Leon J Worth

Summary

Affiliation: Peter MacCallum Cancer Centre
Country: Australia

Publications

  1. doi request reprint Bloodstream infections in haematology: risks and new challenges for prevention
    Leon J Worth
    Department of Infectious Diseases, Peter MacCallum Cancer Centre, Victoria, Australia
    Blood Rev 23:113-22. 2009
  2. doi request reprint Is it possible to achieve a target of zero central line associated bloodstream infections?
    Leon J Worth
    Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
    Curr Opin Infect Dis 25:650-7. 2012
  3. pmc An analysis of the utilisation of chemoprophylaxis against Pneumocystis jirovecii pneumonia in patients with malignancy receiving corticosteroid therapy at a cancer hospital
    L J Worth
    Victorian Infectious Diseases Service, Centre for Clinical Research Excellence in Infectious Diseases, Grattan Street, Parkville, Victoria 3050, Australia
    Br J Cancer 92:867-72. 2005
  4. doi request reprint Use of risk stratification to guide ambulatory management of neutropenic fever. Australian Consensus Guidelines 2011 Steering Committee
    L J Worth
    Department of Infectious Diseases, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Intern Med J 41:82-9. 2011
  5. doi request reprint Infective and thrombotic complications of central venous catheters in patients with hematological malignancy: prospective evaluation of nontunneled devices
    Leon J Worth
    Centre for Clinical Research Excellence in Infectious Disease, Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, 3052, Australia
    Support Care Cancer 17:811-8. 2009
  6. doi request reprint Optimizing antifungal drug dosing and monitoring to avoid toxicity and improve outcomes in patients with haematological disorders
    L J Worth
    Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, Vic
    Intern Med J 38:521-37. 2008
  7. doi request reprint Surveillance for catheter-associated bloodstream infection in hematology units: quantifying the characteristics of a practical case definition
    Leon J Worth
    Department of Infectious Diseases, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Infect Control Hosp Epidemiol 29:358-60. 2008
  8. ncbi request reprint Virulence determinants in vancomycin-resistant Enterococcus faecium vanB: clonal distribution, prevalence and significance of esp and hyl in Australian patients with haematological disorders
    L J Worth
    Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, Australia
    J Hosp Infect 68:137-44. 2008
  9. ncbi request reprint Vancomycin-resistant Enterococcus faecium infection in patients with hematologic malignancy: patients with acute myeloid leukemia are at high-risk
    Leon J Worth
    Department of Infectious Diseases, Peter MacCallum Cancer Centre, East Melbourne, Australia
    Eur J Haematol 79:226-33. 2007
  10. ncbi request reprint Catheter-related bloodstream infections in hematology: time for standardized surveillance?
    Leon J Worth
    Centre for Clinical Research Excellence in Infectious Disease, Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Cancer 109:1215-26. 2007

