Patrick O Humbert

Summary

Affiliation: Peter MacCallum Cancer Centre
Country: Australia

Publications

  1. ncbi hScrib is a functional homologue of the Drosophila tumour suppressor Scribble
    Lukas E Dow
    Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, St Andrew s Place, East Melbourne, Victoria 3002, Australia
    Oncogene 22:9225-30. 2003
  2. ncbi The Scribble and Par complexes in polarity and migration: friends or foes?
    Patrick O Humbert
    Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC 3002, Australia
    Trends Cell Biol 16:622-30. 2006
  3. ncbi Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module
    P O Humbert
    Cell Cycle and Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia
    Oncogene 27:6888-907. 2008
  4. ncbi SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia
    Helen B Pearson
    Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    J Clin Invest 121:4257-67. 2011
  5. ncbi Polarity regulators and the control of epithelial architecture, cell migration, and tumorigenesis
    Lukas E Dow
    Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Center, Melbourne, Australia
    Int Rev Cytol 262:253-302. 2007
  6. ncbi The Scribble-Dlg-Lgl polarity module in development and cancer: from flies to man
    Imogen Elsum
    Cell Cycle and Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia
    Essays Biochem 53:141-68. 2012
  7. ncbi Asymmetric cell division of T cells upon antigen presentation uses multiple conserved mechanisms
    Jane Oliaro
    Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Australia
    J Immunol 185:367-75. 2010
  8. ncbi Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF/Rho-family/JNK pathway is a central driver of tumorigenesis
    Anthony M Brumby
    Peter MacCallum Cancer Center, Melbourne, Victoria, Australia
    Genetics 188:105-25. 2011
  9. ncbi Cell polarity in motion: redefining mammary tissue organization through EMT and cell polarity transitions
    Nathan J Godde
    Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Center, East Melbourne, VIC 3002, Australia
    J Mammary Gland Biol Neoplasia 15:149-68. 2010
  10. ncbi Transcriptional output of the Salvador/warts/hippo pathway is controlled in distinct fashions in Drosophila melanogaster and mammalian cell lines
    Xiaomeng Zhang
    Cell Growth and Proliferation Laboratory and Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Cancer Res 69:6033-41. 2009

Collaborators

Detail Information

Publications12

  1. ncbi hScrib is a functional homologue of the Drosophila tumour suppressor Scribble
    Lukas E Dow
    Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, St Andrew s Place, East Melbourne, Victoria 3002, Australia
    Oncogene 22:9225-30. 2003
    ..These data demonstrate that hScrib is a functional homologue of DmScrib and therefore predict an important role for hScrib in the suppression of mammalian tumorigenesis...
  2. ncbi The Scribble and Par complexes in polarity and migration: friends or foes?
    Patrick O Humbert
    Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC 3002, Australia
    Trends Cell Biol 16:622-30. 2006
    ..Based on the known interactions of Scribble and Par complexes with each other and with other signalling pathways, we propose models by which Par and Scribble might interact to regulate cell migration...
  3. ncbi Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module
    P O Humbert
    Cell Cycle and Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia
    Oncogene 27:6888-907. 2008
    ..We review the evidence for the involvement of Scribble, Dlg, and Lgl in cancer, and how the various functions ascribed to these tumour suppressors in Drosophila and mammalian systems may impact on the process of tumourigenesis...
  4. ncbi SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia
    Helen B Pearson
    Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    J Clin Invest 121:4257-67. 2011
    ..These data suggest that the polarity network could provide a new avenue for therapeutic intervention...
  5. ncbi Polarity regulators and the control of epithelial architecture, cell migration, and tumorigenesis
    Lukas E Dow
    Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Center, Melbourne, Australia
    Int Rev Cytol 262:253-302. 2007
    ..Particular reference will be made as to how the Scribble and Par polarity complexes may be involved in the regulation of apical-basal polarity, migration, and tumorigenesis...
  6. ncbi The Scribble-Dlg-Lgl polarity module in development and cancer: from flies to man
    Imogen Elsum
    Cell Cycle and Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia
    Essays Biochem 53:141-68. 2012
    ..In addition to these physiological roles, an important role for polarity proteins in cancer progression has also been uncovered, with loss of polarity and tissue architecture being strongly correlated with metastatic disease...
  7. ncbi Asymmetric cell division of T cells upon antigen presentation uses multiple conserved mechanisms
    Jane Oliaro
    Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Australia
    J Immunol 185:367-75. 2010
    ..These findings suggest that T cells have selectively adapted a number of evolutionarily conserved mechanisms to generate diversity through asymmetric cell division...
  8. ncbi Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF/Rho-family/JNK pathway is a central driver of tumorigenesis
    Anthony M Brumby
    Peter MacCallum Cancer Center, Melbourne, Victoria, Australia
    Genetics 188:105-25. 2011
    ..Collectively our analysis reveals the importance of the RhoGEF/Rho-family/JNK pathway in cooperative tumorigenesis with Ras(ACT)...
  9. ncbi Cell polarity in motion: redefining mammary tissue organization through EMT and cell polarity transitions
    Nathan J Godde
    Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Center, East Melbourne, VIC 3002, Australia
    J Mammary Gland Biol Neoplasia 15:149-68. 2010
    ....
  10. ncbi Transcriptional output of the Salvador/warts/hippo pathway is controlled in distinct fashions in Drosophila melanogaster and mammalian cell lines
    Xiaomeng Zhang
    Cell Growth and Proliferation Laboratory and Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Cancer Res 69:6033-41. 2009
    ..melanogaster and optimally activate Sd. This shows that Yki/YAP WW domains have distinct regulatory roles in different cell types and implies the existence of proteins that promote tissue growth in collaboration with Yki and Sd...
  11. ncbi A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation
    Mandy J Ludford-Menting
    Immune Signalling Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    Immunity 22:737-48. 2005
    ..By dynamically coordinating molecular distribution throughout the T cell, this network provides a mechanism by which T cell function and polarity are linked...
  12. ncbi New tricks for old dogs: unexpected roles for cell cycle regulators revealed using animal models
    Patrick O Humbert
    Cell Cycle and Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, East Melbourne, Australia
    Curr Opin Cell Biol 16:614-22. 2004
    ..Moreover, checkpoint regulators, which are not essential for viability in yeast and cultured cells, play important roles in cell cycle control during development...