Ilia Voskoboinik

Summary

Affiliation: Peter MacCallum Cancer Centre
Country: Australia

Publications

  1. ncbi request reprint Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491
    Ilia Voskoboinik
    Cancer Immunology Program, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St 8006 and The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Biol Chem 280:8426-34. 2005
  2. doi request reprint The molecular basis for perforin oligomerization and transmembrane pore assembly
    Katherine Baran
    Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrew s Place, East Melbourne, Victoria 3002, Australia
    Immunity 30:684-95. 2009
  3. pmc Molecular study of the perforin gene in familial hematological malignancies
    Rim El Abed
    Département d oncologie génétique, de Prévention et Dépistage, Institut Paoli Calmettes, 232 Boulevard Sainte Marguerite, Marseille, 13009, France
    Hered Cancer Clin Pract 9:9. 2011
  4. ncbi request reprint A functional analysis of the putative polymorphisms A91V and N252S and 22 missense perforin mutations associated with familial hemophagocytic lymphohistiocytosis
    Ilia Voskoboinik
    Cancer Immunology Program, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St, Melbourne, VIC 8006, Australia
    Blood 105:4700-6. 2005
  5. ncbi request reprint Addressing the mysteries of perforin function
    Ilia Voskoboinik
    Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
    Immunol Cell Biol 84:66-71. 2006
  6. ncbi request reprint Perforin-mediated target-cell death and immune homeostasis
    Ilia Voskoboinik
    Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrew s Place, East Melbourne, Victoria 3002, Australia
    Nat Rev Immunol 6:940-52. 2006
  7. ncbi request reprint Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function
    Ilia Voskoboinik
    Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Australia
    Blood 110:1184-90. 2007
  8. ncbi request reprint Perforin: structure, function, and role in human immunopathology
    Ilia Voskoboinik
    Cancer Cell Death Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC 8006, Australia
    Immunol Rev 235:35-54. 2010
  9. doi request reprint Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack
    Jamie A Lopez
    Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Vic, Australia
    Blood 121:2659-68. 2013
  10. doi request reprint Fatal immune dysregulation due to a gain of glycosylation mutation in lymphocyte perforin
    Jenny Chia
    Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Vic, Australia
    Blood 119:1713-6. 2012

Collaborators

  • Joseph A Trapani
  • James C Whisstock
  • M J Smyth
  • Phillip I Bird
  • Hideo Yagita
  • Michael E D'Angelo
  • Stuart I Mannering
  • Elena V Orlova
  • Amelia J Brennan
  • Nigel J Waterhouse
  • Sabine Hoves
  • J F Mercer
  • MICHAEL PETRIS
  • Misty R Jenkins
  • Jamie A Lopez
  • Jenny Chia
  • Katherine Baran
  • Ruby H P Law
  • Natalya Lukoyanova
  • Vivien R Sutton
  • Michelle A Dunstone
  • Kylie A Browne
  • Helen R Saibil
  • Rim El Abed
  • Catherina H Bird
  • Annette Ciccone
  • Paul Bolitho
  • Carlos J Rosado
  • Jillian C Danne
  • Olivia Susanto
  • Angus Johnston
  • Jesse A Rudd-Schmidt
  • Bronwyn Williams
  • Margaret Little
  • Kevin Thia
  • Monia Zaier
  • Violaine Bourdon
  • Zohra Soua
  • Catherine Dugast
  • Francois Eisinger
  • Halima Omri
  • Testsuro Noguchi
  • Hagay Sobol
  • Helene Zattara
  • Liliane Demange
  • Marc Frenay
  • Laetitia Rabayrol
  • Paul Gesta
  • Mohamed Adnène Laatiri
  • Saloua Yacoub Jemni
  • Helene Dreyfus
  • Laetitia Huiart
  • Laurence Faivre
  • Yosra Ben Youssef
  • Valerie Bonadona
  • Tom T Caradoc-Davies
  • Fasseli Coulibaly
  • Sandra Verschoor
  • Michael J Kuiper
  • Christopher J P Clarke
  • Helen Saibil
  • Kim Pin Yeo
  • Michelle Dunstone
  • Kylie Browne
  • Wilson Wong
  • Jonas Emsley
  • Wan Ting Kan
  • A Ian Smith
  • Corrine J Porter
  • Tanya A Bashtannyk-Puhalovich
  • Kheng Ung
  • Rebecca E Butcher
  • Elizabeth L Hartland
  • Stephen P Bottomley
  • Jamie Rossjohn
  • Mary C Pearce
  • Andrew M Ellisdon
  • Noel G Faux
  • Robert N Pike
  • Ashley M Buckle

