Stuart Macgregor

Summary

Affiliation: Queensland Institute of Medical Research
Country: Australia

Publications

  1. ncbi request reprint Use of phenotypic covariates in association analysis by sequential addition of cases
    Stuart Macgregor
    Biostatistics and Bioinformatics Unit, Department of Psychological Medicine, Cardiff University, Cardiff, UK
    Eur J Hum Genet 14:529-34. 2006
  2. doi request reprint Vitamin D receptor gene polymorphisms have negligible effect on human height
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Australia
    Twin Res Hum Genet 11:488-94. 2008
  3. ncbi request reprint Most pooling variation in array-based DNA pooling is attributable to array error rather than pool construction error
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
    Eur J Hum Genet 15:501-4. 2007
  4. ncbi request reprint Bias, precision and heritability of self-reported and clinically measured height in Australian twins
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Herston Road, Brisbane, Australia
    Hum Genet 120:571-80. 2006
  5. pmc Analysis of pooled DNA samples on high density arrays without prior knowledge of differential hybridization rates
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
    Nucleic Acids Res 34:e55. 2006
  6. ncbi request reprint False disease region identification from identity-by-descent haplotype sharing in the presence of phenocopies
    Stuart Macgregor
    Institute of Evolutionary Biology, University of Edinburgh, West Mains Road, Edinburgh, United Kingdom
    Twin Res Hum Genet 9:9-16. 2006
  7. pmc GAIA: an easy-to-use web-based application for interaction analysis of case-control data
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
    BMC Med Genet 7:34. 2006
  8. pmc Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Hum Mol Genet 18:580-93. 2009
  9. pmc Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3
    Stuart Macgregor
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Nat Genet 43:1114-8. 2011
  10. doi request reprint P2RX7: A bipolar and unipolar disorder candidate susceptibility gene?
    Elaine K Green
    Department of Psychological Medicine, Wales College of Medicine, Cardiff University, Heath Park, UK
    Am J Med Genet B Neuropsychiatr Genet 150:1063-9. 2009

Detail Information

Publications52

  1. ncbi request reprint Use of phenotypic covariates in association analysis by sequential addition of cases
    Stuart Macgregor
    Biostatistics and Bioinformatics Unit, Department of Psychological Medicine, Cardiff University, Cardiff, UK
    Eur J Hum Genet 14:529-34. 2006
    ..We also illustrate the use of the method for taking account of a dimensional measure of psychosis in a study of the schizophrenia susceptibility gene, dysbindin, in bipolar disorder...
  2. doi request reprint Vitamin D receptor gene polymorphisms have negligible effect on human height
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Australia
    Twin Res Hum Genet 11:488-94. 2008
    ..Our results did not support any role for two other regions (rs10735810, rs7139166) of VDR in explaining variation in height...
  3. ncbi request reprint Most pooling variation in array-based DNA pooling is attributable to array error rather than pool construction error
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
    Eur J Hum Genet 15:501-4. 2007
    ..This has important implications for optimal study design for array-based pooling. Given carefully constructed pools, resources should be allocated to increasing the number of arrays per sample rather than to constructing multiple pools...
  4. ncbi request reprint Bias, precision and heritability of self-reported and clinically measured height in Australian twins
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Herston Road, Brisbane, Australia
    Hum Genet 120:571-80. 2006
    ..Moderate reduction in error (through the use of accurate clinical or multiple self-report measures) increased the effective sample size by 22%; elimination of measurement error led to increases in effective sample size of 41%...
  5. pmc Analysis of pooled DNA samples on high density arrays without prior knowledge of differential hybridization rates
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
    Nucleic Acids Res 34:e55. 2006
    ..With 20 arrays (10 for cases, 10 for controls), over half of the information could be extracted from this sample...
  6. ncbi request reprint False disease region identification from identity-by-descent haplotype sharing in the presence of phenocopies
    Stuart Macgregor
    Institute of Evolutionary Biology, University of Edinburgh, West Mains Road, Edinburgh, United Kingdom
    Twin Res Hum Genet 9:9-16. 2006
    ....
