Penelope A Lind

Summary

Affiliation: Queensland Institute of Medical Research
Country: Australia

Publications

  1. ncbi Association between in vivo alcohol metabolism and genetic variation in pathways that metabolize the carbon skeleton of ethanol and NADH reoxidation in the alcohol challenge twin study
    Penelope A Lind
    Molecular Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Alcohol Clin Exp Res 36:2074-85. 2012
  2. ncbi No association between Cholinergic Muscarinic Receptor 2 (CHRM2) genetic variation and cognitive abilities in three independent samples
    Penelope A Lind
    Genetic Epidemiology Unit, PO Royal Brisbane Hospital, Brisbane, QLD, 4029, Australia
    Behav Genet 39:513-23. 2009
  3. ncbi Association between harmful alcohol consumption behavior and dopamine transporter (DAT1) gene polymorphisms in a male Finnish population
    Penelope A Lind
    Genetic Epidemiology, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Queensland, Australia
    Psychiatr Genet 19:117-25. 2009
  4. ncbi Dyslexia and DCDC2: normal variation in reading and spelling is associated with DCDC2 polymorphisms in an Australian population sample
    Penelope A Lind
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Eur J Hum Genet 18:668-73. 2010
  5. ncbi The role of GABRA2 in alcohol dependence, smoking, and illicit drug use in an Australian population sample
    Penelope A Lind
    Genetic Epidemiology, Queensland Institute of Medical Research, Royal BrisbaneHospital, Brisbane, Queensland, Australia
    Alcohol Clin Exp Res 32:1721-31. 2008
  6. ncbi A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations
    Penelope A Lind
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 13:10-29. 2010
  7. ncbi Effects of GABRA2 variation on physiological, psychomotor and subjective responses in the alcohol challenge twin study
    Penelope A Lind
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 11:174-82. 2008
  8. ncbi Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Hum Mol Genet 18:580-93. 2009
  9. ncbi Can we identify genes for alcohol consumption in samples ascertained for heterogeneous purposes?
    Narelle K Hansell
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Alcohol Clin Exp Res 33:729-39. 2009
  10. ncbi Association study of candidate variants from brain-derived neurotrophic factor and dystrobrevin-binding protein 1 with neuroticism, anxiety, and depression
    Naomi R Wray
    Queensland Institute of Medical Research, Brisbane, Australia
    Psychiatr Genet 18:219-25. 2008

