Wayne A Phillips
Affiliation: Peter MacCallum Cancer Centre
Kinross K, Montgomery K, Mangiafico S, Hare L, Kleinschmidt M, Bywater M, et al
. Ubiquitous expression of the Pik3caH1047R mutation promotes hypoglycemia, hypoinsulinemia, and organomegaly. FASEB J. 2015;29:1426-34 pubmed publisher
..This mouse model demonstrates the critical role of PI3K in the regulation of both organ size and glucose metabolism at the whole animal level. ..
Read M, Liu D, Duong C, Cullinane C, Murray W, Fennell C, et al
. Intramuscular Transplantation Improves Engraftment Rates for Esophageal Patient-Derived Tumor Xenografts. Ann Surg Oncol. 2016;23:305-11 pubmed publisher
..It is hoped that this advancement will help expedite the development and testing of new therapies for esophageal cancer. ..
Layton M, Rynkiewicz N, Ivetac I, Horan K, Mitchell C, Phillips W. Assessing the subcellular distribution of oncogenic phosphoinositide 3-kinase using microinjection into live cells. Biosci Rep. 2014;34: pubmed
Phillips W, Russell S, Ciavarella M, Choong D, Montgomery K, Smith K, et al
. Mutation analysis of PIK3CA and PIK3CB in esophageal cancer and Barrett's esophagus. Int J Cancer. 2006;118:2644-6 pubmed
Phillips W, Lord R, Nancarrow D, Watson D, Whiteman D. Barrett's esophagus. J Gastroenterol Hepatol. 2011;26:639-48 pubmed publisher
..Although known to arise as a consequence of chronic gastroesophageal reflux, the cellular and molecular mechanisms underlying development Barrett's esophagus and its progression to cancer remain unclear...
Hare L, Schwarz Q, Wiszniak S, Gurung R, Montgomery K, Mitchell C, et al
. Heterozygous expression of the oncogenic Pik3ca(H1047R) mutation during murine development results in fatal embryonic and extraembryonic defects. Dev Biol. 2015;404:14-26 pubmed publisher
..Our results confirm the lethality associated with heterozygous expression of the Pik3ca(H1047R) mutation during development and likely explain the lack of inherited germline PIK3CA mutations in humans. ..
To H, Clemons N, Duong C, Trainer A, Phillips W. The Genetics of Barrett's Esophagus: A Familial and Population-Based Perspective. Dig Dis Sci. 2016;61:1826-34 pubmed publisher
..Here we review the current evidence for a genetic predisposition to BE and discuss the potential implications of these findings. ..