Nicholas Martin

Summary

Affiliation: Queensland Institute of Medical Research
Country: Australia

Publications

  1. ncbi request reprint A twin-pronged attack on complex traits
    N Martin
    Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Australia
    Nat Genet 17:387-92. 1997
  2. doi request reprint Effects of GABRA2 variation on physiological, psychomotor and subjective responses in the alcohol challenge twin study
    Penelope A Lind
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 11:174-82. 2008
  3. ncbi request reprint KRAS variation and risk of endometriosis
    Zhen Zhen Zhao
    Molecular Epidemiology Laboratory and Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Mol Hum Reprod 12:671-6. 2006
  4. ncbi request reprint Major depressive disorder, suicidal ideation, and suicide attempt in twins discordant for cannabis dependence and early-onset cannabis use
    Michael T Lynskey
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Arch Gen Psychiatry 61:1026-32. 2004
  5. pmc Linkage analysis of a model quantitative trait in humans: finger ridge count shows significant multivariate linkage to 5q14.1
    Sarah E Medland
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    PLoS Genet 3:1736-44. 2007
  6. pmc A genome-wide linkage scan for age at menarche in three populations of European descent
    Carl A Anderson
    Queensland Institute of Medical Research, Royal Brisbane Hospital, Queensland 4029, Australia
    J Clin Endocrinol Metab 93:3965-70. 2008
  7. pmc A three-single-nucleotide polymorphism haplotype in intron 1 of OCA2 explains most human eye-color variation
    David L Duffy
    Queensland Institute of Medical Research, Brisbane, Australia
    Am J Hum Genet 80:241-52. 2007
  8. pmc Common SNPs explain a large proportion of the heritability for human height
    Jian Yang
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Nat Genet 42:565-9. 2010
  9. ncbi request reprint Epidermal growth factor gene (EGF) polymorphism and risk of melanocytic neoplasia
    Michael R James
    Queensland Institute of Medical Research, Brisbane, Australia
    J Invest Dermatol 123:760-2. 2004
  10. doi request reprint Genetic covariation among facets of openness to experience and general cognitive ability
    Mark A Wainwright
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, Queensland 4029, Australia
    Twin Res Hum Genet 11:275-86. 2008

Research Grants

Detail Information

Publications107 found, 100 shown here

  1. ncbi request reprint A twin-pronged attack on complex traits
    N Martin
    Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Australia
    Nat Genet 17:387-92. 1997
    ....
  2. doi request reprint Effects of GABRA2 variation on physiological, psychomotor and subjective responses in the alcohol challenge twin study
    Penelope A Lind
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 11:174-82. 2008
    ..Because of the large number of phenotypes tested, these possibly significant findings will need to be confirmed in further studies...
  3. ncbi request reprint KRAS variation and risk of endometriosis
    Zhen Zhen Zhao
    Molecular Epidemiology Laboratory and Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Mol Hum Reprod 12:671-6. 2006
    ..No germline variants for KRAS or BRAF were detected. Our results demonstrate that any risk of endometriosis in women because of common variation in KRAS must be very small...
  4. ncbi request reprint Major depressive disorder, suicidal ideation, and suicide attempt in twins discordant for cannabis dependence and early-onset cannabis use
    Michael T Lynskey
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Arch Gen Psychiatry 61:1026-32. 2004
    ..Previous research has reported both a moderate degree of comorbidity between cannabis dependence and major depressive disorder (MDD) and that early-onset cannabis use is associated with increased risks for MDD...
  5. pmc Linkage analysis of a model quantitative trait in humans: finger ridge count shows significant multivariate linkage to 5q14.1
    Sarah E Medland
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    PLoS Genet 3:1736-44. 2007
    ....
  6. pmc A genome-wide linkage scan for age at menarche in three populations of European descent
    Carl A Anderson
    Queensland Institute of Medical Research, Royal Brisbane Hospital, Queensland 4029, Australia
    J Clin Endocrinol Metab 93:3965-70. 2008
    ..Age at menarche (AAM) is an important trait both biologically and socially, a clearly defined event in female pubertal development, and has been associated with many clinically significant phenotypes...
  7. pmc A three-single-nucleotide polymorphism haplotype in intron 1 of OCA2 explains most human eye-color variation
    David L Duffy
    Queensland Institute of Medical Research, Brisbane, Australia
    Am J Hum Genet 80:241-52. 2007
    ....
  8. pmc Common SNPs explain a large proportion of the heritability for human height
    Jian Yang
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Nat Genet 42:565-9. 2010
    ....
