Robert I McLachlan

Summary

Affiliation: Prince Henry's Institute of Medical Research
Country: Australia

Publications

  1. doi request reprint Approach to the patient with oligozoospermia
    Robert I McLachlan
    Prince Henry s Institute of Medical Research, P O Box 5152, Clayton 3168, Australia
    J Clin Endocrinol Metab 98:873-80. 2013
  2. doi request reprint When is azoospermic infertility treatable without intracytoplasmic sperm injection?
    Robert I McLachlan
    Prince Henry s Institute of Medical Research, Monash Medical Centre, Monash University, Clayton, VIC 3168, Australia
    Clin Endocrinol (Oxf) 78:176-80. 2013
  3. doi request reprint Normal live birth after testicular sperm extraction and intracytoplasmic sperm injection in variant primary ciliary dyskinesia with completely immotile sperm and structurally abnormal sperm tails
    Robert I McLachlan
    Monash IVF, Hawthorn, Australia
    Fertil Steril 97:313-8. 2012
  4. doi request reprint Clinical Review#: State of the art for genetic testing of infertile men
    Robert I McLachlan
    Prince Henry s Institute of Medical Research, P O Box 5152, Clayton 3168, Australia
    J Clin Endocrinol Metab 95:1013-24. 2010
  5. ncbi request reprint Histological evaluation of the human testis--approaches to optimizing the clinical value of the assessment: mini review
    R I McLachlan
    Prince Henry s Institute, Monash University, Clayton, Victoria, Australia
    Hum Reprod 22:2-16. 2007
  6. ncbi request reprint Hypogonadotropism with elevated serum testosterone: reversible causes of secondary infertility
    Robert I McLachlan
    Prince Henry s Institute, Melbourne, Australia
    Nat Clin Pract Urol 3:560-5. 2006
  7. ncbi request reprint The relative roles of follicle-stimulating hormone and luteinizing hormone in maintaining spermatogonial maturation and spermiation in normal men
    Kati L Matthiesson
    Prince Henry s Institute, and Departments of Obstetrics and Gynaecology, Monash University, P O Box 5152, Monash Medical Center, Clayton, Victoria 3168, Australia
    J Clin Endocrinol Metab 91:3962-9. 2006
  8. ncbi request reprint Effects of testosterone and levonorgestrel combined with a 5alpha-reductase inhibitor or gonadotropin-releasing hormone antagonist on spermatogenesis and intratesticular steroid levels in normal men
    Kati L Matthiesson
    Prince Henry s Institute of Medical Research, Monash University, Monash Medical Center, Clayton, Victoria 3168, Australia
    J Clin Endocrinol Metab 90:5647-55. 2005
  9. doi request reprint Gonadotrophins regulate germ cell survival, not proliferation, in normal adult men
    Saleela M Ruwanpura
    Prince Henry s Institute, Clayton, Level 4, 43 51 Kanooka Grove, Victoria 3168, Australia
    Hum Reprod 23:403-11. 2008
  10. pmc Determinants of male reproductive health disorders: the Men in Australia Telephone Survey (MATeS)
    Carol A Holden
    Andrology Australia, Monash Institute of Medical Research, Monash University, Melbourne, Victoria, Australia
    BMC Public Health 10:96. 2010

Collaborators

Detail Information

Publications55

  1. doi request reprint Approach to the patient with oligozoospermia
    Robert I McLachlan
    Prince Henry s Institute of Medical Research, P O Box 5152, Clayton 3168, Australia
    J Clin Endocrinol Metab 98:873-80. 2013
    ....
  2. doi request reprint When is azoospermic infertility treatable without intracytoplasmic sperm injection?
    Robert I McLachlan
    Prince Henry s Institute of Medical Research, Monash Medical Centre, Monash University, Clayton, VIC 3168, Australia
    Clin Endocrinol (Oxf) 78:176-80. 2013
    ..A range of uncommon endocrinocrinopathies may also result in reversible azoospermia. Finally, obstructive azoospermia may be surgically remediable in selected cases...
