Research Topics
| Gregory Jon AndersonSummaryAffiliation: Queensland Institute of Medical Research Country: Australia Publications
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Detail Information
Publications
Essential but toxic: controlling the flux of iron in the bodyGregory J Anderson
Iron Metabolism Laboratory, Queensland Institute of Medical Research, Brisbane, QLD, Australia
Clin Exp Pharmacol Physiol 39:719-24. 2012..At the cellular level, ferroportin 1 can also be regulated independently of hepcidin by hypoxia-inducible factors and the iron regulatory proteins. The hepcidin-ferroportin axis plays a critical role in regulating body iron homeostasis...
A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in developmentAlyson Ashe
Epigenetics Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Herston, Queensland 4006, Australia
Genome Biol 9:R182. 2008..The identification of Dnmt1 and Smarca5 attest to the effectiveness of the screen design...- SNP selection for genes of iron metabolism in a study of genetic modifiers of hemochromatosisClare C Constantine
The Centre for Molecular, Environmental, Genetic and Analytic MEGA Epidemiology, School of Population Health, The University of Melbourne, Melbourne, Australia
BMC Med Genet 9:18. 2008..We report our experience of selecting tag SNPs in 35 genes involved in iron metabolism in a cohort study seeking to discover genetic modifiers of hereditary hemochromatosis... 
Hepatic iron metabolismGregory J Anderson
Iron Metabolism Laboratory, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Australia
Semin Liver Dis 25:420-32. 2005..The liver can divest itself of iron through the plasma membrane iron exporter ferroportin 1, a process that also requires ceruloplasmin. Hepcidin can regulate this iron release through its interaction with ferroportin...- Regulation of systemic iron homeostasis: how the body responds to changes in iron demandGregory J Anderson
Iron Metabolism Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
Biometals 20:665-74. 2007..The continuing analysis of inherited disorders of iron metabolism combined with biochemical analysis of signal transduction pathways is essential to fully define this important regulatory system... - Recent advances in intestinal iron transportGregory J Anderson
Iron Metabolism Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
Curr Gastroenterol Rep 7:365-72. 2005..Future studies investigating how these molecules interact will provide a comprehensive understanding of this essential physiologic process... - Iron absorption and metabolismGregory J Anderson
Iron Metabolism Laboratory, Queensland Institute of Medical Research, University of Queensland, Brisbane, Queensland, Australia
Curr Opin Gastroenterol 25:129-35. 2009..Intestinal iron absorption is an essential physiological process that is regulated by the liver-derived peptide hepcidin. This review will describe recent advances in hepcidin biology and enterocyte iron transport... - Mammalian iron transportGregory Jon Anderson
Iron Metabolism Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, QLD, Australia
Cell Mol Life Sci 66:3241-61. 2009..At the systemic level, iron transport is regulated by the liver-derived peptide hepcidin which acts on ferroportin to control iron release to the plasma... - Serum hyaluronic acid with serum ferritin accurately predicts cirrhosis and reduces the need for liver biopsy in C282Y hemochromatosisDarrell H G Crawford
School of Medicine, The University of Queensland, Greenslopes Private Hospital, Brisbane, Australia
Hepatology 49:418-25. 2009..78; P = 0.01). Conclusion: In HH, the measurement of hyaluronic acid in patients with serum ferritin >1,000 microg/L is a noninvasive, accurate, and cost-effective method for the diagnosis of cirrhosis. (HEPATOLOGY 2009;49:418-425.)... - Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasisKim R Bridle
Hepatic Fibrosis Group, Queensland Institute of Medical Research, Royal Brisbane Hospital, Queensland, Herston, Australia
Lancet 361:669-73. 2003..Furthermore, the increase in hepatic IREG1 expression in haemochromatosis suggests that IREG1 could function to facilitate the removal of excess iron from the liver... - Elevated iron absorption in the neonatal rat reflects high expression of iron transport genes in the distal alimentary tractDavid M Frazer
Iron Metabolism Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029 Australia
Am J Physiol Gastrointest Liver Physiol 293:G525-31. 2007.... - The orchestration of body iron intake: how and where do enterocytes receive their cues?David M Frazer
Joint Clinical Sciences Program, Queensland Institute of Medical Research and University of Queensland, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
Blood Cells Mol Dis 30:288-97. 2003..This model can explain the regulation of iron absorption under normal conditions and also the inappropriate absorption seen in pathological states such as hemochromatosis and thalassemia... - The clinical relevance of compound heterozygosity for the C282Y and H63D substitutions in hemochromatosisAlissa Walsh
The Department of Gastroenterology and Hepatology, Royal Brisbane and Women s Hospital, Brisbane, Australia
