Denise L Doolan

Summary

Affiliation: Queensland Institute of Medical Research
Country: Australia

Publications

  1. pmc Plasmodium immunomics
    Denise L Doolan
    Division of Immunology, Queensland Institute of Medical Research, The Bancroft Centre, 300 Herston Road, P O Royal Brisbane Hospital, Brisbane, QLD 4029, Australia
    Int J Parasitol 41:3-20. 2011
  2. pmc Evaluation of approaches to identify the targets of cellular immunity on a proteome-wide scale
    Fernanda C Cardoso
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    PLoS ONE 6:e27666. 2011
  3. pmc Identification of minimal human MHC-restricted CD8+ T-cell epitopes within the Plasmodium falciparum circumsporozoite protein (CSP)
    Martha Sedegah
    US Military Malaria Vaccine Program, Naval Medical Research Center, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    Malar J 12:185. 2013
  4. pmc Intermittent preventive treatment with sulfadoxine-pyrimethamine does not modify plasma cytokines and chemokines or intracellular cytokine responses to Plasmodium falciparum in Mozambican children
    Diana Quelhas
    Centro de Investigação em Saúde da Manhiça, Manhiça, Mozambique
    BMC Immunol 13:5. 2012
  5. pmc Schistosomiasis vaccine discovery using immunomics
    Patrick Driguez
    Molecular Parasitology Laboratory, The Queensland Institute of Medical Institute, Herston, Queensland 4006, Australia
    Parasit Vectors 3:4. 2010
  6. pmc Measuring naturally acquired immune responses to candidate malaria vaccine antigens in Ghanaian adults
    Daniel Dodoo
    Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
    Malar J 10:168. 2011
  7. pmc Human T cell recognition of the blood stage antigen Plasmodium hypoxanthine guanine xanthine phosphoribosyl transferase (HGXPRT) in acute malaria
    Tonia Woodberry
    International Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Malar J 8:122. 2009
  8. pmc Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein
    Martha Sedegah
    USMMVP, Malaria Department, NMRC, Silver Spring, MD 20910, USA
    Malar J 9:241. 2010
  9. pmc Induction of multi-antigen multi-stage immune responses against Plasmodium falciparum in rhesus monkeys, in the absence of antigen interference, with heterologous DNA prime/poxvirus boost immunization
    George Jiang
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
    Malar J 6:135. 2007
  10. pmc Acquired immunity to malaria
    Denise L Doolan
    Queensland Institute of Medical Research, The Bancroft Centre, Post Office Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Clin Microbiol Rev 22:13-36, Table of Contents. 2009

