Penelope A Lind

Summary

Affiliation: Queensland Institute of Medical Research
Country: Australia

Publications

  1. pmc Association between in vivo alcohol metabolism and genetic variation in pathways that metabolize the carbon skeleton of ethanol and NADH reoxidation in the alcohol challenge twin study
    Penelope A Lind
    Molecular Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Alcohol Clin Exp Res 36:2074-85. 2012
  2. pmc A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations
    Penelope A Lind
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 13:10-29. 2010
  3. pmc The role of GABRA2 in alcohol dependence, smoking, and illicit drug use in an Australian population sample
    Penelope A Lind
    Genetic Epidemiology, Queensland Institute of Medical Research, Royal BrisbaneHospital, Brisbane, Queensland, Australia
    Alcohol Clin Exp Res 32:1721-31. 2008
  4. pmc Dyslexia and DCDC2: normal variation in reading and spelling is associated with DCDC2 polymorphisms in an Australian population sample
    Penelope A Lind
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Eur J Hum Genet 18:668-73. 2010
  5. doi request reprint No association between Cholinergic Muscarinic Receptor 2 (CHRM2) genetic variation and cognitive abilities in three independent samples
    Penelope A Lind
    Genetic Epidemiology Unit, PO Royal Brisbane Hospital, Brisbane, QLD, 4029, Australia
    Behav Genet 39:513-23. 2009
  6. doi request reprint Association between harmful alcohol consumption behavior and dopamine transporter (DAT1) gene polymorphisms in a male Finnish population
    Penelope A Lind
    Genetic Epidemiology, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Queensland, Australia
    Psychiatr Genet 19:117-25. 2009
  7. doi request reprint Effects of GABRA2 variation on physiological, psychomotor and subjective responses in the alcohol challenge twin study
    Penelope A Lind
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 11:174-82. 2008
  8. ncbi request reprint A haplotype spanning KIAA0319 and TTRAP is associated with normal variation in reading and spelling ability
    Michelle Luciano
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
    Biol Psychiatry 62:811-7. 2007
  9. pmc Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Hum Mol Genet 18:580-93. 2009
  10. pmc Can we identify genes for alcohol consumption in samples ascertained for heterogeneous purposes?
    Narelle K Hansell
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Alcohol Clin Exp Res 33:729-39. 2009