  9. ncbi request reprint Epidermal growth factor gene (EGF) polymorphism and risk of melanocytic neoplasia
    Michael R James
    Queensland Institute of Medical Research, Brisbane, Australia
    J Invest Dermatol 123:760-2. 2004
    ..05), in keeping with two previous studies. The EGF polymorphism does not appear to predispose to melanoma or nevus development, but its significant association with tumor thickness implies that it may be a useful marker of prognosis...
  10. doi request reprint Genetic covariation among facets of openness to experience and general cognitive ability
    Mark A Wainwright
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, Queensland 4029, Australia
    Twin Res Hum Genet 11:275-86. 2008
    ..06 to .79. Results were interpreted as suggesting that Openness is related to general cognitive ability (g) through a genetic mechanism and that gengenders a minor but discernable disposition towards Openness for the majority of facets...
  11. ncbi request reprint An analysis of risk factors for cutaneous melanoma by anatomical site (Australia)
    Victor Siskind
    Division of Population Studies and Human Genetics, Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Cancer Causes Control 16:193-9. 2005
    ..We sought to test this hypothesis in a population-based study in Queensland, Australia...
  12. ncbi request reprint Genetic dissection of myopia: evidence for linkage of ocular axial length to chromosome 5q
    Gu Zhu
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    Ophthalmology 115:1053-1057.e2. 2008
    ..To estimate heritability and locate quantitative trait loci influencing axial length...
  13. ncbi request reprint A genome-wide scan for naevus count: linkage to CDKN2A and to other chromosome regions
    Gu Zhu
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Eur J Hum Genet 15:94-102. 2007
    ..001). We replicate our earlier finding of linkage to CDKN2A and discovering linkage to several novel regions that may also influence risk of the development of malignant melanoma...
  14. ncbi request reprint Estimation of variance components for age at menarche in twin families
    Carl A Anderson
    Genetic Epidemiology Group, Queensland Institute of Medical Research, Brisbane 4029, Australia
    Behav Genet 37:668-77. 2007
    ..50 and 0.54, and common environmental effects to be 0.31 and 0.29, respectively. We conclude that variation in AAM can be explained by additive genetic and common environmental components...
  15. ncbi request reprint Effects of variation at the ALDH2 locus on alcohol metabolism, sensitivity, consumption, and dependence in Europeans
    Peter A Dickson
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    Alcohol Clin Exp Res 30:1093-100. 2006
    ..We have tested whether other polymorphisms in the ALDH2 gene have similar effects in people of European ancestry...
  16. ncbi request reprint Evidence of age-dependent genetic influences on plasma total cholesterol
    Rita Middelberg
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    Eur J Cardiovasc Prev Rehabil 12:380-6. 2005
    ....
  17. ncbi request reprint Use of monozygotic twins to investigate the relationship between 5HTTLPR genotype, depression and stressful life events: an application of Item Response Theory
    Naomi R Wray
    Genetic and Molecular Epidemiology Laboratories, Queensland Institute of Medical Research, Brisbane, 4006, Australia
    Novartis Found Symp 293:48-59; discussion 59-70. 2008
    ..The use of MZT provides a novel framework for examining genotype x environment interaction in the absence of measures on SLE...
  18. ncbi request reprint New concepts for distinguishing the hidden patterns of linkage disequilibrium which underlie association between genotypes and complex phenotypes
    Jacqueline Wicks
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 8:95-100. 2005
    ..This provides a basis for distinguishing the hidden LD patterns and might help to locate the functional variants responsible for the association...
  19. doi request reprint Linkage and association analysis of spectrophotometrically quantified hair color in Australian adolescents: the effect of OCA2 and HERC2
    Sri N Shekar
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    J Invest Dermatol 128:2807-14. 2008
    ..03 after correction for multiple testing, respectively). These two SNPs explain 1.54 and 0.85% of variation in the A650t index, respectively...
  20. ncbi request reprint Heritability of NEO PI-R extraversion facets and their relationship with IQ
    Jennifer L Pincombe
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 10:462-9. 2007
    ..These common genetic effects may stem from a dependence on brain dopamine, a neurotransmitter that has been implicated in both personality and cognition...
  21. pmc Quantifying the heritability of task-related brain activation and performance during the N-back working memory task: a twin fMRI study
    Gabriëlla A M Blokland
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Biol Psychol 79:70-9. 2008
    ..44-0.55). This study, which will be expanded over the next 3 years, provides the first support that individual variation in working memory-related brain activation is to some extent influenced by genes...