Collaborators

Detail Information

Publications37

  1. pmc Plasmodium immunomics
    Denise L Doolan
    Division of Immunology, Queensland Institute of Medical Research, The Bancroft Centre, 300 Herston Road, P O Royal Brisbane Hospital, Brisbane, QLD 4029, Australia
    Int J Parasitol 41:3-20. 2011
    ..Herein, current progress and perspectives regarding Plasmodium immunomics are reviewed...
  2. pmc Evaluation of approaches to identify the targets of cellular immunity on a proteome-wide scale
    Fernanda C Cardoso
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    PLoS ONE 6:e27666. 2011
    ..Herein, we report a novel approach for proteome-wide scale identification of the antigenic targets of T cell responses using IVTT products...
  3. pmc Identification of minimal human MHC-restricted CD8+ T-cell epitopes within the Plasmodium falciparum circumsporozoite protein (CSP)
    Martha Sedegah
    US Military Malaria Vaccine Program, Naval Medical Research Center, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    Malar J 12:185. 2013
    ..The finding that CSP delivered by an appropriate vaccine platform likely elicits protective cell-mediated immunity provided a rationale for identifying class I-restricted epitopes within this leading vaccine candidate antigen...
  4. pmc Intermittent preventive treatment with sulfadoxine-pyrimethamine does not modify plasma cytokines and chemokines or intracellular cytokine responses to Plasmodium falciparum in Mozambican children
    Diana Quelhas
    Centro de Investigação em Saúde da Manhiça, Manhiça, Mozambique
    BMC Immunol 13:5. 2012
    ..Multiple cytokines and chemokines were quantified in plasma by luminex, and antigen-specific cytokine production in whole blood was determined by intracellular cytokine staining and flow cytometry, at ages 5, 9, 12 and 24 months...
  5. pmc Schistosomiasis vaccine discovery using immunomics
    Patrick Driguez
    Molecular Parasitology Laboratory, The Queensland Institute of Medical Institute, Herston, Queensland 4006, Australia
    Parasit Vectors 3:4. 2010
    ..This highly innovative technology has the potential to transform vaccine research for schistosomiasis and other parasitic diseases of humans and animals...
  6. pmc Measuring naturally acquired immune responses to candidate malaria vaccine antigens in Ghanaian adults
    Daniel Dodoo
    Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
    Malar J 10:168. 2011
    ..Assessing T cell responses is especially challenging, given genetic restriction, low responses observed in endemic areas, their variability over time, potential suppression by parasitaemia and the intrinsic variability of the assays...
  7. pmc Human T cell recognition of the blood stage antigen Plasmodium hypoxanthine guanine xanthine phosphoribosyl transferase (HGXPRT) in acute malaria
    Tonia Woodberry
    International Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Malar J 8:122. 2009
    ..It is not known whether natural exposure to Plasmodium falciparum stimulates HGXPRT T cell reactivity in humans...
  8. pmc Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein
    Martha Sedegah
    USMMVP, Malaria Department, NMRC, Silver Spring, MD 20910, USA
    Malar J 9:241. 2010
    ..Since CD8+ T cell responses have been implicated in protection against pre-erythrocytic stage malaria, this study was designed to identify MHC class I-restricted epitopes within AMA1...
  9. pmc Induction of multi-antigen multi-stage immune responses against Plasmodium falciparum in rhesus monkeys, in the absence of antigen interference, with heterologous DNA prime/poxvirus boost immunization
    George Jiang
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
    Malar J 6:135. 2007
    ....
  10. pmc Acquired immunity to malaria
    Denise L Doolan
    Queensland Institute of Medical Research, The Bancroft Centre, Post Office Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Clin Microbiol Rev 22:13-36, Table of Contents. 2009
    ..The mechanism of naturally acquired immunity that occurs among adults living in areas of hyper- to holoendemicity should be understood with a view toward duplicating such protection in infants and young children in areas of endemicity...
  11. ncbi request reprint The path of discovery
    Denise L Doolan
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Hum Vaccin 4:324-6. 2008
  12. doi request reprint Status of malaria vaccine R&D in 2007. Malaria Vaccines for the World 2007, September 17-19th, 2007, London, UK
    Denise L Doolan
    The Queensland Institute of Medical Research, The Bancroft Centre, 300 Herston Road, PO Royal Brisbane Hospital, Brisbane QLD 4029, Australia
    Expert Rev Vaccines 6:903-5. 2007
