Michelle L Gatton

Summary

Affiliation: Queensland Institute of Medical Research
Country: Australia

Publications

  1. pmc Blood transfer devices for malaria rapid diagnostic tests: evaluation of accuracy, safety and ease of use
    Heidi Hopkins
    Foundation for Innovative New Diagnostics, Lumumba Avenue, Kampala, Uganda
    Malar J 10:30. 2011
  2. pmc Global sequence variation in the histidine-rich proteins 2 and 3 of Plasmodium falciparum: implications for the performance of malaria rapid diagnostic tests
    Joanne Baker
    Department of Drug Resistance and Diagnostics, Australian Army Malaria Institute, Brisbane, Australia
    Malar J 9:129. 2010
  3. pmc A large proportion of asymptomatic Plasmodium infections with low and sub-microscopic parasite densities in the low transmission setting of Temotu Province, Solomon Islands: challenges for malaria diagnostics in an elimination setting
    Ivor Harris
    Australian Army Malaria Institute, Weary Dunlop Drive, Gallipoli Barracks Enoggera, QLD 4051, Australia
    Malar J 9:254. 2010
  4. pmc Can estimates of antimalarial efficacy from field studies be improved?
    Michelle L Gatton
    Malaria Drug Resistance and Chemotherapy Laboratory, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Herston, Queensland 4029, Australia
    Trends Parasitol 24:68-73. 2008
  5. pmc Interrupting malaria transmission: quantifying the impact of interventions in regions of low to moderate transmission
    Michelle L Gatton
    Malaria Drug Resistance and Chemotherapy Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    PLoS ONE 5:e15149. 2010
  6. pmc Detection sensitivity and quantitation of Plasmodium falciparum var gene transcripts by real-time RT-PCR in comparison with conventional RT-PCR
    Michelle L Gatton
    Australian Centre for International and Tropical Health and Nutrition, University of Queensland, Queensland, Australia
    Am J Trop Med Hyg 75:212-8. 2006
  7. pmc Plasmodium falciparum infection dynamics and transmission potential following treatment with sulfadoxine-pyrimethamine
    Michelle L Gatton
    Australian Centre for International and Tropical Health and Nutrition, University of Queensland Brisbane, Australia
    J Antimicrob Chemother 58:47-51. 2006
  8. pmc Phenotypic changes in artemisinin-resistant Plasmodium falciparum lines in vitro: evidence for decreased sensitivity to dormancy and growth inhibition
    Franka Teuscher
    Drug Resistance and Diagnostics, Australian Army Malaria Institute, Brisbane, Australia
    Antimicrob Agents Chemother 56:428-31. 2012
  9. pmc Physical linkage to drug resistance genes results in conservation of var genes among West Pacific Plasmodium falciparum isolates
    Elizabeth V Fowler
    Drug Resistance and Diagnostics, Australian Army Malaria Institute, Brisbane, Australia
    J Infect Dis 194:939-48. 2006
  10. pmc Evolution of resistance to sulfadoxine-pyrimethamine in Plasmodium falciparum
    Michelle L Gatton
    Malaria and Scabies Group, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Queensland 4029, Australia
    Antimicrob Agents Chemother 48:2116-23. 2004