  22. doi request reprint A study of diabetes mellitus within a large sample of Australian twins
    Julianne Condon
    Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 11:28-40. 2008
    ..The bivariate genetic analysis (under the multifactorial threshold model) estimated the genetic correlation between body mass index (BMI) and T2D to be 0.46, and the environmental correlation at only 0.06...
  23. ncbi request reprint Sex-limited genome-wide linkage scan for body mass index in an unselected sample of 933 Australian twin families
    Belinda K Cornes
    Genetic Epidemiology, Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, QLD, Australia
    Twin Res Hum Genet 8:616-32. 2005
    ....
  24. ncbi request reprint Novel variants in growth differentiation factor 9 in mothers of dizygotic twins
    James S Palmer
    Molecular Epidemiology, Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia
    J Clin Endocrinol Metab 91:4713-6. 2006
    ..We previously identified a deletion mutation in GDF9 in sisters with spontaneous dizygotic (DZ) twins, but the prevalence of rare GDF9 variants in twinning families is unknown...
  25. ncbi request reprint Limitations of DSM-IV operationalizations of alcohol abuse and dependence in a sample of Australian twins
    Michael T Lynskey
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Twin Res Hum Genet 8:574-84. 2005
    ....
  26. pmc Variation in bone morphogenetic protein 15 is not associated with spontaneous human dizygotic twinning
    Zhen Zhen Zhao
    Molecular Epidemiology, Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, QLD, Australia
    Hum Reprod 23:2372-9. 2008
    ..Spontaneous dizygotic (DZ) twinning in humans is under genetic control. In sheep, heterozygous loss of function mutations in bone morphogenetic protein 15 (BMP15) increase ovulation and hence twinning rates...
  27. pmc Genome-wide association study of height and body mass index in Australian twin families
    Jimmy Z Liu
    Queensland Statistical Genetics, Genetic Epidemiology and Molecular Epidemiology Laboratories, Queensland Institute of Medical Research, Australia
    Twin Res Hum Genet 13:179-93. 2010
    ..Together, these variants explain less than 2% of total phenotypic variation for height and 0.5% for BMI...
  28. pmc A population-based study of Australian twins with melanoma suggests a strong genetic contribution to liability
    Sri N Shekar
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    J Invest Dermatol 129:2211-9. 2009
    ..Using these data and population prevalences, it was estimated that 55% of the variation in liability to melanoma is due to genetic influences...
  29. pmc Genetic and environmental influences on cannabis use initiation and problematic use: a meta-analysis of twin studies
    Karin J H Verweij
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Addiction 105:417-30. 2010
    ....
  30. pmc ADH single nucleotide polymorphism associations with alcohol metabolism in vivo
    Andrew J Birley
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Hum Mol Genet 18:1533-42. 2009
    ....
  31. pmc A versatile gene-based test for genome-wide association studies
    Jimmy Z Liu
    Genetics and Population Health Division, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia
    Am J Hum Genet 87:139-45. 2010
    ..We have implemented the approach in both an easy-to-use web interface, which only requires the uploading of markers with their association p-values, and a separate downloadable application...
  32. pmc IRF4 variants have age-specific effects on nevus count and predispose to melanoma
    David L Duffy
    Queensland Institute of Medical Research, Brisbane 4029, Australia
    Am J Hum Genet 87:6-16. 2010
    ..14, p = 0.0035; excluding Australian, the UK, and Swedish samples typed at rs12203592: OR 1.08, p = 0.08)...
  33. ncbi request reprint Replicated effects of sex and genotype on gene expression in human lymphoblastoid cell lines
    Allan F McRae
    Genetic Epidemiology Group, Queensland Institute of Medical Research, Herston, QLD 4029, Australia
    Hum Mol Genet 16:364-73. 2007
    ..Analysis of the variability of probe binding intensities within a probe set indicated that results are robust to the possible presence of polymorphisms in the target sequences...
  34. ncbi request reprint Anxiety and comorbid measures associated with PLXNA2
    Naomi R Wray
    Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, QLD 4029, Australia
    Arch Gen Psychiatry 64:318-26. 2007
    ..Common genetic liabilities have been reported between psychiatric and psychological measures, but few examples exist of common genetic variants...
  35. pmc A variant in LIN28B is associated with 2D:4D finger-length ratio, a putative retrospective biomarker of prenatal testosterone exposure
    Sarah E Medland
    Genetic Epidemiology, Queensland Institute of Medical Research, Australia
    Am J Hum Genet 86:519-25. 2010
    ..Our findings call into question the validity of 2D:4D as a simplistic retrospective biomarker for prenatal testosterone exposure...
  36. pmc A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations
    Penelope A Lind
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 13:10-29. 2010
    ..Further studies will be required before the detailed causes of comorbidity between AD and ND are understood...
