Thomas S Peat

Summary

Country: Australia

Publications

  1. pmc Determination of the structure of the catabolic N-succinylornithine transaminase (AstC) from Escherichia coli
    Janet Newman
    CSIRO Materials, Science and Engineering, Parkville, Australia
    PLoS ONE 8:e58298. 2013
  2. pmc The DINGO dataset: a comprehensive set of data for the SAMPL challenge
    Janet Newman
    CSIRO Division of Materials, Science and Engineering, 343 Royal Parade, Parkville, VIC 3052, Australia
    J Comput Aided Mol Des 26:497-503. 2012
  3. pmc Small molecule inhibitors of the LEDGF site of human immunodeficiency virus integrase identified by fragment screening and structure based design
    Thomas S Peat
    CSIRO Materials, Science and Engineering, Parkville, Victoria, Australia
    PLoS ONE 7:e40147. 2012
  4. pmc Exploring the chemical space around 8-mercaptoguanine as a route to new inhibitors of the folate biosynthesis enzyme HPPK
    Sandeep Chhabra
    Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia
    PLoS ONE 8:e59535. 2013
  5. doi request reprint Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification?
    Jerome Wielens
    St Vincent s Institute, Fitzroy, Victoria, Australia
    J Biomol Screen 18:147-59. 2013
  6. pmc Cyanuric acid hydrolase: evolutionary innovation by structural concatenation
    Thomas S Peat
    CSIRO Materials, Science and Engineering, Parkville, Vic, 3801, Australia
    Mol Microbiol 88:1149-63. 2013
  7. pmc Crystal structure of an indole-3-acetic acid amido synthetase from grapevine involved in auxin homeostasis
    Thomas S Peat
    The Commonwealth Scientific and Industrial Research Organization Materials, Science and Engineering, Parkville, Victoria 3052, Australia
    Plant Cell 24:4525-38. 2012
  8. ncbi request reprint Unprecedented conformational flexibility revealed in the ligand-binding domains of the Bovicola ovis ecdysone receptor (EcR) and ultraspiracle (USP) subunits
    Bin Ren
    CSIRO Materials Science and Engineering, 343 Royal Parade, Parkville, VIC 3052, Australia
    Acta Crystallogr D Biol Crystallogr 70:1954-64. 2014
  9. ncbi request reprint Interrogating HIV integrase for compounds that bind- a SAMPL challenge
    Thomas S Peat
    CSIRO, Parkville, Vic, Australia
    J Comput Aided Mol Des 28:347-62. 2014
  10. pmc Expression, purification, crystallization and preliminary X-ray diffraction analysis of a lactococcal bacteriophage small terminase subunit
    Bin Ren
    Materials Science and Engineering, CSIRO, 343 Royal Parade, Parkville, Victoria 3052, Australia
    Acta Crystallogr Sect F Struct Biol Cryst Commun 69:275-9. 2013

