Genomes and Genes
K K Khanna
Affiliation: Queensland Institute of Medical Research
- Engagement of CD40 antigen with soluble CD40 ligand up-regulates peptide transporter expression and restores endogenous processing function in Burkitt's lymphoma cellsR Khanna
EBV Unit, Queensland Institute of Medical Research, Herston, Australia
J Immunol 159:5782-5. 1997..These findings raise the possibility that CD40L treatment of tumor cells might be exploited in immunotherapeutic protocols...
- Low frequency of CHEK2 1100delC allele in Australian multiple-case breast cancer families: functional analysis in heterozygous individualsC R Jekimovs
Division of Cancer and Cell Biology, Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, Brisbane, QLD 4029, Australia
Br J Cancer 92:784-90. 2005..Such compensation of the 1100delC defect in CHEK2 might explain the rather low breast cancer risk associated with the CHEK2 variant, compared to that associated with truncating mutations in BRCA1 or BRCA2...
- Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaksEmma Bolderson
Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
Nucleic Acids Res 38:1821-31. 2010..These data establish a role for Exo1 in resection of DSBs in human cells, highlighting the critical requirement of Exo1 for DSB repair via HR and thus the maintenance of genomic stability...
- Functional characterization of alternatively spliced human SECISBP2 transcript variantsLaura V Papp
Signal Transduction Laboratory, Queensland Institute of Medical Research, Herston, Queensland, Australia
Nucleic Acids Res 36:7192-206. 2008..Overall, our data broadens the functional scope of a housekeeping protein essential to selenium metabolism...
- Involvement of Exo1b in DNA damage-induced apoptosisEmma Bolderson
Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia
Nucleic Acids Res 37:3452-63. 2009..We conclude that Exo1 has a role in the timely induction of apoptosis and that it is subsequently cleaved and degraded during apoptosis, potentially inhibiting DNA damage repair...
- Beta-amyloid increases the expression level of ATBF1 responsible for death in cultured cortical neuronsCha Gyun Jung
Department of Alzheimer s Disease Research, Research Institute, National Center for Geriatrics and Gerontology NCGG, 35, Morioka, Obu, Aichi 474 8511, Japan
Mol Neurodegener 6:47. 2011..abstract:..
- BCoR-L1 variation and breast cancerFelicity Lose
Cancer and Cell Biology Division, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland, Australia, 4006
Breast Cancer Res 9:R54. 2007..BCoR-L1 is located on the X chromosome and is subject to X inactivation...
- Cancer risk and the ATM gene: a continuing debateK K Khanna
The Queensland Institute of Medical Research, Brisbane, Australia
J Natl Cancer Inst 92:795-802. 2000..Thus, ATM appears to act as a caretaker of the genome...
- ATM associates with and phosphorylates p53: mapping the region of interactionK K Khanna
The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Australia
Nat Genet 20:398-400. 1998..These results demonstrate that ATM can bind p53 directly and is responsible for its serine 15 phosphorylation, thereby contributing to the activation and stabilization of p53 during the IR-induced DNA damage response...
- ATM and genome maintenance: defining its role in breast cancer susceptibilityKum Kum Khanna
The Queensland Institute of Medical Research, 300 Herston Road, Herston, Queensland 4006, Australia
J Mammary Gland Biol Neoplasia 9:247-62. 2004..A more comprehensive analysis of ATM is needed in large case-control studies, and in multiple-case breast cancer families...
- Defective signaling through the B cell antigen receptor in Epstein-Barr virus-transformed ataxia-telangiectasia cellsK K Khanna
Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Herston, Brisbane 4029, Australia
J Biol Chem 272:9489-95. 1997..Our results provide evidence for a role for the ATM gene product in intracellular signaling which may account at least in part for the abnormalities in B cell function in A-T...
- DNA double-strand breaks: signaling, repair and the cancer connectionK K Khanna
The Queensland Institute of Medical Research, and Department of Pathology, University of Queensland, PO Royal Brisbane Hospital, Brisbane, Queensland, Australia
Nat Genet 27:247-54. 2001..Moreover, we discuss how tumor suppressor proteins such as p53, ATM, Brca1 and Brca2 have been linked to such pathways, and how accumulating evidence is connecting deficiencies in cellular responses to DNA DSBs with tumorigenesis...
- Role for ATM in DNA damage-induced phosphorylation of BRCA1M Gatei
Queensland Institute of Medical Research, The University of Queensland, Royal Brisbane Hospital, Australia
Cancer Res 60:3299-304. 2000..This interaction between ATM and BRCA1 argues in favor of the involvement of particular aspects of ATM function in breast cancer predisposition...
- Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal formsD Watters
Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Herston, Australia
Oncogene 14:1911-21. 1997..These results provide further support for a role for the ATM protein as a sensor of DNA damage and in a more general role in cell signalling, compatible with the broader phenotype of the syndrome...
- Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodiesM Gatei
Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Brisbane QLD 4029, Australia
J Biol Chem 276:17276-80. 2001..Taken together, our results support a model in which ATM and ATR act in parallel but somewhat overlapping pathways of DNA damage signaling but respond primarily to different types of DNA lesion...