  37. ncbi request reprint Sex differences in genetic variation in weight: a longitudinal study of body mass index in adolescent twins
    Belinda K Cornes
    Genetic Epidemiology, Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, Herston, Brisbane 4029, QLD, Australia
    Behav Genet 37:648-60. 2007
    ..Although, over 1,000 pairs of twins were used, this study still lacked the power to properly discriminate between additive and non-additive genetic variance...
  38. pmc Linkage analysis of alcohol dependence symptoms in the community
    Narelle K Hansell
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
    Alcohol Clin Exp Res 34:158-63. 2010
    ..We have previously identified suggestive linkage for alcohol consumption in a community-based sample of Australian adults. In this companion paper, we explore the strength of genetic linkage signals for alcohol dependence symptoms...
  39. pmc Common variants in TMPRSS6 are associated with iron status and erythrocyte volume
    Beben Benyamin
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Nat Genet 41:1173-5. 2009
    ..1 x 10(-10)). We also find suggestive evidence of association with blood hemoglobin levels (combined P = 5.3 x 10(-7)). These findings demonstrate the involvement of TMPRSS6 in control of iron homeostasis and in normal erythropoiesis...
  40. pmc Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis
    Jodie N Painter
    Molecular Epidemiology, Queensland Institute of Medical Research, Herston, Queensland, Australia
    Nat Genet 43:51-4. 2011
    ..4 × 10⁻⁹ (OR = 1.20, 95% CI 1.13-1.27) for 'all' endometriosis in our combined datasets of 5,586 cases and 9,331 controls. rs12700667 is located in an intergenic region upstream of the plausible candidate genes NFE2L3 and HOXA10...
  41. pmc A high-density association screen of 155 ion transport genes for involvement with common migraine
    Dale R Nyholt
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane4029, Queensland, Australia
    Hum Mol Genet 17:3318-31. 2008
    ..Multiple rare variants or trans-regulatory elements of these genes are not ruled out...
  42. pmc Geographical structure and differential natural selection among North European populations
    Brian P McEvoy
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Genome Res 19:804-14. 2009
    ....
  43. doi request reprint Linkage and association analyses of longitudinally measured lipid phenotypes in adolescence
    Rita P Middelberg
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Australia
    Twin Res Hum Genet 11:603-20. 2008
    ..42 x 10(-5) and 2.77 x 10(-4), respectively). Further longitudinal genetic studies of cardiovascular risk factors, focused on critical periods of development or change, are needed...
  44. pmc "No thanks, it keeps me awake": the genetics of coffee-attributed sleep disturbance
    Michelle Luciano
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
    Sleep 30:1378-86. 2007
    ..In this study, the heritability of coffee-attributed sleep disturbance and its relationship with other sleep measures were estimated, and chromosomal regions influencing this trait were identified...
  45. pmc Accurate, Large-Scale Genotyping of 5HTTLPR and Flanking Single Nucleotide Polymorphisms in an Association Study of Depression, Anxiety, and Personality Measures
    Naomi R Wray
    Genetic and Molecular Epidemiology Laboratories, Queensland Institute of Medical Research, 300 Herston Road, Brisbane 4006, Australia
    Biol Psychiatry 66:468-76. 2009
    ..However, the original 5HTTLPR assay is prone to bias toward short allele calling...
  46. doi request reprint Sexual orientation and psychiatric vulnerability: a twin study of neuroticism and psychoticism
    Brendan P Zietsch
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Arch Sex Behav 40:133-42. 2011
    ....
  47. doi request reprint Genetic and environmental influences on optimism and its relationship to mental and self-rated health: a study of aging twins
    Miriam A Mosing
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, 300 Herston Rd, Brisbane, QLD, 4029, Australia
    Behav Genet 39:597-604. 2009
    ....
  48. ncbi request reprint QTLs identified for P3 amplitude in a non-clinical sample: importance of neurodevelopmental and neurotransmitter genes
    Margaret J Wright
    Queensland Institute of Medical Research, School of Psychology, University of Queensland, Brisbane, Australia
    Biol Psychiatry 63:864-73. 2008
    ..The P3(00) event-related potential is an index of processing capacity (P3 amplitude) and stimulus evaluation (P3 latency) as well as a phenotypic marker of various forms of psychopathology where P3 abnormalities have been reported...
  49. ncbi request reprint Escalation of drug use in early-onset cannabis users vs co-twin controls
    Michael T Lynskey
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    JAMA 289:427-33. 2003
    ..Previous studies have reported that early initiation of cannabis (marijuana) use is a significant risk factor for other drug use and drug-related problems...
