Martin F Lavin

Summary

Affiliation: Queensland Institute of Medical Research
Country: Australia

Publications

  1. ncbi request reprint Lipopolysaccharide biosynthesis genes in koala type I Chlamydia: cloning and characterization
    A A Girjes
    Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, Bancroft Centre, Brisbane, Australia
    Res Microbiol 148:413-25. 1997
  2. ncbi request reprint ATM-dependent phosphorylation of nibrin in response to radiation exposure
    M Gatei
    The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland, Australia
    Nat Genet 25:115-9. 2000
  3. ncbi request reprint Aprataxin forms a discrete branch in the HIT (histidine triad) superfamily of proteins with both DNA/RNA binding and nucleotide hydrolase activities
    Amanda W Kijas
    Queensland Institute of Medical Research, P O Box Royal Brisbane Hospital, Queensland, Australia 4029
    J Biol Chem 281:13939-48. 2006
  4. ncbi request reprint ATM: the product of the gene mutated in ataxia-telangiectasia
    M F Lavin
    Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, Australia
    Int J Biochem Cell Biol 31:735-40. 1999
  5. ncbi request reprint Functional consequences of sequence alterations in the ATM gene
    Martin F Lavin
    The Queensland Cancer Fund Research Unit, The Queensland Institute of Medical Research, P O Box Royal Brisbane Hospital, Herston, Brisbane 4029, QLD, Australia
    DNA Repair (Amst) 3:1197-205. 2004
  6. ncbi request reprint The Mre11 complex and ATM: a two-way functional interaction in recognising and signaling DNA double strand breaks
    Martin F Lavin
    Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, P O Box Royal Brisbane Hospital, Herston, Brisbane, QLD 4029, Australia
    DNA Repair (Amst) 3:1515-20. 2004
  7. ncbi request reprint ATM signaling and genomic stability in response to DNA damage
    Martin F Lavin
    Queensland Cancer Fund Research Unit, The Queensland Institute of Medical Research, PO Box Royal Brisbane Hospital, Herston, Brisbane 4029, Australia
    Mutat Res 569:123-32. 2005
  8. ncbi request reprint ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia
    M F Lavin
    The Queensland Cancer Fund Research Unit, The Queensland Institute of Medical Research, Brisbane, Australia
    Int J Radiat Biol 75:1201-14. 1999
  9. ncbi request reprint Upregulation of FasL and apoptosis in thymic lymphomas in Atm knock-in mice
    Martin F Lavin
    The Queensland Cancer Fund Research Laboratories, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Herston, Brisbane, QLD 4029, Australia
    Toxicology 181:483-9. 2002
  10. ncbi request reprint ATM activation and DNA damage response
    Martin F Lavin
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Cell Cycle 6:931-42. 2007

Research Grants

  1. ROLE OF ATM IN DNA DAMAGE RECOGNITION
    Martin Lavin; Fiscal Year: 2000
  2. ROLE OF ATM IN DNA DAMAGE RECOGNITION
    Martin Lavin; Fiscal Year: 2001
  3. ROLE OF ATM IN DNA DAMAGE RECOGNITION
    Martin Lavin; Fiscal Year: 2002
  4. Missense mutant Atm and radiation-induced tumorgenesis
    Martin Lavin; Fiscal Year: 2003
  5. Missense mutant Atm and radiation-induced tumorgenesis
    Martin Lavin; Fiscal Year: 2004
  6. Missense mutant Atm and radiation-induced tumorgenesis
    Martin Lavin; Fiscal Year: 2005

Detail Information

Publications108 found, 100 shown here

  1. ncbi request reprint Lipopolysaccharide biosynthesis genes in koala type I Chlamydia: cloning and characterization
    A A Girjes
    Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, Bancroft Centre, Brisbane, Australia
    Res Microbiol 148:413-25. 1997
    ..4-kb fragment, were evident, and mRNA species corresponding to these ORFs were detected by Northern analysis. Both ORF1 and ORF2 are required for the appearance of chlamydia-specific LPS on the surface of recombinant E. coli...
  2. ncbi request reprint ATM-dependent phosphorylation of nibrin in response to radiation exposure
    M Gatei
    The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland, Australia
    Nat Genet 25:115-9. 2000
    ..ATM phosphorylation of nibrin does not affect nibrin-MRE11-RAD50 association as revealed by radiation-induced foci formation. Our data provide a biochemical explanation for the similarity in phenotype between A-T and NBS...
  3. ncbi request reprint Aprataxin forms a discrete branch in the HIT (histidine triad) superfamily of proteins with both DNA/RNA binding and nucleotide hydrolase activities
    Amanda W Kijas
    Queensland Institute of Medical Research, P O Box Royal Brisbane Hospital, Queensland, Australia 4029
    J Biol Chem 281:13939-48. 2006
    ....
  4. ncbi request reprint ATM: the product of the gene mutated in ataxia-telangiectasia
    M F Lavin
    Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, Australia
    Int J Biochem Cell Biol 31:735-40. 1999
    ..It is clear that a better definition of the role of ATM in DNA damage recognition, cell cycle control and cell signalling may assist in the treatment of the progressive neurodegeneration in this syndrome...
  5. ncbi request reprint Functional consequences of sequence alterations in the ATM gene
    Martin F Lavin
    The Queensland Cancer Fund Research Unit, The Queensland Institute of Medical Research, P O Box Royal Brisbane Hospital, Herston, Brisbane 4029, QLD, Australia
    DNA Repair (Amst) 3:1197-205. 2004
    ..In this review, we explore the domain structure of the ATM molecule, sites of interaction with other proteins and the consequences of specific amino acid changes on function...
