Morag J Young

Summary

Affiliation: Prince Henry's Institute of Medical Research
Country: Australia

Publications

  1. doi request reprint Mineralocorticoid receptors in the heart: lessons from cell-selective transgenic animals
    Morag J Young
    Cardiovascular EndocrinologyMIMR PHI Institute, 27 31 Wright St, Clayton 3168, AustraliaDepartment of PhysiologyMonash University, Clayton 3168, Australia Cardiovascular EndocrinologyMIMR PHI Institute, 27 31 Wright St, Clayton 3168, AustraliaDepartment of PhysiologyMonash University, Clayton 3168, Australia
    J Endocrinol 224:R1-13. 2015
  2. doi request reprint Endothelial cell mineralocorticoid receptors regulate deoxycorticosterone/salt-mediated cardiac remodeling and vascular reactivity but not blood pressure
    Amanda J Rickard
    Prince Henry s Institute of Medical Research, P O Box 5152, Clayton 3168, Australia
    Hypertension 63:1033-40. 2014
  3. doi request reprint Targeting the mineralocorticoid receptor in cardiovascular disease
    Morag J Young
    Monash University, Prince Henry s Institute of Medical Research, Cardiovascular Endocrinology Laboratory and Department of Physiology, Clayton, Australia
    Expert Opin Ther Targets 17:321-31. 2013
  4. doi request reprint Mechanisms of mineralocorticoid salt-induced hypertension and cardiac fibrosis
    Morag J Young
    Prince Henry s Institute of Medical Research, Department of Physiology, Monash University, Clayton, VIC 3168, Australia
    Mol Cell Endocrinol 350:248-55. 2012
  5. doi request reprint Activation of mineralocorticoid receptors by exogenous glucocorticoids and the development of cardiovascular inflammatory responses in adrenalectomized rats
    Morag J Young
    P O Box 5152, Clayton 3168, Victoria, Australia
    Endocrinology 151:2622-8. 2010
  6. doi request reprint Mechanisms of mineralocorticoid receptor-mediated cardiac fibrosis and vascular inflammation
    Morag J Young
    Prince Henry s Institute of Medical Research, Clayton, Australia
    Curr Opin Nephrol Hypertens 17:174-80. 2008
  7. ncbi request reprint Mineralocorticoid receptor activation and cardiac fibrosis
    Morag J Young
    Prince Henry s Institute of Medical Research, PO Box 5152, Clayton, Melbourne, Victoria 3167, Australia
    Clin Sci (Lond) 112:467-75. 2007
  8. ncbi request reprint Does glucocorticoid receptor blockade exacerbate tissue damage after mineralocorticoid/salt administration?
    Amanda J Rickard
    Prince Henry s Institute of Medical Research, Clayton 3168, Australia
    Endocrinology 148:4829-35. 2007
  9. doi request reprint Deletion of mineralocorticoid receptors from macrophages protects against deoxycorticosterone/salt-induced cardiac fibrosis and increased blood pressure
    Amanda J Rickard
    Prince Henry s Institute of Medical Research, Clayton 3168, Australia
    Hypertension 54:537-43. 2009
  10. doi request reprint Mediators of mineralocorticoid receptor-induced profibrotic inflammatory responses in the heart
    Peter Wilson
    Prince Henry s Institute of Medical Research, P O Box 5152 Clayton, Melbourne, Vic, Australia
    Clin Sci (Lond) 116:731-9. 2009