  3. doi request reprint Normal live birth after testicular sperm extraction and intracytoplasmic sperm injection in variant primary ciliary dyskinesia with completely immotile sperm and structurally abnormal sperm tails
    Robert I McLachlan
    Monash IVF, Hawthorn, Australia
    Fertil Steril 97:313-8. 2012
    ..To report on the investigation and fertility management of variant primary ciliary dyskinesia (PCD)...
  4. doi request reprint Clinical Review#: State of the art for genetic testing of infertile men
    Robert I McLachlan
    Prince Henry s Institute of Medical Research, P O Box 5152, Clayton 3168, Australia
    J Clin Endocrinol Metab 95:1013-24. 2010
    ..Testing for less common genetic associations/defects linked with different reproductive dysfunction may be applicable to specific patients but have not entered routine practice...
  5. ncbi request reprint Histological evaluation of the human testis--approaches to optimizing the clinical value of the assessment: mini review
    R I McLachlan
    Prince Henry s Institute, Monash University, Clayton, Victoria, Australia
    Hum Reprod 22:2-16. 2007
    ..We propose a new diagnosis code for testicular biopsies that addresses the needs of ART clinicians and allows data storage and retrieval of value in clinical practice and research...
  6. ncbi request reprint Hypogonadotropism with elevated serum testosterone: reversible causes of secondary infertility
    Robert I McLachlan
    Prince Henry s Institute, Melbourne, Australia
    Nat Clin Pract Urol 3:560-5. 2006
    ..A 33-year-old man presented with secondary infertility, increased libido, and extreme oligospermia. Testicular volumes were reduced, but no gynecomastia was apparent and androgen abuse was denied...
  7. ncbi request reprint The relative roles of follicle-stimulating hormone and luteinizing hormone in maintaining spermatogonial maturation and spermiation in normal men
    Kati L Matthiesson
    Prince Henry s Institute, and Departments of Obstetrics and Gynaecology, Monash University, P O Box 5152, Monash Medical Center, Clayton, Victoria 3168, Australia
    J Clin Endocrinol Metab 91:3962-9. 2006
    ..Male hormonal contraception via gonadotropin and intratesticular androgen withdrawal disrupts spermatogenesis at two principal sites: 1) spermatogonial maturation, and 2) spermiation...
  8. ncbi request reprint Effects of testosterone and levonorgestrel combined with a 5alpha-reductase inhibitor or gonadotropin-releasing hormone antagonist on spermatogenesis and intratesticular steroid levels in normal men
    Kati L Matthiesson
    Prince Henry s Institute of Medical Research, Monash University, Monash Medical Center, Clayton, Victoria 3168, Australia
    J Clin Endocrinol Metab 90:5647-55. 2005
    ..Combination of a GnRH antagonist (acyline), types I and II, 5alpha-reductase inhibitor (dutasteride) or levonorgestrel (LNG) with testosterone (T) treatment may augment the suppression of spermatogenesis and intratesticular (iT) steroids...
  9. doi request reprint Gonadotrophins regulate germ cell survival, not proliferation, in normal adult men
    Saleela M Ruwanpura
    Prince Henry s Institute, Clayton, Level 4, 43 51 Kanooka Grove, Victoria 3168, Australia
    Hum Reprod 23:403-11. 2008
    ..Gonadotrophins support spermatogenesis via poorly understood mechanisms. We aimed to determine the effect of FSH/LH suppression in regulating germ cell apoptosis and proliferation in normal fertile men...
  10. pmc Determinants of male reproductive health disorders: the Men in Australia Telephone Survey (MATeS)
    Carol A Holden
    Andrology Australia, Monash Institute of Medical Research, Monash University, Melbourne, Victoria, Australia
    BMC Public Health 10:96. 2010
    ....
  11. ncbi request reprint Men in Australia Telephone Survey (MATeS): predictors of men's help-seeking behaviour for reproductive health disorders
    Carol A Holden
    Andrology Australia, Monash University, Melbourne, Vic, Australia
    Med J Aust 185:418-22. 2006
    ..To identify sociodemographic factors associated with help-seeking behaviour for reproductive health disorders in middle-aged and older Australian men...
