Nuri Gueven

Summary

Affiliation: Queensland Institute of Medical Research
Country: Australia

Publications

  1. pmc DeltaNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation
    Ashley L Craig
    Cell Signalling Unit, Cancer Research Center, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XR, UK
    Mol Cancer 9:195. 2010
  2. ncbi request reprint Aprataxin, a novel protein that protects against genotoxic stress
    Nuri Gueven
    Radiation Biology and Oncology, The Queensland Institute of Medical Research, Herston, Australia
    Hum Mol Genet 13:1081-93. 2004
  3. doi request reprint Atm and cellular response to DNA damage
    Martin F Lavin
    Radiation Biology and Oncology, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Herston, Queensland, Australia
    Adv Exp Med Biol 570:457-76. 2005
  4. ncbi request reprint Functional consequences of sequence alterations in the ATM gene
    Martin F Lavin
    The Queensland Cancer Fund Research Unit, The Queensland Institute of Medical Research, P O Box Royal Brisbane Hospital, Herston, Brisbane 4029, QLD, Australia
    DNA Repair (Amst) 3:1197-205. 2004
  5. ncbi request reprint Analyzing the regulation and function of ATM
    Martin F Lavin
    The Queensland Cancer Fund Research Unit, The Queensland Institute of Medical Research, Royal Brisbane Hospital, Herston, Australia
    Methods Mol Biol 281:163-78. 2004
  6. ncbi request reprint ATM signaling and genomic stability in response to DNA damage
    Martin F Lavin
    Queensland Cancer Fund Research Unit, The Queensland Institute of Medical Research, PO Box Royal Brisbane Hospital, Herston, Brisbane 4029, Australia
    Mutat Res 569:123-32. 2005
  7. pmc CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response
    Olivier J Becherel
    Queensland Institute of Medical Research, Radiation Biology and Oncology, Brisbane, QLD 4029, Australia
    Nucleic Acids Res 38:1489-503. 2010
  8. ncbi request reprint ATP activates ataxia-telangiectasia mutated (ATM) in vitro. Importance of autophosphorylation
    Sergei Kozlov
    The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Herston QLD 4029, Australia
    J Biol Chem 278:9309-17. 2003
  9. ncbi request reprint Site-directed mutagenesis of the ATM promoter: consequences for response to proliferation and ionizing radiation
    Nuri Gueven
    Queensland Cancer Fund Research Laboratory, The Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, Queensland, Australia
    Genes Chromosomes Cancer 38:157-67. 2003
  10. ncbi request reprint Defective responses to DNA single- and double-strand breaks in spinocerebellar ataxia
    Martin F Lavin
    Radiation Biology and Oncology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    DNA Repair (Amst) 7:1061-76. 2008

