Kieran Harvey

Summary

Affiliation: Peter MacCallum Cancer Centre
Country: Australia

Publications

  1. Vissers J, Froldi F, Schröder J, Papenfuss A, Cheng L, Harvey K. The Scalloped and Nerfin-1 Transcription Factors Cooperate to Maintain Neuronal Cell Fate. Cell Rep. 2018;25:1561-1576.e7 pubmed publisher
    ..Our data indicate that this transcription factor pair exhibits remarkable biochemical and functional conservation across metazoans. ..
  2. Poon C, Liu W, Song Y, Gomez M, Kulaberoglu Y, Zhang X, et al. A Hippo-like Signaling Pathway Controls Tracheal Morphogenesis in Drosophila melanogaster. Dev Cell. 2018;47:564-575.e5 pubmed publisher
    ..The Hippo-like signaling pathway we have delineated has a potential role in the human vascular disease cerebral cavernous malformation. ..
  3. Harvey K. Growth control: re-examining Zyxin's role in the hippo pathway. Curr Biol. 2015;25:R230-R231 pubmed publisher
    ..A new study examines the role of the Hippo pathway protein Zyxin and finds that it antagonises Expanded to modulate F-actin and organ size. ..
  4. Manning S, Dent L, Kondo S, Zhao Z, Plachta N, Harvey K. Dynamic Fluctuations in Subcellular Localization of the Hippo Pathway Effector Yorkie In Vivo. Curr Biol. 2018;28:1651-1660.e4 pubmed publisher
    ..Yorkie's association with mitotic chromatin is Scalloped dependent, suggesting a potential role in mitotic bookmarking. ..
  5. Harvey K, Zhang X, Thomas D. The Hippo pathway and human cancer. Nat Rev Cancer. 2013;13:246-57 pubmed publisher
  6. Manning S, Harvey K. Warts Opens Up for Activation. Dev Cell. 2015;35:666-8 pubmed publisher
    ..In this issue of Developmental Cell, by assessing Warts conformation in vivo, Vrabioiu and Struhl (2015) report that the Mob family protein Mats regulates Warts activity allosterically, independent of phosphorylation by Hippo. ..
  7. Poon C, Mitchell K, Kondo S, Cheng L, Harvey K. The Hippo Pathway Regulates Neuroblasts and Brain Size in Drosophila melanogaster. Curr Biol. 2016;26:1034-42 pubmed publisher
    ..These studies reveal a novel mechanism that controls stem cell proliferative potential during postembryonic neurogenesis to regulate brain size. ..
  8. Harvey K, Mattila J, Sofer A, Bennett F, Ramsey M, Ellisen L, et al. FOXO-regulated transcription restricts overgrowth of Tsc mutant organs. J Cell Biol. 2008;180:691-6 pubmed publisher
    ..Analogous transcriptional changes are observed in mammalian cells, which implies that FOXO attenuates TOR-driven growth in diverse species. ..
  9. Milton C, Grusche F, Degoutin J, Yu E, Dai Q, Lai E, et al. The Hippo pathway regulates hematopoiesis in Drosophila melanogaster. Curr Biol. 2014;24:2673-80 pubmed publisher
    ..Further, Yorkie or Scalloped hyperactivation induced ectopic crystal cells in a non-cell-autonomous and Notch-pathway-dependent fashion. ..

More Information

Publications11

  1. Dent L, Poon C, Zhang X, Degoutin J, Tipping M, Veraksa A, et al. The GTPase regulatory proteins Pix and Git control tissue growth via the Hippo pathway. Curr Biol. 2015;25:124-30 pubmed publisher
    ..Therefore, we provide important new insights into an ancient signaling network that controls the growth of metazoan tissues. ..
  2. Gebhardt T, Harvey K. Hippo Wades into Cancer Immunology. Dev Cell. 2016;39:635-637 pubmed publisher
    ..This could explain the rarity of pathway mutations in cancers and suggests Hippo pathway repression as a cancer immunotherapy modality. ..