- ATM, a central controller of cellular responses to DNA damageK K Khanna
The Queensland Institute of Medical Research, and Department of Pathology and Surgery, University of Queensland, PO Royal Brisbane Hospital, Brisbane, QLD4029, Australia
Cell Death Differ 8:1052-65. 2001..ATM also functions in the regulation of DNA repair and apoptosis, suggesting that it is a central regulator of responses to DNA double-strand breaks...
- ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasiaM F Lavin
The Queensland Cancer Fund Research Unit, The Queensland Institute of Medical Research, Brisbane, Australia
Int J Radiat Biol 75:1201-14. 1999..To provide an update on the product of the ATM gene mutated in the human genetic disorder ataxia-telangiectasia (A-T)...
- Ataxia-telangiectasia: chronic activation of damage-responsive functions is reduced by alpha-lipoic acidM Gatei
Queensland Cancer Fund Research Laboratories, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Herston, Brisbane, QLD, 4029, Australia
Oncogene 20:289-94. 2001..These findings suggest that the absence of functional ATM results in a mild but continuous state of oxidative stress, which could account for several features of the pleiotropic phenotype of A-T...
- Centrobin regulates the assembly of functional mitotic spindlesJ M Jeffery
Signal Transduction Laboratory, Cancer and Cell Biology Division, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Oncogene 29:2649-58. 2010..Furthermore, this anchoring is required for the stability of microtubule-kinetochore attachments and biogenesis of tension-ridden and properly functioning mitotic spindle...
- Induction of inositol 1,4,5 trisphosphate receptor genes by ionizing radiationJ Yan
Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, Royal Brisbane Hospital, Australia
Int J Radiat Biol 69:539-46. 1996..The induction of the InsP3R type 1, which is primarily located in the endoplasmic reticulum, may play an important role in radiation signal transduction...
- Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomesF Al-Ejeh
Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Oncogene 29:6085-98. 2010....
- Potential roles for prions and protein-only inheritance in cancerH Antony
Griffith Health Institute, Griffith University, Southport, Queensland, Australia
Cancer Metastasis Rev 31:1-19. 2012..Here, we highlight evidence in the literature for an involvement of prion or prion-like mechanisms in cancer and how they may in the future be viewed as diagnostic markers and potential therapeutic targets...
- A missense mutation in the transcription factor Foxo3a causes teratomas and oocyte abnormalities in miceN A Youngson
Queensland Institute of Medical Research, Herston, Brisbane, QLD, 4006, Australia
Mamm Genome 22:235-48. 2011..The MommeR1 mice provide a novel platform to investigate teratocarcinogenesis and link Foxo3a with parthenogenesis and ovarian cancer. The finding of Foxo3a as a modifier of epigenetic reprogramming is discussed...
- Interaction between ATM protein and c-Abl in response to DNA damageT Shafman
Joint Center for Radiation Therapy, Dana Farber Cancer Institutes, Boston, Massachusetts 02115, USA
Nature 387:520-3. 1997..These findings indicate that ATM is involved in the activation of c-Abl by DNA damage and this interaction may in part mediate radiation-induced G1 arrest...
- Purification and characterization of ATM from human placenta. A manganese-dependent, wortmannin-sensitive serine/threonine protein kinaseD W Chan
Department of Biological Sciences, University of Calgary, Calgary, Alberta T2N 1N4, Canada
J Biol Chem 275:7803-10. 2000..The related protein, DNA-dependent protein kinase catalytic subunit, also phosphorylated PHAS-I, RPA, and Chk2 in the presence of manganese, suggesting that the requirement for manganese is a characteristic of this class of enzyme...
- Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activityB B Zhou
Department of Oncology Research, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
J Biol Chem 275:10342-8. 2000..Inhibition of ATM provides a molecular explanation for the increased radiosensitivity of caffeine-treated cells...
- Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasiaN Gueven
Section for Radiobiology and Molecular Environmental Research, , , Germany
J Biol Chem 276:8884-91. 2001..Taken together these data support complex control of ATM function that has important repercussions for targeting ATM to improve radiotherapeutic benefit...
- The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent mannerR Ye
Department of Biological Sciences, University of Calgary, Calgary, Alberta T2N 1N4, Canada
J Biol Chem 276:4828-33. 2001..Together our data suggest that ATM is required for activation of a DNA damage-induced pathway that activates p53 and Chk2 in response to genistein...
- UV-induced hyperphosphorylation of replication protein a depends on DNA replication and expression of ATM proteinG G Oakley
Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Mol Biol Cell 12:1199-213. 2001..Successful resolution of these replication intermediates reduces the accumulation of chromosomal aberrations that would otherwise occur as a consequence of UV radiation...
- Transactivation-deficient p73alpha (p73Deltaexon2) inhibits apoptosis and competes with p53I Fillippovich
Laboratory of Molecular Radiobiology, Institute of Biophysics, Russian Ministry of Health, Moscow, 123182, Russia
Oncogene 20:514-22. 2001..However, a large spectrum of normal and malignant tissues need to be surveyed to determine whether this transdominant p73 variant occurs in a tumor-specific manner...