Collaborators

Detail Information

Publications36

  1. doi request reprint Mineralocorticoid receptors in the heart: lessons from cell-selective transgenic animals
    Morag J Young
    Cardiovascular EndocrinologyMIMR PHI Institute, 27 31 Wright St, Clayton 3168, AustraliaDepartment of PhysiologyMonash University, Clayton 3168, Australia Cardiovascular EndocrinologyMIMR PHI Institute, 27 31 Wright St, Clayton 3168, AustraliaDepartment of PhysiologyMonash University, Clayton 3168, Australia
    J Endocrinol 224:R1-13. 2015
    ..The goal of this review is to discuss recent advances in this area that have emerged from the study of tissue-selective MR-null mice, and other targeted transgenic models and their relevance to clinical disease. ..
  2. doi request reprint Endothelial cell mineralocorticoid receptors regulate deoxycorticosterone/salt-mediated cardiac remodeling and vascular reactivity but not blood pressure
    Amanda J Rickard
    Prince Henry s Institute of Medical Research, P O Box 5152, Clayton 3168, Australia
    Hypertension 63:1033-40. 2014
    ....
  3. doi request reprint Targeting the mineralocorticoid receptor in cardiovascular disease
    Morag J Young
    Monash University, Prince Henry s Institute of Medical Research, Cardiovascular Endocrinology Laboratory and Department of Physiology, Clayton, Australia
    Expert Opin Ther Targets 17:321-31. 2013
    ..It is now well accepted that the MR plays a critical role in many aspects of cardiovascular disease...
  4. doi request reprint Mechanisms of mineralocorticoid salt-induced hypertension and cardiac fibrosis
    Morag J Young
    Prince Henry s Institute of Medical Research, Department of Physiology, Monash University, Clayton, VIC 3168, Australia
    Mol Cell Endocrinol 350:248-55. 2012
    ..This review will discuss the mechanisms by which MR, located in the various cell types that comprise the heart, plays a central role in the development of cardiomyocyte failure, tissue inflammation, remodelling and hypertension...
  5. doi request reprint Activation of mineralocorticoid receptors by exogenous glucocorticoids and the development of cardiovascular inflammatory responses in adrenalectomized rats
    Morag J Young
    P O Box 5152, Clayton 3168, Victoria, Australia
    Endocrinology 151:2622-8. 2010
    ....
  6. doi request reprint Mechanisms of mineralocorticoid receptor-mediated cardiac fibrosis and vascular inflammation
    Morag J Young
    Prince Henry s Institute of Medical Research, Clayton, Australia
    Curr Opin Nephrol Hypertens 17:174-80. 2008
    ....
  7. ncbi request reprint Mineralocorticoid receptor activation and cardiac fibrosis
    Morag J Young
    Prince Henry s Institute of Medical Research, PO Box 5152, Clayton, Melbourne, Victoria 3167, Australia
    Clin Sci (Lond) 112:467-75. 2007
    ..Given that few patients had elevated plasma aldosterone, novel mechanisms involved in activating the MR in the failing heart are now being investigated...
  8. ncbi request reprint Does glucocorticoid receptor blockade exacerbate tissue damage after mineralocorticoid/salt administration?
    Amanda J Rickard
    Prince Henry s Institute of Medical Research, Clayton 3168, Australia
    Endocrinology 148:4829-35. 2007
    ....
  9. doi request reprint Deletion of mineralocorticoid receptors from macrophages protects against deoxycorticosterone/salt-induced cardiac fibrosis and increased blood pressure
    Amanda J Rickard
    Prince Henry s Institute of Medical Research, Clayton 3168, Australia
    Hypertension 54:537-43. 2009
    ....
  10. doi request reprint Mediators of mineralocorticoid receptor-induced profibrotic inflammatory responses in the heart
    Peter Wilson
    Prince Henry s Institute of Medical Research, P O Box 5152 Clayton, Melbourne, Vic, Australia
    Clin Sci (Lond) 116:731-9. 2009
    ....
  11. doi request reprint Cardiomyocyte mineralocorticoid receptors are essential for deoxycorticosterone/salt-mediated inflammation and cardiac fibrosis
    Amanda J Rickard
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Hypertension 60:1443-50. 2012
    ....
  12. doi request reprint Macrophage mineralocorticoid receptor signaling plays a key role in aldosterone-independent cardiac fibrosis
    Laura A Bienvenu
    Prince Henry s Institute, Clayton 3168, Victoria, Australia
    Endocrinology 153:3416-25. 2012
    ..286 ± 0.255). These data demonstrate that macrophage MR are necessary for the translation of inflammation and oxidative stress into interstitial and perivascular fibrosis after NO deficiency, even when plasma aldosterone is not elevated...
  13. ncbi request reprint The role of the glucocorticoid receptor in mineralocorticoid/salt-mediated cardiac fibrosis
    Amanda J Rickard
    Dr Prince Henry s Institute of Medical Research, Endocrine Genetics, P O Box 5152, Clayton, Victoria 3168, Australia
    Endocrinology 147:5901-6. 2006
    ..Thus, blocking agonist activity at the GR neither enhances nor attenuates the fibrotic response, although it may modulate systolic blood pressure and macrophage recruitment in the mineralocorticoid/salt model...