Collaborators

Detail Information

Publications18

  1. pmc DeltaNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation
    Ashley L Craig
    Cell Signalling Unit, Cancer Research Center, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XR, UK
    Mol Cancer 9:195. 2010
    ..Previous studies revealed that UV-damage induced p53 phosphorylation is confined to DeltaNp63alpha-positive cells in the basal layer of human epithelium...
  2. ncbi request reprint Aprataxin, a novel protein that protects against genotoxic stress
    Nuri Gueven
    Radiation Biology and Oncology, The Queensland Institute of Medical Research, Herston, Australia
    Hum Mol Genet 13:1081-93. 2004
    ..These results demonstrate that aprataxin influences the cellular response to genotoxic stress very likely by its capacity to interact with a number of proteins involved in DNA repair...
  3. doi request reprint Atm and cellular response to DNA damage
    Martin F Lavin
    Radiation Biology and Oncology, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Herston, Queensland, Australia
    Adv Exp Med Biol 570:457-76. 2005
  4. ncbi request reprint Functional consequences of sequence alterations in the ATM gene
    Martin F Lavin
    The Queensland Cancer Fund Research Unit, The Queensland Institute of Medical Research, P O Box Royal Brisbane Hospital, Herston, Brisbane 4029, QLD, Australia
    DNA Repair (Amst) 3:1197-205. 2004
    ..In this review, we explore the domain structure of the ATM molecule, sites of interaction with other proteins and the consequences of specific amino acid changes on function...
  5. ncbi request reprint Analyzing the regulation and function of ATM
    Martin F Lavin
    The Queensland Cancer Fund Research Unit, The Queensland Institute of Medical Research, Royal Brisbane Hospital, Herston, Australia
    Methods Mol Biol 281:163-78. 2004
    ..Missense mutations affecting ATM kinase activity are detected using in vitro mutagenesis of ATM cDNA followed by the procedures outlined above...
  6. ncbi request reprint ATM signaling and genomic stability in response to DNA damage
    Martin F Lavin
    Queensland Cancer Fund Research Unit, The Queensland Institute of Medical Research, PO Box Royal Brisbane Hospital, Herston, Brisbane 4029, Australia
    Mutat Res 569:123-32. 2005
    ..Mechanisms for recognising double strand breaks in DNA, maintaining genome stability and minimizing risk of cancer are discussed...
  7. pmc CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response
    Olivier J Becherel
    Queensland Institute of Medical Research, Radiation Biology and Oncology, Brisbane, QLD 4029, Australia
    Nucleic Acids Res 38:1489-503. 2010
    ..These results indicate that aprataxin is involved not only in single strand break repair but also in the processing of a subset of double strand breaks presumably through its interaction with MDC1...
  8. ncbi request reprint ATP activates ataxia-telangiectasia mutated (ATM) in vitro. Importance of autophosphorylation
    Sergei Kozlov
    The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Herston QLD 4029, Australia
    J Biol Chem 278:9309-17. 2003
    ..The relationship of this activation to DNA damage activation remains unclear but represents a useful model for understanding in vivo activation...
  9. ncbi request reprint Site-directed mutagenesis of the ATM promoter: consequences for response to proliferation and ionizing radiation
    Nuri Gueven
    Queensland Cancer Fund Research Laboratory, The Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, Queensland, Australia
    Genes Chromosomes Cancer 38:157-67. 2003
    ..The data described here provide additional evidence that basal and radiation-induced regulation of the ATM promoter is under multifactorial control...
  10. ncbi request reprint Defective responses to DNA single- and double-strand breaks in spinocerebellar ataxia
    Martin F Lavin
    Radiation Biology and Oncology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    DNA Repair (Amst) 7:1061-76. 2008
    ..This theme is further developed in this review...
  11. ncbi request reprint Current and potential therapeutic strategies for the treatment of ataxia-telangiectasia
    Martin F Lavin
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Br Med Bull 81:129-47. 2007
    ..We describe the natural course of disease, some supportive therapeutic approaches already in use and those with potential based on our knowledge of molecular and cellular characteristics of this disorder...
  12. ncbi request reprint Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM
    Heather Beamish
    Queensland Cancer Fund Research Laboratories, The Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Herston, Brisbane, QLD 4029, Australia
    J Biol Chem 277:30515-23. 2002
    ..These data suggest that ATM and BLM function together in recognizing abnormal DNA structures by direct interaction and that these phosphorylation sites in BLM are important for radiosensitivity status but not for SCE frequency...
  13. ncbi request reprint Dramatic extension of tumor latency and correction of neurobehavioral phenotype in Atm-mutant mice with a nitroxide antioxidant
    Nuri Gueven
    Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Free Radic Biol Med 41:992-1000. 2006
    ..These data suggest that antioxidant therapy has considerable potential in the management of ataxia telangiectasia and possibly other neurodegenerative disorders where oxidative stress is implicated...
  14. pmc Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage
    Amila Suraweera
    Radiation Biology and Oncology Laboratory, Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia
    J Cell Biol 177:969-79. 2007
    ..These results provide evidence that an additional member of the autosomal recessive AOA is also characterized by a defective response to DNA damage, which may contribute to the neurodegeneration seen in this syndrome...
  15. ncbi request reprint Nucleolar localization of aprataxin is dependent on interaction with nucleolin and on active ribosomal DNA transcription
    Olivier J Becherel
    Radiation Biology and Oncology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
    Hum Mol Genet 15:2239-49. 2006
    ..These results demonstrate a cross-dependence between aprataxin and nucleolin in the nucleolus and while aprataxin does not appear to be directly involved in rRNA synthesis its nucleolar localization is dependent on this synthesis...
  16. ncbi request reprint Regulation of the Atm promoter in vivo
    Nuri Gueven
    Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia
    Genes Chromosomes Cancer 45:61-71. 2006
    ..These results demonstrate that, in addition to activation by autophosphorylation, Atm can also be regulated in vivo at the transcriptional level possibly ensuring a more sustained response to radiation and other stimuli...
  17. pmc Down-regulation of ATM protein sensitizes human prostate cancer cells to radiation-induced apoptosis
    Jean Philip Truman
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 280:23262-72. 2005
    ....
  18. ncbi request reprint Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype
    Nuri Gueven
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Cancer Res 66:2907-12. 2006
    ..These results suggest that ATM-dependent stabilization of p53 and induction of apoptosis by radiation involve an additional factor(s) that is defective in ATL2ABR cells...