Collaborators

Detail Information

Publications35

  1. pmc Blood transfer devices for malaria rapid diagnostic tests: evaluation of accuracy, safety and ease of use
    Heidi Hopkins
    Foundation for Innovative New Diagnostics, Lumumba Avenue, Kampala, Uganda
    Malar J 10:30. 2011
    ..Blood transfer devices were evaluated for accuracy and precision of volume transferred, safety and ease of use, to identify the most appropriate devices for use with RDTs in routine clinical care...
  2. pmc Global sequence variation in the histidine-rich proteins 2 and 3 of Plasmodium falciparum: implications for the performance of malaria rapid diagnostic tests
    Joanne Baker
    Department of Drug Resistance and Diagnostics, Australian Army Malaria Institute, Brisbane, Australia
    Malar J 9:129. 2010
    ..This is of particular concern for Plasmodium falciparum histidine-rich protein 2 (PfHRP2)-detecting RDTs since PfHRP2 has been reported to be highly variable in isolates of the Asia-Pacific region...
  3. pmc A large proportion of asymptomatic Plasmodium infections with low and sub-microscopic parasite densities in the low transmission setting of Temotu Province, Solomon Islands: challenges for malaria diagnostics in an elimination setting
    Ivor Harris
    Australian Army Malaria Institute, Weary Dunlop Drive, Gallipoli Barracks Enoggera, QLD 4051, Australia
    Malar J 9:254. 2010
    ....
  4. pmc Can estimates of antimalarial efficacy from field studies be improved?
    Michelle L Gatton
    Malaria Drug Resistance and Chemotherapy Laboratory, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Herston, Queensland 4029, Australia
    Trends Parasitol 24:68-73. 2008
    ..Therefore, assessing haplotype frequency and distribution should form an integral part of all studies investigating the therapeutic efficacy of antimalarial treatment regimes...
  5. pmc Interrupting malaria transmission: quantifying the impact of interventions in regions of low to moderate transmission
    Michelle L Gatton
    Malaria Drug Resistance and Chemotherapy Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    PLoS ONE 5:e15149. 2010
    ..This novel finding requires further investigation in the field because, if confirmed, such a change would have a negative impact on attempts to eliminate the disease from areas of moderate transmission...
  6. pmc Detection sensitivity and quantitation of Plasmodium falciparum var gene transcripts by real-time RT-PCR in comparison with conventional RT-PCR
    Michelle L Gatton
    Australian Centre for International and Tropical Health and Nutrition, University of Queensland, Queensland, Australia
    Am J Trop Med Hyg 75:212-8. 2006
    ..These results provide valuable information comparing RT-PCR and real-time RT-PCR analysis of samples with small quantities of RNA as might be expected in the analysis of field or clinical samples...
  7. pmc Plasmodium falciparum infection dynamics and transmission potential following treatment with sulfadoxine-pyrimethamine
    Michelle L Gatton
    Australian Centre for International and Tropical Health and Nutrition, University of Queensland Brisbane, Australia
    J Antimicrob Chemother 58:47-51. 2006
    ..To investigate the overall efficacy of sulfadoxine-pyrimethamine (SP) treatment and the corresponding transmission potential for patients infected with SP-resistant Plasmodium falciparum...
  8. pmc Phenotypic changes in artemisinin-resistant Plasmodium falciparum lines in vitro: evidence for decreased sensitivity to dormancy and growth inhibition
    Franka Teuscher
    Drug Resistance and Diagnostics, Australian Army Malaria Institute, Brisbane, Australia
    Antimicrob Agents Chemother 56:428-31. 2012
    ..Our results demonstrate that the AL resistance phenotype has (i) decreased sensitivity of mature-stage parasites, (ii) decreased sensitivity of the ring stage to the induction of dormancy, and (iii) a faster recovery from dormancy...
  9. pmc Physical linkage to drug resistance genes results in conservation of var genes among West Pacific Plasmodium falciparum isolates
    Elizabeth V Fowler
    Drug Resistance and Diagnostics, Australian Army Malaria Institute, Brisbane, Australia
    J Infect Dis 194:939-48. 2006
    ..Thus, the conservation of these var genes is the result of their physical linkage with drug-resistant genes in combination with the antimalarial drug pressure in the region...
  10. pmc Evolution of resistance to sulfadoxine-pyrimethamine in Plasmodium falciparum
    Michelle L Gatton
    Malaria and Scabies Group, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Queensland 4029, Australia
    Antimicrob Agents Chemother 48:2116-23. 2004
    ..Therefore, the model output reaffirms the importance of correct treatment of confirmed malaria cases in slowing the development of parasite resistance to sulfadoxine-pyrimethamine...
  11. ncbi request reprint Switching rates of Plasmodium falciparum var genes: faster than we thought?
    Michelle L Gatton
    Malaria Biology Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Queensland 4029, Australia
    Trends Parasitol 19:202-8. 2003
    ..The implications of the predicted switching rates are discussed...
  12. pmc Characterization of the antibody response against Plasmodium falciparum erythrocyte membrane protein 1 in human volunteers
    Darren R Krause