  50. ncbi request reprint ViewPoint and ViewDist: utilities for rapid graphing of linkage distributions and identification of outliers
    Harry N Beeby
    Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Australia
    Behav Genet 36:7-11. 2006
    ....
  51. pmc Robust estimation of experimentwise P values applied to a genome scan of multiple asthma traits identifies a new region of significant linkage on chromosome 20q13
    Manuel A R Ferreira
    Queensland Institute of Medical Research, Brisbane, Australia
    Am J Hum Genet 77:1075-85. 2005
    ....
  52. ncbi request reprint BRAF polymorphisms and risk of melanocytic neoplasia
    Michael R James
    Queensland Institute of Medical Research, Brisbane, Australia
    J Invest Dermatol 125:1252-8. 2005
    ..The burden of disease associated with this variant is greater than that associated with the major melanoma susceptibility locus CDKN2A, which has an estimated attributable risk of 0.2%...
  53. ncbi request reprint Association between polymorphisms in the progesterone receptor gene and endometriosis
    Susan A Treloar
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Mol Hum Reprod 11:641-7. 2005
    ..Further, analysis of our results pooled with those from two previous studies suggested that neither the T2 allele of the AluIns nor the T1/T2 genotype was associated with endometriosis...
  54. ncbi request reprint Osteoarthritis of the hands, hips and knees in an Australian twin sample--evidence of association with the aggrecan VNTR polymorphism
    Katherine M Kirk
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res 6:62-6. 2003
    ....
  55. pmc Genomewide linkage study in 1,176 affected sister pair families identifies a significant susceptibility locus for endometriosis on chromosome 10q26
    Susan A Treloar
    Cooperative Research Centre for Discovery of Genes for Common Human Diseases, Melbourne, Australia
    Am J Hum Genet 77:365-76. 2005
    ..Greater understanding of the aberrant cellular and molecular mechanisms involved in the etiology and pathophysiology of endometriosis should lead to better diagnostic methods and targeted treatments...
  56. ncbi request reprint A deletion mutation in GDF9 in sisters with spontaneous DZ twins
    Grant W Montgomery
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res 7:548-55. 2004
    ..We conclude that rare mutations in GDF9 may influence twinning, but twinning frequency is not associated with common variation in GDF9...
  57. ncbi request reprint Latent class and genetic analysis does not support migraine with aura and migraine without aura as separate entities
    Dale R Nyholt
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Genet Epidemiol 26:231-44. 2004
    ....
  58. doi request reprint No association between Cholinergic Muscarinic Receptor 2 (CHRM2) genetic variation and cognitive abilities in three independent samples
    Penelope A Lind
    Genetic Epidemiology Unit, PO Royal Brisbane Hospital, Brisbane, QLD, 4029, Australia
    Behav Genet 39:513-23. 2009
    ..No significant association was found between CHRM2 and diverse measures of cognitive ability in any of the samples. In conclusion, this study does not support a role for CHRM2 in cognitive ability...
  59. ncbi request reprint Dizygotic twinning is not associated with methylenetetrahydrofolate reductase haplotypes
    Grant W Montgomery
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Hum Reprod 18:2460-4. 2003
    ..Polymorphisms in 5,10-methylenetetrahydrofolate reductase (MTHFR) have been associated with dizygotic (DZ) twinning through pregnancy loss...
  60. ncbi request reprint Special twin environments, genetic influences and their effects on the handedness of twins and their siblings
    Sarah E Medland
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4029, Australia
    Twin Res 6:119-30. 2003
    ....
  61. pmc Assumption-free estimation of heritability from genome-wide identity-by-descent sharing between full siblings
    Peter M Visscher
    Genetic Epidemiology Group, Queensland Institute of Medical Research, Brisbane, Australia
    PLoS Genet 2:e41. 2006
    ....
  62. ncbi request reprint Bias, precision and heritability of self-reported and clinically measured height in Australian twins
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Herston Road, Brisbane, Australia
    Hum Genet 120:571-80. 2006
    ..Moderate reduction in error (through the use of accurate clinical or multiple self-report measures) increased the effective sample size by 22%; elimination of measurement error led to increases in effective sample size of 41%...
  63. ncbi request reprint Longitudinal genetic analysis of plasma lipids
    Rita P Middelberg
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Twin Res Hum Genet 9:550-7. 2006
    ..In addition our data suggest that different genes may affect the risk profile at different ages...