Detail Information

Publications16

  1. pmc Determination of the structure of the catabolic N-succinylornithine transaminase (AstC) from Escherichia coli
    Janet Newman
    CSIRO Materials, Science and Engineering, Parkville, Australia
    PLoS ONE 8:e58298. 2013
    ....
  2. pmc The DINGO dataset: a comprehensive set of data for the SAMPL challenge
    Janet Newman
    CSIRO Division of Materials, Science and Engineering, 343 Royal Parade, Parkville, VIC 3052, Australia
    J Comput Aided Mol Des 26:497-503. 2012
    ..This overview sets out to give the parameters of the experiments done and what might be done differently for future studies...
  3. pmc Small molecule inhibitors of the LEDGF site of human immunodeficiency virus integrase identified by fragment screening and structure based design
    Thomas S Peat
    CSIRO Materials, Science and Engineering, Parkville, Victoria, Australia
    PLoS ONE 7:e40147. 2012
    ..The compounds identified represent a potential framework for the development of a new series of HIV integrase inhibitors that do not bind to the catalytic site of the enzyme...
  4. pmc Exploring the chemical space around 8-mercaptoguanine as a route to new inhibitors of the folate biosynthesis enzyme HPPK
    Sandeep Chhabra
    Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia
    PLoS ONE 8:e59535. 2013
    ....
  5. doi request reprint Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification?
    Jerome Wielens
    St Vincent s Institute, Fitzroy, Victoria, Australia
    J Biomol Screen 18:147-59. 2013
    ..Comparison of hits identified in the two studies highlights a key role for both the conditions under which fragment binding is measured and the criteria selected to classify hits...
  6. pmc Cyanuric acid hydrolase: evolutionary innovation by structural concatenation
    Thomas S Peat
    CSIRO Materials, Science and Engineering, Parkville, Vic, 3801, Australia
    Mol Microbiol 88:1149-63. 2013
    ....
  7. pmc Crystal structure of an indole-3-acetic acid amido synthetase from grapevine involved in auxin homeostasis
    Thomas S Peat
    The Commonwealth Scientific and Industrial Research Organization Materials, Science and Engineering, Parkville, Victoria 3052, Australia
    Plant Cell 24:4525-38. 2012
    ..This suggests a reason for the increased effectiveness of NAA and BTOA as auxins in planta and provides a tool for designing new and effective auxins...
  8. ncbi request reprint Unprecedented conformational flexibility revealed in the ligand-binding domains of the Bovicola ovis ecdysone receptor (EcR) and ultraspiracle (USP) subunits
    Bin Ren
    CSIRO Materials Science and Engineering, 343 Royal Parade, Parkville, VIC 3052, Australia
    Acta Crystallogr D Biol Crystallogr 70:1954-64. 2014
    ..Interestingly, the new USP conformation presents an open, unoccupied ligand-binding pocket. ..
  9. ncbi request reprint Interrogating HIV integrase for compounds that bind- a SAMPL challenge
    Thomas S Peat
    CSIRO, Parkville, Vic, Australia
    J Comput Aided Mol Des 28:347-62. 2014
    ..We have supplied unpublished data related to a drug discovery program run several years ago on HIV integrase for the SAMPL4 challenge. This paper describes the methods used to obtain these data and the chemistry involved. ..
  10. pmc Expression, purification, crystallization and preliminary X-ray diffraction analysis of a lactococcal bacteriophage small terminase subunit
    Bin Ren
    Materials Science and Engineering, CSIRO, 343 Royal Parade, Parkville, Victoria 3052, Australia
    Acta Crystallogr Sect F Struct Biol Cryst Commun 69:275-9. 2013
    ..A self-rotation function calculation revealed that the terminase oligomerizes into an octamer in the asymmetric unit, although size-exclusion chromatography suggests that it is possible for it to form an oligomer of up to 13 subunits...
  11. pmc Crystallization reports are the backbone of Acta Cryst. F, but do they have any spine?
    Janet Newman
    Materials, Science and Engineering Division, CSIRO, 343 Royal Parade, Parkville, VIC 3052, Australia
    Acta Crystallogr Sect F Struct Biol Cryst Commun 69:712-8. 2013
    ....
  12. pmc On the need for an international effort to capture, share and use crystallization screening data
    Janet Newman
    Materials Science and Engineering, CSIRO, 343 Royal Parade, Parkville, VIC 3052, Australia
    Acta Crystallogr Sect F Struct Biol Cryst Commun 68:253-8. 2012
    ..This is brought to the attention of the wider audience of crystallographers so that they are aware of these early efforts and can contribute to the process going forward...
  13. pmc Structure of S. aureus HPPK and the discovery of a new substrate site inhibitor
    Sandeep Chhabra
    Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia
    PLoS ONE 7:e29444. 2012
    ..This work describes a comprehensive analysis of a new HPPK inhibitor, and may provide a foundation for the development of novel antimicrobials targeting the folate biosynthetic pathway...
  14. pmc Structural and functional basis of resistance to neuraminidase inhibitors of influenza B viruses
    Aaron J Oakley
    CSIRO Materials Science and Engineering, Parkville, 343 Royal Parade, Parkville, Victoria, 3052, Australia
    J Med Chem 53:6421-31. 2010
    ..Lack of the E275 rotation would also account for the loss of slow binding and the partial resistance of influenza B wild type NAs to oseltamivir...
  15. pmc Crystallization of an apo form of human arginase: using all the tools in the toolbox simultaneously
    Janet Newman
    Materials Science and Engineering, CSIRO, 343 Royal Parade, Parkville, VIC 3052, Australia
    Acta Crystallogr Sect F Struct Biol Cryst Commun 67:90-3. 2011
    ..The crystals belonged to space group P2(1)2(1)2(1) and have approximate unit-cell parameters a=53, b=67.5, c=250 Å. The crystals showed slightly anisotropic diffraction to beyond 2.0 Å resolution...
  16. doi request reprint Nitrate in the active site of protein tyrosine phosphatase 1B is a putative mimetic of the transition state
    Peter W Kenny
    CSIRO Materials, Science and Engineering, 343 Royal Parade, Parkville, VIC 3052, Australia
    Acta Crystallogr D Biol Crystallogr 70:565-71. 2014
    ..Nitrate was observed bound to each protomer, making close contacts with the S atom of the catalytic cysteine and a tyrosine residue from a crystallographically related protomer. ..