapted species and strains...
  64. doi request reprint Immunopathogenesis of human schistosomiasis
    M L Burke
    The Queensland Institute of Medical Research, Herston, Australia
    Parasite Immunol 31:163-76. 2009
    ....
  65. ncbi request reprint Mapping of linear B-cell epitopes on the 14-kDa fatty-acid binding protein of Chinese Schistosoma japonicum
    G J Waine
    Molecular Parasitology Unit, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, Australia
    Int J Parasitol 28:303-8. 1998
    ..They indicate that epitopes recognised during vaccination with functionally active rSjFABP, at least in the murine model, differ from those recognised during natural infection...
  66. ncbi request reprint Proteolytic degradation of host hemoglobin by schistosomes
    P J Brindley
    Molecular Parasitology Unit, Queensland Institute of Medical Research, Royal Brisbane Hospital, Australia
    Mol Biochem Parasitol 89:1-9. 1997
    ..More specifically, the review concentrates on five proteolytic enzymes, and their associated genes, which have been ascribed key roles in the pathway of hemoglobin degradation...
  67. ncbi request reprint SerpinB2 deficiency modulates Th1⁄Th2 responses after schistosome infection
    W A Schroder
    Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Parasite Immunol 32:764-8. 2010
    ..SerpinB2-/- mice immunized with soluble egg antigen (SEA) also showed reduced levels of SEA-specific IgG1. SerpinB2 deficiency thus promoted certain Th1 and reduced certain Th2 responses in response to this Th2 immunogen...
  68. ncbi request reprint Engineering and expression of a full length cDNA encoding Schistosoma japonicum paramyosin. Purification of the recombinant protein and its recognition by infected patient sera
    B H Kalinna
    Molecular Parasitology Unit, Queensland Institute of Medical Research, Bancroft Centre, Royal Brisbane Hospital, Australia
    Acta Trop 65:111-5. 1997
    ..The engineering of the full-length cDNA encoding Schistosoma japonicum paramyosin, its bacterial expression and purification will facilitate future studies aimed at determining its efficacy as an anti-schistosomiasis vaccine...
  69. ncbi request reprint Schistosoma japonicum cathepsin D aspartic protease cleaves human IgG and other serum components
    C K Verity
    Division of Infectious Diseases and Immunology and The CRC for Vaccine Technology, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Australia
    Parasitology 122:415-21. 2001
    ....
  70. ncbi request reprint A novel recombinant antigen for immunodiagnosis of human cystic echinococcosis
    Jun Li
    Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research and the University of Queensland, Brisbane, Australia
    J Infect Dis 188:1951-60. 2003
    ..6%. The combined levels of sensitivity and specificity achieved with the rEpC1-GST fusion protein for diagnosis of CE are unprecedented, taking into account the large panel of serum samples that were tested...
  71. ncbi request reprint The ultrastructural localization of Echinococcus granulosus antigen 5
    M K Jones
    Centre for Microscopy and Microanalysis, University of Queensland, Brisbane, Australia
    Parasitology 113:213-22. 1996
    ..The 38 kDa subunit occurs along the extracellular face of cell membranes, suggesting that antigen 5 is either a component of the membranes or associated extracellular matrices...
  72. ncbi request reprint Ultrastructural localization of an Echinococcus granulosus laminin-binding protein
    M K Jones
    Centre for Microscopy and Microanalysis, University of Queensland, Brisbane, Australia
    Parasitology 118:319-25. 1999
    ..A low degree of label was consistently detected in extracellular matrices of the protoscolex...
  73. ncbi request reprint Ultrasound organometry: the importance of body height adjusted normal ranges in assessing liver and spleen parameters among Chinese subjects with Schistosoma japonicum infection
    Y S Li
    Tropical Health Program, Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research, The University of Queensland, 3000 Herston Road, Herston, Brisbane, QLD 4029, Australia
    Acta Trop 92:133-8. 2004
    ..Thus, height-based normal ranges established in this study can be applied in hospital routine and in field studies of patients infected with S. japonicum in Hunan province and in other endemic areas of China...