  6. ncbi request reprint The Mre11 complex and ATM: a two-way functional interaction in recognising and signaling DNA double strand breaks
    Martin F Lavin
    Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, P O Box Royal Brisbane Hospital, Herston, Brisbane, QLD 4029, Australia
    DNA Repair (Amst) 3:1515-20. 2004
    ..Paradoxically members of the Mre11 complex are also downstream of ATM in these pathways. Here, Lavin attempts to make sense of this sensing mechanism with reference to a series of recent reports on the topic...
  7. ncbi request reprint ATM signaling and genomic stability in response to DNA damage
    Martin F Lavin
    Queensland Cancer Fund Research Unit, The Queensland Institute of Medical Research, PO Box Royal Brisbane Hospital, Herston, Brisbane 4029, Australia
    Mutat Res 569:123-32. 2005
    ..Mechanisms for recognising double strand breaks in DNA, maintaining genome stability and minimizing risk of cancer are discussed...
  8. ncbi request reprint ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia
    M F Lavin
    The Queensland Cancer Fund Research Unit, The Queensland Institute of Medical Research, Brisbane, Australia
    Int J Radiat Biol 75:1201-14. 1999
    ..To provide an update on the product of the ATM gene mutated in the human genetic disorder ataxia-telangiectasia (A-T)...
  9. ncbi request reprint Upregulation of FasL and apoptosis in thymic lymphomas in Atm knock-in mice
    Martin F Lavin
    The Queensland Cancer Fund Research Laboratories, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Herston, Brisbane, QLD 4029, Australia
    Toxicology 181:483-9. 2002
    ..These results demonstrate that expression of mutant Atm in mice gives rise to phenotypic differences compared to Atm(-/-) mice and has implications for heterogeneity described in the human syndrome...
  10. ncbi request reprint ATM activation and DNA damage response
    Martin F Lavin
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Cell Cycle 6:931-42. 2007
    ..The aim here is to examine the evidence for the involvement of these various steps in ATM activation and attempt to put together a comprehensive picture of the overall process and its significance to DNA damage signaling...
  11. ncbi request reprint Current and potential therapeutic strategies for the treatment of ataxia-telangiectasia
    Martin F Lavin
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Br Med Bull 81:129-47. 2007
    ..We describe the natural course of disease, some supportive therapeutic approaches already in use and those with potential based on our knowledge of molecular and cellular characteristics of this disorder...
  12. ncbi request reprint Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage
    Janelle L Harris
    Queensland Institute of Medical Research, Radiation Biology and Oncology, Brisbane, Queensland 4029, Australia
    Hum Mol Genet 18:4102-17. 2009
    ..These data support both direct and indirect modulating functions for aprataxin on base excision repair...
  13. pmc ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control
    Magtouf Gatei
    Radiation Biology and Oncology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
    J Biol Chem 286:31542-56. 2011
    ....
  14. pmc Involvement of novel autophosphorylation sites in ATM activation
    Sergei V Kozlov
    The Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, Herston, Brisbane, Queensland, Australia
    EMBO J 25:3504-14. 2006
    ..We conclude that there are at least three functionally important radiation-induced autophosphorylation events in ATM...
  15. ncbi request reprint Analyzing the regulation and function of ATM
    Martin F Lavin
    The Queensland Cancer Fund Research Unit, The Queensland Institute of Medical Research, Royal Brisbane Hospital, Herston, Australia
    Methods Mol Biol 281:163-78. 2004
    ..Missense mutations affecting ATM kinase activity are detected using in vitro mutagenesis of ATM cDNA followed by the procedures outlined above...
  16. doi request reprint Atm and cellular response to DNA damage
    Martin F Lavin
    Radiation Biology and Oncology, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Herston, Queensland, Australia
    Adv Exp Med Biol 570:457-76. 2005
  17. ncbi request reprint Dramatic extension of tumor latency and correction of neurobehavioral phenotype in Atm-mutant mice with a nitroxide antioxidant
    Nuri Gueven
    Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Free Radic Biol Med 41:992-1000. 2006
    ..These data suggest that antioxidant therapy has considerable potential in the management of ataxia telangiectasia and possibly other neurodegenerative disorders where oxidative stress is implicated...
  18. pmc Autophosphorylation and ATM activation: additional sites add to the complexity
    Sergei V Kozlov
    Radiation Biology and Oncology, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
    J Biol Chem 286:9107-19. 2011
    ..These data provide further support for the importance of autophosphorylation in the activation and function of ATM in vivo...
  19. ncbi request reprint The diversity of bioactive proteins in Australian snake venoms
    Geoff W Birrell
    The Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Brisbane 4029, Australia
    Mol Cell Proteomics 6:973-86. 2007
    ....
  20. ncbi request reprint Nucleolar localization of aprataxin is dependent on interaction with nucleolin and on active ribosomal DNA transcription
    Olivier J Becherel
    Radiation Biology and Oncology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
    Hum Mol Genet 15:2239-49. 2006
    ..These results demonstrate a cross-dependence between aprataxin and nucleolin in the nucleolus and while aprataxin does not appear to be directly involved in rRNA synthesis its nucleolar localization is dependent on this synthesis...