  64. ncbi request reprint Interactive effects of MC1R and OCA2 on melanoma risk phenotypes
    David L Duffy
    Queensland Insititute of Medical Research, Brisbane, Australia
    Hum Mol Genet 13:447-61. 2004
    ..Amongst individuals with a R/R genotype (but not R/r), those who also had brown eyes had a mole count twice that of those with blue eyes. This suggests that other OCA2 polymorphisms influence mole count and remain to be described...
  65. pmc Novel genes identified in a high-density genome wide association study for nicotine dependence
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, Box 8134, St Louis, MO 63110, USA
    Hum Mol Genet 16:24-35. 2007
    ..This work anticipates the future directions of large-scale genome wide association studies with state-of-the-art methodological approaches and sharing of data with the scientific community...
  66. ncbi request reprint Significant evidence of one or more susceptibility loci for endometriosis with near-Mendelian inheritance on chromosome 7p13-15
    Krina T Zondervan
    Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Hum Reprod 22:717-28. 2007
    ..The aim was to investigate whether the apparent concentration of cases in a proportion of families could be explained by one or more rare variants with (near-)Mendelian autosomal inheritance...
  67. doi request reprint An autosomal linkage scan for cannabis use disorders in the nicotine addiction genetics project
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8134, St Louis, MO 63110, USA
    Arch Gen Psychiatry 65:713-21. 2008
    ..Despite accumulating evidence that there is a genetic basis for cannabis use disorders (ie, abuse and dependence), few studies have identified genomic regions that may harbor biological risk and protective factors...
  68. ncbi request reprint The genetics of alcohol intake and of alcohol dependence
    John B Whitfield
    Department of Clinical Biochemistry, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia
    Alcohol Clin Exp Res 28:1153-60. 2004
    ..The aims of this study were to assess the long-term repeatability and genetic or environmental causes of variation in alcohol intake and to estimate the degree of overlap with causes of susceptibility to alcohol dependence...
  69. ncbi request reprint Defining nicotine dependence for genetic research: evidence from Australian twins
    Christina N Lessov
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Psychol Med 34:865-79. 2004
    ....
  70. ncbi request reprint Gender diagnosticity and androgen receptor gene CAG repeat sequence
    John C Loehlin
    Department of Psychology, University of Texas, Austin, TX 78712 0187, USA
    Twin Res 7:456-61. 2004
    ..Clarification of these relationships will require large samples and measurements at additional ages...
  71. pmc Searching for an environmental effect of parental alcoholism on offspring alcohol use disorder: a genetically informed study of children of alcoholics
    Wendy S Slutske
    Department of Psychological Sciences, Midwest Alcoholism Research Center, University of Missouri Columbia, Columbia, MO 65211, USA
    J Abnorm Psychol 117:534-51. 2008
    ..The results of this study suggest that the direct causal effect of being exposed to an alcoholic parent on offspring alcohol use disorder is modest at best...
  72. ncbi request reprint Empirical evaluation of the genetic similarity of samples from twin registries in Australia and the Netherlands using 359 STRP markers
    Patrick F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 7264, United States of America
    Twin Res Hum Genet 9:600-2. 2006
    ..30% between the Australian and the Netherlands cohorts, a smaller value than between many European groups. We conclude that it is reasonable to combine the Australian and the Netherlands samples for joint genetic analyses...
  73. ncbi request reprint Sex differences in heritability of BMI: a comparative study of results from twin studies in eight countries
    Karoline Schousboe
    The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Denmark
    Twin Res 6:409-21. 2003
    ..Furthermore, they suggest that strategies to identify predisposing genes may benefit from taking into account potential sex specific effects...
  74. ncbi request reprint Use of latent profile analysis to identify eating disorder phenotypes in an adult Australian twin cohort
    Tracey D Wade
    School of Psychology, Flinders University, PO Box 2100, Adelaide, SA 5001, Australia
    Arch Gen Psychiatry 63:1377-84. 2006
    ..The relationships among the different eating disorders that exist in the community are poorly understood, especially for residual disorders in which bingeing or purging occurs in the absence of other behaviors...
  75. ncbi request reprint Gene-environment interaction effects on behavioral variation and risk of complex disorders: the example of alcoholism and other psychiatric disorders
    Andrew C Heath
    Missouri Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis 63108, USA
    Twin Res 5:30-7. 2002
    ..Since few separated twin pairs will be available for study in the future, we also consider methods for modifying variance components linkage analysis to allow for environmental interactions with linked loci...
  76. ncbi request reprint Heritabilities of apolipoprotein and lipid levels in three countries
    Marian Beekman
    Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Center, Leiden, The Netherlands
    Twin Res 5:87-97. 2002
    ..Although sample specific effects are present, we have shown that genes play a major role in determining the variance of apolipoprotein and lipid levels in four independent twin samples from three different countries...