  12. ncbi request reprint Oestrogen does not affect the restoration of spermatogenesis in the gonadotrophin-releasing hormone-immunised adult rat
    Sarah J Meachem
    Prince Henry s Institute of Medical Research Block E, Level 4, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia
    J Endocrinol 185:529-38. 2005
    ..Co-administration of ICI 182780 had no effect on any of these germ cell numbers. We conclude that oestrogen action plays no role in the short-term restoration of spermatogenesis by testosterone in the GnRH-immunised rat...
  13. ncbi request reprint Novel male hormonal contraceptive combinations: the hormonal and spermatogenic effects of testosterone and levonorgestrel combined with a 5alpha-reductase inhibitor or gonadotropin-releasing hormone antagonist
    Kati L Matthiesson
    Prince Henry s Institute of Medical Research and Department of Obstetrics and Gynaecology, Monash University, Monash Medical Centre, P O Box 5152, Clayton, Victoria 3168, Australia
    J Clin Endocrinol Metab 90:91-7. 2005
    ....
  14. pmc Proteomic changes in rat spermatogenesis in response to in vivo androgen manipulation; impact on meiotic cells
    Peter G Stanton
    Prince Henry s Institute, Monash Medical Centre, Clayton, Victoria, Australia
    PLoS ONE 7:e41718. 2012
    ..We conclude that Sertoli cells, in response to androgens, modulate protein translation and post-translational events in spermatocytes that impact on their metabolism, survival, and completion of meiosis...
  15. ncbi request reprint Male hormonal contraception: concept proven, product in sight?
    Kati L Matthiesson
    Department of Obstetrics and Gynaecology, Prince Henry s Institute of Medical Research, Monash University, Monash Medical Centre, Clayton, Victoria 3168, Australia
    Hum Reprod Update 12:463-82. 2006
    ..At present, a prototype MHC product using a long-acting injectable testosterone and depot progestin is well advanced...
  16. ncbi request reprint Stereological analysis of the human testis after vasectomy indicates impairment of spermatogenic efficiency with increasing obstructive interval
    Daniel Raleigh
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Fertil Steril 81:1595-603. 2004
    ..To quantify germ cell loss and the extent of testicular fibrosis in vasectomized patients of varying obstructive intervals...
  17. pmc Waist-to-height ratio as a predictor of serum testosterone in ageing men with symptoms of androgen deficiency
    Carolyn A Allan
    Prince Henry s Institute, Clayton, VIC 3168, Australia
    Asian J Androl 13:424-31. 2011
    ..05 for all). In conclusion, WHt ratio is the best anthropometric predictor of both TT and cFT in this group of healthy but symptomatic ageing men...
  18. ncbi request reprint Follicle-stimulating hormone affects spermatogonial survival by regulating the intrinsic apoptotic pathway in adult rats
    Saleela M Ruwanpura
    Prince Henry s Institute of Medical Research, Clayton, Victoria 3168, Australia
    Biol Reprod 78:705-13. 2008
    ..This study reveals that FSH predominantly acts as a survival factor for spermatogonia by regulating the intrinsic pathway while having no affect on germ cell proliferation in rats in vivo...
  19. ncbi request reprint Transcriptional profiling of the hormone-responsive stages of spermatogenesis reveals cell-, stage-, and hormone-specific events
    Liza O'Donnell
    Prince Henry s Institute of Medical Research, PO Box 5152, Clayton, VIC 3168, Australia
    Endocrinology 150:5074-84. 2009
    ....
  20. ncbi request reprint Response of serum inhibin B and pro-alphaC levels to gonadotrophic stimulation in normal men before and after steroidal contraceptive treatment
    Kati L Matthiesson
    Prince Henry s Institute of Medical Research, Monash Medical Centre, Monash University, Clayton, Victoria 3168, Australia
    Hum Reprod 18:734-43. 2003
    ..Testicular regulation of inhibin B may be influenced by the germ cell complement...
  21. doi request reprint Androgens and obesity
    Carolyn A Allan
    Prince Henry s Institute, Clayton, Victoria, Australia
    Curr Opin Endocrinol Diabetes Obes 17:224-32. 2010
    ....
