Jonathan Beesley

Summary

Affiliation: Queensland Institute of Medical Research
Country: Australia

Publications

  1. pmc Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers
    Jonathan Beesley
    Division of Genetics and Population Health, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    PLoS ONE 6:e24987. 2011
  2. pmc Effects of BRCA2 cis-regulation in normal breast and cancer risk amongst BRCA2 mutation carriers
    Ana Teresa Maia
    Cambridge Research Institute CRUK, Li Ka Shing Centre, Cancer Research UK, Robinson Way, Cambridge, CB2 0RE, UK
    Breast Cancer Res 14:R63. 2012
  3. pmc Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"
    Sharon E Johnatty
    Queensland Institute of Medical Research, Brisbane, Australia
    PLoS Genet 6:e1001016. 2010
  4. doi request reprint The BARD1 Cys557Ser polymorphism and breast cancer risk: an Australian case-control and family analysis
    Sharon E Johnatty
    Cancer and Cell Biology, Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Breast Cancer Res Treat 115:145-50. 2009
  5. pmc Common genetic variation at BARD1 is not associated with breast cancer risk in BRCA1 or BRCA2 mutation carriers
    Amanda B Spurdle
    QueenslanInstitute for Medical Research, Brisbane, Australia
    Cancer Epidemiol Biomarkers Prev 20:1032-8. 2011
  6. pmc Polymorphisms in the FGF2 gene and risk of serous ovarian cancer: results from the ovarian cancer association consortium
    Sharon E Johnatty
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Twin Res Hum Genet 12:269-75. 2009
  7. doi request reprint No evidence that CDKN1B (p27) polymorphisms modify breast cancer risk in BRCA1 and BRCA2 mutation carriers
    Amanda B Spurdle
    Queensland Institute of Medical Research, Brisbane, Australia
    Breast Cancer Res Treat 115:307-13. 2009
  8. pmc ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: a comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas
    Sharon E Johnatty
    Queensland Institute of Medical Research, Brisbane, Australia
    Gynecol Oncol 131:8-14. 2013
  9. pmc No evidence that GATA3 rs570613 SNP modifies breast cancer risk
    Sharon E Johnatty
    Cancer and Cell Biology, Queensland Institute of Medical Research, c o Royal Brisbane Hospital Post Office, Herston, Brisbane, QLD 4029, Australia
    Breast Cancer Res Treat 117:371-9. 2009
  10. pmc Genome-wide association study for ovarian cancer susceptibility using pooled DNA
    Yi Lu
    Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 15:615-23. 2012