Clin Gastroenterol Hepatol 4:1403-10. 2006..This study assessed the phenotypic expression in C282Y/H63D subjects as compared with C282Y homozygotes... - Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overloadDaniel F Wallace
Membrane Transport Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Hepatology 50:1992-2000. 2009..Analysis of Hfe/Tfr2 double-null mice suggests that Hfe and Tfr2 regulate hepcidin through parallel pathways involving Erk1/2 and Smad1/5/8... - Increased hepcidin expression and hypoferraemia associated with an acute phase response are not affected by inactivation of HFEDavid M Frazer
Iron Metabolism Laboratory, The Queensland Institute of Medical Research and The University of Queensland, PO Royal Brisbane Hospital, Brisbane, Queensland, Australia
Br J Haematol 126:434-6. 2004..Hypoferraemia also occurred in all strains, indicating that both the upregulation of hepcidin and the decrease in transferrin saturation associated with an acute phase response is not dependent on HFE function... - Interacting signals in the control of hepcidin expressionDeepak Darshan
Iron Metabolism Laboratory, Queensland Institute of Medical Research and the University of Queensland, PO Royal Brisbane Hospital, Brisbane, QLD, Australia
Biometals 22:77-87. 2009..The BMP-SMAD pathway appears to be particularly important and disruption of this pathway will abrogate the response of hepcidin to many stimuli... - Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in ratsDavid M Frazer
Joint Clinical Sciences Program, The Queensland Institute of Medical Research and The University of Queensland, Royal Brisbane Hospital, Brisbane, Queensland, Australia
Gastroenterology 123:835-44. 2002..Both hepcidin expression and iron absorption can be regulated before iron stores and erythropoiesis are affected, and transferrin saturation may signal such changes... - Iron imports. I. Intestinal iron absorption and its regulationDavid M Frazer
Iron Metabolism Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
Am J Physiol Gastrointest Liver Physiol 289:G631-5. 2005..Research now focuses on the role of the liver as the primary regulator of iron absorption, and this review considers some of the recent highlights and controversies in this area... - HFE and non-HFE hemochromatosisGregory J Anderson
The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Australia
Int J Hematol 76:203-7. 2002..Recently, other forms of HH have been described that are not related to HFE but are due to mutations in genes coding iron transport proteins... - The ceruloplasmin homolog hephaestin and the control of intestinal iron absorptionGregory J Anderson
Iron Metabolism Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
Blood Cells Mol Dis 29:367-75. 2002.... - Hepcidin regulation in wild-type and Hfe knockout mice in response to alcohol consumption: evidence for an alcohol-induced hypoxic responseMandy L Heritage
School of Medicine and Gallipoli Research Foundation University of Queensland, Brisbane, Australia
Alcohol Clin Exp Res 33:1391-400. 2009..Since chronic alcohol consumption is also associated with disturbances in iron metabolism, we investigated the effects of alcohol consumption on hepcidin mRNA expression in Hfe(-/-) mice... - The expression and regulation of the iron transport molecules hephaestin and IREG1: implications for the control of iron export from the small intestineGregory J Anderson
Iron Metabolism Laboratory, The Queensland Institute of Medical Research, Australia
Cell Biochem Biophys 36:137-46. 2002..This, in turn, modulates the intracellular iron content of mature epithelial cells, which ultimately determines the activity of the brush-border transporter DMT1... - Mechanisms of haem and non-haem iron absorption: lessons from inherited disorders of iron metabolismGregory J Anderson
Iron Metabolism Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Australia
Biometals 18:339-48. 2005.... - Screening for hemochromatosis in asymptomatic subjects with or without a family historyLawrie W Powell
Centre for the Advancement of Clinical Research, Royal Brisbane and Women s Hospital, Brisbane, Queensland 4029, Australia
Arch Intern Med 166:294-301. 2006..This study compared screening for hemochromatosis in subjects with or without a family history... - Mechanisms of iron loading and toxicityGregory J Anderson
Iron Metabolism Laboratory, Queensland Institute of Medical Research, Brisbane Queensland, Australia Greg Anderson qimr edu au
Am J Hematol 82:1128-31. 2007..The clinical consequences as well as the differences between primary and secondary iron loading are also reviewed, and some future research priorities are discussed... - Iron metabolism in the hemoglobin-deficit mouse: correlation of diferric transferrin with hepcidin expressionSarah J Wilkins
Iron Metabolism Laboratory, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
Blood 107:1659-64. 2006..These data strengthen the proposal that diferric transferrin is a key indicator of body iron requirements... - Liver-gut axis in the regulation of iron homeostasisDeepak Darshan
Iron Metabolism Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane Queensland 4029, Australia
World J Gastroenterol 13:4737-45. 2007..This review will summarize recent findings on the role played by the liver and hepcidin in the regulation of body iron absorption... - Increased duodenal expression of divalent metal transporter 1 and iron-regulated gene 1 in cirrhosisKatherine Anne Stuart
Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Australia
Hepatology 39:492-9. 2004..The mechanism by which cirrhosis mediates this change in DMT1 expression has yet to be determined. Increased expression of DMT1 may play an important role in the pathogenesis of cirrhosis-associated hepatic iron overload... - A novel mutation in ferroportin implicated in iron overloadDaniel F Wallace
Membrane Transport Laboratory, The Queensland Institute of Medical Research, Brisbane, QLD, Australia
J Hepatol 46:921-6. 2007..In this study we examined the molecular basis of iron overload in an individual from New Zealand and characterised the molecular and cellular defect... - Systemic regulation of intestinal iron absorptionTeresa M Steele
Iron Metabolism Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
IUBMB Life 57:499-503. 2005..The mechanisms underlying the regulation of hepcidin expression and how it acts on cells to control iron release are key areas of ongoing research... - DHPLC mutation analysis of Jagged1 (JAG1) reveals six novel mutations in Australian alagille syndrome patientsMandy L Heritage
Joint Clinical Sciences Program, The Queensland Institute of Medical Research and The University of Queensland, Brisbane, Queensland, Australia
Hum Mutat 20:481. 2002..The results of this study are consistent with the proposal that either haploinsufficiency for wild-type JAG1 and/or dominant negative effects produced by mutated JAG1 are responsible for the AGS phenotype... - Molecular basis of iron-loading disordersDeepak Darshan
Iron Metabolism Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Expert Rev Mol Med 12:e36. 2010..Recent advances in our understanding of hepcidin and body iron homeostasis provide the potential for a range of new diagnostic and therapeutic tools for haemochromatosis and related conditions... - Identification of an intestinal heme transporterMajid Shayeghi
Department of Life Sciences, Nutritional Sciences Research Division, Franklin Wilkins Building, Kings College London, 150 Stamford Street, London SE1 9NN, UK
Cell 122:789-801. 2005..HCP 1 protein was iron regulated and localized to the brush-border membrane of duodenal enterocytes in iron deficiency. Our data indicate that HCP 1 is the long-sought intestinal heme transporter... - Circulating gastrin is increased in hemochromatosisKelly A Smith
University of Melbourne Department of Surgery, Austin Health, Level 8, Lance Townsend Building, Studley Road, Heidelberg, VIC 3084, Australia
FEBS Lett 580:6195-8. 2006..The discovery of a relationship between iron status and circulating gastrin concentrations opens a new perspective on the mechanisms of iron homeostasis... - The role of duodenal cytochrome b in intestinal iron absorption remains unclearDavid M Frazer
Blood 106:4413; author reply 4414. 2005 - Systemic regulation of Hephaestin and Ireg1 revealed in studies of genetic and nutritional iron deficiencyHuijun Chen
Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA
Blood 102:1893-9. 2003..Thus, the basolateral transport step appears to be the primary site at which the small intestine responds to alterations in body iron requirements... - Hephaestin is a ferroxidase that maintains partial activity in sex-linked anemia miceHuijun Chen
Department of Nutrition and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA
Blood 103:3933-9. 2004..We suggest that hephaestin, by way of its ferroxidase activity, facilitates iron export from intestinal enterocytes, most likely in cooperation with the basolateral iron transporter, Ireg1... - Hemojuvelin (HJV)-associated hemochromatosis: analysis of HJV and HFE mutations and iron overload in three familiesDaniel F Wallace
Haematologica 90:254-5. 2005..In this study we identified the molecular basis of juvenile hemochromatosis in three Australian families and assessed the role of potential modifying genes in individuals carrying HFE mutations... - Overexpression of cellular iron import proteins is associated with malignant progression of esophageal adenocarcinomaJessica Boult
Cancer Research UK Institute for Cancer Studies, University of Birmingham, UK
Clin Cancer Res 14:379-87. 2008..In this study, we investigated the expression of iron transport proteins involved in cellular iron import, export, and storage in the premalignant lesion Barrett's metaplasia and esophageal adenocarcinoma... - Iron-overload-related disease in HFE hereditary hemochromatosisKatrina J Allen
Murdoch Children s Research Institute, University of Melbourne, Melbourne, Australia
N Engl J Med 358:221-30. 2008..Diseases related to iron overload develop in some C282Y homozygotes, but the extent of the risk is controversial... - Iron metabolism meets signal transductionGregory J Anderson
Nat Genet 38:503-4. 2006 - Cystic fibrosis: ironing out the problem of infection?David W Reid
Am J Physiol Lung Cell Mol Physiol 295:L23-4. 2008 - Decreased hephaestin activity in the intestine of copper-deficient mice causes systemic iron deficiencyHuijun Chen
Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720 3104, USA
J Nutr 136:1236-41. 2006..Both in vivo and in vitro studies indicate that copper is required for the proper processing and/or stability of hephaestin...