Margaret E E Jones

Summary

Affiliation: Prince Henry's Institute of Medical Research
Country: Australia

Publications

  1. ncbi The phenotype of the aromatase knockout mouse reveals dietary phytoestrogens impact significantly on testis function
    Kirsten M Robertson
    Prince Henry s Institute of Medical Research, Clayton, 3168 Victoria, Australia
    Endocrinology 143:2913-21. 2002
  2. ncbi Of mice and men: the evolving phenotype of aromatase deficiency
    Margaret E E Jones
    Prince Henry s Institute of Medical Research, PO Box 5152, Clayton, Victoria 3168, Australia
    Trends Endocrinol Metab 17:55-64. 2006
  3. ncbi Recognizing rare disorders: aromatase deficiency
    Margaret E E Jones
    Prince Henry s Institute of Medical Research, PO Box 5152 Clayton, VIC 3168, Australia
    Nat Clin Pract Endocrinol Metab 3:414-21. 2007
  4. ncbi Oestrogen replacement in vivo rescues the dysfunction of pituitary somatotropes in ovariectomised aromatase knockout mice
    Ming Yan
    Prince Henry's Institute of Medical Research, Clayton, Victoria, Australia
    Neuroendocrinology 81:158-66. 2005
  5. ncbi Estrogen replacement reverses the hepatic steatosis phenotype in the male aromatase knockout mouse
    Kylie N Hewitt
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Endocrinology 145:1842-8. 2004
  6. ncbi Estrogen regulates development of the somatic cell phenotype in the eutherian ovary
    Kara L Britt
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    FASEB J 16:1389-97. 2002
  7. ncbi Estrogen deficiency results in apoptosis in the frontal cortex of adult female aromatase knockout mice
    Rachel A Hill
    Prince Henry s Institute of Medical Research, Clayton, VIC 3168, Australia
    Mol Cell Neurosci 41:1-7. 2009
  8. ncbi The aromatase knockout mouse presents with a sexually dimorphic disruption to cholesterol homeostasis
    Kylie N Hewitt
    Prince Henry s Institute of Medical Research and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Endocrinology 144:3895-903. 2003
  9. ncbi Estrogen deficient male mice develop compulsive behavior
    Rachel A Hill
    Prince Henry s Institute of Medical Research, Monash University, Clayton, Australia
    Biol Psychiatry 61:359-66. 2007
  10. ncbi Functional modification of pituitary somatotropes in the aromatase knockout mouse and the effect of estrogen replacement
    Ming Yan
    Prince Henry s Institute of Medical Research, Clayton, Victoria 3168, Australia
    Endocrinology 145:604-12. 2004