Detail Information

Publications19

  1. pmc Association between in vivo alcohol metabolism and genetic variation in pathways that metabolize the carbon skeleton of ethanol and NADH reoxidation in the alcohol challenge twin study
    Penelope A Lind
    Molecular Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Alcohol Clin Exp Res 36:2074-85. 2012
    ....
  2. pmc A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations
    Penelope A Lind
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 13:10-29. 2010
    ..Further studies will be required before the detailed causes of comorbidity between AD and ND are understood...
  3. pmc The role of GABRA2 in alcohol dependence, smoking, and illicit drug use in an Australian population sample
    Penelope A Lind
    Genetic Epidemiology, Queensland Institute of Medical Research, Royal BrisbaneHospital, Brisbane, Queensland, Australia
    Alcohol Clin Exp Res 32:1721-31. 2008
    ..The present study tested for association between GABRA2 and alcohol dependence, smoking, and illicit drug use within the Australian population...
  4. pmc Dyslexia and DCDC2: normal variation in reading and spelling is associated with DCDC2 polymorphisms in an Australian population sample
    Penelope A Lind
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Eur J Hum Genet 18:668-73. 2010
    ..This study provides support for DCDC2 as a risk gene for reading disorder, and suggests that this risk factor acts on normally varying reading skill in the general population...
  5. doi request reprint No association between Cholinergic Muscarinic Receptor 2 (CHRM2) genetic variation and cognitive abilities in three independent samples
    Penelope A Lind
    Genetic Epidemiology Unit, PO Royal Brisbane Hospital, Brisbane, QLD, 4029, Australia
    Behav Genet 39:513-23. 2009
    ..No significant association was found between CHRM2 and diverse measures of cognitive ability in any of the samples. In conclusion, this study does not support a role for CHRM2 in cognitive ability...
  6. doi request reprint Association between harmful alcohol consumption behavior and dopamine transporter (DAT1) gene polymorphisms in a male Finnish population
    Penelope A Lind
    Genetic Epidemiology, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Queensland, Australia
    Psychiatr Genet 19:117-25. 2009
    ..Within this reward system, the DA transporter (DAT1) plays a key role in the regulation of dopaminergic neurotransmission through presynaptic DA reuptake...
  7. doi request reprint Effects of GABRA2 variation on physiological, psychomotor and subjective responses in the alcohol challenge twin study
    Penelope A Lind
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 11:174-82. 2008
    ..Because of the large number of phenotypes tested, these possibly significant findings will need to be confirmed in further studies...
  8. ncbi request reprint A haplotype spanning KIAA0319 and TTRAP is associated with normal variation in reading and spelling ability
    Michelle Luciano
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
    Biol Psychiatry 62:811-7. 2007
    ..We aimed to find further support for this gene by examining its association with reading and spelling ability in adolescent twins and their siblings unselected for dyslexia...
  9. pmc Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Hum Mol Genet 18:580-93. 2009
    ..The absence of study-wide significant effects on AD results from the low P-value required when testing multiple single nucleotide polymorphisms and phenotypes...
  10. pmc Can we identify genes for alcohol consumption in samples ascertained for heterogeneous purposes?
    Narelle K Hansell
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Alcohol Clin Exp Res 33:729-39. 2009
    ..e., selected on other traits and forms of psychopathology), which nevertheless assess consumption as a risk factor. Is it reasonable to expect that genes contributing to variation in alcohol consumption can be identified in such samples?..
  11. pmc The role of aldehyde dehydrogenase-1 (ALDH1A1) polymorphisms in harmful alcohol consumption in a Finnish population
    Penelope A Lind
    Department of Genetic Epidemiology, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, QLD 4029, Australia
    Hum Genomics 3:24-35. 2008
    ..12-0.84) are implicated in alcohol dependence status. This study provides further evidence for a role for ALDH1A1 in alcohol consumption behaviour, including problem drinking and possibly alcohol dependence, in our Finnish population...
  12. doi request reprint Association study of candidate variants from brain-derived neurotrophic factor and dystrobrevin-binding protein 1 with neuroticism, anxiety, and depression
    Naomi R Wray
    Queensland Institute of Medical Research, Brisbane, Australia
    Psychiatr Genet 18:219-25. 2008
    ..Here, association between variants of BDNF and DTNBP1, and multiple anxiety and depression phenotypes is explored...
  13. pmc Linkage analysis of alcohol dependence symptoms in the community
    Narelle K Hansell
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
    Alcohol Clin Exp Res 34:158-63. 2010
    ..We have previously identified suggestive linkage for alcohol consumption in a community-based sample of Australian adults. In this companion paper, we explore the strength of genetic linkage signals for alcohol dependence symptoms...
  14. doi request reprint Long-term stability and heritability of telephone interview measures of alcohol consumption and dependence
    Narelle K Hansell
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, Queensland, 4029, Australia
    Twin Res Hum Genet 11:287-305. 2008
    ..42 to .51 for dependence and from .31 to .51 for consumption. Consumption was significantly less heritable in the younger Phase 2 cohort (23-39 years) compared to the older Phase 1 cohort (28-90 years)...
  15. doi request reprint Association study of candidate variants of COMT with neuroticism, anxiety and depression
    Naomi R Wray
    Queensland Institute of Medical Research, Brisbane, Australia
    Am J Med Genet B Neuropsychiatr Genet 147:1314-8. 2008
    ..Haplotype T-G-G showed weak association (P = 0.042) with PDAG before correction for multiple testing; association between this haplotype and schizophrenia has been previously reported in an Australian sample...
  16. pmc Genome-wide association study of a quantitative disordered gambling trait
    Penelope A Lind
    Quantitative Genetics, Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Addict Biol 18:511-22. 2013
    ..While further replication is required, the identification of susceptibility loci and biological pathways will be important in characterizing the biological mechanisms that underpin disordered gambling...
  17. doi request reprint Vitamin D receptor gene polymorphisms have negligible effect on human height
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Australia
    Twin Res Hum Genet 11:488-94. 2008
    ..Our results did not support any role for two other regions (rs10735810, rs7139166) of VDR in explaining variation in height...
  18. pmc GWAS of butyrylcholinesterase activity identifies four novel loci, independent effects within BCHE and secondary associations with metabolic risk factors
    Beben Benyamin
    Queensland Institute of Medical Research, Brisbane 4006, Australia
    Hum Mol Genet 20:4504-14. 2011
    ..We conclude that variation in BCHE activity is due to multiple variants across the spectrum from uncommon/large effect to common/small effect, and partly results from (rather than causes) metabolic abnormalities...
  19. pmc Case-control association testing of common variants from sequencing of DNA pools
    Allan F McRae
    University of Queensland Diamantina Institute, Brisbane, Australia
    PLoS ONE 8:e65410. 2013
    ..The utility of this method is demonstrated on a sequence from the alcohol dehydrogenase (ADH) gene cluster on a case-control sample for heavy alcohol consumption...