  21. pmc The structure of human microplasmin in complex with textilinin-1, an aprotinin-like inhibitor from the Australian brown snake
    Emma Karin I Millers
    School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia
    PLoS ONE 8:e54104. 2013
    ..The unusual mode of interaction between textilinin-1 and plasmin explains textilinin-1's selectivity for human plasmin over plasma kallikrein. This difference can be exploited in future drug design efforts...
  22. doi request reprint Identification and characterisation of Kunitz-type plasma kallikrein inhibitors unique to Oxyuranus sp. snake venoms
    Stephen T H Earl
    The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane 4029, Australia
    Biochimie 94:365-73. 2012
    ..057 ± 0.019 nM. TSPI also inhibited fibrinolysis in whole blood and prolonged the intrinsic clotting time. These inhibitors are also unique in that they appear to be found only in Oxyuranus sp. venoms...
  23. ncbi request reprint Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype
    Nuri Gueven
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Cancer Res 66:2907-12. 2006
    ..These results suggest that ATM-dependent stabilization of p53 and induction of apoptosis by radiation involve an additional factor(s) that is defective in ATL2ABR cells...
  24. doi request reprint Functional role for senataxin, defective in ataxia oculomotor apraxia type 2, in transcriptional regulation
    Amila Suraweera
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Hum Mol Genet 18:3384-96. 2009
    ..These data suggest that senataxin, similar to its yeast homolog Sen1p, plays a role in coordinating transcriptional events, in addition to its role in DNA repair...
  25. ncbi request reprint Post-translational modification accounts for the presence of varied forms of nerve growth factor in Australian elapid snake venoms
    Stephen T H Earl
    The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Australia
    Proteomics 6:6554-65. 2006
    ..It is possible that these modifications alter the stability, activity and other characteristics of the snake NGFs. Further characterisation is necessary to delineate the function of the individual NGF isoforms...
  26. ncbi request reprint Cloning and functional expression of venom prothrombin activator protease from Pseudonaja textilis with whole blood procoagulant activity
    Igor Filippovich
    The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Herston, Australia
    Br J Haematol 131:237-46. 2005
    ..This study identified the complete cDNA sequence of a factor Xa-like protease from P. textilis and demonstrated for the first time the expression of a recombinant form of P. textilis protease capable of blood coagulation...
  27. doi request reprint Crystal structure of textilinin-1, a Kunitz-type serine protease inhibitor from the venom of the Australian common brown snake (Pseudonaja textilis)
    Emma Karin I Millers
    School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, Australia
    FEBS J 276:3163-75. 2009
    ..5 nm versus 0.053 nm) and could also account for an observed narrower binding specificity...
  28. ncbi request reprint ATP activates ataxia-telangiectasia mutated (ATM) in vitro. Importance of autophosphorylation
    Sergei Kozlov
    The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Herston QLD 4029, Australia
    J Biol Chem 278:9309-17. 2003
    ..The relationship of this activation to DNA damage activation remains unclear but represents a useful model for understanding in vivo activation...
  29. ncbi request reprint Regulation of the Atm promoter in vivo
    Nuri Gueven
    Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia
    Genes Chromosomes Cancer 45:61-71. 2006
    ..These results demonstrate that, in addition to activation by autophosphorylation, Atm can also be regulated in vivo at the transcriptional level possibly ensuring a more sustained response to radiation and other stimuli...
  30. pmc CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response
    Olivier J Becherel
    Queensland Institute of Medical Research, Radiation Biology and Oncology, Brisbane, QLD 4029, Australia
    Nucleic Acids Res 38:1489-503. 2010
    ..These results indicate that aprataxin is involved not only in single strand break repair but also in the processing of a subset of double strand breaks presumably through its interaction with MDC1...
  31. doi request reprint Textilinin-1, an alternative anti-bleeding agent to aprotinin: Importance of plasmin inhibition in controlling blood loss
    Simone M Flight
    School of Medicine, University of Queensland, Brisbane, Australia
    Br J Haematol 145:207-11. 2009
    ..Based on these data, textilinin-1 merits further investigation as a therapeutic alternative to aprotinin...
  32. doi request reprint Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer
    Martin F Lavin
    Radiation Biology and Oncology Laboratory, Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia
    Nat Rev Mol Cell Biol 9:759-69. 2008
    ....
  33. ncbi request reprint Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM
    Heather Beamish
    Queensland Cancer Fund Research Laboratories, The Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Herston, Brisbane, QLD 4029, Australia
    J Biol Chem 277:30515-23. 2002
    ..These data suggest that ATM and BLM function together in recognizing abnormal DNA structures by direct interaction and that these phosphorylation sites in BLM are important for radiosensitivity status but not for SCE frequency...
  34. pmc Missense mutations but not allelic variants alter the function of ATM by dominant interference in patients with breast cancer
    Shaun P Scott
    Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Herston, Brisbane 4029, Australia
    Proc Natl Acad Sci U S A 99:925-30. 2002
    ..This approach represents a means of identifying genuine ATM mutations and addressing the significance of missense changes in the ATM gene in a variety of cancers including breast cancer...
  35. ncbi request reprint Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer
    Kevin Spring
    Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Herston, 4029, Australia
    Nat Genet 32:185-90. 2002
    ..This finding provides further support for cancer predisposition in human ataxia-telangiectasia carriers...
  36. ncbi request reprint Role for ATM in DNA damage-induced phosphorylation of BRCA1
    M Gatei
    Queensland Institute of Medical Research, The University of Queensland, Royal Brisbane Hospital, Australia
    Cancer Res 60:3299-304. 2000
    ..This interaction between ATM and BRCA1 argues in favor of the involvement of particular aspects of ATM function in breast cancer predisposition...