  7. pmc GAIA: an easy-to-use web-based application for interaction analysis of case-control data
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
    BMC Med Genet 7:34. 2006
    ..The importance of testing for interactions between loci in association analysis has been highlighted in a number of recent high profile publications...
  8. pmc Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Hum Mol Genet 18:580-93. 2009
    ..The absence of study-wide significant effects on AD results from the low P-value required when testing multiple single nucleotide polymorphisms and phenotypes...
  9. pmc Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3
    Stuart Macgregor
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Nat Genet 43:1114-8. 2011
    ..3 locus span a region with ten genes, and plausible candidate genes for melanoma susceptibility include ARNT and SETDB1. Variants at the 1q21.3 locus do not seem to be associated with human pigmentation or measures of nevus density...
  10. doi request reprint P2RX7: A bipolar and unipolar disorder candidate susceptibility gene?
    Elaine K Green
    Department of Psychological Medicine, Wales College of Medicine, Cardiff University, Heath Park, UK
    Am J Med Genet B Neuropsychiatr Genet 150:1063-9. 2009
    ..Our data do not provide support for rs2230912 or the other polymorphisms studied within the P2RX7 locus, being involved in susceptibility to mood disorders...
  11. pmc Common variants in the trichohyalin gene are associated with straight hair in Europeans
    Sarah E Medland
    Queensland Institute of Medical Research, Brisbane 4029, Australia
    Am J Hum Genet 85:750-5. 2009
    ..5x10(-31)). These variants are at their highest frequency in Northern Europeans, paralleling the distribution of the straight-hair EDAR variant in Asian populations...
  12. pmc Genome-wide association meta-analysis identifies new endometriosis risk loci
    Dale R Nyholt
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Nat Genet 44:1355-9. 2012
    ..8 × 10(-11)), indicating that many weakly associated SNPs represent true endometriosis risk loci and that risk prediction and future targeted disease therapy may be transferred across these populations...
  13. ncbi request reprint Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder: case-control study of over 3000 individuals from the UK
    Elaine K Green
    Department of Psychological Medicine, Henry Wellcome Building, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF4 4XN, Wales, UK
    Br J Psychiatry 188:21-5. 2006
    ..Three family-based studies have shown association of the common Valine (Val) allele of the Val66Met polymorphism of the BDNF gene with susceptibility to bipolar disorder...
  14. doi request reprint Effects of GABRA2 variation on physiological, psychomotor and subjective responses in the alcohol challenge twin study
    Penelope A Lind
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 11:174-82. 2008
    ..Because of the large number of phenotypes tested, these possibly significant findings will need to be confirmed in further studies...
  15. pmc The role of GABRA2 in alcohol dependence, smoking, and illicit drug use in an Australian population sample
    Penelope A Lind
    Genetic Epidemiology, Queensland Institute of Medical Research, Royal BrisbaneHospital, Brisbane, Queensland, Australia
    Alcohol Clin Exp Res 32:1721-31. 2008
    ..The present study tested for association between GABRA2 and alcohol dependence, smoking, and illicit drug use within the Australian population...
  16. pmc A versatile gene-based test for genome-wide association studies
    Jimmy Z Liu
    Genetics and Population Health Division, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia
    Am J Hum Genet 87:139-45. 2010
    ..We have implemented the approach in both an easy-to-use web interface, which only requires the uploading of markers with their association p-values, and a separate downloadable application...
  17. pmc A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations
    Penelope A Lind
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 13:10-29. 2010
    ..Further studies will be required before the detailed causes of comorbidity between AD and ND are understood...
  18. pmc Association between in vivo alcohol metabolism and genetic variation in pathways that metabolize the carbon skeleton of ethanol and NADH reoxidation in the alcohol challenge twin study
    Penelope A Lind
    Molecular Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Alcohol Clin Exp Res 36:2074-85. 2012
    ....
