Research Topics
Genomes and Genes
Species | Jonathan BeesleySummaryAffiliation: Queensland Institute of Medical Research Country: Australia Publications
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Detail Information
Publications
Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancersJonathan Beesley
Division of Genetics and Population Health, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
PLoS ONE 6:e24987. 2011..We demonstrate that the minor alleles at rs2736109, and at an additional TERT promoter SNP, rs2736108, are associated with decreased breast cancer risk, and that the combination of both SNPs substantially reduces TERT promoter activity...- Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"Sharon E Johnatty
Queensland Institute of Medical Research, Brisbane, Australia
PLoS Genet 6:e1001016. 2010..ORper-allele 1.14 (1.04-1.24) p=0.003]. Our study adds to the growing evidence that, like the 8q24 locus, the telomerase reverse transcriptase locus at 5p15.33, is a general cancer susceptibility locus... 
The BARD1 Cys557Ser polymorphism and breast cancer risk: an Australian case-control and family analysisSharon E Johnatty
Cancer and Cell Biology, Queensland Institute of Medical Research, Brisbane, QLD, Australia
Breast Cancer Res Treat 115:145-50. 2009..Segregation analysis of 14 kConFab variant-carrying families containing 157 genotyped individuals provided no evidence of segregation with disease. We conclude that the BARD1 Cys557Ser variant is not associated with breast cancer risk...- Common genetic variation at BARD1 is not associated with breast cancer risk in BRCA1 or BRCA2 mutation carriersAmanda B Spurdle
QueenslanInstitute for Medical Research, Brisbane, Australia
Cancer Epidemiol Biomarkers Prev 20:1032-8. 2011..Inherited BRCA1 and BRCA2 (BRCA1/2) mutations confer elevated breast cancer risk. Knowledge of factors that can improve breast cancer risk assessment in BRCA1/2 mutation carriers may improve personalized cancer prevention strategies... - Polymorphisms in the FGF2 gene and risk of serous ovarian cancer: results from the ovarian cancer association consortiumSharon E Johnatty
Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Twin Res Hum Genet 12:269-75. 2009..Overall genetic variation in FGF2 does not appear to play a role in susceptibility to ovarian cancer... - No evidence that CDKN1B (p27) polymorphisms modify breast cancer risk in BRCA1 and BRCA2 mutation carriersAmanda B Spurdle
Queensland Institute of Medical Research, Brisbane, Australia
Breast Cancer Res Treat 115:307-13. 2009..99-2.18; P = 0.06 for BRCA2). The 95% confidence intervals for per allele risk estimates excluded a twofold risk, indicating that common CDKN1B polymorphisms do not markedly modify breast cancer risk among BRCA1 or BRCA2 carriers... - No evidence that GATA3 rs570613 SNP modifies breast cancer riskSharon E Johnatty
Cancer and Cell Biology, Queensland Institute of Medical Research, c o Royal Brisbane Hospital Post Office, Herston, Brisbane, QLD 4029, Australia
Breast Cancer Res Treat 117:371-9. 2009..93, 95% CI 0.80-1.07). We conclude that there is no evidence that either GATA3 rs570613, or any variant in strong linkage disequilibrium with it, is associated with breast cancer risk in women... - Evidence for SMAD3 as a modifier of breast cancer risk in BRCA2 mutation carriersLogan C Walker
Division of Genetics and Population Health, Queensland Institute of Medical Research, Brisbane, Australia
Breast Cancer Res 12:R102. 2010..In this study, we evaluated 24 SNPs tagged to 14 candidate genes derived through a novel approach that analysed gene expression differences to prioritise candidate modifier genes for association studies... - No evidence for an association between the earwax-associated polymorphism in ABCC11 and breast cancer risk in Caucasian womenJonathan Beesley
Genetics and Population Health Division, Queensland Institute of Medical Research, Herston, 4006, Brisbane, Australia
Breast Cancer Res Treat 126:235-9. 2011..We therefore analysed the frequency of the functional SNP in 1342 cases and 2256 controls from two breast cancer studies of Caucasian women but found no evidence for an association with breast cancer risk... - Association between single-nucleotide polymorphisms in hormone metabolism and DNA repair genes and epithelial ovarian cancer: results from two Australian studies and an additional validation setJonathan Beesley
Queensland Institute of Medical Research, Herston, Queensland, Australia
Cancer Epidemiol Biomarkers Prev 16:2557-65. 2007..Further analyses of SNPs in this gene are therefore warranted to determine whether SRD5A2 plays a role in ovarian cancer predisposition... - Genome-wide association study for ovarian cancer susceptibility using pooled DNAYi Lu
Queensland Institute of Medical Research, Brisbane, Australia
Twin Res Hum Genet 15:615-23. 2012..However, our study lacked power to make clear statements on the existence of hitherto untagged small-effect variants... - ABCB1 (MDR 1) polymorphisms and progression-free survival among women with ovarian cancer following paclitaxel/carboplatin chemotherapySharon E Johnatty
Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Clin Cancer Res 14:5594-601. 2008..Although the functional consequences of ABCB1 polymorphisms have been the subject of numerous studies, few have assessed the association with clinical outcome... 
Progesterone receptor polymorphisms and risk of breast cancer: results from two Australian breast cancer studiesSharon E Johnatty
Cancer and Cell Biology, Queensland Institute of Medical Research, c o Royal Brisbane Hospital Post Office, Herston, Brisbane, QLD, 4029, Australia
Breast Cancer Res Treat 109:91-9. 2008....- HER3 and downstream pathways are involved in colonization of brain metastases from breast cancerLeonard Da Silva
Molecular and Cellular Pathology, The University of Queensland Centre for Clinical Research, and School of Medicine, Building 918 B71, RBWH complex, Brisbane, 4029, Australia
Breast Cancer Res 12:R46. 2010..Metastases to the brain from breast cancer have a high mortality, and basal-like breast cancers have a propensity for brain metastases. However, the mechanisms that allow cells to colonize the brain are unclear...