  37. pmc Senataxin plays an essential role with DNA damage response proteins in meiotic recombination and gene silencing
    Olivier J Becherel
    Radiation Biology and Oncology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    PLoS Genet 9:e1003435. 2013
    ..These data support key roles for senataxin in coordinating meiotic crossing-over with transcription and in gene silencing to protect the integrity of the genome...
  38. ncbi request reprint Oxidative stress is responsible for deficient survival and dendritogenesis in purkinje neurons from ataxia-telangiectasia mutated mutant mice
    Philip Chen
    The Queensland Institute of Medical Research, Royal Brisbane Hospital, Herston, Queensland 4029, Australia
    J Neurosci 23:11453-60. 2003
    ..These data provide strong evidence for a defect in the cerebellum of Atm-deficient mice and suggest that oxidative stress contributes to this phenotype...
  39. pmc A novel role for hSMG-1 in stress granule formation
    James A L Brown
    Radiation Biology and Oncology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
    Mol Cell Biol 31:4417-29. 2011
    ..Thus, SG formation appears more complex than originally envisaged and hSMG-1 plays a central role in this process...
  40. ncbi request reprint Cloning and characterisation of natriuretic peptides from the venom glands of Australian elapids
    Liam St Pierre
    The Queensland Institute of Medical Research, Brisbane, Australia
    Biochimie 88:1923-31. 2006
    ..The data presented in this study represent a significant resource for understanding the role of various natriuretic peptides isoforms during the envenomation process by Australian elapid snakes...
  41. pmc Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage
    Amila Suraweera
    Radiation Biology and Oncology Laboratory, Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia
    J Cell Biol 177:969-79. 2007
    ..These results provide evidence that an additional member of the autosomal recessive AOA is also characterized by a defective response to DNA damage, which may contribute to the neurodegeneration seen in this syndrome...
  42. doi request reprint Cloning and characterisation of novel cystatins from elapid snake venom glands
    Renée Richards
    The Queensland Institute of Medical Research, Herston, Brisbane, QLD, Australia
    Biochimie 93:659-68. 2011
    ..The widespread, low level expression of type 2 cystatins in snake venom, as well as the presence of only one highly conserved isoform in each species, imply essential housekeeping or regulatory roles for these proteins...
  43. ncbi request reprint Site-directed mutagenesis of the ATM promoter: consequences for response to proliferation and ionizing radiation
    Nuri Gueven
    Queensland Cancer Fund Research Laboratory, The Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, Queensland, Australia
    Genes Chromosomes Cancer 38:157-67. 2003
    ..The data described here provide additional evidence that basal and radiation-induced regulation of the ATM promoter is under multifactorial control...
  44. ncbi request reprint One-step site-directed mutagenesis of ATM cDNA in large (20kb) plasmid constructs
    Shaun P Scott
    The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Herston, 4029, QLD, Australia
    Hum Mutat 20:323. 2002
    ..This approach makes it possible to introduce multiple mutations into large cDNA for structural/functional studies...
  45. ncbi request reprint How important is ATM?
    Martin F Lavin
    Queensland Institute of Medical Research, The University of Queensland, Brisbane, Australia
    Radiat Res 163:704. 2005
  46. pmc BMCC1 is an AP-2 associated endosomal protein in prostate cancer cells
    Janelle L Harris
    Queensland Institute of Medical Research, Herston, Brisbane, Queensland, Australia
    PLoS ONE 8:e73880. 2013
    ..Instead, we posit a novel role for BMCC1 in post-endocytic trafficking. This study provides fundamental characterisation of the BMCC1 complex in prostate cancer cells and for the first time implicates it in vesicle trafficking. ..
  47. ncbi request reprint Diversity of toxic components from the venom of the evolutionarily distinct black whip snake, Demansia vestigiata
    Liam St Pierre
    The Queensland Institute of Medical Research, Brisbane, Australia
    J Proteome Res 6:3093-107. 2007
    ..The results of this study have important implications not only for the further characterization of venom from whip snakes, but also for our understanding of the evolutionary relationship of Australian snake species...
  48. ncbi request reprint Molecular diversity in venom from the Australian Brown snake, Pseudonaja textilis
    Geoff W Birrell
    The Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Brisbane 4029, Australia
    Mol Cell Proteomics 5:379-89. 2006
    ..Indeed two of the identified proteins, a procoagulant and a plasmin inhibitor, are currently in development as human therapeutic agents...
  49. doi request reprint Calcium prevents retinoic acid-induced disruption of the spectrin-based cytoskeleton in keratinocytes through the Src/PI3K-p85α/AKT/PKCδ/β-adducin pathways
    Kong Nan Zhao
    Centre for Kidney Disease Venomics Research, School of Medicine, The University of Queensland, Princess Alexandra Hospital, Woolloongabba, Brisbane, QLD 4102, Australia
    Cell Calcium 54:151-62. 2013
    ..These data highlight the importance of Ca2+ in both spectrin expression and the organizational integrity of the spectrin-based cytoskeleton in differentiating keratinocytes and assist in elucidating the signalling pathways involved...
  50. doi request reprint Genotoxicity of hydroquinone in A549 cells
    Cheng Peng
    National Research Centre for Environmental Toxicology EnTox, The University of Queensland, 39 Kessels Road, Coopers Plains, Brisbane, 4108, Australia
    Cell Biol Toxicol 29:213-27. 2013
    ..Together these results demonstrate that HQ exerts its cytotoxic and genotoxic effects in A549 lung cells, probably through DNA damage via oxidative stress. ..
