Gregory Jon Anderson

Summary

Affiliation: Queensland Institute of Medical Research
Country: Australia

Publications

  1. doi request reprint Essential but toxic: controlling the flux of iron in the body
    Gregory J Anderson
    Iron Metabolism Laboratory, Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Clin Exp Pharmacol Physiol 39:719-24. 2012
  2. pmc A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development
    Alyson Ashe
    Epigenetics Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Herston, Queensland 4006, Australia
    Genome Biol 9:R182. 2008
  3. pmc SNP selection for genes of iron metabolism in a study of genetic modifiers of hemochromatosis
    Clare C Constantine
    The Centre for Molecular, Environmental, Genetic and Analytic MEGA Epidemiology, School of Population Health, The University of Melbourne, Melbourne, Australia
    BMC Med Genet 9:18. 2008
  4. ncbi request reprint Hepatic iron metabolism
    Gregory J Anderson
    Iron Metabolism Laboratory, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Australia
    Semin Liver Dis 25:420-32. 2005
  5. ncbi request reprint Regulation of systemic iron homeostasis: how the body responds to changes in iron demand
    Gregory J Anderson
    Iron Metabolism Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Biometals 20:665-74. 2007
  6. ncbi request reprint Recent advances in intestinal iron transport
    Gregory J Anderson
    Iron Metabolism Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Curr Gastroenterol Rep 7:365-72. 2005
  7. doi request reprint Iron absorption and metabolism
    Gregory J Anderson
    Iron Metabolism Laboratory, Queensland Institute of Medical Research, University of Queensland, Brisbane, Queensland, Australia
    Curr Opin Gastroenterol 25:129-35. 2009
  8. doi request reprint Mammalian iron transport
    Gregory Jon Anderson
    Iron Metabolism Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, QLD, Australia
    Cell Mol Life Sci 66:3241-61. 2009
  9. doi request reprint Serum hyaluronic acid with serum ferritin accurately predicts cirrhosis and reduces the need for liver biopsy in C282Y hemochromatosis
    Darrell H G Crawford
    School of Medicine, The University of Queensland, Greenslopes Private Hospital, Brisbane, Australia
    Hepatology 49:418-25. 2009
  10. ncbi request reprint Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis
    Kim R Bridle
    Hepatic Fibrosis Group, Queensland Institute of Medical Research, Royal Brisbane Hospital, Queensland, Herston, Australia
    Lancet 361:669-73. 2003