  77. ncbi request reprint Estimating two-stage models for genetic influences on alcohol, tobacco or drug use initiation and dependence vulnerability in twin and family data
    Andrew C Heath
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    Twin Res 5:113-24. 2002
    ..Illustrative application of the model to Australian twin data on smoking confirmed substantial heritability of smoking persistence (42%) with minimal overlap with genetic influences on initiation...
  78. ncbi request reprint Repeated blood pressure measurements in a sample of Swedish twins: heritabilities and associations with polymorphisms in the renin-angiotensin-aldosterone system
    Anastasia Iliadou
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    J Hypertens 20:1543-50. 2002
    ..However, many studies have not been able to replicate findings of association between specific polymorphisms and diastolic and systolic blood pressure...
  79. ncbi request reprint Genetic covariation between serum gamma-glutamyltransferase activity and cardiovascular risk factors
    John B Whitfield
    Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Camperdown NSW 2050, Australia
    Clin Chem 48:1426-31. 2002
    ....
  80. pmc A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000074. 2008
    ..The signals detected in a region around the MC1R gene were explained by MC1R red hair color alleles. Our results suggest that the IRF4 and SLC24A4 loci are associated with human hair color and skin pigmentation...
  81. pmc Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs
    Scott F Saccone
    Department of Psychiatry, Box 8134, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Hum Mol Genet 16:36-49. 2007
    ..Other genes among the top signals were KCNJ6 and GABRA4. This study represents one of the most powerful and extensive studies of nicotine dependence to date and has found novel risk loci that require confirmation by replication studies...
  82. ncbi request reprint The role of melanocortin-1 receptor polymorphism in skin cancer risk phenotypes
    Richard A Sturm
    Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia
    Pigment Cell Res 16:266-72. 2003
    ..Such genetic association studies combined with the functional analysis of MC1R variant alleles in melanocytic cells should provide a link in understanding the association between pigmentary phototypes and skin cancer risk...
  83. ncbi request reprint Evidence for a QTL on chromosome 19 influencing LDL cholesterol levels in the general population
    Marian Beekman
    Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Hum Genet 11:845-50. 2003
    ..Our study provides strong evidence for the presence of a QTL on chromosome 19 with a major effect on LDL-C plasma levels in outbred Caucasian populations...
  84. doi request reprint Investigation of the relationship between smoking and appendicitis in Australian twins
    Chris Oldmeadow
    Department of Mathematical Sciences, Queensland University of Technology, Mathematical Sciences, O Block, Gardens Point Campus, Brisbane, Australia
    Ann Epidemiol 18:631-6. 2008
    ..Previous studies have shown an increased risk for cigarette smokers but no accounts for the timing of exposure to smoking relative to appendectomy were made...
  85. ncbi request reprint Multivariate genetic analysis of chronic pelvic pain and associated phenotypes
    Krina T Zondervan
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, United Kingdom
    Behav Genet 35:177-88. 2005
    ..CPP itself is unlikely to be a useful independent phenotype to conduct genetic aetiological studies; contributing conditions such as endometriosis and variation in nociception are likely to provide more useful phenotypes...
  86. ncbi request reprint Erythrocyte aldehyde dehydrogenase activity: lack of association with alcohol use and dependence or alcohol reactions in Australian twins
    Narelle K Hansell
    The Queensland Institute of Medical Research, Brisbane, Australia
    Alcohol Alcohol 40:343-8. 2005
    ....
  87. ncbi request reprint A transdiagnostic approach to understanding eating disorders
    Tracey D Wade
    School of Psychology, Flinders University, Adelaide, South Australia, Australia
    J Nerv Ment Dis 194:510-7. 2006
    ..The number of LEDB was associated with the degree of impaired functioning. This impairment was associated with conflict between parents and criticism from parents when growing up...
  88. ncbi request reprint Familial clustering of major depression and anxiety disorders in Australian and Dutch twins and siblings
    Christel M Middeldorp
    Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
    Twin Res Hum Genet 8:609-15. 2005
    ..Furthermore, different genetic risk factors appear to contribute to the vulnerability for panic disorder and/or agoraphobia in men and women. No other sex differences were found...
  89. ncbi request reprint A comparison of twin birthweight data from Australia, the Netherlands, the United States, Japan, and South Korea: are genetic and environmental variations in birthweight similar in Caucasians and East Asians?
    Yoon Mi Hur
    Seoul National University Hospital, Seoul, South Korea
    Twin Res Hum Genet 8:638-48. 2005
    ..Recent molecular findings and specific environmental factors that are subsumed by maternal effects are discussed...