  51. ncbi request reprint A role for homologous recombination and abnormal cell-cycle progression in radioresistance of glioma-initiating cells
    Yi Chieh Lim
    Queensland Institute of Medical Research, University of Queensland Centre for Clinical Research, Royal Brisbane Hospital Campus, Herston, Queensland, Australia
    Mol Cancer Ther 11:1863-72. 2012
    ..These data suggest that homologous recombination and cell-cycle checkpoint abnormalities may contribute to the radioresistance of glioma-initiating cells and that both processes may be suitable targets for therapy...
  52. ncbi request reprint Defective responses to DNA single- and double-strand breaks in spinocerebellar ataxia
    Martin F Lavin
    Radiation Biology and Oncology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    DNA Repair (Amst) 7:1061-76. 2008
    ..This theme is further developed in this review...
  53. ncbi request reprint DNA damage-induced signalling in ataxia-telangiectasia and related syndromes
    Martin F Lavin
    Queensland Institute of Medical Research, Brisbane, Australia School of Medicine, The University of Queensland, Brisbane, Australia
    Radiother Oncol 83:231-7. 2007
    ..This knowledge can also be used to advantage in sensitizing cells to radiation and ultimately deriving novel therapeutic approaches for the treatment of cancer...
  54. doi request reprint Characterisation of a mannose-binding C-type lectin from Oxyuranus scutellatus snake venom
    Stephen T H Earl
    The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Australia
    Biochimie 93:519-27. 2011
    ..Experimental evidence and molecular modelling also suggest that this protein exhibits a unique dimeric structure. This is the first confirmed example of a snake venom C-lectin with mannose-binding activity...
  55. ncbi request reprint Comparative analysis of prothrombin activators from the venom of Australian elapids
    Liam St Pierre
    The Queensland Cancer Fund Research Unit, The Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, Australia
    Mol Biol Evol 22:1853-64. 2005
    ..The molecular phylogenetic analysis described here represents a new approach for distinguishing group C and D snake prothrombin activators and correlates well with previous classifications...
  56. ncbi request reprint Aprataxin, a novel protein that protects against genotoxic stress
    Nuri Gueven
    Radiation Biology and Oncology, The Queensland Institute of Medical Research, Herston, Australia
    Hum Mol Genet 13:1081-93. 2004
    ..These results demonstrate that aprataxin influences the cellular response to genotoxic stress very likely by its capacity to interact with a number of proteins involved in DNA repair...
  57. ncbi request reprint ATM mutations, haplotype analysis, and immunological status of Russian patients with ataxia telangiectasia
    Geoff W Birrell
    Department of Cancer and Cell Biology, Queensland Institute of Medical Research, 300 Herston Rd, Brisbane, 4029, Australia
    Hum Mutat 25:593. 2005
    ..Nine of the remaining mutations were previously unreported, and add to the multitude of unique mutations found throughout the gene...
  58. ncbi request reprint Atm knock-in mice harboring an in-frame deletion corresponding to the human ATM 7636del9 common mutation exhibit a variant phenotype
    K Spring
    Queensland Cancer Fund Research Laboratories, The Queensland Institute of Medical Research, P O Box Royal Brisbane Hospital, Herston, Brisbane, Queensland 4029, Australia
    Cancer Res 61:4561-8. 2001
    ..Thus, expression of mutant protein in Atm-DeltaSRI knock-in mice gives rise to a discernibly different phenotype to Atm(-/-) mice, which may account for the heterogeneity seen in A-T patients with different mutations...
  59. ncbi request reprint ATM, a central controller of cellular responses to DNA damage
    K K Khanna
    The Queensland Institute of Medical Research, and Department of Pathology and Surgery, University of Queensland, PO Royal Brisbane Hospital, Brisbane, QLD4029, Australia
    Cell Death Differ 8:1052-65. 2001
    ..ATM also functions in the regulation of DNA repair and apoptosis, suggesting that it is a central regulator of responses to DNA double-strand breaks...
  60. ncbi request reprint Ataxia-telangiectasia: a multifaceted genetic disorder associated with defective signal transduction
    M F Lavin
    Queensland Institute of Medical Research, The Bancroft Centre and Department of Surgery, University of Queensland, Post Office, Royal Brisbane Hospital, Herston, Australia
    Curr Opin Immunol 8:459-64. 1996
    ..The elucidation of the role of the ATM gene product will provide valuable insight into the radiosensitivity, cancer predisposition, immunodeficiency and neuropathology that characterize this syndrome...
  61. pmc Crystallization and preliminary X-ray analysis of a Kunitz-type inhibitor, textilinin-1 from Pseudonaja textilis textilis
    Emma Karin I Millers
    School of Molecular and Microbial Sciences, University of Queensland, Brisbane 4072, QLD, Australia
    Acta Crystallogr Sect F Struct Biol Cryst Commun 62:642-5. 2006
    ..Crystals of the rTxln-1-bovine trypsin complex diffracted to 2.0 angstroms resolution, while crystals of free rTxln-1 diffracted to 1.63 angstroms resolution...
  62. ncbi request reprint A novel profluorescent nitroxide as a sensitive probe for the cellular redox environment
    Benjamin J Morrow
    ARC Centre of Excellence for Free Radical Chemistry, School of Physical and Chemical Sciences, Queensland University of Technology, Brisbane, Qld 4001, Australia
    Free Radic Biol Med 49:67-76. 2010
    ..The reversible nature of the probe's detection mechanism offers the unique advantage of being able to monitor redox changes in both oxidizing and reducing directions in real time...
