Manuel A R Ferreira

Summary

Affiliation: Queensland Institute of Medical Research
Country: Australia

Publications

  1. doi request reprint A multivariate test of association
    Manuel A R Ferreira
    Department of Psychiatry, Massachusetts General Hospital, Boston, USA
    Bioinformatics 25:132-3. 2009
  2. pmc Identification of IL6R and chromosome 11q13.5 as risk loci for asthma
    Manuel A R Ferreira
    The Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Lancet 378:1006-14. 2011
  3. pmc Sequence variants in three loci influence monocyte counts and erythrocyte volume
    Manuel A R Ferreira
    Queensland Institute of Medical Research QIMR, Brisbane, QLD 4029, Australia
    Am J Hum Genet 85:745-9. 2009
  4. pmc Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia
    Manuel A R Ferreira
    Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Eur J Hum Genet 19:458-64. 2011
  5. pmc Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control
    Manuel A R Ferreira
    Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Am J Hum Genet 86:88-92. 2010
  6. pmc Common variants in the trichohyalin gene are associated with straight hair in Europeans
    Sarah E Medland
    Queensland Institute of Medical Research, Brisbane 4029, Australia
    Am J Hum Genet 85:750-5. 2009
  7. pmc Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits
    Rita P S Middelberg
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    BMC Med Genet 12:123. 2011
  8. ncbi request reprint A simple method to localise pleiotropic susceptibility loci using univariate linkage analyses of correlated traits
    Manuel A R Ferreira
    Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, Australia
    Eur J Hum Genet 14:953-62. 2006
  9. pmc Assumption-free estimation of heritability from genome-wide identity-by-descent sharing between full siblings
    Peter M Visscher
    Genetic Epidemiology Group, Queensland Institute of Medical Research, Brisbane, Australia
    PLoS Genet 2:e41. 2006
  10. doi request reprint LPAR1 and ITGA4 regulate peripheral blood monocyte counts
    Narelle Maugeri
    Queensland Institute of Medical Research, Brisbane, Australia
    Hum Mutat 32:873-6. 2011