  19. pmc Genome-wide association identifies ATOH7 as a major gene determining human optic disc size
    Stuart Macgregor
    Genetics and Population Health, Queensland Institute of Medical Research, Brisbane, Australia
    Hum Mol Genet 19:2716-24. 2010
    ..0136). Furthermore, the Arg65Gly variant was found to have very low frequency (0.00066) in an additional set of 672 controls...
  20. ncbi request reprint No association between schizophrenia and polymorphisms in COMT in two large samples
    Hywel J Williams
    Department of Psychological Medicine, Henry Wellcome Building for Biomedical Research, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Am J Psychiatry 162:1736-8. 2005
    ..The authors examined these hypotheses...
  21. pmc Highly cost-efficient genome-wide association studies using DNA pools and dense SNP arrays
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
    Nucleic Acids Res 36:e35. 2008
    ..The large cost savings with Illumina HumanHap300-based pooling imply that future studies need only be limited by the availability of samples and not cost...
  22. pmc Genome partitioning of genetic variation for height from 11,214 sibling pairs
    Peter M Visscher
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
    Am J Hum Genet 81:1104-10. 2007
    ....
  23. pmc Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus
    Yi Lu
    Queensland Institute of Medical Research, Statistical Genetics, Herston, Brisbane, Queensland, Australia
    Nat Genet 45:155-63. 2013
    ..FNDC3B was also associated with primary open-angle glaucoma (P = 5.6 × 10(-4); tested in 3 cohorts with 2,979 cases and 7,399 controls). Further analyses implicate the collagen and extracellular matrix pathways in the regulation of CCT...
  24. pmc Covariate linkage analysis of GAW14 simulated data incorporating subclinical phenotype, sex, population, parent-of-origin, and interaction
    Marian L Hamshere
    Biostatistics and Bioinformatics Unit, Cardiff University, Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    BMC Genet 6:S45. 2005
    ..Focusing on a randomly chosen replicate (42) we investigated the effect of the 12 subclinical phenotypes, sex, population, and parent-of-origin on the linkage signal from a model-free linkage analysis of Kofendrerd Personality Disorder...
  25. pmc Quantitative trait locus analysis of longitudinal quantitative trait data in complex pedigrees
    Stuart Macgregor
    Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 171:1365-76. 2005
    ..The CF-based techniques should allow efficient multivariate analyses of many data sets in human and natural population genetics...
  26. pmc Genome-wide association study for ovarian cancer susceptibility using pooled DNA
    Yi Lu
    Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 15:615-23. 2012
    ..However, our study lacked power to make clear statements on the existence of hitherto untagged small-effect variants...
  27. pmc Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia
    Lyudmila Georgieva
    Department of Psychological Medicine, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom
    Proc Natl Acad Sci U S A 103:12469-74. 2006
    ..Our data provide strong convergent evidence that variation in OLIG2 confers susceptibility to schizophrenia alone and as part of a network of genes implicated in oligodendrocyte function...
  28. pmc GWAS findings for human iris patterns: associations with variants in genes that influence normal neuronal pattern development
    Mats Larsson
    Queensland Institute of Medical Research, Brisbane, Australia
    Am J Hum Genet 89:334-43. 2011
    ..These findings suggest that genes involved in normal neuronal pattern development may also influence tissue structures in the human iris...
  29. pmc ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: a comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas
    Sharon E Johnatty
    Queensland Institute of Medical Research, Brisbane, Australia
    Gynecol Oncol 131:8-14. 2013
    ..We comprehensively evaluated this gene and flanking regions for an association with clinical outcome in epithelial ovarian cancer (EOC)...
  30. pmc Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"
    Sharon E Johnatty
    Queensland Institute of Medical Research, Brisbane, Australia
    PLoS Genet 6:e1001016. 2010
    ..ORper-allele 1.14 (1.04-1.24) p=0.003]. Our study adds to the growing evidence that, like the 8q24 locus, the telomerase reverse transcriptase locus at 5p15.33, is a general cancer susceptibility locus...