  13. pmc Highly sensitive quantitative real-time PCR for the detection of Plasmodium liver-stage parasite burden following low-dose sporozoite challenge
    Sophie Schussek
    Infectious Diseases Programme, Queensland Institute of Medical Research, Herston, Queensland, Australia School of Medicine, University of Queensland, St Lucia, Queensland, Australia
    PLoS ONE 8:e77811. 2013
    ....
  14. pmc Vaccination with lipid core peptides fails to induce epitope-specific T cell responses but confers non-specific protective immunity in a malaria model
    Simon H Apte
    Infectious Diseases Programme, Queensland Institute of Medical Research, Herston, Queensland, Australia
    PLoS ONE 7:e40928. 2012
    ....
  15. doi request reprint High-throughput multi-parameter flow-cytometric analysis from micro-quantities of plasmodium-infected blood
    Simon H Apte
    Queensland Institute of Medical Research, and The Australian Centre for Vaccine Development, 300 Herston Road, Locked Bag 2000, Royal Brisbane Hospital, Brisbane, QLD 4029, Australia
    Int J Parasitol 41:1285-94. 2011
    ..Herein, we describe the technique and demonstrate its application in vaccinology and with a range of rodent and human parasite species including Plasmodium yoelii, Plasmodium chabaudi, Plasmodium berghei and Plasmodium falciparum...
  16. pmc Immunization with apical membrane antigen 1 confers sterile infection-blocking immunity against Plasmodium sporozoite challenge in a rodent model
    Sophie Schussek
    Queensland Institute of Medical Research, Infectious Diseases Programme, Herston, Queensland, Australia
    Infect Immun 81:3586-99. 2013
    ..These data establish AMA-1 as a target of both preerythrocytic- and erythrocytic-stage protective immune responses and validate vaccine approaches designed to induce both cellular and humoral immunity. ..
  17. doi request reprint Subcutaneous cholera toxin exposure induces potent CD103⁺ dermal dendritic cell activation and migration
    Simon H Apte
    Queensland Institute of Medical Research, Queensland Tropical Health Alliance and Australian Centre for Vaccine Development, Royal Brisbane Hospital, Brisbane, Australia
    Eur J Immunol 43:2707-17. 2013
    ....
  18. doi request reprint Harnessing immune responses against Plasmodium for rational vaccine design
    Bruno Douradinha
    Division of Immunology, Queensland Institute of Medical Research, Brisbane, Australia
    Trends Parasitol 27:274-83. 2011
    ..In this review, we discuss the latest developments in the field and speculate on how immune responses against Plasmodium could be harnessed for rational vaccine design and application...
  19. pmc Sterile protective immunity to malaria is associated with a panel of novel P. falciparum antigens
    Angela Trieu
    Division of Immunology, Queensland Institute of Medical Research, Brisbane, QLD 4006, Australia
    Mol Cell Proteomics 10:M111.007948. 2011
    ..These results have important implications for vaccine development, suggesting that an efficacious malaria vaccine should be multivalent and targeted at a select panel of key antigens, many of which have not been previously characterized...
  20. doi request reprint IFN-gamma inhibits IL-4-induced type 2 cytokine expression by CD8 T cells in vivo and modulates the anti-tumor response
    Simon H Apte
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    J Immunol 185:998-1004. 2010
    ..These findings may explain the anomalies in the reported functional phenotype of type 2 polarized CD8 T cells...
  21. doi request reprint Genome- and proteome-wide screening strategies for antigen discovery and immunogen design
    Sophie Schussek
    Infectious Diseases Programme, Queensland Institute of Medical Research, Herston, QLD 4006, Australia School of Medicine, University of Queensland, Herston, QLD 4006, Australia Electronic address
    Biotechnol Adv 32:403-14. 2014
    ....
  22. doi request reprint Vaccinomics for the major blood feeding helminths of humans
    Alex Loukas
    Queensland Tropical Health Alliance, James Cook University, Cairns, Queensland, Australia
    OMICS 15:567-77. 2011
    ..This research has resulted in the discovery, development, and early stage clinical trials of subunit vaccines against hookworms and schistosomes...
  23. doi request reprint Malaria vaccine design: immunological considerations
    Michael F Good
    Division of Immunology, The Queensland Institute of Medical Research, Brisbane, QLD 4006, Australia
    Immunity 33:555-66. 2010
    ..These and other concepts will be discussed in this review...
  24. ncbi request reprint Nucleic acid vaccines against malaria
    Denise L Doolan
    Malaria Program, Naval Medical Research Center, Silver Spring, MD, USA
    Chem Immunol 80:308-21. 2002