  63. doi request reprint The appropriateness of the mouse model for ataxia-telangiectasia: neurological defects but no neurodegeneration
    Martin F Lavin
    Queensland Institute of Medical Research, Radiation Biology and Oncology, Brisbane, QLD 4029, Australia
    DNA Repair (Amst) 12:612-9. 2013
    ..The focus of this review is to evaluate the appropriateness of Atm mutant mouse models for A-T, particularly with reference to neurological abnormalities and how they might relate to neurodegeneration. ..
  64. ncbi request reprint Resistance of porcine blood clots to lysis relates to poor activation of porcine plasminogen by tissue plasminogen activator
    Simone M Flight
    School of Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
    Blood Coagul Fibrinolysis 17:417-20. 2006
    ..5 +/- 1.5 h). These results suggest caution in using the pig as an experimental model when studying the effects of various agents on fibrinolysis...
  65. pmc ATM and the DNA damage response. Workshop on ataxia-telangiectasia and related syndromes
    Martin F Lavin
    The Queensland Institute of Medical Researchand and University of Queensland, Brisbane, PO Royal Brisbane Hospital, Brisbane 4029, QLD, Australia
    EMBO Rep 7:154-60. 2006
  66. ncbi request reprint Use of multiple biomarkers for a molecular diagnosis of prostate cancer
    Kelly A Landers
    Department of Surgery, Central Clinical Division, School of Medicine, University of Queensland, Herston, Queensland 4072, Australia
    Int J Cancer 114:950-6. 2005
    ..Supplemental material for this article can be found on the International Journal of Cancer website at http://www.interscience.wiley.com/jpages/0020-7136/suppmat/index.html.)..
  67. doi request reprint A patient-derived olfactory stem cell disease model for ataxia-telangiectasia
    Romal Stewart
    Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia
    Hum Mol Genet 22:2495-509. 2013
    ....
  68. doi request reprint Mitochondrial dysfunction in a novel form of autosomal recessive ataxia
    Nor Azian Abdul Murad
    Cancer and Cell Biology, Queensland Institute of Medical Research, Brisbane, Australia
    Mitochondrion 13:235-45. 2013
    ..Sequencing of mitochondrial DNA revealed a mutation, I349T, in the mitochondrial cytochrome b gene. These results describe a patient with an apparently novel form of AOA characterised by a defect at the level of the mitochondrion...
  69. pmc Smg1 haploinsufficiency predisposes to tumor formation and inflammation
    Tara L Roberts
    Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia
    Proc Natl Acad Sci U S A 110:E285-94. 2013
    ..These data suggest that the inflammation observed in Smg1 haploinsufficiency contributes to susceptibility to cancer and that Smg1-deficient animals represent a model of inflammation-enhanced cancer development...
  70. ncbi request reprint ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks
    M F Lavin
    Radiation Biology and Oncology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Oncogene 26:7749-58. 2007
    ..We focus here on the relationship between ATM and the MRN complex in recognizing and responding to DNA DSBs...
  71. ncbi request reprint Novel gene containing multiple epidermal growth factor-like motifs transiently expressed in the papillae of the ascidian tadpole larvae
    J M Arnold
    Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, Brisbane, Australia
    Dev Dyn 210:264-73. 1997
    ..As recent evidence indicates that the signal for metamorphosis originates in the anterior trunk region, these results suggest that this gene may have a role in signalling the initiation of metamorphosis...
  72. ncbi request reprint Defective signaling through the B cell antigen receptor in Epstein-Barr virus-transformed ataxia-telangiectasia cells
    K K Khanna
    Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Herston, Brisbane 4029, Australia
    J Biol Chem 272:9489-95. 1997
    ..Our results provide evidence for a role for the ATM gene product in intracellular signaling which may account at least in part for the abnormalities in B cell function in A-T...
  73. ncbi request reprint Exon skipping in the ATM gene in normal individuals: the effect of blood sample storage on RT-PCR analysis
    G W Birrell
    The Queensland Cancer Fund Research Laboratories, Queensland Institute of Medical Research, Brisbane, Australia
    Hum Mutat 17:75-6. 2001
    ..These data suggest that mRNA-based mutation analysis on ATM should be carried out on unstored blood samples to avoid artificial loss of exons that give rise to apparent mutations...
  74. ncbi request reprint Transcriptional downregulation of ATM by EGF is defective in ataxia-telangiectasia cells expressing mutant protein
    K E Keating
    The Queensland Cancer Fund Research Laboratory, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Qld. 4029, Australia
    Oncogene 20:4281-90. 2001
    ..The results demonstrate that EGF-induced downregulation of ATM (mutant) protein in A-T cells is defective and this appears to be due to less efficient EGFR activation and abnormal Sp1 regulation...
  75. pmc Resistance of actin to cleavage during apoptosis
    Q Song
    Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, Bancroft Centre, Herston, Brisbane, Australia
    Proc Natl Acad Sci U S A 94:157-62. 1997
    ....
  76. ncbi request reprint The complexity of p53 stabilization and activation
    M F Lavin
    The Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Cell Death Differ 13:941-50. 2006
    ..The stability of p53 is also influenced by a series of other interacting proteins. In this review, we discuss the post-translational modifications to p53 in response to different stresses and the consequences of these changes...