  22. doi request reprint Hormonal regulation of male germ cell development
    Saleela M Ruwanpura
    Prince Henry s Institute of Medical Research, Clayton, Victoria 3168, Australia
    J Endocrinol 205:117-31. 2010
    ..Therefore understanding the basic mechanisms by which hormones govern germ cell progression are important steps towards improved understating of fertility regulation in health diseases...
  23. doi request reprint Hormonal regulation of sertoli cell micro-RNAs at spermiation
    Peter K Nicholls
    Prince Henry s Institute, Monash Medical Centre, Clayton 3152, Victoria, Australia
    Endocrinology 152:1670-83. 2011
    ....
  24. ncbi request reprint Relationship between serum gonadotropins and spermatogenic suppression in men undergoing steroidal contraceptive treatment
    Robert I McLachlan
    Prince Henry s Institute of Medical Research, Monash Medical Center, Clayton, Victoria 3168, Australia
    J Clin Endocrinol Metab 89:142-9. 2004
    ..On the other hand, the greater spermatogenic suppression in regimens containing DSG or CPA suggests that these progestins have additional actions to suppress spermatogenesis via a gonadotropin-independent mechanism(s)..
  25. doi request reprint Pathways involved in testicular germ cell apoptosis in immature rats after FSH suppression
    Saleela M Ruwanpura
    Prince Henry s Institute of Medical Research, Clayton, Victoria 3168, Australia
    J Endocrinol 197:35-43. 2008
    ..This study demonstrates that, in the seminiferous tubules, FSH suppression induces spermatogonial apoptosis predominantly via the intrinsic pathway, while spermatocyte apoptosis occurs via both the intrinsic and extrinsic pathways...
  26. ncbi request reprint Hormonal regulation of spermatogenesis in primates and man: insights for development of the male hormonal contraceptive
    Robert I McLachlan
    Prince Henry s Institute of Medical Research, Monash Medical Centre, Clayton, Victoria, Australia
    J Androl 23:149-62. 2002
  27. ncbi request reprint Semen analysis: its place in modern reproductive medical practice
    Robert I McLachlan
    Prince Henry s Institute of Medical Research and Monash IVF, Victoria, Australia
    Pathology 35:25-33. 2003
    ....
  28. ncbi request reprint Windows of opportunity: a holistic approach to men's health
    Carol A Holden
    Andrology Australia, Monash University, Melbourne, Vic, Australia
    Med J Aust 192:708-11. 2010
    ..Further men's health research is needed in Australia to guide policy, innovative health promotion, and clinical practice...
  29. doi request reprint Molecular analysis of the PArkin co-regulated gene and association with male infertility
    Gabrielle R Wilson
    Bruce Lefroy Centre for Genetic Health Research, Murdoch Children s Research Institute, Melbourne, 3052, Victoria, Australia
    Fertil Steril 93:2262-8. 2010
    ..To investigate the potential role of PArkin co-regulated gene (PACRG) in human male infertility...
  30. doi request reprint Serum testosterone, dihydrotestosterone and estradiol concentrations in older men self-reporting very good health: the healthy man study
    Gideon Sartorius
    Andrology Department, Concord Hospital, Clayton, Vic, Australia
    Clin Endocrinol (Oxf) 77:755-63. 2012
    ..To determine serum concentrations, intra-individual variability and impact of age-related co-morbidities on serum testosterone (T), dihydrotestosterone (DHT), estradiol (E(2)) and estrone (E(1)) in older men...
  31. doi request reprint Genetic variants in the ETV5 gene in fertile and infertile men with nonobstructive azoospermia associated with Sertoli cell-only syndrome
    Moira K O'Bryan
    Department of Anatomy and Developmental Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing, and Health Sciences, Monash University, Clayton, Victoria, Australia
    Fertil Steril 98:827-35.e1-3. 2012
    ..To assess the association between genetic variants in the ETV5 gene with nonobstructive azoospermia (NOA) associated with Sertoli cell-only (SCO) syndrome...
  32. ncbi request reprint The association between obesity and the diagnosis of androgen deficiency in symptomatic ageing men
    Carolyn A Allan
    Prince Henry s Institute, Melbourne, Vic, Australia
    Med J Aust 185:424-7. 2006
    ..To determine the influence of obesity on the diagnosis of age-related androgen deficiency (AD) in symptomatic men according to current Australian guidelines...