Detail Information

Publications18

  1. pmc Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers
    Jonathan Beesley
    Division of Genetics and Population Health, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    PLoS ONE 6:e24987. 2011
    ..We demonstrate that the minor alleles at rs2736109, and at an additional TERT promoter SNP, rs2736108, are associated with decreased breast cancer risk, and that the combination of both SNPs substantially reduces TERT promoter activity...
  2. pmc Effects of BRCA2 cis-regulation in normal breast and cancer risk amongst BRCA2 mutation carriers
    Ana Teresa Maia
    Cambridge Research Institute CRUK, Li Ka Shing Centre, Cancer Research UK, Robinson Way, Cambridge, CB2 0RE, UK
    Breast Cancer Res 14:R63. 2012
    ..We have previously reported that BRCA2 shows differential allelic expression and we hypothesize that the known variable penetrance of BRCA2 mutations might be associated with this mechanism...
  3. pmc Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"
    Sharon E Johnatty
    Queensland Institute of Medical Research, Brisbane, Australia
    PLoS Genet 6:e1001016. 2010
    ..ORper-allele 1.14 (1.04-1.24) p=0.003]. Our study adds to the growing evidence that, like the 8q24 locus, the telomerase reverse transcriptase locus at 5p15.33, is a general cancer susceptibility locus...
  4. doi request reprint The BARD1 Cys557Ser polymorphism and breast cancer risk: an Australian case-control and family analysis
    Sharon E Johnatty
    Cancer and Cell Biology, Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Breast Cancer Res Treat 115:145-50. 2009
    ..Segregation analysis of 14 kConFab variant-carrying families containing 157 genotyped individuals provided no evidence of segregation with disease. We conclude that the BARD1 Cys557Ser variant is not associated with breast cancer risk...
  5. pmc Common genetic variation at BARD1 is not associated with breast cancer risk in BRCA1 or BRCA2 mutation carriers
    Amanda B Spurdle
    QueenslanInstitute for Medical Research, Brisbane, Australia
    Cancer Epidemiol Biomarkers Prev 20:1032-8. 2011
    ..Inherited BRCA1 and BRCA2 (BRCA1/2) mutations confer elevated breast cancer risk. Knowledge of factors that can improve breast cancer risk assessment in BRCA1/2 mutation carriers may improve personalized cancer prevention strategies...
  6. pmc Polymorphisms in the FGF2 gene and risk of serous ovarian cancer: results from the ovarian cancer association consortium
    Sharon E Johnatty
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Twin Res Hum Genet 12:269-75. 2009
    ..Overall genetic variation in FGF2 does not appear to play a role in susceptibility to ovarian cancer...
  7. doi request reprint No evidence that CDKN1B (p27) polymorphisms modify breast cancer risk in BRCA1 and BRCA2 mutation carriers
    Amanda B Spurdle
    Queensland Institute of Medical Research, Brisbane, Australia
    Breast Cancer Res Treat 115:307-13. 2009
    ..99-2.18; P = 0.06 for BRCA2). The 95% confidence intervals for per allele risk estimates excluded a twofold risk, indicating that common CDKN1B polymorphisms do not markedly modify breast cancer risk among BRCA1 or BRCA2 carriers...
  8. pmc ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: a comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas
    Sharon E Johnatty
    Queensland Institute of Medical Research, Brisbane, Australia
    Gynecol Oncol 131:8-14. 2013
    ..We comprehensively evaluated this gene and flanking regions for an association with clinical outcome in epithelial ovarian cancer (EOC)...
  9. pmc No evidence that GATA3 rs570613 SNP modifies breast cancer risk
    Sharon E Johnatty
    Cancer and Cell Biology, Queensland Institute of Medical Research, c o Royal Brisbane Hospital Post Office, Herston, Brisbane, QLD 4029, Australia
    Breast Cancer Res Treat 117:371-9. 2009
    ..93, 95% CI 0.80-1.07). We conclude that there is no evidence that either GATA3 rs570613, or any variant in strong linkage disequilibrium with it, is associated with breast cancer risk in women...
  10. pmc Genome-wide association study for ovarian cancer susceptibility using pooled DNA
    Yi Lu
    Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 15:615-23. 2012
    ..However, our study lacked power to make clear statements on the existence of hitherto untagged small-effect variants...
  11. doi request reprint No evidence for an association between the earwax-associated polymorphism in ABCC11 and breast cancer risk in Caucasian women
    Jonathan Beesley
    Genetics and Population Health Division, Queensland Institute of Medical Research, Herston, 4006, Brisbane, Australia
    Breast Cancer Res Treat 126:235-9. 2011
    ..We therefore analysed the frequency of the functional SNP in 1342 cases and 2256 controls from two breast cancer studies of Caucasian women but found no evidence for an association with breast cancer risk...
  12. pmc Evidence for SMAD3 as a modifier of breast cancer risk in BRCA2 mutation carriers
    Logan C Walker
    Division of Genetics and Population Health, Queensland Institute of Medical Research, Brisbane, Australia
    Breast Cancer Res 12:R102. 2010
    ..In this study, we evaluated 24 SNPs tagged to 14 candidate genes derived through a novel approach that analysed gene expression differences to prioritise candidate modifier genes for association studies...
  13. pmc Association between single-nucleotide polymorphisms in hormone metabolism and DNA repair genes and epithelial ovarian cancer: results from two Australian studies and an additional validation set
    Jonathan Beesley
    Queensland Institute of Medical Research, Herston, Queensland, Australia
    Cancer Epidemiol Biomarkers Prev 16:2557-65. 2007
    ..Further analyses of SNPs in this gene are therefore warranted to determine whether SRD5A2 plays a role in ovarian cancer predisposition...
  14. pmc Beyond GWASs: illuminating the dark road from association to function
    Stacey L Edwards
    Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia Electronic address
    Am J Hum Genet 93:779-97. 2013
    ..These approaches have already accelerated progress from genetic studies to biological knowledge and might ultimately guide the development of prognostic, preventive, and therapeutic measures. ..
  15. doi request reprint ABCB1 (MDR 1) polymorphisms and progression-free survival among women with ovarian cancer following paclitaxel/carboplatin chemotherapy
    Sharon E Johnatty
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Clin Cancer Res 14:5594-601. 2008
    ..Although the functional consequences of ABCB1 polymorphisms have been the subject of numerous studies, few have assessed the association with clinical outcome...
  16. ncbi request reprint Progesterone receptor polymorphisms and risk of breast cancer: results from two Australian breast cancer studies
    Sharon E Johnatty
    Cancer and Cell Biology, Queensland Institute of Medical Research, c o Royal Brisbane Hospital Post Office, Herston, Brisbane, QLD, 4029, Australia
    Breast Cancer Res Treat 109:91-9. 2008
    ....
  17. pmc Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers
    Juliet D French
    School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia
    Am J Hum Genet 92:489-503. 2013
    ..Chromatin conformation studies demonstrate that these enhancer and silencer elements interact with each other and with their likely target gene, CCND1...
  18. pmc HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer
    Leonard Da Silva
    Molecular and Cellular Pathology, The University of Queensland Centre for Clinical Research, and School of Medicine, Building 918 B71, RBWH complex, Brisbane, 4029, Australia
    Breast Cancer Res 12:R46. 2010
    ..Metastases to the brain from breast cancer have a high mortality, and basal-like breast cancers have a propensity for brain metastases. However, the mechanisms that allow cells to colonize the brain are unclear...