  74. pmc Cloning and characterization of an orphan seven transmembrane receptor from Schistosoma mansoni
    M S Pearson
    Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research and Australian Centre for International and Tropical Health and Nutrition, The University of Queensland, Brisbane, Queensland, Australia
    Parasitology 134:2001-8. 2007
    ..A polyclonal antiserum against this domain was used to detect Sm-7TM in detergent-soluble parasite extracts and to immunolocalize the receptor to the tegument of adult S. mansoni...
  75. ncbi request reprint Schistosomiasis vaccine development--the current picture
    G J Waine
    Molecular Parasitology Unit, Queensland Institute of Medical Research, Australia
    Bioessays 19:435-43. 1997
    ..This review examines progress currently being undertaken in a number of different areas towards achieving the goal of a safe and effective human vaccine for schistosomiasis...
  76. pmc Identification of a diagnostic antibody-binding region on the immunogenic protein EpC1 from Echinococcus granulosus and its application in population screening for cystic echinococcosis
    W B Zhang
    Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research and The University of Queensland, Brisbane, Queensland, Australia
    Clin Exp Immunol 149:80-6. 2007
    ..Low numbers of surgical CE cases have been reported from this population, suggesting that HCF-based serology lacks specificity and that EpC1 or its contained P5 peptide may prove more accurate for seroepidemiological surveys of CE...
  77. ncbi request reprint Further studies on an intermediate host murine model showing that a primary Echinococcus granulosus infection is protective against subsequent oncospheral challenge
    W Zhang
    Molecular Parasitology Unit, The Queensland Institute of Medical Research, 300 Herston Road, P.O. Royal Brisbane Hospital, Brisbane, QLD 4029, Australia
    Parasitol Int 50:279-83. 2001
    ..These older sheep may have been earlier infected and have subsequently self-cured, with the primary infection stimulating an immune response that protects the intermediate host animals from further infection...
  78. ncbi request reprint Epidemiological and morbidity assessment of Schistosoma japonicum infection in a migrant fisherman community, the Dongting Lake region, China
    Y S Li
    Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, University of Queensland, Brisbane, Australia
    Trans R Soc Trop Med Hyg 97:177-81. 2003
    ..Clearly, new approaches for schistosomiasis control, especially in communities like these mobile fishermen, should be explored...
  79. pmc Prevalence, intensity and associated morbidity of Schistosoma japonicum infection in the Dongting Lake region, China
    Julie Balen
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Bull World Health Organ 85:519-26. 2007
    ..To determine the prevalence and intensity of Schistosoma japonicum infection and associated morbidity, and to estimate the infected human and buffalo populations in the Dongting Lake region, Hunan province, China...
  80. doi request reprint Familial aggregation of human helminth infection in the Poyang lake area of China with a focus on genetic susceptibility to schistosomiasis japonica and associated markers of disease
    M K Ellis
    Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research 300, Herston Road, Herston, Brisbane, Queensland 4029, Australia
    Parasitology 136:699-712. 2009
    ..We discuss the role of sICAM-1 and TNFR-I and -II as candidate markers for schistosome-induced hepatomegaly and fibrosis, and their potential for assessing disease stage and progression in schistosomiasis...
  81. ncbi request reprint Gene cloning and complete nucleotide sequence of philippine Schistosoma japonicum paramyosin
    M M Becker
    Molecular Parasitology Unit, Queensland Institute of Medical Research, Bancroft Centre, Brisbane, Australia
    Acta Trop 59:143-7. 1995
    ..1991; Dahmen et al., 1993; Landa et al., 1993; Mühlschlegel et al., 1993, Nara et al., 1994). The cloning and nucleotide sequence of S. Japonicum paramyosin is described...