  77. ncbi request reprint Localization of a portion of extranuclear ATM to peroxisomes
    D Watters
    Cancer Research Unit, Queensland Institute of Medical Research, Royal Brisbane Hospital, Herston, Brisbane, Australia, 4029
    J Biol Chem 274:34277-82. 1999
    ..Significantly decreased catalase activity and increased lipid peroxidation was observed in several A-T cell lines. The localization of ATM to peroxisomes may contribute to the pleiotropic nature of A-T...
  78. ncbi request reprint ATM associates with and phosphorylates p53: mapping the region of interaction
    K K Khanna
    The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Australia
    Nat Genet 20:398-400. 1998
    ..These results demonstrate that ATM can bind p53 directly and is responsible for its serine 15 phosphorylation, thereby contributing to the activation and stabilization of p53 during the IR-induced DNA damage response...
  79. pmc Disruption of spectrin-like cytoskeleton in differentiating keratinocytes by PKCδ activation is associated with phosphorylated adducin
    Kong Nan Zhao
    University of Queensland Centre for Clinical Research, The University of Queensland, Brisbane, Queensland, Australia
    PLoS ONE 6:e28267. 2011
    ....
  80. doi request reprint Drug development from Australian elapid snake venoms and the Venomics pipeline of candidates for haemostasis: Textilinin-1 (Q8008), Haempatch™ (Q8009) and CoVase™ (V0801)
    Stephen T H Earl
    Venomics Pty Ltd, PO Box 1810, North Sydney, NSW 2059, Australia
    Toxicon 59:456-63. 2012
    ..This review focuses on drug discovery from Australian elapid snake venoms, with emphasis on the QRxPharma/VPL drug discovery project undertaken in collaboration with UQ and candidates at further stages of development...
  81. doi request reprint Evaluation of the Becton-Dickinson rapid serum tube: does it provide a suitable alternative to lithium heparin plasma tubes?
    Goce Dimeski
    School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Australia
    Clin Chem Lab Med 48:651-7. 2010
    ..Although lithium heparin plasma has unique problems, it has become an alternative in hospital-based laboratories...
  82. ncbi request reprint Isolation of a cDNA clone, encoding a human beta-galactoside binding protein, overexpressed during glucocorticoid-induced cell death
    S D Goldstone
    Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, Herston, Brisbane, Australia
    Biochem Biophys Res Commun 178:746-50. 1991
    ..This clone was shown by DNA sequence analysis to represent the human HL14 gene, encoding a beta-galactoside binding protein, the mouse homologue of which has recently been reported to act as a cell growth inhibitory factor...
  83. ncbi request reprint Ataxia-telangiectasia: chronic activation of damage-responsive functions is reduced by alpha-lipoic acid
    M Gatei
    Queensland Cancer Fund Research Laboratories, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Herston, Brisbane, QLD, 4029, Australia
    Oncogene 20:289-94. 2001
    ..These findings suggest that the absence of functional ATM results in a mild but continuous state of oxidative stress, which could account for several features of the pleiotropic phenotype of A-T...
  84. pmc A randomised trial of robotic and open prostatectomy in men with localised prostate cancer
    Robert A Gardiner
    University of Queensland Centre for Clinical Research, Royal Brisbane Hospital, Queensland, Australia
    BMC Cancer 12:189. 2012
    ..This paper presents the design of a randomised trial of Robotic and Open Prostatectomy for men newly diagnosed with localised prostate cancer that seeks to answer this question...
  85. ncbi request reprint Gene expression during early ascidian metamorphosis requires signalling by Hemps, an EGF-like protein
    Rick G Woods
    The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Herston, Brisbane 4029, Australia
    Development 131:2921-33. 2004
    ..These results suggest that there is significant gene activity during the very early stages of H. curvata metamorphosis and that the Hemps pathway plays a key role in regulating the expression of many of these genes...
  86. ncbi request reprint Ecological regulation of development: induction of marine invertebrate metamorphosis
    Daniel Jackson
    Department of Zoology and Entomology, University of Queensland, Brisbane, Australia
    Int J Dev Biol 46:679-86. 2002
    ..Induction of settlement and metamorphosis results in further changes in developmental gene expression, which apparently is necessary for the complete transformation of the larval body plan into the adult form...
  87. ncbi request reprint Cloning and characterization of cDNA encoding a human arginyl-tRNA synthetase
    A A Girjes
    Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, Bancroft Centre, Brisbane, Australia
    Gene 164:347-50. 1995
    ..2.2 kb. The results described here demonstrate that ArgRS is highly conserved in mammalian cells and confirm the presence of a hydrophobic N-terminal region in the higher-molecular-weight complexed form of ArgRS...
  88. ncbi request reprint Calpain activation is upstream of caspases in radiation-induced apoptosis
    N J Waterhouse
    Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, Royal Brisbane Hospital, Herston, Australia
    Cell Death Differ 5:1051-61. 1998
    ..These results support a role for calpain in the early phases of the radiation-induced apoptosis pathway, upstream of the caspases...
  89. ncbi request reprint Evidence of multiple transcription initiation and termination sites within the rDNA intergenic spacer and rRNA readthrough transcription in the urochordate Herdmania curvata
    B M Degnan
    Department of Zoology and Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia
    Mol Mar Biol Biotechnol 7:294-302. 1998
    ..0 kb...
  90. ncbi request reprint A subgroup of spinocerebellar ataxias defective in DNA damage responses
    N Gueven
    Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia
    Neuroscience 145:1418-25. 2007
    ..These data provide further evidence that different forms of AOA have in common a reduced capacity to cope with damage to DNA, which may account for the neurodegeneration observed in these syndromes...