Collaborators

Detail Information

Publications18

  1. ncbi The phenotype of the aromatase knockout mouse reveals dietary phytoestrogens impact significantly on testis function
    Kirsten M Robertson
    Prince Henry s Institute of Medical Research, Clayton, 3168 Victoria, Australia
    Endocrinology 143:2913-21. 2002
    ..Our study highlights the importance of estrogen in spermatogenesis and shows that relatively low levels of dietary phytoestrogens have a biological effect in the testis...
  2. ncbi Of mice and men: the evolving phenotype of aromatase deficiency
    Margaret E E Jones
    Prince Henry s Institute of Medical Research, PO Box 5152, Clayton, Victoria 3168, Australia
    Trends Endocrinol Metab 17:55-64. 2006
    ..By studying the naturally occurring aromatase-deficient humans, together with studies of the aromatase-knockout mouse, we are expanding our understanding of the essential role of estrogen in male physiology...
  3. ncbi Recognizing rare disorders: aromatase deficiency
    Margaret E E Jones
    Prince Henry s Institute of Medical Research, PO Box 5152 Clayton, VIC 3168, Australia
    Nat Clin Pract Endocrinol Metab 3:414-21. 2007
    ..Estrogen replacement therapy reverses the symptoms in male and female patients...
  4. ncbi Oestrogen replacement in vivo rescues the dysfunction of pituitary somatotropes in ovariectomised aromatase knockout mice
    Ming Yan
    Prince Henry's Institute of Medical Research, Clayton, Victoria, Australia
    Neuroendocrinology 81:158-66. 2005
    ....
  5. ncbi Estrogen replacement reverses the hepatic steatosis phenotype in the male aromatase knockout mouse
    Kylie N Hewitt
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Endocrinology 145:1842-8. 2004
    ....
  6. ncbi Estrogen regulates development of the somatic cell phenotype in the eutherian ovary
    Kara L Britt
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    FASEB J 16:1389-97. 2002
    ..These findings constitute definitive evidence that estrogen plays a critical role in maintaining female somatic interstitial and granulosa cells in the eutherian ovary...
  7. ncbi Estrogen deficiency results in apoptosis in the frontal cortex of adult female aromatase knockout mice
    Rachel A Hill
    Prince Henry s Institute of Medical Research, Clayton, VIC 3168, Australia
    Mol Cell Neurosci 41:1-7. 2009
    ..Our observations also demonstrate the sexually dimorphic susceptibility of neurons to estrogen deficiency...
  8. ncbi The aromatase knockout mouse presents with a sexually dimorphic disruption to cholesterol homeostasis
    Kylie N Hewitt
    Prince Henry s Institute of Medical Research and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Endocrinology 144:3895-903. 2003
    ..This study reveals a sexually dimorphic difference in mouse hepatic cholesterol homeostasis and roles for estrogen in the regulation of cholesterol uptake, biosynthesis, and catabolism in the female, but not in the male...
  9. ncbi Estrogen deficient male mice develop compulsive behavior
    Rachel A Hill
    Prince Henry s Institute of Medical Research, Monash University, Clayton, Australia
    Biol Psychiatry 61:359-66. 2007
    ..Thus, the aromatase knockout (ArKO) mouse is estrogen deficient. We investigated the compulsive behaviors of these animals and the protein levels of catechol-O-methyltransferase (COMT) in frontal cortex, hypothalamus and liver...
  10. ncbi Functional modification of pituitary somatotropes in the aromatase knockout mouse and the effect of estrogen replacement
    Ming Yan
    Prince Henry s Institute of Medical Research, Clayton, Victoria 3168, Australia
    Endocrinology 145:604-12. 2004
    ..It is suggested that aging is another important impact factor for the pituitary expression and regulation of GH mRNA in female mice...
  11. ncbi Cellular and molecular characterization of the adipose phenotype of the aromatase-deficient mouse
    Marie L Misso
    Prince Henry s Institute of Medical Research, Clayton, Victoria 3168, Australia
    Endocrinology 144:1474-80. 2003
    ....
  12. ncbi A selective estrogen receptor α agonist ameliorates hepatic steatosis in the male aromatase knockout mouse
    Jenny D Y Chow
    Prince Henry s Institute, Clayton, Victoria 3168, Australia
    J Endocrinol 210:323-34. 2011
    ..Since the liver, adipose tissue and arcuate nucleus express mainly ERα, estrogens could regulate hepatic functions via peripheral and central pathways...
  13. ncbi Anti-androgenic action by red clover-derived dietary isoflavones reduces non-malignant prostate enlargement in aromatase knockout (ArKo) mice
    Renea A Jarred
    Centre for Urological Research, Monash Institute of Reproduction and Development, Monash University, Clayton, Victoria, Australia
    Prostate 56:54-64. 2003
    ....
  14. ncbi Estrogen deficiency leads to apoptosis in dopaminergic neurons in the medial preoptic area and arcuate nucleus of male mice
    Rachel A Hill
    Prince Henry s Institute of Medical Research, Clayton 3168, Vic, Australia
    Mol Cell Neurosci 27:466-76. 2004
    ..Thus, we have provided direct evidence that estrogen is required to maintain the survival and functional integrity of dopaminergic neurons in the MPO and Arc of male, but not female mice...
  15. ncbi Estrogen is not directly required for oocyte developmental competence
    Kim Huynh
    Department of Anatomy, Monash University, Clayton, Victoria 3800, Australia
    Biol Reprod 70:1263-9. 2004
    ....
  16. ncbi Hippocampal NMDA receptor subunit expression and watermaze learning in estrogen deficient female mice
    Wah Chin Boon
    Prince Henry s Institute of Medical Research, P O Box 5152, Clayton, VIC 3168, Australia
    Brain Res Mol Brain Res 140:127-32. 2005
    ..These findings show that selective loss of estrogen synthesis is associated with changes in NMDA receptor subunit expression in the hippocampus but little change in spatial learning ability...
  17. ncbi The estrogenic component of tibolone reduces adiposity in female aromatase knockout mice
    Michelle L Van Sinderen
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Menopause 16:582-8. 2009
    ..To explore the effects of tibolone on adiposity in the absence of aromatase and determine which of the hormonal properties of tibolone are exerting these effects...
  18. ncbi Potential roles for estrogen regulation of telomerase activity in aging
    Sharyn Bayne
    Department of Immunology, Central and Eastern Clinical School, Monash University, Prahan, Victoria 3181, Australia
    Ann N Y Acad Sci 1114:48-55. 2007
    ..In some estrogen-responsive tissues, estrogen appears important in regulating telomerase activity in vivo. Further characterization will provide a greater understanding of the link between estrogen, telomerase, and aging...