  82. pmc A Bayesian approach to estimate the age-specific prevalence of Schistosoma mansoni and implications for schistosomiasis control
    Giovanna Raso
    Molecular Parasitology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia School of Population Health, The University of Queensland, Brisbane, Australia
    Int J Parasitol 37:1491-500. 2007
    ..The model presented here can be utilized to estimate S. mansoni community infection prevalences, which in turn helps in the strategic planning of schistosomiasis control...
  83. ncbi request reprint Mathematical modelling of schistosomiasis japonica: comparison of control strategies in the People's Republic of China
    Gail M Williams
    Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research, The University of Queensland, Brisbane, Australia
    Acta Trop 82:253-62. 2002
    ..If it is accompanied by an initial period of human treatment and by a 45% improvement in human sanitation or a 30% reduction in contaminated water contact by humans, elimination is then possible...
  84. ncbi request reprint Oligonucleotide microarray analysis of strain- and gender-associated gene expression in the human blood fluke, Schistosoma japonicum
    Luke Moertel
    Molecular Parasitology Laboratory, Infectious Diseases and Immunology Division, Queensland Institute of Medical Research and Australian Centre for International Health and Nutrition, Brisbane, Australia
    Mol Cell Probes 20:280-9. 2006
    ....
  85. pmc Isolation of cDNAs encoding secreted and transmembrane proteins from Schistosoma mansoni by a signal sequence trap method
    Danielle Smyth
    Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research and The University of Queensland, Brisbane, Queensland 4029, Australia
    Infect Immun 71:2548-54. 2003
    ..mansoni cDNAs. This is the first report describing the use of SST as a tool for identifying secreted proteins from any pathogenic organism...
  86. ncbi request reprint Microarrays: new tools to unravel parasite transcriptomes
    G N Gobert
    Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, QLD 4029 Australia
    Parasitology 131:439-48. 2005
    ..Now in 2005, microarrays represent a very powerful resource that can play an important role in the characterization and annotation of the transcriptomes of many parasites of medical and veterinary importance...
  87. ncbi request reprint An evaluation of Schistosoma japonicum infections in three villages in the Dongting lake region of China. I. Prevalence, intensity and morbidity before the implementation of adequate control strategies
    Y S Li
    Hunan Institute of Parasitic Diseases, People s Republic of China
    Acta Trop 68:77-91. 1997
    ..japonicum and its associated clinical manifestations in the villages under study...
  88. pmc Biology of the schistosome lung-stage schistosomulum
    G N Gobert
    Molecular Parasitology Laboratory, Infectious Diseases and Immunology Division, The Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4006 Australia
    Parasitology 134:453-60. 2007
    ..The microarray profiling studies suggest caution is required when considering the use of schistosomes obtained by in vitro means for molecular or biochemical studies...
  89. pmc Artemether treatment of prepatent Schistosoma japonicum induces resistance to reinfection in association with reduced pathology
    Paul B Bartley
    Molecular Parasitology Laboratory, Queensland Institute of Medical Research, Herston, Australia
    Am J Trop Med Hyg 78:929-35. 2008
    ..There was also an anti-pathology effect observed in ART-treated mice that remained significant after reinfection...
  90. ncbi request reprint CD4+ T-cell counts, CD4+/CD8+ T-cell count ratios, and antibody levels in migrant fishermen infected with Schistosoma japonicum in the Dongting Lake, China
    Yuesheng Li
    Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, The University of Queensland, Brisbane, Queensland, Australia
    Am J Trop Med Hyg 75:910-3. 2006
    ..These results suggest an imbalance between cell-mediated and humoral immunity in these fishermen, the precise cause of which remains undetermined...
  91. pmc Co-ordinated gene expression in the liver and spleen during Schistosoma japonicum infection regulates cell migration
    Melissa L Burke
    Molecular Parasitology Laboratory, Queensland Institute of Medical Research, Herston, Queensland, Australia
    PLoS Negl Trop Dis 4:e686. 2010
    ....