  14. doi request reprint Mineralocorticoid receptors and the heart, multiple cell types and multiple mechanisms: a focus on the cardiomyocyte
    Laura A Bienvenu
    Prince Henry s Institute of Medical Research, Clayton, VIC 3168, Australia
    Clin Sci (Lond) 125:409-21. 2013
    ..Further research targeted to identify sex differences in cardiomyocyte MR activation and signalling processes has the potential to provide the basis for the development of cardiac-specific MR therapies that may also be sex-specific...
  15. ncbi request reprint Mineralocorticoid receptor blockade but not steroid withdrawal reverses renal fibrosis in deoxycorticosterone/salt rats
    Emily Y M Lam
    Prince Henry s Institute of Medical Research, Endocrine Genetics, Clayton, Victoria 3168, Australia
    Endocrinology 147:3623-9. 2006
    ..We hypothesize that continuing tubular inflammation and fibrosis despite DOC withdrawal indicates that the renal tissue may reflect MR activation in the context of tissue damage...
  16. doi request reprint Identification of ligand-selective peptide antagonists of the mineralocorticoid receptor using phage display
    Jun Yang
    Prince Henry s Institute of Medical Research, Clayton, Victoria 3168, Australia
    Mol Endocrinol 25:32-43. 2011
    ..This represents a novel mechanism of MR antagonism that may be manipulated in the rational design of a ligand- or tissue-selective MR modulator to treat diseases like heart failure without side effects such as hyperkalemia...
  17. doi request reprint GEMIN4 functions as a coregulator of the mineralocorticoid receptor
    Jun Yang
    MIMR PHI InstitutePO Box 5152, Clayton, Victoria 3168, AustraliaDepartment of MedicineMonash University, Clayton, Victoria 3168, AustraliaDepartment of EndocrinologyMetabolism, Rheumatology and Nephrology, Oita University, Yufu 879 5593, Japan MIMR PHI InstitutePO Box 5152, Clayton, Victoria 3168, AustraliaDepartment of MedicineMonash University, Clayton, Victoria 3168, AustraliaDepartment of EndocrinologyMetabolism, Rheumatology and Nephrology, Oita University, Yufu 879 5593, Japan
    J Mol Endocrinol 54:149-60. 2015
    ..A physical interaction between GEMIN4 and MR is suggested by their nuclear co-localization upon agonist treatment. These findings indicate that GEMIN4 functions as a novel coregulator of the MR. ..
  18. doi request reprint Use of phage display to identify novel mineralocorticoid receptor-interacting proteins
    Jun Yang
    MIMR PHI Medical Research Institute J Y, P J F, J M, C D C, M J Y, Department of Medicine J Y, P J F, M J Y, Monash University, Clayton, Victoria 3168, Australia Department of Endocrinology, Metabolism, Rheumatology, and Nephrology H S, Oita University, Yufu 879 5593, Japan and Department of Pharmacology and Cancer Biology D P M, Duke University Medical Center, Durham, North Carolina 27710
    Mol Endocrinol 28:1571-84. 2014
    ....
  19. doi request reprint Corticosteroids, heart failure, and hypertension: a role for immune cells?
    Jimmy Z Shen
    Prince Henry s Institute, of Medical Research P O Box 5152, Clayton 3168, Australia
    Endocrinology 153:5692-700. 2012
    ..This review will discuss the current understanding of the role of corticosteroid receptors in macrophages and their effect on cardiovascular diseases involving inflammation...
  20. doi request reprint Corticosteroid receptors, macrophages and cardiovascular disease
    Amanda J Rickard
    Prince Henry s Institute of Medical Research, Victoria, Australia
    J Mol Endocrinol 42:449-59. 2009
    ..This review will discuss the current understanding of the role of corticosteroid receptors in macrophages and their effect on diseases involving inflammation, with a particular focus on cardiovascular disease...
  21. ncbi request reprint A direct effect of aldosterone on endothelin-1 gene expression in vivo
    Stephen Wong
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Endocrinology 148:1511-7. 2007
    ..5-fold after 1 h in the kidney and colon, respectively. These results suggest that ET-1 is a direct aldosterone gene target in the kidney and colon and may play an important role in aldosterone-regulated ion homeostasis...
  22. pmc Myeloid mineralocorticoid receptor activation contributes to progressive kidney disease
    Louis L Huang
    Department of Nephrology and Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia, and
    J Am Soc Nephrol 25:2231-40. 2014
    ..In conclusion, MR signaling in myeloid cells, but not podocytes, contributes to the progression of renal injury in mouse GN, and myeloid deficiency of MR provides protection similar to eplerenone in this disease. ..
  23. ncbi request reprint Mechanisms of mineralocorticoid action
    Peter J Fuller
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Hypertension 46:1227-35. 2005
    ..It is these nonepithelial actions of MR activation that need to be exploited for the development of antagonists that target the cardiovascular system while avoiding the undesirable side effects of renal MR blockade...
  24. doi request reprint Mechanisms of ligand specificity of the mineralocorticoid receptor
    Peter J Fuller
    Prince Henry s Institute and the Monash University, Department of Medicine, Clayton, Victoria 3168, Australia