    Malaria Drug Resistance and Chemotherapy, Infectious Diseases and Immunology Division, The Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, QLD 4029, Australia
    Infect Immun 75:5967-73. 2007
    ..falciparum suggests that the anti-PfEMP1 antibodies often persisted for more than 100 days after a single infection. These results help to further our understanding of the development of acquired immunity to P. falciparum infections...
  13. pmc Identification of optimal epitopes for Plasmodium falciparum rapid diagnostic tests that target histidine-rich proteins 2 and 3
    Nelson Lee
    Clinical Tropical Medicine Laboratory, Queensland Institute of Medical Research, University of Queensland, Herston, Queensland, Australia
    J Clin Microbiol 50:1397-405. 2012
    ..This study therefore informs the selection of MAbs to include in malaria RDTs as well as in the generation of improved MAbs that should improve the performance of HRP-detecting malaria RDTs...
  14. pmc Artemisinin-induced parasite dormancy: a plausible mechanism for treatment failure
    Andrea Codd
    Malaria Drug Resistance and Chemotherapy Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Malar J 10:56. 2011
    ..The dormancy recovery hypothesis has been proposed to explain this phenomenon, which is different from the slower parasite clearance times reported as the first evidence of the development of ART resistance...
  15. pmc Effect of sequence variation in Plasmodium falciparum histidine- rich protein 2 on binding of specific monoclonal antibodies: Implications for rapid diagnostic tests for malaria
    Nelson Lee
    Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research and School of Population Health, University of Queensland, Queensland, Australia
    J Clin Microbiol 44:2773-8. 2006
    ..These findings support the role of sequence variation as an explanation for variations in the performance of HRP2-based RDTs and point toward possible approaches to improve their diagnostic sensitivities...
  16. pmc Transcription and expression of Plasmodium falciparum histidine-rich proteins in different stages and strains: implications for rapid diagnostic tests
    Joanne Baker
    Department of Drug Resistance and Diagnostics, Australian Army Malaria Institute, Gallipoli Barracks, Enoggera, Queensland, Australia
    PLoS ONE 6:e22593. 2011
    ..One possible explanation for variable test performance is differences in expression level of PfHRP in different parasite isolates...
  17. doi request reprint Spatial-temporal epidemiological analyses of two sympatric, co-endemic alphaviral diseases in Queensland, Australia
    Anita M Pelecanos
    Malaria Drug Resistance and Chemotherapy Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Vector Borne Zoonotic Dis 11:375-82. 2011
    ..Although these viruses are thought to share similar vectors and vertebrate hosts, RRV is four times more prevalent than BFV in Queensland...
  18. pmc An analytical method for assessing stage-specific drug activity in Plasmodium vivax malaria: implications for ex vivo drug susceptibility testing
    Douglas H Kerlin
    Malaria Drug Resistance and Chemotherapy Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    PLoS Negl Trop Dis 6:e1772. 2012
    ..The statistical methodology which has been developed also provides a novel means of detecting stage-specific drug activity for new antimalarials...
  19. pmc An improved method for undertaking limiting dilution assays for in vitro cloning of Plasmodium falciparum parasites
    Alice S Butterworth
    Clinical Tropical Medicine Laboratory, Queensland Institute of Medical Research, Herston, Brisbane, 4006, Australia
    Malar J 10:95. 2011
    ..An alternative method for the detection of parasite growth in limiting dilution assays is using a commercial ELISA histidine-rich protein II (HRP2) detection kit...
  20. pmc Artemisininā€induced dormancy in plasmodium falciparum: duration, recovery rates, and implications in treatment failure
    Franka Teuscher
    Malaria Drug Resistance and Chemotherapy Laboratory, Queensland Institute of Medical Research, Australian Army Malaria Institute, Brisbane, Australia
    J Infect Dis 202:1362-8. 2010
    ..The temporary arrest of the growth of ring-stage parasites (dormancy) after exposure to artemisinin drugs provides a plausible explanation for this phenomenon...
  21. ncbi request reprint Genetic diversity of the DBLalpha region in Plasmodium falciparum var genes among Asia-Pacific isolates
    Elizabeth V Fowler
    Malaria Laboratory, Infectious Diseases Unit, The Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Queensland 4029, Australia
    Mol Biochem Parasitol 120:117-26. 2002
    ....
  22. pmc Modeling the development of acquired clinical immunity to Plasmodium falciparum malaria
    Michelle L Gatton
    Australian Centre for International and Tropical Health and Nutrition, University of Queensland, Herston
    Infect Immun 72:6538-45. 2004
    ..The results also illustrate a novel use for simulation models of P. falciparum infections, investigation of the influence of intervention strategies on the development of naturally acquired clinical immunity...
  23. pmc Differential changes in Plasmodium falciparum var transcription during adaptation to culture
    Jennifer M Peters
    Malaria Drug Resistance and Chemotherapy Laboratory, Queensland Institute of Medical Research, Herston, Australia
    J Infect Dis 195:748-55. 2007