  92. pmc Temporal expression of chemokines dictates the hepatic inflammatory infiltrate in a murine model of schistosomiasis
    Melissa L Burke
    Molecular Parasitology Laboratory, Queensland Institute of Medical Research, Queensland, Australia
    PLoS Negl Trop Dis 4:e598. 2010
    ..japonicum-induced granulomas and fibrosis and may provide correlative insight into the pathogenesis of other chronic inflammatory diseases of the liver where fibrosis is a common feature...
  93. ncbi request reprint Transcriptomics tool for the human Schistosoma blood flukes using microarray gene expression profiling
    Geoffrey N Gobert
    Queensland Institute of Medical Research and Australian Centre for International Health and Nutrition, Brisbane, QLD, Australia
    Exp Parasitol 114:160-72. 2006
    ..This is the first microarray commercially manufactured for studying schistosomes, and the large size and verified quality of the resource demonstrate its power for characterising the schistosome transcriptome...
  94. pmc Familial aggregation of human susceptibility to co- and multiple helminth infections in a population from the Poyang Lake region, China
    Magda K Ellis
    Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research, The University of Queensland, Herston, Brisbane, QLD 4029, Australia
    Int J Parasitol 37:1153-61. 2007
    ..Further, the results suggest that susceptibility to one helminth infection is not completely independent of another, and that there exist common genetic factors underlying infection with multiple helminth species...
  95. pmc Tracking the fate of iron in early development of human blood flukes
    Malcolm K Jones
    Queensland Institute of Medical Research, Herston, QLD 4029, Australia
    Int J Biochem Cell Biol 39:1646-58. 2007
    ..These observations emphasise the importance of Fe in schistosome metabolism and egg formation and suggest new avenues for disruption of egg formation in these pathogenic parasites...
  96. doi request reprint Exposed proteins of the Schistosoma japonicum tegument
    Jason Mulvenna
    Helminth Biology Laboratory, Division of Infectious Diseases, Queensland Institute of Medical Research, QLD 4006, Australia
    Int J Parasitol 40:543-54. 2010
    ..The ability of the parasite to rapidly internalise proteins at its surface has implications for the development of vaccines and may explain how these parasites are able to avoid the host immune system for long periods of time...
  97. pmc Correlative and dynamic imaging of the hatching biology of Schistosoma japonicum from eggs prepared by high pressure freezing
    Malcolm K Jones
    Queensland Institute of Medical Research, Herston, Queensland, Australia
    PLoS Negl Trop Dis 2:e334. 2008
    ..In view of the lack of knowledge of the behaviour of egg hatching in schistosomes, we undertook a detailed dynamic and correlative study of the hatching biology of Schistosoma japonicum...
  98. pmc Pumping iron: a potential target for novel therapeutics against schistosomes
    Amber Glanfield
    Division of Infectious Diseases and Immunology, The Queensland Institute of Medical Research, 300 Herston Road, Herston, Queensland 4006, Australia
    Trends Parasitol 23:583-8. 2007
    ..Elucidation of these metabolic mechanisms could lead to the development of new interventions for the control of schistosomiasis and other helminth diseases...
  99. pmc sTNFR-II and sICAM-1 are associated with acute disease and hepatic inflammation in schistosomiasis japonica
    Magda K Ellis
    Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research, The University of Queensland, Brisbane, QLD 4029, Australia
    Int J Parasitol 38:717-23. 2008
    ..Measurement of sTNFR-II and sICAM-1 levels in serum could serve as additional markers for the diagnosis of acute stage disease and the monitoring of hepatic inflammation in human schistosomiasis japonica...
  100. pmc Analysis of the 5q31 33 locus shows an association between single nucleotide polymorphism variants in the IL-5 gene and symptomatic infection with the human blood fluke, Schistosoma japonicum
    Magda K Ellis
    Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research and University of Queensland, Australia
    J Immunol 179:8366-71. 2007
    ..This haplotype was located in the 3'-untranslated region of IL-5, suggesting that variants in this region of IL-5 may modulate the immune response in these individuals with symptomatic infection...