Detail Information

Publications26

  1. doi request reprint A multivariate test of association
    Manuel A R Ferreira
    Department of Psychiatry, Massachusetts General Hospital, Boston, USA
    Bioinformatics 25:132-3. 2009
    ..Although genetic association studies often test multiple, related phenotypes, few formal multivariate tests of association are available. We describe a test of association that can be efficiently applied to large population-based designs...
  2. pmc Identification of IL6R and chromosome 11q13.5 as risk loci for asthma
    Manuel A R Ferreira
    The Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Lancet 378:1006-14. 2011
    ..We aimed to identify novel genetic variants affecting asthma risk, since these might provide novel insights into molecular mechanisms underlying the disease...
  3. pmc Sequence variants in three loci influence monocyte counts and erythrocyte volume
    Manuel A R Ferreira
    Queensland Institute of Medical Research QIMR, Brisbane, QLD 4029, Australia
    Am J Hum Genet 85:745-9. 2009
    ..001, 9.9x10(-5), and 7x10(-5), respectively). The identification of these QTL provides new opportunities for furthering our understanding of the mechanisms regulating hemopoietic cell fate...
  4. pmc Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia
    Manuel A R Ferreira
    Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Eur J Hum Genet 19:458-64. 2011
    ..In conclusion, we confirm the association between asthma risk and variants in ORMDL3 and identify a novel risk variant in IL1RL1. Follow-up of the 17q21 deletion in larger cohorts is warranted...
  5. pmc Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control
    Manuel A R Ferreira
    Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Am J Hum Genet 86:88-92. 2010
    ....
  6. pmc Common variants in the trichohyalin gene are associated with straight hair in Europeans
    Sarah E Medland
    Queensland Institute of Medical Research, Brisbane 4029, Australia
    Am J Hum Genet 85:750-5. 2009
    ..5x10(-31)). These variants are at their highest frequency in Northern Europeans, paralleling the distribution of the straight-hair EDAR variant in Asian populations...
  7. pmc Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits
    Rita P S Middelberg
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    BMC Med Genet 12:123. 2011
    ....
  8. ncbi request reprint A simple method to localise pleiotropic susceptibility loci using univariate linkage analyses of correlated traits
    Manuel A R Ferreira
    Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, Australia
    Eur J Hum Genet 14:953-62. 2006
    ..We illustrate the utility of our approach with a genome scan of three asthma traits measured in families with a twin proband...
  9. pmc Assumption-free estimation of heritability from genome-wide identity-by-descent sharing between full siblings
    Peter M Visscher
    Genetic Epidemiology Group, Queensland Institute of Medical Research, Brisbane, Australia
    PLoS Genet 2:e41. 2006
    ....
  10. doi request reprint LPAR1 and ITGA4 regulate peripheral blood monocyte counts
    Narelle Maugeri
    Queensland Institute of Medical Research, Brisbane, Australia
    Hum Mutat 32:873-6. 2011
    ..Further studies that investigate the downstream mechanism involved and the impact on immune function are warranted...
  11. pmc Common variants in TMPRSS6 are associated with iron status and erythrocyte volume
    Beben Benyamin
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Nat Genet 41:1173-5. 2009
    ..1 x 10(-10)). We also find suggestive evidence of association with blood hemoglobin levels (combined P = 5.3 x 10(-7)). These findings demonstrate the involvement of TMPRSS6 in control of iron homeostasis and in normal erythropoiesis...
  12. pmc Robust estimation of experimentwise P values applied to a genome scan of multiple asthma traits identifies a new region of significant linkage on chromosome 20q13
    Manuel A R Ferreira
    Queensland Institute of Medical Research, Brisbane, Australia
    Am J Hum Genet 77:1075-85. 2005
    ....
  13. ncbi request reprint GENOVA: gene overlap analysis of GWAS results
    Clara S Tang
    Queensland Institute of Medical Research, Brisbane, Australia
    Stat Appl Genet Mol Biol 11:Article 6. 2012
    ..A weaker association was observed for BMI (1.09-fold, P = 0.008) and WHR (1.09-fold, P = 0.014). GENOVA is implemented in C++ and is freely available at https://genepi.qimr.edu.au/staff/manuelF/genova/main.html...
  14. pmc Multivariate genomewide linkage scan of neurocognitive traits and ADHD symptoms: suggestive linkage to 3q13
    Alysa E Doyle
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1399-411. 2008
    ..Overall, these data support the utility of neurocognitive traits as ADHD endophenotypes, but also highlight their limited genetic overlap with the disorder...
  15. ncbi request reprint Sex-limited genome-wide linkage scan for body mass index in an unselected sample of 933 Australian twin families
    Belinda K Cornes
    Genetic Epidemiology, Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, QLD, Australia
    Twin Res Hum Genet 8:616-32. 2005
    ....
  16. pmc A genomewide association study of response to lithium for prevention of recurrence in bipolar disorder
    Roy H Perlis
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
    Am J Psychiatry 166:718-25. 2009
    ....
  17. pmc Genomewide significant linkage to migrainous headache on chromosome 5q21
    Dale R Nyholt
    Queensland Institute of Medical Research, Brisbane, Australia
    Am J Hum Genet 77:500-12. 2005
    ..These results will prove to be invaluable in the design and analysis of future linkage and linkage disequilibrium studies of migraine...
  18. pmc Practical aspects of imputation-driven meta-analysis of genome-wide association studies
    Paul I W de Bakker
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School Partners Healthcare Systems Center for Genetics and Genomics, Boston, MA 02115, USA
    Hum Mol Genet 17:R122-8. 2008
    ..As many groups are forming collaborations to engage in these efforts, this review collects a series of guidelines, practical detail and learned experiences from a variety of individuals who have contributed to the subject...
  19. pmc PLINK: a tool set for whole-genome association and population-based linkage analyses
    Shaun Purcell
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Hum Genet 81:559-75. 2007
    ..Analysis of the patterns of segmental sharing has the potential to map disease loci that contain multiple rare variants in a population-based linkage analysis...
  20. pmc Cytokine expression in allergic inflammation: systematic review of in vivo challenge studies
    Manuel A R Ferreira
    Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Brisbane 4029, Australia
    Mediators Inflamm 12:259-67. 2003
    ..Allergic inflammatory responses are driven by cells of the immune system that rely on cytokines to regulate the activity of other immune and structural cells...
  21. doi request reprint Association between microdeletion and microduplication at 16p11.2 and autism
    Lauren A Weiss
    Autism Consortium, Boston, USA
    N Engl J Med 358:667-75. 2008
    ..Autism spectrum disorder is a heritable developmental disorder in which chromosomal abnormalities are thought to play a role...
  22. ncbi request reprint Linkage analysis: principles and methods for the analysis of human quantitative traits
    Manuel A R Ferreira
    Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, Australia
    Twin Res 7:513-30. 2004
    ..The type-I error rate and power of these methods are discussed. Finally, rough guidelines are provided to help guide the choice of linkage statistics...
  23. doi request reprint A gene-based test of association using canonical correlation analysis
    Clara S Tang
    Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia
    Bioinformatics 28:845-50. 2012
    ..We reasoned that CCA could provide an efficient and powerful approach for both univariate and multivariate gene-based tests of association without the need for permutation testing...
  24. ncbi request reprint Ascertainment through family history of disease often decreases the power of family-based association studies
    Manuel A R Ferreira
    Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge St, Boston, MA 02114, USA
    Behav Genet 37:631-6. 2007
    ..Our analytic approach to estimate the asymptotic power of the TDT is implemented online at http://pngu.mgh.harvard.edu/ ~purcell/gpc/...
  25. pmc Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
    Manuel A R Ferreira
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 40:1056-8. 2008
    ..0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder...
  26. ncbi request reprint Inflammation in allergic asthma: initiating events, immunological response and risk factors
    Manuel A R Ferreira
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Respirology 9:16-24. 2004
    ..Finally, it integrates these concepts in a theoretical causal model for atopic asthma...