    ..These results have significant implications for the investigation of associations between var transcription and clinical manifestations using parasites that have been enriched by in vitro culture...
  24. pmc Antibody reactivity to linear epitopes of Plasmodium falciparum cytoadherence-linked asexual gene 9 in asymptomatic children and adults from papua new Guinea
    Katharine R Trenholme
    Division of Infectious Diseases and Immunology, The Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Am J Trop Med Hyg 72:708-13. 2005
    ..While CLAG 9 peptides are immunogenic in humans, longitudinal studies will be required to determine the longevity of antibody responses to CLAG 9 and their role in protection from disease...
  25. ncbi request reprint Environmental predictors of Ross River virus disease outbreaks in Queensland, Australia
    Michelle L Gatton
    Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research and the University of Queensland, Brisbane, Queensland, Australia
    Am J Trop Med Hyg 72:792-9. 2005
    ..Identification of factors leading to RRV disease outbreaks will help local authorities identify periods of high risk, optimizing the provision of additional mosquito control measures...
  26. ncbi request reprint Spatial-temporal analysis of Ross River virus disease patterns in Queensland, Australia
    Michelle L Gatton
    Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, Herston, Queensland 4029, Australia
    Am J Trop Med Hyg 71:629-35. 2004
    ..This analysis highlights the variability in Ross River virus disease notification rates across Queensland, and provides a robust method for identifying disease outbreaks...
  27. pmc Modelling the dynamics of Plasmodium falciparum histidine-rich protein 2 in human malaria to better understand malaria rapid diagnostic test performance
    Louise Marquart
    Statistics Unit, Queensland Institute of Medical Research, Herston, Australia
    Malar J 11:74. 2012
    ..However, concerns have been raised about the longevity of the PfHRP2 antigenaemia following curative treatment in endemic regions...
  28. pmc Suppression of mRNAs encoding tegument tetraspanins from Schistosoma mansoni results in impaired tegument turnover
    Mai H Tran
    Division of Infectious Diseases, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    PLoS Pathog 6:e1000840. 2010
    ..These results imply that tetraspanins play important structural roles impacting tegument development, maturation or stability...
  29. pmc Preferential invasion by Plasmodium merozoites and the self-regulation of parasite burden
    Douglas H Kerlin
    Malaria Drug Resistance and Chemotherapy Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    PLoS ONE 8:e57434. 2013
    ..falciparum appearing to exhibit a combination of characteristics which are able to self-regulate parasite density...
  30. pmc Outbreak detection algorithms for seasonal disease data: a case study using Ross River virus disease
    Anita M Pelecanos
    Malaria Drug Resistance and Chemotherapy Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    BMC Med Inform Decis Mak 10:74. 2010
    ..Although many algorithms have been designed for detecting outbreaks, few have been specifically assessed against diseases that have distinct seasonal incidence patterns, such as those caused by vector-borne pathogens...
  31. ncbi request reprint Evaluation of the pyrogenic threshold for Plasmodium falciparum malaria in naive individuals
    Michelle L Gatton
    Malaria Biology Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Australia
    Am J Trop Med Hyg 66:467-73. 2002
    ..These results provide further information on the pyrogenic threshold of malaria...
  32. ncbi request reprint Critical evaluation of quantitative sampling methods for Aedes aegypti (Diptera: Culicidae) immatures in water storage containers in Vietnam
    Tessa B Knox
    Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, Brisbane, Australia
    J Med Entomol 44:192-204. 2007
    ..610 and 0.328, respectively); however, the relationship between immature abundance and emergent adult populations remains to be defined...
  33. ncbi request reprint Inhibition of 19-kDa C-terminal region of merozoite surface protein-1-specific antibody responses in neonatal pups by maternally derived 19-kDa C-terminal region of merozoite surface protein-1-specific antibodies but not whole parasite-specific antibodies
    Danielle I Stanisic
    Queensland Institute of Medical Research and CRC for Vaccine Technology, Brisbane, Australia
    J Immunol 172:5570-81. 2004
    ..If a neonate's ability to respond to MSP1(19) vaccination depends on the level of maternal Abs present at the time of vaccination, it may be necessary to delay immunization until Abs specific for the vaccinating Ag have decreased...
  34. ncbi request reprint Efficacy of sulfadoxine-pyrimethamine in the treatment of uncomplicated Plasmodium falciparum malaria in East Timor
    Matthew Burns
    Medical Emergency Relief International, London, United Kingdom
    Am J Trop Med Hyg 74:361-6. 2006
    ..falciparum dihydrofolate reductase (S108N/C59R). The data from this study also highlights that the presence of gametocytes may significantly influence the estimate of SP efficacy determined by genotyping...
  35. ncbi request reprint HIV-malaria interactions: don't forget the drugs
    Katherine T Andrews
    Science 315:1791; author reply 1791. 2007