Margaret E E Jones

Summary

Affiliation: Prince Henry's Institute of Medical Research
Country: Australia

Publications

  1. ncbi request reprint The phenotype of the aromatase knockout mouse reveals dietary phytoestrogens impact significantly on testis function
    Kirsten M Robertson
    Prince Henry s Institute of Medical Research, Clayton, 3168 Victoria, Australia
    Endocrinology 143:2913-21. 2002
  2. ncbi request reprint Of mice and men: the evolving phenotype of aromatase deficiency
    Margaret E E Jones
    Prince Henry s Institute of Medical Research, PO Box 5152, Clayton, Victoria 3168, Australia
    Trends Endocrinol Metab 17:55-64. 2006
  3. ncbi request reprint Recognizing rare disorders: aromatase deficiency
    Margaret E E Jones
    Prince Henry s Institute of Medical Research, PO Box 5152 Clayton, VIC 3168, Australia
    Nat Clin Pract Endocrinol Metab 3:414-21. 2007
  4. ncbi request reprint Oestrogen replacement in vivo rescues the dysfunction of pituitary somatotropes in ovariectomised aromatase knockout mice
    Ming Yan
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Neuroendocrinology 81:158-66. 2005
  5. ncbi request reprint Estrogen replacement reverses the hepatic steatosis phenotype in the male aromatase knockout mouse
    Kylie N Hewitt
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Endocrinology 145:1842-8. 2004
  6. ncbi request reprint Estrogen regulates development of the somatic cell phenotype in the eutherian ovary
    Kara L Britt
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    FASEB J 16:1389-97. 2002
  7. ncbi request reprint The aromatase knockout mouse presents with a sexually dimorphic disruption to cholesterol homeostasis
    Kylie N Hewitt
    Prince Henry s Institute of Medical Research and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Endocrinology 144:3895-903. 2003
  8. ncbi request reprint Functional modification of pituitary somatotropes in the aromatase knockout mouse and the effect of estrogen replacement
    Ming Yan
    Prince Henry s Institute of Medical Research, Clayton, Victoria 3168, Australia
    Endocrinology 145:604-12. 2004
  9. doi request reprint Estrogen deficiency results in apoptosis in the frontal cortex of adult female aromatase knockout mice
    Rachel A Hill
    Prince Henry s Institute of Medical Research, Clayton, VIC 3168, Australia
    Mol Cell Neurosci 41:1-7. 2009
  10. ncbi request reprint Estrogen deficient male mice develop compulsive behavior
    Rachel A Hill
    Prince Henry s Institute of Medical Research, Monash University, Clayton, Australia
    Biol Psychiatry 61:359-66. 2007