  25. pmc Persistence of protective immunity to malaria induced by DNA priming and poxvirus boosting: characterization of effector and memory CD8(+)-T-cell populations
    Martha Sedegah
    Malaria Program, Naval Medical Research Center, Silver Spring, Maryland 20910 7500, USA
    Infect Immun 70:3493-9. 2002
    ..These results demonstrate that a heterologous priming and boosting vaccination can provide lasting protection against malaria in this model system...
  26. ncbi request reprint DNA vaccination
    Richard C Hedstrom
    Regulatory Affairs Section, DynPort Vaccine Company, Frederick, MD, USA
    Methods Mol Med 72:347-59. 2002
  27. pmc Identification of Plasmodium falciparum antigens by antigenic analysis of genomic and proteomic data
    Denise L Doolan
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
    Proc Natl Acad Sci U S A 100:9952-7. 2003
    ..The data suggest that immune responses to Plasmodium are dispersed on a relatively large number of parasite antigens. These studies have implications for our understanding of immunodominance and breadth of responses to complex pathogens...
  28. ncbi request reprint Induction in humans of CD8+ and CD4+ T cell and antibody responses by sequential immunization with malaria DNA and recombinant protein
    Ruobing Wang
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910, USA
    J Immunol 172:5561-9. 2004
    ..The induction in humans of the three primary Ag-specific adaptive immune responses establishes a strategy for developing immunization regimens against diseases in desperate need of vaccines...
  29. pmc A small peptide (CEL-1000) derived from the beta-chain of the human major histocompatibility complex class II molecule induces complete protection against malaria in an antigen-independent manner
    Yupin Charoenvit
    Cel Sci Corporation, 8229 Boone Blvd, Suite 802, Vienna, VA 22182, USA
    Antimicrob Agents Chemother 48:2455-63. 2004
    ....
  30. ncbi request reprint Vaxfectin enhances immunogenicity and protective efficacy of P. yoelii circumsporozoite DNA vaccines
    Martha Sedegah
    Malaria Program, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910 7500, USA
    Vaccine 24:1921-7. 2006
    ..Clinical trials of pDNA vaccines have often used low pDNA doses based on a per kilogram weight basis. Formulation of pDNA vaccines in Vaxfectin may improve their potency in human clinical trials...
  31. ncbi request reprint Viral vectors for malaria vaccine development
    Shengqiang Li
    PATH Malaria Vaccine Initiative, Bethesda, MD, USA
    Vaccine 25:2567-74. 2007
    ..Understanding the vector's ability to induce an immune response and the expression of malaria antigens in mammalian cells will be critical in designing the next generation of viral-vectored malaria vaccines...
  32. ncbi request reprint Targeting antigen to MHC Class I and Class II antigen presentation pathways for malaria DNA vaccines
    Carlota Dobano
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, United States
    Immunol Lett 111:92-102. 2007
    ..Our data highlight the antigen dependence of immune enhancement strategies that target antigen to the MHC Class I and II pathways for vaccine development...
  33. ncbi request reprint Enhancement of antibody and cellular immune responses to malaria DNA vaccines by in vivo electroporation
    Carlota Dobano
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, United States
    Vaccine 25:6635-45. 2007
    ..Moreover, IFN-gamma responses were increased by approximately 2-fold. Data demonstrate the potential of EP to enhance immune responses to DNA vaccines against infectious agents...
  34. ncbi request reprint Malaria's journey through the lymph node
    Michael F Good
    Nat Med 13:1023-4. 2007
  35. ncbi request reprint Extended immunization intervals enhance the immunogenicity and protective efficacy of plasmid DNA vaccines
    Gary T Brice
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
    Microbes Infect 9:1439-46. 2007
    ..Our studies establish that the dosing interval significantly impacts the immunogenicity and protective efficacy of plasmid DNA vaccines...
  36. pmc Transcriptionally active PCR for antigen identification and vaccine development: in vitro genome-wide screening and in vivo immunogenicity
    David P Regis
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, United States
    Mol Biochem Parasitol 158:32-45. 2008
    ..These data support the potential of a TAP approach for rapid high throughput functional screening and identification of potential candidate vaccine antigens from genomic sequence data...
  37. ncbi request reprint Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites
    Stephen L Hoffman
    Malaria Program, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20850, USA
    J Infect Dis 185:1155-64. 2002
    ....