  31. pmc Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis
    Jodie N Painter
    Molecular Epidemiology, Queensland Institute of Medical Research, Herston, Queensland, Australia
    Nat Genet 43:51-4. 2011
    ..4 × 10⁻⁹ (OR = 1.20, 95% CI 1.13-1.27) for 'all' endometriosis in our combined datasets of 5,586 cases and 9,331 controls. rs12700667 is located in an intergenic region upstream of the plausible candidate genes NFE2L3 and HOXA10...
  32. pmc Legacy of mutiny on the Bounty: founder effect and admixture on Norfolk Island
    Stuart Macgregor
    Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Eur J Hum Genet 18:67-72. 2010
    ..In conclusion, both founder effect and extreme admixture have substantially influenced the genetic architecture of a variety of CVD-related traits in this population...
  33. pmc Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers
    Jonathan Beesley
    Division of Genetics and Population Health, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    PLoS ONE 6:e24987. 2011
    ..We demonstrate that the minor alleles at rs2736109, and at an additional TERT promoter SNP, rs2736108, are associated with decreased breast cancer risk, and that the combination of both SNPs substantially reduces TERT promoter activity...
  34. pmc A simple and fast two-locus quality control test to detect false positives due to batch effects in genome-wide association studies
    Sang Hong Lee
    Queensland Institute of Medical Research, Herston, Queensland, Australia
    Genet Epidemiol 34:854-62. 2010
    ..This novel QC approach is easy to implement and computationally efficient, and can lead to a better quality of genotypes for subsequent genotype-phenotype investigations...
  35. pmc Longitudinal variance-components analysis of the Framingham Heart Study data
    Stuart Macgregor
    Biostatistics and Bioinformatics Unit, University of Wales College of Medicine, Heath Hospital, Cardiff, United Kingdom
    BMC Genet 4:S22. 2003
    ..The traits of interest were BMI, HDLC, total cholesterol, and height. The longitudinal method allowed the characterization of the change in QTL effects with aging. A QTL affecting BMI was shown to act mainly at early ages...
  36. ncbi request reprint Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1)
    Rachel Raybould
    Department of Psychological Medicine, Wales College of Medicine, Cardiff University, Cardiff, Wales, UK
    Biol Psychiatry 57:696-701. 2005
    ..We previously reported that variation at a specific 3-locus haplotype influences susceptibility to schizophrenia in a large United Kingdom (UK) Caucasian case-control sample...
  37. ncbi request reprint A single nucleotide polymorphism in CHAT influences response to acetylcholinesterase inhibitors in Alzheimer's disease
    Denise Harold
    Department of Psychological Medicine, Cardiff University, Cardiff, UK
    Pharmacogenet Genomics 16:75-7. 2006
    ..Treatment with acetylcholinesterase (AChE) inhibitors aims to reverse this deficit and does ameliorate the decline in cognition in some AD patients, although response is variable...
  38. pmc Genetic variants near PDGFRA are associated with corneal curvature in Australians
    Aniket Mishra
    Queensland Institute of Medical Research, Brisbane, Australia
    Invest Ophthalmol Vis Sci 53:7131-6. 2012
    ..Results of initial genomewide association studies (GWAS) for CC in Australians were also reported...
  39. doi request reprint Melanoma genetics: recent findings take us beyond well-traveled pathways
    Matthew H Law
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    J Invest Dermatol 132:1763-74. 2012
    ..We take this opportunity to summarize these new and exciting findings and integrate them into the current framework of our understanding of melanoma genetics...
  40. ncbi request reprint Is schizophrenia linked to chromosome 1q?