  33. ncbi request reprint Basis, diagnosis and treatment of immunological infertility in men
    Robert I McLachlan
    Prince Henry s Institute of Medical Research, Clayton, Australia
    J Reprod Immunol 57:35-45. 2002
    ....
  34. ncbi request reprint Genetic screening of infertile men
    David Cram
    Monash Institute of Reproduction and Development, Monash University, Clayton, Australia
    Reprod Fertil Dev 16:573-80. 2004
    ..Such information will form the basis of new genetic tests that will allow the clinician to make an accurate diagnosis of the male partner and a more informed decision about treatment options for the couple...
  35. doi request reprint Application of laser-capture microdissection to analysis of gene expression in the testis
    Pavel Sluka
    Prince Henry s Institute of Medical Research, Monash Medical Centre, Clayton, Victoria 3168, Australia
    Prog Histochem Cytochem 42:173-201. 2008
    ....
  36. ncbi request reprint Effects of testosterone plus medroxyprogesterone acetate on semen quality, reproductive hormones, and germ cell populations in normal young men
    Robert I McLachlan
    Prince Henry s Institute of Medical Research, Monash Medical Centre, Clayton, Victoria, Australia 3168
    J Clin Endocrinol Metab 87:546-56. 2002
    ....
  37. ncbi request reprint Age-related changes in testosterone and the role of replacement therapy in older men
    Carolyn A Allan
    Prince Henry s Institute of Medical Research, Monash Medical Centre and Department O and G, Monash University, Clayton, Australia
    Clin Endocrinol (Oxf) 60:653-70. 2004
  38. ncbi request reprint Genetic variants in the RABL2A gene in fertile and oligoasthenospermic infertile men
    Duangporn Jamsai
    Department of Anatomy and Developmental Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia Electronic address
    Fertil Steril 102:223-9. 2014
    ..To define RABL2A localization in human sperm and to assess any potential association between RABL2A variants and male infertility associated with oligoasthenospermia...
  39. ncbi request reprint The prevalence and diagnosis rates of Klinefelter syndrome: an Australian comparison
    Amy S Herlihy
    Murdoch Childrens Research Institute, Melbourne, Vic, Australia
    Med J Aust 194:24-8. 2011
    ..To determine the prevalence and diagnosis rates of Klinefelter syndrome (KS) in Victoria, Australia, and compare these to previous international findings...
  40. ncbi request reprint 'Male friendly' services
    Carol A Holden
    Monash Institute of Medical Research, Monash University, Melbourne, Victoria, Australia
    Aust Fam Physician 39:9-10. 2010
    ..As part of a strategy to reduce barriers for men accessing health care, the Australian Government's proposed National Men's Health Policy has stated that a focus on 'male friendly' settings will be adopted...
  41. ncbi request reprint Men in Australia Telephone Survey (MATeS): a national survey of the reproductive health and concerns of middle-aged and older Australian men
    Carol A Holden
    Andrology Australia, Monash Institute of Medical Research, Monash University, Melbourne, Australia
    Lancet 366:218-24. 2005
    ..The Men in Australia Telephone Survey (MATeS) describes the prevalence of self-reported reproductive health disorders as well as related concerns and health behaviours among middle-aged and older Australian men...
  42. ncbi request reprint Management of the infertile couple
    Robert I McLachlan
    Prince Henry s Institute of Medical Research, Monash Medical Centre, Victoria
    Aust Fam Physician 34:111-3, 115-7. 2005
    ..With the further development of reproductive technology over the past 2 decades, options for subfertile couples have greatly increased...
  43. ncbi request reprint Testosterone deficiency in men. Diagnosis and management
    Carolyn A Allan
    Prince Henry s Institute of Medical Research, Department of Obstetrics and Gynaecology, Monash University, Victoria
    Aust Fam Physician 32:422-7. 2003
    ..Testosterone deficiency (hypoandrogenism) is the commonest hormonal deficiency in men but its clinical presentation may be subtle and its diagnosis overlooked unless actively considered...