Detail Information

Publications27

  1. doi request reprint Bloodstream infections in haematology: risks and new challenges for prevention
    Leon J Worth
    Department of Infectious Diseases, Peter MacCallum Cancer Centre, Victoria, Australia
    Blood Rev 23:113-22. 2009
    ..To reduce the rate and impact of bloodstream infections multifaceted and customised strategies are required within individual haematology units...
  2. doi request reprint Is it possible to achieve a target of zero central line associated bloodstream infections?
    Leon J Worth
    Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
    Curr Opin Infect Dis 25:650-7. 2012
    ..Although a zero target is proposed, the feasibility has not been evaluated. The objective of this review is to identify factors contributing to CLABSI and determine whether current evidence supports attainment of a zero infection rate...
  3. pmc An analysis of the utilisation of chemoprophylaxis against Pneumocystis jirovecii pneumonia in patients with malignancy receiving corticosteroid therapy at a cancer hospital
    L J Worth
    Victorian Infectious Diseases Service, Centre for Clinical Research Excellence in Infectious Diseases, Grattan Street, Parkville, Victoria 3050, Australia
    Br J Cancer 92:867-72. 2005
    ..Successful primary prevention of PCP in this population will require a multifaceted approach targeting the suboptimal prescribing patterns for chemoprophylaxis...
  4. doi request reprint Use of risk stratification to guide ambulatory management of neutropenic fever. Australian Consensus Guidelines 2011 Steering Committee
    L J Worth
    Department of Infectious Diseases, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Intern Med J 41:82-9. 2011
    ..Due consideration is given to infrastructural requirements and other supportive measures at a resourcing and operational level. An analysis of the relevant health economics is also presented...
  5. doi request reprint Infective and thrombotic complications of central venous catheters in patients with hematological malignancy: prospective evaluation of nontunneled devices
    Leon J Worth
    Centre for Clinical Research Excellence in Infectious Disease, Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, 3052, Australia
    Support Care Cancer 17:811-8. 2009
    ..The objectives of this study were to determine the natural history and rate of CVC-related complications and risk factors for CR-BSI and to compare device-specific complications in a hematology population...
  6. doi request reprint Optimizing antifungal drug dosing and monitoring to avoid toxicity and improve outcomes in patients with haematological disorders
    L J Worth
    Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, Vic
    Intern Med J 38:521-37. 2008
    ..Further randomised study of newer antifungal agents, such as posaconazole, is required to explore the potential for improved clinical outcomes in association with TDM...
  7. doi request reprint Surveillance for catheter-associated bloodstream infection in hematology units: quantifying the characteristics of a practical case definition
    Leon J Worth
    Department of Infectious Diseases, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Infect Control Hosp Epidemiol 29:358-60. 2008
    ..0% sensitivity and 94.3% specificity. This case definition provides a practical method for effectively excluding CVC-associated bloodstream infection...
  8. ncbi request reprint Virulence determinants in vancomycin-resistant Enterococcus faecium vanB: clonal distribution, prevalence and significance of esp and hyl in Australian patients with haematological disorders
    L J Worth
    Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, Australia
    J Hosp Infect 68:137-44. 2008
    ..When compared to European and US reports, a high esp gene prevalence and low hyl gene prevalence was observed in polyclonal VRE isolates obtained from this immunocompromised population...
  9. ncbi request reprint Vancomycin-resistant Enterococcus faecium infection in patients with hematologic malignancy: patients with acute myeloid leukemia are at high-risk
    Leon J Worth
    Department of Infectious Diseases, Peter MacCallum Cancer Centre, East Melbourne, Australia
    Eur J Haematol 79:226-33. 2007
    ..Vancomycin-resistant enterococci (VRE) are significant nosocomial pathogens in patients with hematologic malignancy. Identification of risk factors for infection is necessary for targeted prevention and surveillance...
  10. ncbi request reprint Catheter-related bloodstream infections in hematology: time for standardized surveillance?
    Leon J Worth
    Centre for Clinical Research Excellence in Infectious Disease, Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Cancer 109:1215-26. 2007
    ..Only when these issues are addressed can a surveillance strategy reliably assess trends and compare data, leading to improved patient outcomes and a reduction in healthcare expenditure for patients with hematologic malignancy...
  11. ncbi request reprint Cytomegalovirus reactivation in patients with chronic lymphocytic leukemia treated with alemtuzumab: prophylaxis vs. pre-emptive strategies for prevention
    Leon J Worth
    Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
    Leuk Lymphoma 47:2435-6. 2006
  12. ncbi request reprint Validation of statewide surveillance system data on central line-associated bloodstream infection in intensive care units in Australia
    Emma S McBryde
    Victorian Infectious Diseases Service, Centre for Clinical Research Excellence in Infectious Diseases, Royal Melbourne Hospital, Melbourne, Victoria, Australia
    Infect Control Hosp Epidemiol 30:1045-9. 2009
    ....
  13. doi request reprint Use of FDG PET/CT for investigation of febrile neutropenia: evaluation in high-risk cancer patients
    Stephen D Guy
    Department of Infectious Diseases, Western Health, Private Bag, Footscray, Victoria, Australia 3011
    Eur J Nucl Med Mol Imaging 39:1348-55. 2012
    ..The aim of this study was to prospectively evaluate the clinical utility of FDG PET/CT in patients with cancer and severe neutropenia and five or more days of persistent fever despite antibiotic therapy...
  14. doi request reprint Impact of revising the National Nosocomial Infection Surveillance System definition for catheter-related bloodstream infection in ICU: reproducibility of the National Healthcare Safety Network case definition in an Australian cohort of infection control p