Collaborators

Detail Information

Publications19

  1. ncbi request reprint The phenotype of the aromatase knockout mouse reveals dietary phytoestrogens impact significantly on testis function
    Kirsten M Robertson
    Prince Henry s Institute of Medical Research, Clayton, 3168 Victoria, Australia
    Endocrinology 143:2913-21. 2002
    ..Our study highlights the importance of estrogen in spermatogenesis and shows that relatively low levels of dietary phytoestrogens have a biological effect in the testis...
  2. ncbi request reprint Of mice and men: the evolving phenotype of aromatase deficiency
    Margaret E E Jones
    Prince Henry s Institute of Medical Research, PO Box 5152, Clayton, Victoria 3168, Australia
    Trends Endocrinol Metab 17:55-64. 2006
    ..By studying the naturally occurring aromatase-deficient humans, together with studies of the aromatase-knockout mouse, we are expanding our understanding of the essential role of estrogen in male physiology...
  3. ncbi request reprint Recognizing rare disorders: aromatase deficiency
    Margaret E E Jones
    Prince Henry s Institute of Medical Research, PO Box 5152 Clayton, VIC 3168, Australia
    Nat Clin Pract Endocrinol Metab 3:414-21. 2007
    ..Estrogen replacement therapy reverses the symptoms in male and female patients...
  4. ncbi request reprint Oestrogen replacement in vivo rescues the dysfunction of pituitary somatotropes in ovariectomised aromatase knockout mice
    Ming Yan
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Neuroendocrinology 81:158-66. 2005
    ....
  5. ncbi request reprint Estrogen replacement reverses the hepatic steatosis phenotype in the male aromatase knockout mouse
    Kylie N Hewitt
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Endocrinology 145:1842-8. 2004
    ....
  6. ncbi request reprint Estrogen regulates development of the somatic cell phenotype in the eutherian ovary
    Kara L Britt
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    FASEB J 16:1389-97. 2002
    ..These findings constitute definitive evidence that estrogen plays a critical role in maintaining female somatic interstitial and granulosa cells in the eutherian ovary...
  7. ncbi request reprint The aromatase knockout mouse presents with a sexually dimorphic disruption to cholesterol homeostasis
    Kylie N Hewitt
    Prince Henry s Institute of Medical Research and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Endocrinology 144:3895-903. 2003
    ..This study reveals a sexually dimorphic difference in mouse hepatic cholesterol homeostasis and roles for estrogen in the regulation of cholesterol uptake, biosynthesis, and catabolism in the female, but not in the male...
  8. ncbi request reprint Functional modification of pituitary somatotropes in the aromatase knockout mouse and the effect of estrogen replacement
    Ming Yan
    Prince Henry s Institute of Medical Research, Clayton, Victoria 3168, Australia
    Endocrinology 145:604-12. 2004
    ..It is suggested that aging is another important impact factor for the pituitary expression and regulation of GH mRNA in female mice...
  9. doi request reprint Estrogen deficiency results in apoptosis in the frontal cortex of adult female aromatase knockout mice
    Rachel A Hill
    Prince Henry s Institute of Medical Research, Clayton, VIC 3168, Australia
    Mol Cell Neurosci 41:1-7. 2009
    ..Our observations also demonstrate the sexually dimorphic susceptibility of neurons to estrogen deficiency...
  10. ncbi request reprint Estrogen deficient male mice develop compulsive behavior
    Rachel A Hill
    Prince Henry s Institute of Medical Research, Monash University, Clayton, Australia
    Biol Psychiatry 61:359-66. 2007
    ..Thus, the aromatase knockout (ArKO) mouse is estrogen deficient. We investigated the compulsive behaviors of these animals and the protein levels of catechol-O-methyltransferase (COMT) in frontal cortex, hypothalamus and liver...
  11. ncbi request reprint Cellular and molecular characterization of the adipose phenotype of the aromatase-deficient mouse
    Marie L Misso
    Prince Henry s Institute of Medical Research, Clayton, Victoria 3168, Australia
    Endocrinology 144:1474-80. 2003
    ....
  12. ncbi request reprint Anti-androgenic action by red clover-derived dietary isoflavones reduces non-malignant prostate enlargement in aromatase knockout (ArKo) mice
    Renea A Jarred
    Centre for Urological Research, Monash Institute of Reproduction and Development, Monash University, Clayton, Victoria, Australia
    Prostate 56:54-64. 2003
    ..This study investigated whether dietary isoflavones inhibit prostate growth in vivo in the aromatase knock-out (ArKO) mouse that exhibits lifelong elevation of androgens leading to prostate enlargement...
  13. ncbi request reprint A selective estrogen receptor α agonist ameliorates hepatic steatosis in the male aromatase knockout mouse
    Jenny D Y Chow
    Prince Henry s Institute, Clayton, Victoria 3168, Australia
    J Endocrinol 210:323-34. 2011
    ..Since the liver, adipose tissue and arcuate nucleus express mainly ERα, estrogens could regulate hepatic functions via peripheral and central pathways...
  14. ncbi request reprint Estrogen deficiency leads to apoptosis in dopaminergic neurons in the medial preoptic area and arcuate nucleus of male mice
    Rachel A Hill
    Prince Henry s Institute of Medical Research, Clayton 3168, Vic, Australia
    Mol Cell Neurosci 27:466-76. 2004
    ..Thus, we have provided direct evidence that estrogen is required to maintain the survival and functional integrity of dopaminergic neurons in the MPO and Arc of male, but not female mice...
  15. ncbi request reprint Estrogen is not directly required for oocyte developmental competence
    Kim Huynh
    Department of Anatomy, Monash University, Clayton, Victoria 3800, Australia
    Biol Reprod 70:1263-9. 2004
    ....
  16. ncbi request reprint Hippocampal NMDA receptor subunit expression and watermaze learning in estrogen deficient female mice
    Wah Chin Boon
    Prince Henry s Institute of Medical Research, P O Box 5152, Clayton, VIC 3168, Australia
    Brain Res Mol Brain Res 140:127-32. 2005
    ..These findings show that selective loss of estrogen synthesis is associated with changes in NMDA receptor subunit expression in the hippocampus but little change in spatial learning ability...
  17. doi request reprint The estrogenic component of tibolone reduces adiposity in female aromatase knockout mice
    Michelle L Van Sinderen
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Menopause 16:582-8. 2009
    ..To explore the effects of tibolone on adiposity in the absence of aromatase and determine which of the hormonal properties of tibolone are exerting these effects...
  18. pmc Hepatic Glucose Intolerance Precedes Hepatic Steatosis in the Male Aromatase Knockout (ArKO) Mouse
    Michelle L Van Sinderen
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia
    PLoS ONE 9:e87230. 2014
    ..Therefore, we conclude that male ArKO mice develop hepatic glucose intolerance by the age of 3 months which precedes the sex-specific development of hepatic steatosis. This can be reversed upon the administration of exogenous E2. ..
  19. ncbi request reprint Potential roles for estrogen regulation of telomerase activity in aging
    Sharyn Bayne
    Department of Immunology, Central and Eastern Clinical School, Monash University, Prahan, Victoria 3181, Australia
    Ann N Y Acad Sci 1114:48-55. 2007
    ..In some estrogen-responsive tissues, estrogen appears important in regulating telomerase activity in vivo. Further characterization will provide a greater understanding of the link between estrogen, telomerase, and aging...