  44. ncbi request reprint Tackling inequities in men's health: a reflective lens on the National Male Health Policy
    Veronica R Collins
    Andrology Australia, Monash Institute of Medical Research, Monash University, Melbourne, Vic, Australia
    Med J Aust 194:62-4. 2011
    ..Coordinated action is necessary to improve the health of all Australian males...
  45. ncbi request reprint Reproductive hormone reference intervals for healthy fertile young men: evaluation of automated platform assays
    Ken Sikaris
    Royal College of Pathologists of Australasia and Australasian Association of Clinical Biochemists, Chemical Pathology Quality Assurance Programs Pty Ltd, Flinders Medical Centre, South Australia 5042, Australia
    J Clin Endocrinol Metab 90:5928-36. 2005
    ..Management of male infertility and/or androgen deficiency requires accurate hormonal measurements with valid reference intervals...
  46. doi request reprint Male hormonal contraception: so near and yet so far
    Peter Y Liu
    J Clin Endocrinol Metab 93:2474-6. 2008
  47. ncbi request reprint The effects of gonadotropin suppression and selective replacement on insulin-like factor 3 secretion in normal adult men
    Katrine Bay
    University Department of Growth and Reproduction, Rigshospitalet, GR 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 91:1108-11. 2006
    ..Gonadotropic regulation of the testicular Leydig cell hormone insulin-like factor 3 (INSL3) is incompletely characterized...
  48. ncbi request reprint Induction of spermatogenesis by recombinant follicle-stimulating hormone (puregon) in hypogonadotropic azoospermic men who failed to respond to human chorionic gonadotropin alone
    Pierre Marc G Bouloux
    Department of Endocrinology, The Royal Free Hospital, London, United Kingdom
    J Androl 24:604-11. 2003
    ..In conclusion, a weekly dose of 450 IU (3 x 150 IU or 2 x 225 IU) recFSH, in addition to hCG, was able to induce spermatogenesis in many hypogonadotropic azoospermic men who failed to respond to treatment with hCG alone...
  49. doi request reprint Determinants of the rate and extent of spermatogenic suppression during hormonal male contraception: an integrated analysis
    Peter Y Liu
    Department of Andrology, ANZAC Research Institute, University of Sydney and Concord Hospital, Concord, New South Wales 2139, Australia
    J Clin Endocrinol Metab 93:1774-83. 2008
    ..Male hormonal contraceptive methods require effective suppression of sperm output...
  50. ncbi request reprint Variability in sperm suppression during testosterone administration to adult monkeys is related to follicle stimulating hormone suppression and not to intratesticular androgens
    Anita Narula
    Population Center for Research in Reproduction, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Clin Endocrinol Metab 87:3399-406. 2002
    ....
  51. ncbi request reprint Contraceptive efficacy of a depot progestin and androgen combination in men
    Leo Turner
    Department of Andrology, Concord Hospital, and ANZAC Research Institute, University of Sydney, Sydney, New South Wales 2139, Australia
    J Clin Endocrinol Metab 88:4659-67. 2003
    ..Further studies of purpose-developed products are required to extend the overall safety and efficacy experience with depot androgen/progestin combinations, the most promising approach to hormonal male contraception...
  52. ncbi request reprint Primary testicular failure in Klinefelter's syndrome: the use of bivariate luteinizing hormone-testosterone reference charts
    Lise Aksglaede
    Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Clin Endocrinol (Oxf) 66:276-81. 2007
    ..The combined evaluation of serum LH and testosterone levels in the evaluation of testicular failure has not been widely advocated...
  53. ncbi request reprint 10th Summit Meeting consensus: recommendations for regulatory approval for hormonal male contraception
    Pertti Aaltonen
    Schering AG, Berlin, Germany
    J Androl 28:362-3. 2007
  54. ncbi request reprint Defining the prevalence and incidence of androgen deficiency in aging men: where are the goal posts?
    Robert I McLachlan
    J Clin Endocrinol Metab 89:5916-9. 2004
  55. ncbi request reprint Y chromosome microdeletions: implications for assisted conception
    David S Cram
    Med J Aust 185:433-4. 2006