    J Endocrinol 213:15-24. 2012
    ..The successful identification of ligand-specific interactions of the MR may provide the basis for the development of novel MR ligands with tissue specificity...
  25. doi request reprint Conditional overexpression of liver receptor homolog-1 in female mouse mammary epithelium results in altered mammary morphogenesis via the induction of TGF-β
    Kyren A Lazarus
    Cancer Drug Discovery Laboratory K A L, M J Y, Z Z, R S C, A L C, C D C and Metabolism and Cancer Laboratory K A B, Prince Henry s Institute of Medical Research, Clayton, Victoria 3168, Australia Environmental and Biotechnology Centre K A L, Swinburne University, Hawthorn, Victoria 3122, Australia and Department of Biochemistry and Molecular Biology C D C, Monash University, Clayton, Victoria 3168, Australia
    Endocrinology 155:1606-17. 2014
    ..Collectively, these data demonstrate that LRH-1 regulates TGF-β expression and downstream signaling in mouse mammary glands. ..
  26. doi request reprint Myocardial autophagy activation and suppressed survival signaling is associated with insulin resistance in fructose-fed mice
    Kimberley M Mellor
    Department of Physiology, University of Melbourne, Melbourne, Vic, Australia
    J Mol Cell Cardiol 50:1035-43. 2011
    ..The novel finding that autophagy contributes to cardiac pathology in insulin resistance identifies a new therapeutic target for diabetic cardiomyopathy...
  27. ncbi request reprint Mineralocorticoid receptors and pathophysiological roles for aldosterone in the cardiovascular system
    Morag J Young
    Prince Henry s Institute of Medical Research and Baker Medical Research Institute, Melbourne, Australia
    J Hypertens 20:1465-8. 2002
    ..A brief account of the current state of these mechanisms in at a cellular and tissue level forms the basis of this review...
  28. doi request reprint Evaluation of JNK blockade as an early intervention treatment for type 1 diabetic nephropathy in hypertensive rats
    Andy K H Lim
    Department of Nephrology, Monash Medical Centre, 246 Clayton Road, Clayton, VIC 3168, Australia
    Am J Nephrol 34:337-46. 2011
    ..In this study, we examined whether JNK signaling plays a role in the development of diabetic nephropathy or in regulating hypertension, which exacerbates diabetic renal injury...
  29. doi request reprint 6th International Symposium on Aldosterone and ENaC: from gene to disease. 3-7 October 2007, Zermatt, Switzerland
    Peter J Fuller
    Prince Henry s Institute of Medical Research, P O Box 5152, Clayton, Victoria 3168, Australia
    Expert Opin Ther Targets 12:377-82. 2008
    ..As such the pathways involved in sodium homeostasis are now well recognised as important therapeutic targets...
  30. pmc Purification and characterization of recombinant human mineralocorticoid receptor
    Colin D Clyne
    Prince Henry s Institute of Medical Research, Clayton, Melbourne, Victoria 3168, Australia
    Mol Cell Endocrinol 302:81-5. 2009
    ....
  31. pmc Aldosterone and the mineralocorticoid receptor in the cerebral circulation and stroke
    Quynh N Dinh
    Department of Pharmacology, Monash University Wellington Road, Clayton, Victoria, 3800, Australia
    Exp Transl Stroke Med 4:21. 2012
    ....
  32. doi request reprint The mineralocorticoid receptor and its coregulators
    Jun Yang
    Prince Henry s Institute of Medical Research, Monash University, Victoria, Australia
    J Mol Endocrinol 43:53-64. 2009
    ..Understanding the full complement of MR coregulators is essential for unraveling the complexity of MR signaling pathways and will facilitate the development of selective MR modulators...
  33. doi request reprint Localization and regulation of aromatase liver receptor homologue-1 in the developing rat testis
    Jayne Sierens
    Prince Henry s Institute of Medical Research, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia
    Mol Cell Endocrinol 323:307-13. 2010
    ..These data provide evidence that LRH-1 plays an important role in the regulation of testicular aromatase expression, and implicate LRH-1 as a regulator of rat spermatogenesis, in which estrogens are emerging as important mediators...
  34. doi request reprint Identification and characterization of a ligand-selective mineralocorticoid receptor coactivator
    Fraser M Rogerson
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    FASEB J 28:4200-10. 2014
    ..Tesmin thus represents a novel MR coregulator that exhibits a differential interaction, providing further evidence of the adoption of ligand-dependent conformations by the MR-LBD...
  35. ncbi request reprint Role of CRE-binding protein (CREB) in aromatase expression in breast adipose
    Mariam Sofi
    Prince Henry s Institute of Medical Research, Clayton, VC, Australia
    Breast Cancer Res Treat 79:399-407. 2003
    ....
  36. ncbi request reprint Early inflammatory responses in experimental cardiac hypertrophy and fibrosis: effects of 11 beta-hydroxysteroid dehydrogenase inactivation
    Morag J Young
    Baker Medical Research Institute, Melbourne Prahran 3181, Australia
    Endocrinology 144:1121-5. 2003
    ....