  91. ncbi request reprint Realizing the potential of ejaculate/seminal fluid in detecting and predicting natural history
    R A Gardiner
    Department of Surgery at Royal Brisbane Hospital, University of Queensland, Herston, Australia
    Methods Mol Med 81:199-217. 2003
  92. pmc Metabolomics: a novel approach to early and noninvasive prostate cancer detection
    Matthew J Roberts
    Department of Urology, University of Queensland Centre for Clinical Research, Brisbane, Australia
    Korean J Urol 52:79-89. 2011
    ..Metabolomics promises to be a valuable tool in the early detection of PCa that may enable earlier treatment and improved clinical outcomes...
  93. ncbi request reprint A family of textilinin genes, two of which encode proteins with antihaemorrhagic properties
    Igor Filippovich
    The Queensland Cancer Fund Research Unit, The Queensland Institute of Medical Research, Royal Brisbane Hospital, Herston, Australia
    Br J Haematol 119:376-84. 2002
    ....
  94. ncbi request reprint Identification and analysis of venom gland-specific genes from the coastal taipan (Oxyuranus scutellatus) and related species
    L St Pierre
    The Queensland Cancer Fund Research Unit, The Queensland Institute of Medical Research, PO Box Royal Brisbane Hospital, Herston, Australia
    Cell Mol Life Sci 62:2679-93. 2005
    ..This study represents the most detailed description to date of the cloning and characterisation of different genes associated with envenomation from Australian snakes...
  95. ncbi request reprint Cloning and characterization of a human protein phosphatase 1-encoding cDNA
    Q Song
    Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, Bancroft Centre, Brisbane, Australia
    Gene 129:291-5. 1993
    ..Comparison with the rabbit pp1 cDNA sequence showed some nucleotide differences, largely at the third position of the codon, with complete concordance at the aa level. Northern blot analysis revealed an mRNA of approximately 1.6 kb...
  96. ncbi request reprint Identification and characterization of new BoLA-DRB3 alleles by heteroduplex analysis and direct sequencing
    K Sitte
    Cooperative Research Centre for Vaccine Technology, Queensland Institute of Medical Research, Brisbane, Australia
    Anim Genet 26:413-7. 1995
    ..In conclusion, heteroduplex analysis allows rapid discrimination between homozygotes and heterozygotes, and enables rapid identification of new BoLA-DRB3 alleles...
  97. doi request reprint Common evolution of waprin and kunitz-like toxin families in Australian venomous snakes
    L St Pierre
    The Queensland Cancer Fund Research Unit, The Queensland Institute of Medical Research, Herston, Brisbane, Australia
    Cell Mol Life Sci 65:4039-54. 2008
    ....
  98. ncbi request reprint A novel form of ataxia oculomotor apraxia characterized by oxidative stress and apoptosis resistance
    N Gueven
    Department of Cancer and Cell Biology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Cell Death Differ 14:1149-61. 2007
    ..These results provide evidence for a novel form of AOA characterized by sensitivity to DNA damaging agents, oxidative stress, PARP-1 hyperactivation but resistance to apoptosis...
  99. ncbi request reprint Low dose ionizing radiation-induced activation of connexin 43 expression
    D Glover
    Queensland Institute of Medical Research, Herston, Australia
    Int J Radiat Biol 79:955-64. 2003
    ..It is established here that the expression of connexin 43 is affected by ionizing radiation and the mechanism involved is investigated...
  100. ncbi request reprint Single DNA sequence common to all chlamydial species employed for PCR detection of these organisms
    A A Girjes
    Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, Bancroft Centre, Brisbane, Australia
    Res Microbiol 150:483-9. 1999
    ..Thus we have developed a sensitive and rapid detection method and have used it on samples from patients with respiratory and genital infections...
  101. ncbi request reprint Induction of inositol 1,4,5 trisphosphate receptor genes by ionizing radiation
    J Yan
    Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, Royal Brisbane Hospital, Australia
    Int J Radiat Biol 69:539-46. 1996
    ..The induction of the InsP3R type 1, which is primarily located in the endoplasmic reticulum, may play an important role in radiation signal transduction...

Research Grants6

  1. ROLE OF ATM IN DNA DAMAGE RECOGNITION
    Martin Lavin; Fiscal Year: 2000
    ....
  2. ROLE OF ATM IN DNA DAMAGE RECOGNITION
    Martin Lavin; Fiscal Year: 2001
    ....
  3. ROLE OF ATM IN DNA DAMAGE RECOGNITION
    Martin Lavin; Fiscal Year: 2002
    ....
  4. Missense mutant Atm and radiation-induced tumorgenesis
    Martin Lavin; Fiscal Year: 2003
    ..This model system is expected to add further substance to the hypothesis that ATM missense mutations are the changes in ATM responsible for at least some of the increased cancer risk in gene carriers. ..
  5. Missense mutant Atm and radiation-induced tumorgenesis
    Martin Lavin; Fiscal Year: 2004
    ..This model system is expected to add further substance to the hypothesis that ATM missense mutations are the changes in ATM responsible for at least some of the increased cancer risk in gene carriers. ..
  6. Missense mutant Atm and radiation-induced tumorgenesis
    Martin Lavin; Fiscal Year: 2005
    ..This model system is expected to add further substance to the hypothesis that ATM missense mutations are the changes in ATM responsible for at least some of the increased cancer risk in gene carriers. ..