    Stuart Macgregor
    Institute of Cell, Animal and Population Biology, Ashworth Laboratory, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT, UK
    Science 298:2277; author reply 2277. 2002
  41. ncbi request reprint Familiality of postpartum depression in unipolar disorder: results of a family study
    Liz Forty
    Henry Wellcome Building for Biomedical Research, Wales School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Am J Psychiatry 163:1549-53. 2006
    ..The authors here examine whether vulnerability to postpartum triggering of depressive episodes aggregates in families and assess how this aggregation varies with the definition of postpartum onset...
  42. pmc A genome-wide analysis of 'Bounty' descendants implicates several novel variants in migraine susceptibility
    Hannah C Cox
    Genomics Research Centre, Griffith Health Institute, Griffith University, Queensland 4222, Australia
    Neurogenetics 13:261-6. 2012
    ..Association of SNPs within these neurotransmitter-related genes suggests a disrupted serotoninergic system that is perhaps specific to the Norfolk Island pedigree, but that might provide clues to understanding migraine more generally...
  43. pmc Common genetic variants near the Brittle Cornea Syndrome locus ZNF469 influence the blinding disease risk factor central corneal thickness
    Yi Lu
    Genetics and Population Health, Queensland Institute of Medical Research, Brisbane, Australia
    PLoS Genet 6:e1000947. 2010
    ..Our findings suggest that in addition to rare variants in ZNF469 underlying CCT variation in BCS patients, more common variants near this gene may contribute to CCT variation in the general population...
  44. ncbi request reprint Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder
    Nigel M Williams
    Department of Psychological Medicine and Biostatistics and Bioinformatics Unit, Wales School of Medicine, Cardiff University
    Arch Gen Psychiatry 63:366-73. 2006
    ..Variation at the DAOA/G30 locus has been described to be associated with both schizophrenia and bipolar disorder, but there is little consistency between studies of the tested polymorphisms or variants showing association...
  45. ncbi request reprint Longitudinal data analysis in pedigree studies
    W James Gauderman
    Department of Preventive Medicine, University of Southern California, Los Angeles, 90089, USA
    Genet Epidemiol 25:S18-28. 2003
    ..Several areas for future research are discussed...
  46. ncbi request reprint Operation of the schizophrenia susceptibility gene, neuregulin 1, across traditional diagnostic boundaries to increase risk for bipolar disorder
    Elaine K Green
    Department of Psychological Medicine and Biostatics and Bioinformatics Unit, University of Wales College of Medicine, Cardiff
    Arch Gen Psychiatry 62:642-8. 2005
    ..The most consistent finding has been that one particular haplotype (the "core" haplotype) is overrepresented in cases compared with control subjects...
  47. pmc Common sequence variants on 20q11.22 confer melanoma susceptibility
    Kevin M Brown
    Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, Arizona 85028, USA
    Nat Genet 40:838-40. 2008
    ..The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases...
  48. doi request reprint Linkage analysis in a large family from Pakistan with depression and a high incidence of consanguineous marriages
    Muhammad Ayub
    St Luke s Hospital, Middlesborough, UK
    Hum Hered 66:190-8. 2008
    ..The effect of inbreeding on linkage analysis in an extended pedigree is discussed...
  49. ncbi request reprint Edrecolomab alone or in combination with fluorouracil and folinic acid in the adjuvant treatment of stage III colon cancer: a randomised study
    Cornelis J A Punt
    Department of Medical Oncology, University Medical Center St Radboud, PO Box 9101, 6500 HB Nijmegen, Netherlands
    Lancet 360:671-7. 2002
    ..We did a randomised trial in 27 countries to determine the effect of adding edrecolomab to the combination of fluorouracil and folinic acid in these patients...
  50. pmc Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder
    Ricardo Segurado
    Neuropsychiatric Genetics Unit, Department of Genetics, Trinity College, Dublin 2, Ireland
    Am J Hum Genet 73:49-62. 2003
    ..We note that meta-analysis can sometimes provide support for linkage but cannot disprove linkage in any candidate region...
  51. pmc Optimal two-stage testing for family-based genome-wide association studies
    Stuart Macgregor
    Am J Hum Genet 82:797-9; author reply 799-800. 2008