Detail Information

Publications26

  1. ncbi request reprint Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491
    Ilia Voskoboinik
    Cancer Immunology Program, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St 8006 and The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Biol Chem 280:8426-34. 2005
    ..Finally, after experimentally verifying an optimized three-dimensional model, we have made predictions on the impact of two inherited perforin mutations of the C2 domain on calcium-dependent lipid binding and cell lysis...
  2. doi request reprint The molecular basis for perforin oligomerization and transmembrane pore assembly
    Katherine Baran
    Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrew s Place, East Melbourne, Victoria 3002, Australia
    Immunity 30:684-95. 2009
    ..Our study provides important insights into perforin's mechanism of action...
  3. pmc Molecular study of the perforin gene in familial hematological malignancies
    Rim El Abed
    Département d oncologie génétique, de Prévention et Dépistage, Institut Paoli Calmettes, 232 Boulevard Sainte Marguerite, Marseille, 13009, France
    Hered Cancer Clin Pract 9:9. 2011
    ..However, overexpression of mutated PRF1 in rat basophilic leukemia cells did not affect the lytic function of perforin differently from the wild type protein...
  4. ncbi request reprint A functional analysis of the putative polymorphisms A91V and N252S and 22 missense perforin mutations associated with familial hemophagocytic lymphohistiocytosis
    Ilia Voskoboinik
    Cancer Immunology Program, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St, Melbourne, VIC 8006, Australia
    Blood 105:4700-6. 2005
    ..This report represents the first systematic functional analysis of HLH-associated missense mutations and the 2 most common perforin polymorphisms...
  5. ncbi request reprint Addressing the mysteries of perforin function
    Ilia Voskoboinik
    Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
    Immunol Cell Biol 84:66-71. 2006
    ..This article addresses recent key advances in genetic, clinical and biochemical studies that have reignited the current interest in perforin biology...
  6. ncbi request reprint Perforin-mediated target-cell death and immune homeostasis
    Ilia Voskoboinik
    Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrew s Place, East Melbourne, Victoria 3002, Australia
    Nat Rev Immunol 6:940-52. 2006
    ..This Review describes recent progress in defining the structure, function, biochemistry and cell biology of perforin...
  7. ncbi request reprint Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function
    Ilia Voskoboinik
    Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Australia
    Blood 110:1184-90. 2007
    ..These findings provide the first direct evidence that hPRF-A91V is functionally abnormal and provides a rationale for why it may be responsible for disordered immune homeostasis if inherited with another dysfunctional perforin allele...
  8. ncbi request reprint Perforin: structure, function, and role in human immunopathology
    Ilia Voskoboinik
    Cancer Cell Death Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC 8006, Australia
    Immunol Rev 235:35-54. 2010
    ..In this review, we discuss the current state of affairs in the perforin field: the protein's structure and function as well as its role in immune-mediated diseases...
  9. doi request reprint Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack
    Jamie A Lopez
    Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Vic, Australia
    Blood 121:2659-68. 2013
    ..This study defines the final sequence of events controlling cytotoxic lymphocyte immune defense, in which perforin pores assemble on the target cell plasma membrane, ensuring efficient delivery of lethal granzymes...
  10. doi request reprint Fatal immune dysregulation due to a gain of glycosylation mutation in lymphocyte perforin
    Jenny Chia
    Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Vic, Australia
    Blood 119:1713-6. 2012
    ..Our data provide a rationale for treating some cases of type 2 familial hemophagocytic lymphohistiocytosis, based on the pharmacologic inhibition or modification of glycosylation...
  11. doi request reprint Protection from endogenous perforin: glycans and the C terminus regulate exocytic trafficking in cytotoxic lymphocytes
    Amelia J Brennan
    Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, 3002, Australia
    Immunity 34:879-92. 2011
    ..Overall, an intact C terminus and N-linked glycosylation provide accurate and efficient export of perforin from the endoplasmic reticulum to the secretory granules and are critical for cytotoxic lymphocyte survival...
  12. pmc The functional basis for hemophagocytic lymphohistiocytosis in a patient with co-inherited missense mutations in the perforin (PFN1) gene
    Ilia Voskoboinik