    Leon J Worth
    Victorian Hospital Acquired Infection Surveillance System VICNISS Coordinating Centre, North Melbourne, Victoria, Australia
    Am J Infect Control 37:643-8. 2009
    ..Effective and comparable surveillance for central venous catheter-related bloodstream infections (CLABSIs) in the intensive care unit requires a reproducible case definition that can be readily applied by infection control professionals...
  15. ncbi request reprint Spectrum of infection, risk and recommendations for prophylaxis and screening among patients with lymphoproliferative disorders treated with alemtuzumab*
    Karin A Thursky
    Department of Infectious Diseases, Peter MacCallum Cancer Centre, Victoria, Australia
    Br J Haematol 132:3-12. 2006
    ..This review discusses the infection risks associated with these lymphoproliferative disorders and their treatment, and provide detailed recommendations for screening and prophylaxis...
  16. doi request reprint Epidemiology of infections acquired in intensive care units
    Joseph S Doyle
    Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, VIC Australia
    Semin Respir Crit Care Med 32:115-38. 2011
    ..We also describe how changes in the pattern of antimicrobial use can affect the prevalence of multiresistant pathogens...
  17. ncbi request reprint Staphylococcus aureus bloodstream infection in Australian hospitals: findings from a Victorian surveillance system
    Leon J Worth
    Victorian Healthcare Associated Infection Surveillance System Coordinating Centre, Melbourne, Vic, Australia
    Med J Aust 200:282-4. 2014
    ..To determine the burden of disease and trend over time for rates of Staphylococcus aureus bloodstream (SAB) infections in Victorian health care services...
  18. doi request reprint Stenotrophomonas maltophilia: emerging disease patterns and challenges for treatment
    Iain J Abbott
    Department of Infectious Diseases, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Expert Rev Anti Infect Ther 9:471-88. 2011
    ..Finally, measures to prevent transmission of S. maltophilia within healthcare facilities are reported, especially in at-risk patient populations...
  19. doi request reprint A cost analysis of febrile neutropenia management in Australia: ambulatory v. in-hospital treatment
    Senthil Lingaratnam
    Pharmacy Department, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia
    Aust Health Rev 35:491-500. 2011
    ....
  20. doi request reprint Late-onset Pneumocystis jirovecii pneumonia post-fludarabine, cyclophosphamide and rituximab: implications for prophylaxis
    Gabrielle M Haeusler
    Department of Infectious Diseases and Infection Control, Peter MacCallum Cancer Centre, East Melbourne, Vic, Australia
    Eur J Haematol 91:157-63. 2013
    ..The objective of this study was to review the incidence of PJP during and post-FCR in the era of highly sensitive molecular diagnostics and (18) F-fluorodeoxyglucose (FDG) positron emission tomography (PET)-computerised tomography (CT)...
  21. doi request reprint Prophylactic intravenous immunoglobulin during autologous haemopoietic stem cell transplantation for multiple myeloma is not associated with reduced infectious complications
    Piers Blombery
    Division of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, Melbourne, Victoria, Australia
    Ann Hematol 90:1167-72. 2011
    ..4 g/kg) to reduce infectious complications in a large cohort of patients with myeloma undergoing ASCT. In the absence of data supporting efficacy in this context, there appears to be no benefit in the routine use of IVIG for this purpose...
  22. pmc Oseltamivir resistance in adult oncology and hematology patients infected with pandemic (H1N1) 2009 virus, Australia
    Adrian R Tramontana
    Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    Emerg Infect Dis 16:1068-75. 2010
    ..Oseltamivir resistance in 4 (13.3%) of 30 patients who were administered oseltamivir highlights the need for ongoing surveillance of such resistance and further research on optimal antiviral therapy in the immunocompromised...
  23. doi request reprint The disease and economic burden of neutropenic fever in adult patients in Australian cancer treatment centres 2008: analysis of the Victorian Admitted Episodes Dataset
    S Lingaratnam
    Pharmacy Department, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Intern Med J 41:121-9. 2011
    ..Although the incidence of neutropenic fever (FN) is estimated to be up to 80% for some malignancies, the epidemiological characteristics and economic burden are not well understood for Australian patients...
  24. doi request reprint Changing treatment paradigms for patients with plasma cell myeloma: impact upon immune determinants of infection
    Benjamin W Teh
    Department of Infectious Diseases, Peter MacCallum Cancer Centre, East Melbourne, Australia
    Blood Rev 28:75-86. 2014
    ..Preventative measures and the need for clinically relevant tools to enable infective profiling of patients with PCM are discussed. ..
  25. ncbi request reprint Molecular diagnosis of Pneumocystis jirovecii in patients with malignancy: clinical significance of quantitative polymerase chain reaction
    Benjamin W Teh
    Department of Infectious Diseases, Peter MacCallum Cancer Centre, East Melbourne
    Med Mycol 52:427-32. 2014
    ..In the era of routine molecular diagnostics, patients with malignancy and PJP have improved outcomes. However, there was no demonstrable relationship between qPCR results and clinical features or PCR data and outcomes...
  26. doi request reprint Pneumocystis jirovecii pneumonia in non-HIV-infected patients: new risks and diagnostic tools
    Alistair B Reid
    Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
    Curr Opin Infect Dis 24:534-44. 2011
    ..These patients typically present with severe disease and poorly tolerate invasive diagnostic procedures. This review examines recently reported risks for PJP in non-HIV populations and summarizes new diagnostic techniques...
  27. doi request reprint Thrombolytic therapy for management of complicated catheter-related Candida albicans thrombophlebitis
    A A Block
    Department of Infectious Diseases, Dandenong Hospital, David Street, Dandenong, Victoria 3175, Australia
    Intern Med J 39:61-3. 2009
    ..As an adjunct to antifungal therapy, local thrombolysis may play a contributory role in the management of central venous catheter-related candidal septic thrombosis...