Detail Information

Publications18

  1. ncbi Association between in vivo alcohol metabolism and genetic variation in pathways that metabolize the carbon skeleton of ethanol and NADH reoxidation in the alcohol challenge twin study
    Penelope A Lind
    Molecular Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Alcohol Clin Exp Res 36:2074-85. 2012
    ....
  2. ncbi No association between Cholinergic Muscarinic Receptor 2 (CHRM2) genetic variation and cognitive abilities in three independent samples
    Penelope A Lind
    Genetic Epidemiology Unit, PO Royal Brisbane Hospital, Brisbane, QLD, 4029, Australia
    Behav Genet 39:513-23. 2009
    ..No significant association was found between CHRM2 and diverse measures of cognitive ability in any of the samples. In conclusion, this study does not support a role for CHRM2 in cognitive ability...
  3. ncbi Association between harmful alcohol consumption behavior and dopamine transporter (DAT1) gene polymorphisms in a male Finnish population
    Penelope A Lind
    Genetic Epidemiology, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Queensland, Australia
    Psychiatr Genet 19:117-25. 2009
    ..Within this reward system, the DA transporter (DAT1) plays a key role in the regulation of dopaminergic neurotransmission through presynaptic DA reuptake...
  4. ncbi Dyslexia and DCDC2: normal variation in reading and spelling is associated with DCDC2 polymorphisms in an Australian population sample
    Penelope A Lind
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Eur J Hum Genet 18:668-73. 2010
    ..This study provides support for DCDC2 as a risk gene for reading disorder, and suggests that this risk factor acts on normally varying reading skill in the general population...
  5. ncbi The role of GABRA2 in alcohol dependence, smoking, and illicit drug use in an Australian population sample
    Penelope A Lind
    Genetic Epidemiology, Queensland Institute of Medical Research, Royal BrisbaneHospital, Brisbane, Queensland, Australia
    Alcohol Clin Exp Res 32:1721-31. 2008
    ..The present study tested for association between GABRA2 and alcohol dependence, smoking, and illicit drug use within the Australian population...
  6. ncbi A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations
    Penelope A Lind
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 13:10-29. 2010
    ..Further studies will be required before the detailed causes of comorbidity between AD and ND are understood...
  7. ncbi Effects of GABRA2 variation on physiological, psychomotor and subjective responses in the alcohol challenge twin study
    Penelope A Lind
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 11:174-82. 2008
    ..Because of the large number of phenotypes tested, these possibly significant findings will need to be confirmed in further studies...
  8. ncbi Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Hum Mol Genet 18:580-93. 2009
    ..The absence of study-wide significant effects on AD results from the low P-value required when testing multiple single nucleotide polymorphisms and phenotypes...
  9. ncbi Can we identify genes for alcohol consumption in samples ascertained for heterogeneous purposes?
    Narelle K Hansell
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Alcohol Clin Exp Res 33:729-39. 2009
    ..e., selected on other traits and forms of psychopathology), which nevertheless assess consumption as a risk factor. Is it reasonable to expect that genes contributing to variation in alcohol consumption can be identified in such samples?..
  10. ncbi Association study of candidate variants from brain-derived neurotrophic factor and dystrobrevin-binding protein 1 with neuroticism, anxiety, and depression
    Naomi R Wray
    Queensland Institute of Medical Research, Brisbane, Australia
    Psychiatr Genet 18:219-25. 2008
    ..Here, association between variants of BDNF and DTNBP1, and multiple anxiety and depression phenotypes is explored...
  11. ncbi The role of aldehyde dehydrogenase-1 (ALDH1A1) polymorphisms in harmful alcohol consumption in a Finnish population
    Penelope A Lind
    Department of Genetic Epidemiology, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, QLD 4029, Australia
    Hum Genomics 3:24-35. 2008
    ..12-0.84) are implicated in alcohol dependence status. This study provides further evidence for a role for ALDH1A1 in alcohol consumption behaviour, including problem drinking and possibly alcohol dependence, in our Finnish population...
  12. ncbi Linkage analysis of alcohol dependence symptoms in the community
    Narelle K Hansell
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
    Alcohol Clin Exp Res 34:158-63. 2010
    ..We have previously identified suggestive linkage for alcohol consumption in a community-based sample of Australian adults. In this companion paper, we explore the strength of genetic linkage signals for alcohol dependence symptoms...
  13. ncbi A haplotype spanning KIAA0319 and TTRAP is associated with normal variation in reading and spelling ability
    Michelle Luciano
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
    Biol Psychiatry 62:811-7. 2007
    ..We aimed to find further support for this gene by examining its association with reading and spelling ability in adolescent twins and their siblings unselected for dyslexia...
  14. ncbi Long-term stability and heritability of telephone interview measures of alcohol consumption and dependence
    Narelle K Hansell
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, Queensland, 4029, Australia
    Twin Res Hum Genet 11:287-305. 2008
    ..42 to .51 for dependence and from .31 to .51 for consumption. Consumption was significantly less heritable in the younger Phase 2 cohort (23-39 years) compared to the older Phase 1 cohort (28-90 years)...
  15. ncbi Association study of candidate variants of COMT with neuroticism, anxiety and depression
    Naomi R Wray
    Queensland Institute of Medical Research, Brisbane, Australia
    Am J Med Genet B Neuropsychiatr Genet 147:1314-8. 2008
    ..Haplotype T-G-G showed weak association (P = 0.042) with PDAG before correction for multiple testing; association between this haplotype and schizophrenia has been previously reported in an Australian sample...
  16. ncbi Vitamin D receptor gene polymorphisms have negligible effect on human height
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Australia
    Twin Res Hum Genet 11:488-94. 2008
    ..Our results did not support any role for two other regions (rs10735810, rs7139166) of VDR in explaining variation in height...
  17. ncbi Genome-wide association study of a quantitative disordered gambling trait
    Penelope A Lind
    Quantitative GeneticsGenetic EpidemiologyMolecular EpidemiologyQueensland Institute of Medical Research, Brisbane, QLD, Australia, Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USADepartment of Psychological Sciences, University of Missouri, Columbia, MO, USA
    Addict Biol 18:511-22. 2013
    ..While further replication is required, the identification of susceptibility loci and biological pathways will be important in characterizing the biological mechanisms that underpin disordered gambling...
  18. ncbi GWAS of butyrylcholinesterase activity identifies four novel loci, independent effects within BCHE and secondary associations with metabolic risk factors
    Beben Benyamin
    Queensland Institute of Medical Research, Brisbane 4006, Australia
    Hum Mol Genet 20:4504-14. 2011
    ..We conclude that variation in BCHE activity is due to multiple variants across the spectrum from uncommon/large effect to common/small effect, and partly results from (rather than causes) metabolic abnormalities...