Collaborators

Detail Information

Publications43

  1. doi request reprint Essential but toxic: controlling the flux of iron in the body
    Gregory J Anderson
    Iron Metabolism Laboratory, Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Clin Exp Pharmacol Physiol 39:719-24. 2012
    ..At the cellular level, ferroportin 1 can also be regulated independently of hepcidin by hypoxia-inducible factors and the iron regulatory proteins. The hepcidin-ferroportin axis plays a critical role in regulating body iron homeostasis...
  2. pmc A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development
    Alyson Ashe
    Epigenetics Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Herston, Queensland 4006, Australia
    Genome Biol 9:R182. 2008
    ..The identification of Dnmt1 and Smarca5 attest to the effectiveness of the screen design...
  3. pmc SNP selection for genes of iron metabolism in a study of genetic modifiers of hemochromatosis
    Clare C Constantine
    The Centre for Molecular, Environmental, Genetic and Analytic MEGA Epidemiology, School of Population Health, The University of Melbourne, Melbourne, Australia
    BMC Med Genet 9:18. 2008
    ..We report our experience of selecting tag SNPs in 35 genes involved in iron metabolism in a cohort study seeking to discover genetic modifiers of hereditary hemochromatosis...
  4. ncbi request reprint Hepatic iron metabolism
    Gregory J Anderson
    Iron Metabolism Laboratory, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Australia
    Semin Liver Dis 25:420-32. 2005
    ..The liver can divest itself of iron through the plasma membrane iron exporter ferroportin 1, a process that also requires ceruloplasmin. Hepcidin can regulate this iron release through its interaction with ferroportin...
  5. ncbi request reprint Regulation of systemic iron homeostasis: how the body responds to changes in iron demand
    Gregory J Anderson
    Iron Metabolism Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Biometals 20:665-74. 2007
    ..The continuing analysis of inherited disorders of iron metabolism combined with biochemical analysis of signal transduction pathways is essential to fully define this important regulatory system...
  6. ncbi request reprint Recent advances in intestinal iron transport
    Gregory J Anderson
    Iron Metabolism Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Curr Gastroenterol Rep 7:365-72. 2005
    ..Future studies investigating how these molecules interact will provide a comprehensive understanding of this essential physiologic process...
  7. doi request reprint Iron absorption and metabolism
    Gregory J Anderson
    Iron Metabolism Laboratory, Queensland Institute of Medical Research, University of Queensland, Brisbane, Queensland, Australia
    Curr Opin Gastroenterol 25:129-35. 2009
    ..Intestinal iron absorption is an essential physiological process that is regulated by the liver-derived peptide hepcidin. This review will describe recent advances in hepcidin biology and enterocyte iron transport...
  8. doi request reprint Mammalian iron transport
    Gregory Jon Anderson
    Iron Metabolism Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, QLD, Australia
    Cell Mol Life Sci 66:3241-61. 2009
    ..At the systemic level, iron transport is regulated by the liver-derived peptide hepcidin which acts on ferroportin to control iron release to the plasma...
  9. doi request reprint Serum hyaluronic acid with serum ferritin accurately predicts cirrhosis and reduces the need for liver biopsy in C282Y hemochromatosis
    Darrell H G Crawford
    School of Medicine, The University of Queensland, Greenslopes Private Hospital, Brisbane, Australia
    Hepatology 49:418-25. 2009
    ..78; P = 0.01). Conclusion: In HH, the measurement of hyaluronic acid in patients with serum ferritin >1,000 microg/L is a noninvasive, accurate, and cost-effective method for the diagnosis of cirrhosis. (HEPATOLOGY 2009;49:418-425.)...
  10. ncbi request reprint Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis
    Kim R Bridle
    Hepatic Fibrosis Group, Queensland Institute of Medical Research, Royal Brisbane Hospital, Queensland, Herston, Australia
    Lancet 361:669-73. 2003
    ..To investigate this possible association, we studied the hepatic expression of the gene for hepcidin (HAMP) and a gene important in iron transport (IREG1) in patients with haemochromatosis, in normal controls, and in Hfe-knockout mice...
  11. ncbi request reprint Elevated iron absorption in the neonatal rat reflects high expression of iron transport genes in the distal alimentary tract
    David M Frazer
    Iron Metabolism Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029 Australia
    Am J Physiol Gastrointest Liver Physiol 293:G525-31. 2007
    ....
  12. ncbi request reprint The orchestration of body iron intake: how and where do enterocytes receive their cues?
    David M Frazer
    Joint Clinical Sciences Program, Queensland Institute of Medical Research and University of Queensland, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Blood Cells Mol Dis 30:288-97. 2003
    ..This model can explain the regulation of iron absorption under normal conditions and also the inappropriate absorption seen in pathological states such as hemochromatosis and thalassemia...
  13. ncbi request reprint The clinical relevance of compound heterozygosity for the C282Y and H63D substitutions in hemochromatosis
    Alissa Walsh
    The Department of Gastroenterology and Hepatology, Royal Brisbane and Women s Hospital, Brisbane, Australia
    Clin Gastroenterol Hepatol 4:1403-10. 2006
    ..This study assessed the phenotypic expression in C282Y/H63D subjects as compared with C282Y homozygotes...