  90. ncbi request reprint Spousal concordance for alcohol dependence: evidence for assortative mating or spousal interaction effects?
    Julia D Grant
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Alcohol Clin Exp Res 31:717-28. 2007
    ..The primary goal of the present analyses is to test hypotheses about the source(s) and magnitude of spousal associations for AD using a twin-spouse design...
  91. pmc Genetic linkage to chromosome 22q12 for a heavy-smoking quantitative trait in two independent samples
    Scott F Saccone
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Hum Genet 80:856-66. 2007
    ..Fine mapping of this linkage region may reveal variants contributing to heaviness of smoking, which will lead to a better understanding of the genetic mechanisms underlying nicotine dependence...
  92. ncbi request reprint A comparison of early family life events amongst monozygotic twin women with lifetime anorexia nervosa, bulimia nervosa, or major depression
    Tracey D Wade
    School of Psychology, Flinders University, Adelaide, South Australia, Australia
    Int J Eat Disord 40:679-86. 2007
    ..To investigate the differential profile of early family life events associated with lifetime anorexia nervosa (AN), bulimia nervosa (BN), and major depression (MD)...
  93. pmc Evidence of genetic effects on blood lead concentration
    John B Whitfield
    Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Sydney, Australia
    Environ Health Perspect 115:1224-30. 2007
    ..However, there has been little investigation of individual differences in lead absorption, distribution, or toxicity, or of genetic causes of such variation...
  94. ncbi request reprint Age at first sexual intercourse and teenage pregnancy in Australian female twins
    Mary Waldron
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, United States of America
    Twin Res Hum Genet 10:440-9. 2007
    ....
  95. pmc Intergenerational transmission of childhood conduct problems: a Children of Twins Study
    Brian M D'Onofrio
    Department of Psychological and Brain Sciences, Indiana University, 1101 E 10th St, Bloomington, IN 47405, USA
    Arch Gen Psychiatry 64:820-9. 2007
    ..The familial nature of childhood conduct problems has been well documented, but few genetically informed studies have explicitly explored the processes through which parental conduct problems influence an offspring's behavior problems...
  96. ncbi request reprint Shared temperament risk factors for anorexia nervosa: a twin study
    Tracey D Wade
    School of Psychology, Flinders University, P O Box 2100, Adelaide, SA 5001, Australia
    Psychosom Med 70:239-44. 2008
    ..To answer two questions about the nature of the relationship between anorexia nervosa (AN) and dimensional temperament traits: Which traits are comorbid with AN? Which traits share transmitted liabilities with AN?..
  97. ncbi request reprint Genetic variation of individual alpha frequency (IAF) and alpha power in a large adolescent twin sample
    Christine M Smit
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Herston, Queensland, 4029 Australia
    Int J Psychophysiol 61:235-43. 2006
    ....
  98. pmc Heritability and genome-wide linkage in US and australian twins identify novel genomic regions controlling chromogranin a: implications for secretion and blood pressure
    DANIEL T O'CONNOR
    Departments of Medicine and Pharmacology and Center for Human Genetics and Genomics, University of California at San Diego School of Medicine, Veterans Affairs San Diego Healthcare System, La Jolla, CA 92093 0838, USA
    Circulation 118:247-57. 2008
    ..We approached catestatin heritability using twin pairs, coupled with genome-wide linkage, in a series of twin and sibling pairs from 2 continents...
  99. pmc A genomewide scan for intelligence identifies quantitative trait loci on 2q and 6p
    Danielle Posthuma
    Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
    Am J Hum Genet 77:318-26. 2005
    ..3-22.3 (LOD score 3.20 for full-scale IQ and 2.33 for verbal IQ), overlapping marginally with the 6p22.3-21.31 region implicated in reading disability and dyslexia...
  100. ncbi request reprint Meta-analysis of four new genome scans for lipid parameters and analysis of positional candidates in positive linkage regions
    Bastiaan T Heijmans
    Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    Eur J Hum Genet 13:1143-53. 2005
    ..In conclusion, application of a new meta-analysis approach maximised the power to detect QTLs for lipid levels and improved the precision of their location estimate...
  101. ncbi request reprint The ongoing adaptive evolution of ASPM and Microcephalin is not explained by increased intelligence
    Nitzan Mekel-Bobrov
    Department of Human Genetics, Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USA
    Hum Mol Genet 16:600-8. 2007
    ....

Research Grants5

  1. Molecular Epidemiology of Alcoholism 1: Candidate Gene
    Nicholas Martin; Fiscal Year: 2005
    ..abstract_text> ..