Hongdo Do

Summary

Affiliation: Peter MacCallum Cancer Centre
Country: Australia

Publications

  1. pmc Limited copy number-high resolution melting (LCN-HRM) enables the detection and identification by sequencing of low level mutations in cancer biopsies
    Hongdo Do
    Department of Pathology, University of Melbourne, Parkville, Victoria, 3010, Australia
    Mol Cancer 8:82. 2009
  2. pmc Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil- DNA glycosylase
    Hongdo Do
    Molecular Pathology Research and Development Laboratory, Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
    Oncotarget 3:546-58. 2012
  3. pmc HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer
    Leonard Da Silva
    Molecular and Cellular Pathology, The University of Queensland Centre for Clinical Research, and School of Medicine, Building 918 B71, RBWH complex, Brisbane, 4029, Australia
    Breast Cancer Res 12:R46. 2010
  4. pmc High resolution melting analysis for rapid and sensitive EGFR and KRAS mutation detection in formalin fixed paraffin embedded biopsies
    Hongdo Do
    Molecular Pathology Research and Development Laboratory, Department of Pathology, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St, Melbourne, Victoria 8006, Australia
    BMC Cancer 8:142. 2008
  5. pmc Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting
    Hongdo Do
    Department of Pathology, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St, Melbourne, Victoria, 8006, Australia
    BMC Res Notes 1:14. 2008
  6. pmc Integrated mutation, copy number and expression profiling in resectable non-small cell lung cancer
    Genni M Newnham
    Department of Oncology, St Vincent s Hospital, Victoria Pde, Melbourne, 3065, Australia
    BMC Cancer 11:93. 2011
  7. doi request reprint Reducing sequence artifacts in amplicon-based massively parallel sequencing of formalin-fixed paraffin-embedded DNA by enzymatic depletion of uracil-containing templates
    Hongdo Do
    Molecular Pathology Research and Development Laboratory, Department of Pathology, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Clin Chem 59:1376-83. 2013
  8. doi request reprint DNA methylation biomarkers in cancer: progress towards clinical implementation
    Thomas Mikeska
    Molecular Pathology Research and Development Laboratory, Department of Pathology, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, Melbourne, Victoria 8006, Australia
    Expert Rev Mol Diagn 12:473-87. 2012

Collaborators

  • Alexander Dobrovic
  • Paul L Mitchell
  • Stephen B Fox
  • Christoph Bock
  • Thomas Mikeska
  • Matthew Conron
  • Michael Krypuy
  • Genni M Newnham
  • Leonard Da Silva
  • Natalie Thompson
  • Jason Li
  • Kenneth Opeskin
  • Gavin M Wright
  • SueAnne McLachlan
  • David M Thomas
  • Chanel E Smart
  • BRENT REYNOLDS
  • Margaret Cummings
  • Sunil R Lakhani
  • Brian J Morrison
  • Emilio Pereira
  • Nic Waddell
  • Marcello Franco
  • Alena Skalova
  • Sue Healey
  • Rosemary L Balleine
  • Annette Lane
  • Pria Pakkiri
  • Patricia Keith
  • Nyoman Kurniawan
  • Sibylle Cocciardi
  • Lynne Reid
  • Jonathan Beesley
  • Suzanne Parry
  • Georgia Chenevix-Trench
  • Michael Bilous
  • Peter T Simpson
  • Kum Kum Khanna
  • Paulo Faria
  • Ana Cristina Vargas

Detail Information

Publications8

  1. pmc Limited copy number-high resolution melting (LCN-HRM) enables the detection and identification by sequencing of low level mutations in cancer biopsies
    Hongdo Do
    Department of Pathology, University of Melbourne, Parkville, Victoria, 3010, Australia
    Mol Cancer 8:82. 2009
    ..The dilutions used (based on Ct values) are chosen such that mutations, if present, can be detected by the direct sequencing of amplicons with aberrant melting patterns...
  2. pmc Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil- DNA glycosylase
    Hongdo Do
    Molecular Pathology Research and Development Laboratory, Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
    Oncotarget 3:546-58. 2012
    ....
  3. pmc HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer
    Leonard Da Silva
    Molecular and Cellular Pathology, The University of Queensland Centre for Clinical Research, and School of Medicine, Building 918 B71, RBWH complex, Brisbane, 4029, Australia
    Breast Cancer Res 12:R46. 2010
    ..Metastases to the brain from breast cancer have a high mortality, and basal-like breast cancers have a propensity for brain metastases. However, the mechanisms that allow cells to colonize the brain are unclear...
  4. pmc High resolution melting analysis for rapid and sensitive EGFR and KRAS mutation detection in formalin fixed paraffin embedded biopsies
    Hongdo Do
    Molecular Pathology Research and Development Laboratory, Department of Pathology, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St, Melbourne, Victoria 8006, Australia
    BMC Cancer 8:142. 2008
    ..However, up to now it has not been fully validated for clinical samples when formalin-fixed paraffin-embedded (FFPE) sections are the only material available for analysis as is often the case...
  5. pmc Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting
    Hongdo Do
    Department of Pathology, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St, Melbourne, Victoria, 8006, Australia
    BMC Res Notes 1:14. 2008
    ..HRM represents a rapid cost-effective and robust screening of low frequency mutations such as AKT1 mutations in clinical samples...
  6. pmc Integrated mutation, copy number and expression profiling in resectable non-small cell lung cancer
    Genni M Newnham
    Department of Oncology, St Vincent s Hospital, Victoria Pde, Melbourne, 3065, Australia
    BMC Cancer 11:93. 2011
    ....
  7. doi request reprint Reducing sequence artifacts in amplicon-based massively parallel sequencing of formalin-fixed paraffin-embedded DNA by enzymatic depletion of uracil-containing templates
    Hongdo Do
    Molecular Pathology Research and Development Laboratory, Department of Pathology, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Clin Chem 59:1376-83. 2013
    ..We investigated whether sequence artifacts were problematic in amplicon-based massively parallel sequencing and what effect UDG pretreatment had on reducing these artifacts...
  8. doi request reprint DNA methylation biomarkers in cancer: progress towards clinical implementation
    Thomas Mikeska
    Molecular Pathology Research and Development Laboratory, Department of Pathology, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, Melbourne, Victoria 8006, Australia
    Expert Rev Mol Diagn 12:473-87. 2012
    ..Finally, we summarize the current state of clinical implementation for some of the most widely studied and well-validated DNA methylation biomarkers, including SEPT9, VIM, SHOX2, PITX2 and MGMT...