  14. doi request reprint Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload
    Daniel F Wallace
    Membrane Transport Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Hepatology 50:1992-2000. 2009
    ....
  15. ncbi request reprint Increased hepcidin expression and hypoferraemia associated with an acute phase response are not affected by inactivation of HFE
    David M Frazer
    Iron Metabolism Laboratory, The Queensland Institute of Medical Research and The University of Queensland, PO Royal Brisbane Hospital, Brisbane, Queensland, Australia
    Br J Haematol 126:434-6. 2004
    ..Hypoferraemia also occurred in all strains, indicating that both the upregulation of hepcidin and the decrease in transferrin saturation associated with an acute phase response is not dependent on HFE function...
  16. doi request reprint Interacting signals in the control of hepcidin expression
    Deepak Darshan
    Iron Metabolism Laboratory, Queensland Institute of Medical Research and the University of Queensland, PO Royal Brisbane Hospital, Brisbane, QLD, Australia
    Biometals 22:77-87. 2009
    ..The BMP-SMAD pathway appears to be particularly important and disruption of this pathway will abrogate the response of hepcidin to many stimuli...
  17. ncbi request reprint Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats
    David M Frazer
    Joint Clinical Sciences Program, The Queensland Institute of Medical Research and The University of Queensland, Royal Brisbane Hospital, Brisbane, Queensland, Australia
    Gastroenterology 123:835-44. 2002
    ..To further investigate its role in this process, we examined hepatic and duodenal gene expression in rats after the switch from a control diet to an iron-deficient diet...
  18. ncbi request reprint Iron imports. I. Intestinal iron absorption and its regulation
    David M Frazer
    Iron Metabolism Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Am J Physiol Gastrointest Liver Physiol 289:G631-5. 2005
    ..Research now focuses on the role of the liver as the primary regulator of iron absorption, and this review considers some of the recent highlights and controversies in this area...
  19. ncbi request reprint HFE and non-HFE hemochromatosis
    Gregory J Anderson
    The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Australia
    Int J Hematol 76:203-7. 2002
    ..Recently, other forms of HH have been described that are not related to HFE but are due to mutations in genes coding iron transport proteins...
  20. ncbi request reprint The ceruloplasmin homolog hephaestin and the control of intestinal iron absorption
    Gregory J Anderson
    Iron Metabolism Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Blood Cells Mol Dis 29:367-75. 2002
    ....
  21. doi request reprint Hepcidin regulation in wild-type and Hfe knockout mice in response to alcohol consumption: evidence for an alcohol-induced hypoxic response
    Mandy L Heritage
    School of Medicine and Gallipoli Research Foundation University of Queensland, Brisbane, Australia
    Alcohol Clin Exp Res 33:1391-400. 2009
    ..Since chronic alcohol consumption is also associated with disturbances in iron metabolism, we investigated the effects of alcohol consumption on hepcidin mRNA expression in Hfe(-/-) mice...
  22. ncbi request reprint The expression and regulation of the iron transport molecules hephaestin and IREG1: implications for the control of iron export from the small intestine
    Gregory J Anderson
    Iron Metabolism Laboratory, The Queensland Institute of Medical Research, Australia
    Cell Biochem Biophys 36:137-46. 2002
    ..This, in turn, modulates the intracellular iron content of mature epithelial cells, which ultimately determines the activity of the brush-border transporter DMT1...
  23. ncbi request reprint Mechanisms of haem and non-haem iron absorption: lessons from inherited disorders of iron metabolism
    Gregory J Anderson
    Iron Metabolism Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Australia
    Biometals 18:339-48. 2005
    ....
  24. ncbi request reprint Screening for hemochromatosis in asymptomatic subjects with or without a family history
    Lawrie W Powell
    Centre for the Advancement of Clinical Research, Royal Brisbane and Women s Hospital, Brisbane, Queensland 4029, Australia
    Arch Intern Med 166:294-301. 2006
    ..This study compared screening for hemochromatosis in subjects with or without a family history...
  25. ncbi request reprint Mechanisms of iron loading and toxicity
    Gregory J Anderson
    Iron Metabolism Laboratory, Queensland Institute of Medical Research, Brisbane Queensland, Australia Greg Anderson qimr edu au
    Am J Hematol 82:1128-31. 2007
    ..The clinical consequences as well as the differences between primary and secondary iron loading are also reviewed, and some future research priorities are discussed...
  26. pmc Iron metabolism in the hemoglobin-deficit mouse: correlation of diferric transferrin with hepcidin expression
    Sarah J Wilkins
    Iron Metabolism Laboratory, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Blood 107:1659-64. 2006
    ..These data strengthen the proposal that diferric transferrin is a key indicator of body iron requirements...
  27. ncbi request reprint Liver-gut axis in the regulation of iron homeostasis
    Deepak Darshan
    Iron Metabolism Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane Queensland 4029, Australia
    World J Gastroenterol 13:4737-45. 2007
    ..This review will summarize recent findings on the role played by the liver and hepcidin in the regulation of body iron absorption...
  28. ncbi request reprint Increased duodenal expression of divalent metal transporter 1 and iron-regulated gene 1 in cirrhosis
    Katherine Anne Stuart
    Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Australia
    Hepatology 39:492-9. 2004
    ..The mechanism by which cirrhosis mediates this change in DMT1 expression has yet to be determined. Increased expression of DMT1 may play an important role in the pathogenesis of cirrhosis-associated hepatic iron overload...
  29. ncbi request reprint A novel mutation in ferroportin implicated in iron overload
    Daniel F Wallace
    Membrane Transport Laboratory, The Queensland Institute of Medical Research, Brisbane, QLD, Australia
    J Hepatol 46:921-6. 2007
    ..In this study we examined the molecular basis of iron overload in an individual from New Zealand and characterised the molecular and cellular defect...
  30. ncbi request reprint Systemic regulation of intestinal iron absorption
    Teresa M Steele
    Iron Metabolism Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    IUBMB Life 57:499-503. 2005
    ..The mechanisms underlying the regulation of hepcidin expression and how it acts on cells to control iron release are key areas of ongoing research...
  31. ncbi request reprint DHPLC mutation analysis of Jagged1 (JAG1) reveals six novel mutations in Australian alagille syndrome patients
    Mandy L Heritage
    Joint Clinical Sciences Program, The Queensland Institute of Medical Research and The University of Queensland, Brisbane, Queensland, Australia
    Hum Mutat 20:481. 2002
    ..The results of this study are consistent with the proposal that either haploinsufficiency for wild-type JAG1 and/or dominant negative effects produced by mutated JAG1 are responsible for the AGS phenotype...
  32. doi request reprint Molecular basis of iron-loading disorders
    Deepak Darshan
    Iron Metabolism Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Expert Rev Mol Med 12:e36. 2010
    ..Recent advances in our understanding of hepcidin and body iron homeostasis provide the potential for a range of new diagnostic and therapeutic tools for haemochromatosis and related conditions...
  33. ncbi request reprint Identification of an intestinal heme transporter
    Majid Shayeghi
    Department of Life Sciences, Nutritional Sciences Research Division, Franklin Wilkins Building, Kings College London, 150 Stamford Street, London SE1 9NN, UK
    Cell 122:789-801. 2005
    ..HCP 1 protein was iron regulated and localized to the brush-border membrane of duodenal enterocytes in iron deficiency. Our data indicate that HCP 1 is the long-sought intestinal heme transporter...
  34. pmc Circulating gastrin is increased in hemochromatosis
    Kelly A Smith
    University of Melbourne Department of Surgery, Austin Health, Level 8, Lance Townsend Building, Studley Road, Heidelberg, VIC 3084, Australia
    FEBS Lett 580:6195-8. 2006
    ..The discovery of a relationship between iron status and circulating gastrin concentrations opens a new perspective on the mechanisms of iron homeostasis...
  35. pmc The role of duodenal cytochrome b in intestinal iron absorption remains unclear
    David M Frazer
    Blood 106:4413; author reply 4414. 2005
  36. ncbi request reprint Systemic regulation of Hephaestin and Ireg1 revealed in studies of genetic and nutritional iron deficiency
    Huijun Chen
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA
    Blood 102:1893-9. 2003
    ..Thus, the basolateral transport step appears to be the primary site at which the small intestine responds to alterations in body iron requirements...
  37. ncbi request reprint Hephaestin is a ferroxidase that maintains partial activity in sex-linked anemia mice
    Huijun Chen
    Department of Nutrition and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA
    Blood 103:3933-9. 2004
    ..We suggest that hephaestin, by way of its ferroxidase activity, facilitates iron export from intestinal enterocytes, most likely in cooperation with the basolateral iron transporter, Ireg1...
  38. ncbi request reprint Hemojuvelin (HJV)-associated hemochromatosis: analysis of HJV and HFE mutations and iron overload in three families
    Daniel F Wallace
    Haematologica 90:254-5. 2005
    ..In this study we identified the molecular basis of juvenile hemochromatosis in three Australian families and assessed the role of potential modifying genes in individuals carrying HFE mutations...
  39. doi request reprint Overexpression of cellular iron import proteins is associated with malignant progression of esophageal adenocarcinoma
    Jessica Boult
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, UK
    Clin Cancer Res 14:379-87. 2008
    ..In this study, we investigated the expression of iron transport proteins involved in cellular iron import, export, and storage in the premalignant lesion Barrett's metaplasia and esophageal adenocarcinoma...
  40. doi request reprint Iron-overload-related disease in HFE hereditary hemochromatosis
    Katrina J Allen
    Murdoch Children s Research Institute, University of Melbourne, Melbourne, Australia
    N Engl J Med 358:221-30. 2008
    ..Diseases related to iron overload develop in some C282Y homozygotes, but the extent of the risk is controversial...
  41. ncbi request reprint Iron metabolism meets signal transduction
    Gregory J Anderson
    Nat Genet 38:503-4. 2006
  42. pmc Cystic fibrosis: ironing out the problem of infection?
    David W Reid
    Am J Physiol Lung Cell Mol Physiol 295:L23-4. 2008
  43. ncbi request reprint Decreased hephaestin activity in the intestine of copper-deficient mice causes systemic iron deficiency
    Huijun Chen
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720 3104, USA
    J Nutr 136:1236-41. 2006
    ..Both in vivo and in vitro studies indicate that copper is required for the proper processing and/or stability of hephaestin...