    Cancer Immunology Program, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St, 8006, Australia
    J Exp Med 200:811-6. 2004
    ..This study elucidates the cellular basis for perforin dysfunctions in hemophagocytic lymphohistiocytosis and provides the means for studying structure-function relationships for lymphocyte perforin...
  13. doi request reprint Protecting a serial killer: pathways for perforin trafficking and self-defence ensure sequential target cell death
    Jamie A Lopez
    Peter MacCallum Cancer Centre, East Melbourne, 3002, Victoria, Australia
    Trends Immunol 33:406-12. 2012
    ....
  14. doi request reprint The structural basis for membrane binding and pore formation by lymphocyte perforin
    Ruby H P Law
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Melbourne, Victoria 3800, Australia
    Nature 468:447-51. 2010
    ..These data reveal remarkable flexibility in the mechanism of action of the conserved MACPF/CDC fold and provide new insights into how related immune defence molecules such as complement proteins assemble into pores...
  15. pmc Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer
    Jenny Chia
    Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrew s Place, East Melbourne, Victoria 3002, Australia
    Proc Natl Acad Sci U S A 106:9809-14. 2009
    ....
  16. doi request reprint Measuring cell death mediated by cytotoxic lymphocytes or their granule effector molecules
    Vivien R Sutton
    Cancer Cell Death Laboratory, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, Melbourne, VIC 8006, Australia
    Methods 44:241-9. 2008
    ..As cell death mediated through TNF-superfamily members and their respective receptors is covered elsewhere, this manuscript will deal specifically with cytotoxic granule-mediated cell death...
  17. ncbi request reprint Infective, neoplastic, and homeostatic sequelae of the loss of perforin function in humans
    Joseph A Trapani
    Peter MacCallum Cancer Centre, St Andrew s Place, East Melbourne, Australia
    Adv Exp Med Biol 601:235-42. 2007
    ..This chapter discusses the significance of human perforin polymorphisms, particularly those associated with diseases other than FHL, and recent advances in our understanding of perforin biology and function...
  18. doi request reprint Rapid and unidirectional perforin pore delivery at the cytotoxic immune synapse
    Jamie A Lopez
    Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    J Immunol 191:2328-34. 2013
    ..Our results highlight the remarkable efficiency and specificity of perforin pore delivery by CLs. ..
  19. ncbi request reprint Apoptosis induced by the lymphocyte effector molecule perforin
    Paul Bolitho
    Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrew s Place, East Melbourne, Victoria, Australia
    Curr Opin Immunol 19:339-47. 2007
    ..This clinical picture has prompted further work to uncover the molecular structure of perforin and to define its precise role in immune regulation and immunopathology...
  20. doi request reprint The battlefield of perforin/granzyme cell death pathways
    Sabine Hoves
    Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    J Leukoc Biol 87:237-43. 2010
    ..Mechanistic aspects of the synergy and apoptotic mechanisms are still not fully understood, and the current review will address some of the hotly debated controversies in the field...
  21. doi request reprint Deciphering the syntax of cytotoxic lymphocyte degranulation
    Jamie A Lopez
    Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Australia
    Eur J Immunol 43:46-9. 2013
    ....
  22. ncbi request reprint The complex issue of regulating perforin expression
    Joseph A Trapani
    Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrew s Place, East Melbourne, 3002, Australia
    Trends Immunol 28:243-5. 2007
    ....
  23. ncbi request reprint A common fold mediates vertebrate defense and bacterial attack
    Carlos J Rosado
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia
    Science 317:1548-51. 2007
    ..Sequence similarity between bacterial and vertebrate MACPF domains suggests that the fold of the CDCs, a family of proteins important for bacterial pathogenesis, is probably used by vertebrates for defense against infection...
  24. ncbi request reprint Understanding the mechanism and function of copper P-type ATPases
    Ilia Voskoboinik
    Department of Genetics, University of Melbourne, Parkville, Victoria 3010, Australia
    Adv Protein Chem 60:123-50. 2002
  25. ncbi request reprint Copper-regulated trafficking of the Menkes disease copper ATPase is associated with formation of a phosphorylated catalytic intermediate
    Michael J Petris
    Department of Nutritional Sciences, University of Missouri, Columbia, Missouri 65211, USA
    J Biol Chem 277:46736-42. 2002
    ..Our findings describe a novel mechanism for regulating the subcellular location of a transport protein involving the recognition of intermediate conformations during catalysis...