Kieran Harvey

Summary

Affiliation: Peter MacCallum Cancer Centre
Country: Australia

Publications

  1. doi The Hippo pathway and human cancer
    Kieran F Harvey
    Peter MacCallum Cancer Centre, 7 St Andrews Place, East Melbourne, Victoria 3002, Australia
    Nat Rev Cancer 13:246-57. 2013
  2. pmc Bunched and Madm: a novel growth-regulatory complex?
    Kieran F Harvey
    Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, 7 St Andrews Place, East Melbourne, Victoria 3002, Australia
    J Biol 9:8. 2010
  3. ncbi The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network
    Kieran Harvey
    Peter MacCallum Cancer Centre, St Andrew s Place, East Melbourne, Victoria 3002 Australia
    Nat Rev Cancer 7:182-91. 2007
  4. pmc FOXO-regulated transcription restricts overgrowth of Tsc mutant organs
    Kieran F Harvey
    Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    J Cell Biol 180:691-6. 2008
  5. doi Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms
    Nicola A Grzeschik
    Cell Cycle and Development, Peter MacCallum Cancer Centre, Victoria, Australia
    Curr Biol 20:573-81. 2010
  6. doi Differential requirement of Salvador-Warts-Hippo pathway members for organ size control in Drosophila melanogaster
    Claire C Milton
    Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    Development 137:735-43. 2010
  7. doi Transcriptional output of the Salvador/warts/hippo pathway is controlled in distinct fashions in Drosophila melanogaster and mammalian cell lines
    Xiaomeng Zhang
    Cell Growth and Proliferation Laboratory and Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Cancer Res 69:6033-41. 2009
  8. ncbi Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway
    F Christian Bennett
    Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    Curr Biol 16:2101-10. 2006
  9. doi Upstream regulation of the hippo size control pathway
    Felix A Grusche
    Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Curr Biol 20:R574-82. 2010
  10. pmc The Drosophila melanogaster Apaf-1 homologue ARK is required for most, but not all, programmed cell death
    Kathryn Mills
    Hanson Institute, Institute of Medical and Veterinary Science, Adelaide, Australia 5000
    J Cell Biol 172:809-15. 2006

Collaborators

Detail Information

Publications12

  1. doi The Hippo pathway and human cancer
    Kieran F Harvey
    Peter MacCallum Cancer Centre, 7 St Andrews Place, East Melbourne, Victoria 3002, Australia
    Nat Rev Cancer 13:246-57. 2013
    ....
  2. pmc Bunched and Madm: a novel growth-regulatory complex?
    Kieran F Harvey
    Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, 7 St Andrews Place, East Melbourne, Victoria 3002, Australia
    J Biol 9:8. 2010
    ..Future study of this complex will address the precise mechanism of growth control, regulation of complex activity, the interface with other growth pathways and a potential role in human cancer...
  3. ncbi The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network
    Kieran Harvey
    Peter MacCallum Cancer Centre, St Andrew s Place, East Melbourne, Victoria 3002 Australia
    Nat Rev Cancer 7:182-91. 2007
    ..Here, we review the main findings from Drosophila and the implications that these have for tumorigenesis in mammals...
  4. pmc FOXO-regulated transcription restricts overgrowth of Tsc mutant organs
    Kieran F Harvey
    Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    J Cell Biol 180:691-6. 2008
    ..Analogous transcriptional changes are observed in mammalian cells, which implies that FOXO attenuates TOR-driven growth in diverse species...
  5. doi Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms
    Nicola A Grzeschik
    Cell Cycle and Development, Peter MacCallum Cancer Centre, Victoria, Australia
    Curr Biol 20:573-81. 2010
    ..Here we investigate how these cell polarity regulators control proliferation and survival...
  6. doi Differential requirement of Salvador-Warts-Hippo pathway members for organ size control in Drosophila melanogaster
    Claire C Milton
    Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    Development 137:735-43. 2010
    ..This study highlights the complexity employed by different SWH pathway proteins to control organ size at different stages of development...
  7. doi Transcriptional output of the Salvador/warts/hippo pathway is controlled in distinct fashions in Drosophila melanogaster and mammalian cell lines
    Xiaomeng Zhang
    Cell Growth and Proliferation Laboratory and Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Cancer Res 69:6033-41. 2009
    ..melanogaster and optimally activate Sd. This shows that Yki/YAP WW domains have distinct regulatory roles in different cell types and implies the existence of proteins that promote tissue growth in collaboration with Yki and Sd...
  8. ncbi Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway
    F Christian Bennett
    Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    Curr Biol 16:2101-10. 2006
    ..A newly emerging signaling pathway that controls organ size during development is the Salvador/Warts/Hippo pathway...
  9. doi Upstream regulation of the hippo size control pathway
    Felix A Grusche
    Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Curr Biol 20:R574-82. 2010
    ..Here, we review the existing knowledge of upstream SWH pathway proteins and discuss possible mechanisms of action and signal integration...
  10. pmc The Drosophila melanogaster Apaf-1 homologue ARK is required for most, but not all, programmed cell death
    Kathryn Mills
    Hanson Institute, Institute of Medical and Veterinary Science, Adelaide, Australia 5000
    J Cell Biol 172:809-15. 2006
    ..During metamorphosis, larval salivary gland removal was severely delayed in ark mutants. However, PCD occurred normally in the larval midgut, suggesting that ARK-independent cell death pathways also exist in D. melanogaster...
  11. ncbi The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis
    Kieran F Harvey
    Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, MA 02129, USA
    Cell 114:457-67. 2003
    ..Hpo, Sav, and Wts interact physically and functionally, and regulate DIAP1 levels, likely by Hpo-mediated phosphorylation and subsequent degradation. Thus, Hpo links Sav and Wts to a key regulator of apoptosis...
  12. ncbi salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines
    Nicolas Tapon
    Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown 02129, USA
    Cell 110:467-78. 2002
    ..The human ortholog of salvador (hWW45) is mutated in three cancer cell lines. Thus, salvador restricts cell numbers in vivo by functioning as a dual regulator of cell proliferation and apoptosis...