Affiliation: Prince Henry's Institute of Medical Research
Funder J. Primary aldosteronism and salt. Pflugers Arch. 2015;467:587-94 pubmed publisher
..Finally, at a practical level given even the currently accepted prevalence of primary aldosteronism, a radical reconsideration of first-line antihypertensive therapy is proposed. ..
Funder J, Reincke M. Aldosterone: a cardiovascular risk factor?. Biochim Biophys Acta. 2010;1802:1188-92 pubmed publisher
Funder J. Reconsidering the roles of the mineralocorticoid receptor. Hypertension. 2009;53:286-90 pubmed publisher
Funder J. Aldosterone and mineralocorticoid receptors in the cardiovascular system. Prog Cardiovasc Dis. 2010;52:393-400 pubmed publisher
..These findings on aldosterone action and mineralocorticoid receptor blockade are analyzed in the context of the prevention and treatment of cardiovascular disease. ..
Funder J. The role of aldosterone and mineralocorticoid receptors in cardiovascular disease. Am J Cardiovasc Drugs. 2007;7:151-7 pubmed
..These relatively recent insights suggest the potential therapeutic role for MR antagonists across a spectrum of cardiovascular disease, as vascular protectants even when circulating levels of aldosterone are low. ..
Funder J, Mihailidou A. Aldosterone and mineralocorticoid receptors: Clinical studies and basic biology. Mol Cell Endocrinol. 2009;301:2-6 pubmed publisher
..This poses the question of what is activating cardiac and vascular smooth muscle MR under such circumstances, which in turn leads to a radical reconsideration of the role of glucocorticoids in non-epithelial mineralocorticoid receptors. ..
Funder J. Aldosterone, sodium, and hypertension: lessons from torcetrapib?. Hypertension. 2010;55:221-3 pubmed publisher
Funder J. Medicine as a profession. Clin Med (Lond). 2010;10:246-7 pubmed
..A final consideration goes beyond the terms of the definition proposed--that of our ethical responsibility as professionals to stand up and be counted and, in the context of the disorder around us, to speak out. ..
Funder J. Minireview: Aldosterone and mineralocorticoid receptors: past, present, and future. Endocrinology. 2010;151:5098-102 pubmed publisher
..Two decades later we still do not know the boundaries, and for every answer, two questions are springing up: truly the more we learn, the less we know. ..